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17 条记录 (耗时 0.023 秒)

    Automatic analyzer
    12.
    发明授权
    Automatic analyzer 有权
    自动分析仪

    公开(公告)号：US08741218B2

    公开(公告)日：2014-06-03

    申请号：US13145346

    申请日：2009-12-14

    申请人： Michihiro Saito

    发明人： Michihiro Saito

    IPC分类号： G01N33/00

    CPC分类号： G01N21/6428 ,  G01N2021/6439 ,  G01N2035/0097

    摘要： An analytic method uses a labeled antigen, labeled antibody, tracer, etc. in which a radio isotope, fluorescent dye, luminescent dye, enzyme, etc. is bonded to an antibody or an antigen bonded to a protein as an object of analysis for performing an assay of a trace amount of a substance such as a hormone, tumor marker, infective pathogen marker, infective antibody, etc., for blood, serum, plasma, or body fluid as a sample or specimen. The analysis is enabled at high sensitivity, with less generation of noises and at low background. When an assay is performed based on the antigen-antibody reaction for a sample in an analytic method by fluorometry or luminometry, detection or measurement of non-specific fluorescence or luminescence such as interference light is eliminated or removed effectively irrespective of the property of the sample or the level of the concentration of substances contained in the sample.

    摘要翻译： 分析方法使用标记的抗原，标记的抗体，示踪剂等，其中放射性同位素，荧光染料，发光染料，酶等与抗体或与蛋白质结合的抗原结合作为分析对象进行 作为样品或样品的血液，血清，血浆或体液的微量物质如激素，肿瘤标志物，感染性病原体标志物，感染性抗体等的测定。 该分析能够在高灵敏度下实现，噪声产生较少，背景较差。 当通过荧光测定或发光测定法在分析方法中基于样品的抗原 - 抗体反应进行测定时，检测或测量非特异性荧光或发光如干涉光，无论样品的性质如何，均可有效地消除或去除 或样品中所含物质的浓度水平。

    Immunological analyzing apparatus and immunological analyzing method
    13.
    发明授权
    Immunological analyzing apparatus and immunological analyzing method 有权
    免疫分析仪器及免疫分析方法

    公开(公告)号：US07001730B2

    公开(公告)日：2006-02-21

    申请号：US10092914

    申请日：2002-03-08

    申请人： Michihiro Saito ,  Kazuhiro Tanaka

    发明人： Michihiro Saito ,  Kazuhiro Tanaka

    IPC分类号： G01N33/53 ,  G01N21/01 ,  G01N35/02 ,  G01N35/10

    CPC分类号： G01N33/54333 ,  G01N35/025 ,  G01N35/10 ,  G01N35/1004 ,  G01N2035/00534 ,  G01N2035/00564 ,  G01N2035/0441 ,  G01N2035/0443 ,  G01N2035/0444 ,  G01N2035/0453 ,  Y10T436/113332 ,  Y10T436/115831

    摘要： An immunological analyzing apparatus and method using fine particles bonded with an antigen or an antibody are provided which are capable of obtaining a good analysis result with preferable reproducibility with no effect of carry-over.The immunological apparatus includes plural reagent vessels for containing plural kinds of liquid reagents in which fine particles bonded with an antigen or an antibody are suspended, a stirring vessel for stirring the liquid reagent, a probe for dispensing the liquid reagent, a reaction vessel for mixing and reacting the liquid reagent and a specimen, a measuring device for measuring the reaction in the reaction vessel, and a mechanism for determining as to whether or not the liquid reagent in the reagent vessel is to be stirred prior to dispensing of the liquid reagent in the reagent vessel to the reaction vessel, based on the information regarding the predetermined stirring time interval and the information regarding the carry-over between each of plural kinds of liquid reagents.

    摘要翻译： 提供了使用与抗原或抗体结合的细粒子的免疫学分析装置和方法，其能够以优异的再现性获得良好的分析结果，而没有遗留的影响。

    Automated analyzer and automated analysis
    14.
    发明授权
    Automated analyzer and automated analysis 有权
    自动分析仪和自动分析

    公开(公告)号：US06635488B1

    公开(公告)日：2003-10-21

    申请号：US09598048

    申请日：2000-06-21

    申请人： Michihiro Saito ,  Koshin Tagami

    发明人： Michihiro Saito ,  Koshin Tagami

    IPC分类号： G01N3502

    CPC分类号： G01N35/00594 ,  G01N35/00603 ,  G01N2035/00702 ,  G01N2035/0472 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/114998

    摘要： An automated analyzer which analyzes a sample which might have been affected by carryover, judges the effect of carryover from the analytical value, and indicates the result. The automated analyzer also performs analysis on a specific inspection item necessary for a sample which might have been affected by carryover from its preceding sample and modifies the result of analysis of said sample according to the analytical value.

    摘要翻译： 分析可能受到遗留影响的样本的自动分析仪，从分析值判断结转的影响，并指示结果。 自动分析仪还对可能受到前一样品残留影响的样品所需的特定检查项目进行分析，并根据分析值修改所述样品的分析结果。

    CHEMICAL ANALYSIS DEVICE
    15.
    发明申请
    CHEMICAL ANALYSIS DEVICE 审中-公开
    化学分析装置

    公开(公告)号：US20090016931A1

    公开(公告)日：2009-01-15

    申请号：US12169968

    申请日：2008-07-09

    申请人： Taisaku Seino ,  Hiroshi Umetsu ,  Michihiro Saito ,  Takayuki Kanda ,  Kumiko Hattori

    发明人： Taisaku Seino ,  Hiroshi Umetsu ,  Michihiro Saito ,  Takayuki Kanda ,  Kumiko Hattori

    IPC分类号： G01N35/10 ,  B01L3/02

    CPC分类号： G01N35/10 ,  B01L3/502 ,  G01N2035/103 ,  G01N2035/1051 ,  G01N2035/1062

    摘要： A chemical analysis device capable of suppressing deterioration of analysis and test accuracy while avoiding contamination by residual samples or reagents and having no complicated configuration is constructed.A pipetting unit is equipped with a syringe, plunger, and needle unit in which a carrier for capturing nucleic acid and a detection cell is mounted on the needle unit. A pipetting unit drive system is configured so that the pipetting unit is detachable. After the detection cell is removed from the pipetting unit and fixed to a nucleic acid amplification detection unit, a suction/dispensing operation of samples/reagents is performed by the pipetting unit and components to be measured are captured by the carrier. Captured components are measured after being dispensed into the detection cell fixed to the nucleic acid amplification detection unit. Then, the detection cell is taken out from the nucleic acid amplification detection unit while mounted on the pipetting unit and the whole pipetting unit is removed from the pipetting unit drive system.

    摘要翻译： 能够抑制分析和测试精度恶化的化学分析装置，同时避免残留的样品或试剂的污染并且没有复杂的结构。 移液单元配备有注射器，柱塞和针单元，其中用于捕获核酸的载体和检测单元安装在针单元上。 移液单元驱动系统被构造成使得移液单元可拆卸。 在从移液单元取出检测单元并固定在核酸扩增检测单元上之后，通过移液单元进行样品/试剂的抽吸/分注操作，由载体捕获要测量的成分。 在分配到固定在核酸扩增检测单元上的检测单元之后，测量捕获的成分。 然后，在安装在移液单元上的情况下，从核酸扩增检测单元取出检测单元，从移液单元驱动系统中取出整个移液单元。

    Luminous compounds and labeling reagents using the same
    17.
    发明授权
    Luminous compounds and labeling reagents using the same 有权
    发光化合物和使用其的标记试剂

    公开(公告)号：US07154007B2

    公开(公告)日：2006-12-26

    申请号：US10491788

    申请日：2002-10-10

    申请人： Michihiro Saito ,  Ernoe Pretsch

    发明人： Michihiro Saito ,  Ernoe Pretsch

    IPC分类号： C07C319/00 ,  C07C49/00 ,  C07C231/00 ,  C07C233/00 ,  G01N33/566

    CPC分类号： C07D333/24 ,  C07C45/455 ,  C07C45/46 ,  C07C45/68 ,  C07C45/71 ,  C07C49/80 ,  C07C49/813 ,  C07C49/84 ,  C07C225/22 ,  C07C323/22 ,  C07C2601/14 ,  G01N2458/40 ,  C07C49/782 ,  C07C49/784

    摘要： This invention provides: a compound represented by formula (I): R—Y—(—X-Phe-COCH2COCnF2n+1)m   (I) wherein R denotes hydrogen, alkyl, phenyl, or a group capable of binding to a protein, peptide, amino acid, nucleic acid, or nucleotide; Y denotes CH2, a carbocyclic ring, or a heterocyclic ring; X denotes O, S, NH, CH2, OCH2, CONH, or NHCO; Phe denotes phenylene; n is an integer between 1 and 5; and m is 1, 2, or 3. This inventions also provides a luminous complex of such compound and a rare earth ion, a labeling reagent comprising such compound or luminous complex, and a process for labeling a protein, peptide, amino acid, nucleic acid, or nucleotide using such labeling reagent.

    摘要翻译： 本发明提供：式（I）表示的化合物：<？in-line-formula description =“In-line formula”end =“lead”→RY-（-X-Phe-COCH 2） （I）<？in-line-formula description =“在线公式”结束 =“尾”→其中R表示氢，烷基，苯基或能够结合蛋白质，肽，氨基酸，核酸或核苷酸的基团; Y表示CH 2 2，碳环或杂环; X表示O，S，NH，CH 2，OCH 2，CONH或NHCO; Phe表示亚苯基; n是1和5之间的整数; 本发明还提供了这种化合物和稀土离子的发光配合物，包含这种化合物或发光络合物的标记试剂，以及标记蛋白质，肽，氨基酸，核酸的方法 酸或核苷酸。