公开(公告)号：US20220135806A1

公开(公告)日：2022-05-05

申请号：US17429975

申请日：2020-02-12

Applicant: NISSAN CHEMICAL CORPORATION

Inventor： Miya HIROI ,  Yoshiomi HIROI ,  Kohei SUZUKI ,  Takeaki SHOJI ,  Natsuki ABE ,  Hiroyuki NAKAJIMA

IPC: C09D4/00 ,  C08F220/28 ,  C08F220/36 ,  C08F220/34 ,  C09D133/14 ,  C12N5/073

Abstract: The invention provides a method for producing a copolymer-containing varnish using a monomer having a specific unsaturated bond which does not cause the problem of gelation, a method for producing a composition, a method for producing a coating film, preferably compatible with biomaterials. The method for producing a copolymer-containing varnish comprises copolymerizing a monomer mixture containing compounds of formulas (1) and (2): wherein R1 represents a hydrogen atom or a methyl group, R2 represents an alkylene group having 1 to 6 carbon atoms, n represents an integer of 1 to 30, R11 represents a hydrogen atom or a methyl group, and A1 represents a monovalent organic group having a cationic property, in a solvent for polymerization, in the presence of a radical polymerization initiator, wherein % by mass of the compound of formula (1) in a phosphorus-containing compound contained in the monomer mixture is 70% by mass or more.

公开(公告)号：US20210254055A1

公开(公告)日：2021-08-19

申请号：US16484064

申请日：2018-02-06

Applicant: NISSAN CHEMICAL CORPORATION

Inventor： Yusuke IRIYAMA ,  Hiroyuki NAKAJIMA ,  Tatsuro KANAKI ,  Masatoshi NIWA

IPC: C12N15/113 ,  A61K31/7088

Abstract: The invention provides a single-stranded oligonucleotide represented by the formula (I), wherein X and Y hybridize by a first nucleotide sequence portion and a second nucleotide sequence portion. X is composed of 7 to 100 nucleotides, contains at least one modified-nucleotide, and has a first nucleotide sequence capable of hybridizing with a second oligonucleotide. Y is composed of 4 to 100 nucleotides, enables hybridization with the above-mentioned first oligonucleotide, and has a second nucleotide sequence containing at least one ribonucleotide. At least one of the nucleotide sequences X, Xz and Y has an antisense sequence capable of hybridizing with a target RNA. At least one of L, Lx and Ly is a linking group that contains a non-nucleotide structure.

公开(公告)号：US20210054377A1

公开(公告)日：2021-02-25

申请号：US16982448

申请日：2019-03-20

Applicant: TOKYO INSTITUTE OF TECHNOLOGY ,  NISSAN CHEMICAL CORPORATION

Inventor： Yoshiaki MASAKI ,  Kohji SEIO ,  Atsushi INOUE ,  Yusuke IRIYAMA ,  Tatsuro KANAKI ,  Hiroyuki NAKAJIMA

IPC: C12N15/113 ,  A61K31/7125

Abstract: The invention provides an antisense oligonucleotide reduced in toxicity. The antisense oligonucleotide has a central region, a 5′-side region and a 3′-side region, wherein the central region has a nucleotide (2′-3′ bridged nucleotide) in which the 2′-position and the 3′-position of a sugar moiety are bridged and/or a non-bridged nucleotide (3′-position-modified non-bridged nucleotide) having a substituent at the 3′-position.

公开(公告)号：US20250011602A1

公开(公告)日：2025-01-09

申请号：US18706247

申请日：2022-11-02

Applicant: NISSAN CHEMICAL CORPORATION

Inventor： Yuki UEDA ,  Yoshiomi HIROI ,  Kohei SUZUKI ,  Miya HIROI ,  Hiroyuki NAKAJIMA ,  Hitoshi SASATSUKI

IPC: C09D5/16 ,  A61J1/05 ,  C08F220/28 ,  C09D133/14

Abstract: The invention provides a composition for forming a coating film which comprises (1) a polymer of a monomer mixture containing monomers represented by the following formulae (A) to (D): (wherein Ta, Tb, Tc, Td, Ua1, Ua2, Ub1, Ub2, Ub3, Qa, Qb, Qc, Ra, Rb, Rc, Rd, An−, m and n are as defined herein), where a ratio of a total of the anionic monomer represented by the above-mentioned formula (A) and the cationic monomer represented by the above-mentioned formula (B) based on total monomers contained in the monomer mixture is 40 mol % or more, and (2) a polycarbodiimide containing a structure represented by the following formula (E): —N═C═N—  (E) a coating film which is a cured product thereof and a process for producing the same, and a cured product and a process for producing the same.

公开(公告)号：US20220144775A1

公开(公告)日：2022-05-12

申请号：US17427070

申请日：2020-01-30

Applicant: NISSAN CHEMICAL CORPORATION

Inventor： Taito NISHINO ,  Ayako AIHARA ,  Keiichiro OTSUKA ,  Takumi IWAWAKI ,  Takumi MIKASHIMA ,  Masahiro KAMAURA ,  Natsuki FUKASAWA ,  Hiroyuki NAKAJIMA ,  Yukihiro SHIGETA ,  Toshimasa IWAMOTO

IPC: C07D213/40 ,  C07D213/65 ,  C07D213/74 ,  C07D215/38 ,  C07D231/56 ,  C07D235/08 ,  C07D239/42 ,  C07D241/42 ,  C07D307/52 ,  C07D333/20 ,  A61P1/16

Abstract: The present invention aims to provide a novel compound capable of promoting cell proliferation in a cell culture (particularly three-dimensional cell culture). The hydrazide compound represented by the formula (I); wherein each symbol is as defined in DESCRIPTION, or a salt thereof, and a composition containing same can remarkably promote cell proliferation, sphere formation, cyst formation and/or organoid formation, and can also remarkably inhibit the activities of kinase such as LATS1, LATS2 and the like.

公开(公告)号：US20190327959A1

公开(公告)日：2019-10-31

申请号：US16310325

申请日：2017-06-09

Applicant: NISSAN CHEMICAL CORPORATION

Inventor： Yoshiomi HIROI ,  Hiroyuki NAKAJIMA ,  Taito NISHINO

IPC: A01N1/02 ,  C09D143/02

Abstract: An object of the present invention is to provide a cryopreservation vessel which has a coating that is capable of inhibiting the adhesion of cells or proteins and is resistant not only to aqueous solvents but also to organic solvents (for example, cryoprotectants, in particular, dimethyl sulfoxide). The invention provides a cell or protein cryopreservation vessel including, on at least a portion of the surface thereof, a coating that includes a repeating unit containing a group represented by the following formula (a), and a repeating unit containing a group represented by the following formula (b) (wherein Ua1, Ua2, Ua3, Ub1, Ub2, Ub3 and An− are as defined in the description and the claims)