公开(公告)号：US20160038600A1

公开(公告)日：2016-02-11

申请号：US14595865

申请日：2015-01-13

Applicant: NEONC TECHNOLOGIES INC.

Inventor： Thomas Chen ,  Daniel Levin ,  Satish Pupalli

IPC: A61K47/48 ,  A61N5/10 ,  A61K45/06 ,  A61K31/4015 ,  A61K9/00

CPC classification number: A61K45/06 ,  A61K9/0043 ,  A61K31/4015 ,  A61K31/415 ,  A61K47/54 ,  A61K47/55 ,  A61N5/10 ,  C07D207/26 ,  C07D231/12 ,  C07D487/04

Abstract: The present invention provides for a perillyl alcohol (POH) carbamate, such as POH-Rolipram. The present invention also provides for a method of treating a disease such as cancer, by delivering to a patient a therapeutically effective amount of POH-Rolipram.

Abstract translation: 本发明提供了诸如POH-Rolipram的珀维醇（POH）氨基甲酸酯。 本发明还提供了通过向患者递送治疗有效量的POH-咯利普兰来治疗疾病如癌症的方法。

公开(公告)号：US20140364472A1

公开(公告)日：2014-12-11

申请号：US14455371

申请日：2014-08-08

Applicant: NEONC TECHNOLOGIES INC.

Inventor： Thomas Chen ,  Daniel Levin ,  Satish Pupalli

IPC: A61K47/48 ,  A61K31/495 ,  A61N5/10 ,  A61K45/06

CPC classification number: C07C33/14 ,  A61K9/0043 ,  A61K31/045 ,  A61K31/4015 ,  A61K31/415 ,  A61K31/4188 ,  A61K31/495 ,  A61K45/06 ,  A61K47/54 ,  A61K47/542 ,  A61K47/543 ,  A61N5/10 ,  C07B59/00 ,  C07B2200/05 ,  C07C2601/16 ,  C07D207/26 ,  C07D231/12 ,  C07D487/04

Abstract: The present invention provides for a derivative of monoterpene or sesquiterpene, such as a perillyl alcohol derivative. For example, the perillyl alcohol derivative may be a perillyl alcohol carbamate. The perillyl alcohol derivative may be perillyl alcohol conjugated with a therapeutic agent such as a chemotherapeutic agent. The present invention also provides for a method of treating a disease such as cancer, comprising the step of delivering to a patient a therapeutically effective amount of a derivative of monoterpene (or sesquiterpene). The route of administration may vary, and can include, inhalation, intranasal, oral, transdermal, intravenous, subcutaneous or intramuscular injection.

Abstract translation: 本发明提供单萜或倍半萜衍生物，例如芳香醇衍生物。 例如，紫苏醇衍生物可以是芳族醇氨基甲酸酯。 紫苏醇衍生物可以是与治疗剂如化学治疗剂缀合的紫苏醇。 本发明还提供了治疗诸如癌症的疾病的方法，其包括向患者递送治疗有效量的单萜（或倍半萜烯）衍生物的步骤。 给药途径可以变化，并且可以包括吸入，鼻内，口服，透皮，静脉内，皮下或肌内注射。

公开(公告)号：US11013804B2

公开(公告)日：2021-05-25

申请号：US16388535

申请日：2019-04-18

Applicant: NeOnc Technologies, Inc.

Inventor： Thomas Chen ,  Daniel Levin ,  Satish Pupalli

IPC: A61K45/06 ,  A61K31/4015 ,  A61K9/00 ,  A61K31/415 ,  C07D487/04 ,  C07D231/12 ,  C07D207/26 ,  A61K47/54 ,  A61K47/55 ,  A61N5/10

Abstract: The present invention provides for a perillyl alcohol (POH) carbamate, such as POH-Rolipram. The present invention also provides for a method of treating a disease such as cancer, by delivering to a patient a therapeutically effective amount of POH-Rolipram.

公开(公告)号：US20170190710A1

公开(公告)日：2017-07-06

申请号：US15462553

申请日：2017-03-17

Applicant: NEONC TECHNOLOGIES INC.

Inventor： Thomas Chen ,  Daniel Levin ,  Satish Puppali

IPC: C07D487/04 ,  C07D231/12

CPC classification number: C07D487/04 ,  C07D231/12

Abstract: A pharmaceutical composition is provided which includes perillyl alcohol conjugated with a therapeutic agent and further includes and a hydrolyzable acylated aliphatic tail. A method of using the pharmaceutical composition is also provided for treating a condition or disease of a patient, e.g., cancer.

公开(公告)号：US09498448B2

公开(公告)日：2016-11-22

申请号：US14843097

申请日：2015-09-02

Applicant: NEONC Technologies, Inc.

Inventor： Thomas Chen ,  Daniel Levin ,  Satish Puppali

IPC: C07C35/18 ,  A61K31/045 ,  C07C29/92 ,  C07C67/14 ,  C07C201/12 ,  C07C29/78 ,  C07C29/88 ,  C07C201/16 ,  A61K31/4188 ,  A61K45/06 ,  A61N5/10

CPC classification number: C07C29/92 ,  A61K31/045 ,  A61K31/4188 ,  A61K45/06 ,  A61N5/10 ,  C07B2200/07 ,  C07C29/78 ,  C07C29/86 ,  C07C29/88 ,  C07C67/14 ,  C07C201/12 ,  C07C201/16 ,  C07C2601/16 ,  C07C33/14 ,  C07C205/57 ,  C07C69/76 ,  C07C69/92

Abstract: The present invention provides a process for purifying a monoterpene or sesquiterpene having a purity greater than about 98.5% (w/w). The process comprises the steps of derivatizing the monoterpene (or sesquiterpene) to produce a monoterpene (or sesquiterpene) derivative, separating the monoterpene (or sesquiterpene) derivative, and releasing the monoterpene (or sesquiterpene) from the derivative. Also encompassed by the scope of the present invention is a pharmaceutical composition comprising a monoterpene (or sesquiterpene) having a purity greater than about 98.5% (w/w). The purified monoterpene can be used to treat a disease such as cancer. The present monoterpene (or sesquiterpene) may be administered alone, or may be co-administered with radiation or other therapeutic agents, such as chemotherapeutic agents.

公开(公告)号：US09480659B2

公开(公告)日：2016-11-01

申请号：US14817286

申请日：2015-08-04

Applicant: NEONC Technologies, Inc.

Inventor： Thomas Chen ,  Daniel Levin ,  Satish Puppali

IPC: C07C35/18 ,  A61K31/045 ,  C07C29/92 ,  C07C67/14 ,  C07C201/12 ,  C07C29/78 ,  C07C29/88 ,  C07C201/16 ,  A61K31/4188 ,  A61K45/06 ,  A61N5/10

CPC classification number: C07C29/92 ,  A61K31/045 ,  A61K31/4188 ,  A61K45/06 ,  A61N5/10 ,  C07B2200/07 ,  C07C29/78 ,  C07C29/86 ,  C07C29/88 ,  C07C67/14 ,  C07C201/12 ,  C07C201/16 ,  C07C2601/16 ,  C07C33/14 ,  C07C205/57 ,  C07C69/76 ,  C07C69/92

Abstract: The present invention provides a process for purifying a monoterpene or sesquiterpene having a purity greater than about 98.5% (w/w). The process comprises the steps of derivatizing the monoterpene (or sesquiterpene) to produce a monoterpene (or sesquiterpene) derivative, separating the monoterpene (or sesquiterpene) derivative, and releasing the monoterpene (or sesquiterpene) from the derivative. Also encompassed by the scope of the present invention is a pharmaceutical composition comprising a monoterpene (or sesquiterpene) having a purity greater than about 98.5% (w/w). The purified monoterpene can be used to treat a disease such as cancer. The present monoterpene (or sesquiterpene) may be administered alone, or may be co-administered with radiation or other therapeutic agents, such as chemotherapeutic agents.

公开(公告)号：US20160304528A1

公开(公告)日：2016-10-20

申请号：US15192126

申请日：2016-06-24

Applicant: NEONC TECHNOLOGIES INC.

Inventor： Thomas Chen ,  Daniel Levin ,  Satish Pupalli

IPC: C07D487/04 ,  C07D231/12

CPC classification number: C07D487/04 ,  C07D231/12

Abstract: A pharmaceutical composition is provided which includes perillyl alcohol conjugated with a therapeutic agent and further includes and a hydrolyzable acylated aliphatic tail. A method of using the pharmaceutical composition is also provided for treating a condition or disease of a patient, e.g., cancer.

Abstract translation: 提供一种药物组合物，其包含与治疗剂缀合的紫苏醇，并​​且还包括可水解的酰化脂肪族尾巴。 还提供使用该药物组合物的方法来治疗患者的病症或疾病，例如癌症。

公开(公告)号：US09133085B2

公开(公告)日：2015-09-15

申请号：US13939834

申请日：2013-07-11

Applicant: Neonc Technologies, Inc.

Inventor： Thomas Chen ,  Daniel Levin ,  Satish Puppali

IPC: C07C35/18 ,  C07C29/78 ,  A61K31/045 ,  C07C29/92 ,  C07C67/14 ,  C07C201/12

CPC classification number: C07C29/92 ,  A61K31/045 ,  A61K31/4188 ,  A61K45/06 ,  A61N5/10 ,  C07B2200/07 ,  C07C29/78 ,  C07C29/86 ,  C07C29/88 ,  C07C67/14 ,  C07C201/12 ,  C07C201/16 ,  C07C2601/16 ,  C07C33/14 ,  C07C205/57 ,  C07C69/76 ,  C07C69/92

Abstract: The present invention provides a process for purifying a monoterpene or sesquiterpene having a purity greater than about 98.5% (w/w). The process comprises the steps of derivatizing the monoterpene (or sesquiterpene) to produce a monoterpene (or sesquiterpene) derivative, separating the monoterpene (or sesquiterpene) derivative, and releasing the monoterpene (or sesquiterpene) from the derivative. Also encompassed by the scope of the present invention is a pharmaceutical composition comprising a monoterpene (or sesquiterpene) having a purity greater than about 98.5% (w/w). The purified monoterpene can be used to treat a disease such as cancer. The present monoterpene (or sesquiterpene) may be administered alone, or may be co-administered with radiation or other therapeutic agents, such as chemotherapeutic agents.

Abstract translation: 本发明提供纯化大于约98.5％（w / w）的单萜或倍半萜的方法。 该方法包括衍生单萜（或倍半萜烯）以产生单萜（或倍半萜烯）衍生物，分离单萜（或倍半萜烯）衍生物和从衍生物中释放单萜（或倍半萜烯）的步骤。 包括本发明范围的药物组合物是包含纯度大于约98.5％（w / w）的单萜（或倍半萜烯）的药物组合物。 纯化的单萜可用于治疗癌症等疾病。 本单萜（或倍半萜烯）可以单独施用，或者可以与辐射或其它治疗剂如化学治疗剂共同施用。

公开(公告)号：US11559508B2

公开(公告)日：2023-01-24

申请号：US16606520

申请日：2018-04-18

Applicant: NEONC TECHNOLOGIES, INC.

Inventor： Thomas Chen ,  Daniel Levin ,  Satish Puppali

IPC: A61K31/20 ,  A61K47/55 ,  A61K9/00 ,  A61K31/045 ,  A61K45/06

Abstract: The present invention provides for a method of treating a disease such as cancer, comprising the step of administering to a patient a therapeutically effective amount of a perillyl alcohol derivative such as a perillyl alcohol ester, or an isoperillyl alcohol derivative such as an isoperillyl alcohol ester. The derivative may be a perillyl alcohol or an isoperillyl alcohol conjugated with a therapeutic agent such as valproic acid. The route of administration may vary, including inhalation, intranasal, oral, transdermal, intravenous, subcutaneous or intramuscular injection.

公开(公告)号：US11147809B2

公开(公告)日：2021-10-19

申请号：US16313388

申请日：2017-06-30

Applicant: NeOnc Technologies, Inc.

Inventor： Thomas Chen

IPC: A61K31/495 ,  C07D231/12 ,  A61K31/4188 ,  A61K47/54 ,  C07B59/00 ,  A61K31/4015 ,  A61K9/00 ,  A61K31/045 ,  A61K31/415 ,  C07D207/26 ,  C07C33/14 ,  C07D487/04 ,  A61K45/06 ,  A61N5/10 ,  A61K31/635 ,  A61K47/55 ,  A61K31/366

Abstract: The present methods treat neurofibromatosis by a administering to a subject perillyl alcohol or iso-perillyl alcohol. The present methods also treat neurofibromatosis by administering to a subject a carbamate of perillyl alcohol, or a carbamate of iso-perillyl alcohol. The perillyl alcohol carbamate may comprise perillyl alcohol conjugated with rolipram or temozolomide.