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    Luminous compounds and labeling reagents using the same
    1.
    发明授权
    Luminous compounds and labeling reagents using the same 有权
    发光化合物和使用其的标记试剂

    公开(公告)号：US07154007B2

    公开(公告)日：2006-12-26

    申请号：US10491788

    申请日：2002-10-10

    Applicant: Michihiro Saito ,  Ernoe Pretsch

    Inventor： Michihiro Saito ,  Ernoe Pretsch

    IPC: C07C319/00 ,  C07C49/00 ,  C07C231/00 ,  C07C233/00 ,  G01N33/566

    CPC classification number: C07D333/24 ,  C07C45/455 ,  C07C45/46 ,  C07C45/68 ,  C07C45/71 ,  C07C49/80 ,  C07C49/813 ,  C07C49/84 ,  C07C225/22 ,  C07C323/22 ,  C07C2601/14 ,  G01N2458/40 ,  C07C49/782 ,  C07C49/784

    Abstract: This invention provides: a compound represented by formula (I): R—Y—(—X-Phe-COCH2COCnF2n+1)m   (I) wherein R denotes hydrogen, alkyl, phenyl, or a group capable of binding to a protein, peptide, amino acid, nucleic acid, or nucleotide; Y denotes CH2, a carbocyclic ring, or a heterocyclic ring; X denotes O, S, NH, CH2, OCH2, CONH, or NHCO; Phe denotes phenylene; n is an integer between 1 and 5; and m is 1, 2, or 3. This inventions also provides a luminous complex of such compound and a rare earth ion, a labeling reagent comprising such compound or luminous complex, and a process for labeling a protein, peptide, amino acid, nucleic acid, or nucleotide using such labeling reagent.

    Abstract translation: 本发明提供：式（I）表示的化合物：<？in-line-formula description =“In-line formula”end =“lead”→RY-（-X-Phe-COCH 2） （I）<？in-line-formula description =“在线公式”结束 =“尾”→其中R表示氢，烷基，苯基或能够结合蛋白质，肽，氨基酸，核酸或核苷酸的基团; Y表示CH 2 2，碳环或杂环; X表示O，S，NH，CH 2，OCH 2，CONH或NHCO; Phe表示亚苯基; n是1和5之间的整数; 本发明还提供了这种化合物和稀土离子的发光配合物，包含这种化合物或发光络合物的标记试剂，以及标记蛋白质，肽，氨基酸，核酸的方法 酸或核苷酸。

    AUTOMATIC ANALYZER
    3.
    发明申请
    AUTOMATIC ANALYZER 有权
    自动分析仪

    公开(公告)号：US20110293473A1

    公开(公告)日：2011-12-01

    申请号：US13145346

    申请日：2009-12-14

    Applicant: Michihiro Saito

    Inventor： Michihiro Saito

    IPC: G01N21/76

    CPC classification number: G01N21/6428 ,  G01N2021/6439 ,  G01N2035/0097

    Abstract: An analytic method uses a labeled antigen, labeled antibody, tracer, etc. in which a radio isotope, fluorescent dye, luminescent dye, enzyme, etc. is bonded to an antibody or an antigen bonded to a protein as an object of analysis for performing an assay of a trace amount of a substance such as a hormone, tumor marker, infective pathogen marker, infective antibody, etc., for blood, serum, plasma, or body fluid as a sample or specimen. The analysis is enabled at high sensitivity, with less generation of noises and at low background. When an assay is performed based on the antigen-antibody reaction for a sample in an analytic method by fluorometry or luminometry, detection or measurement of non-specific fluorescence or luminescence such as interference light is eliminated or removed effectively irrespective of the property of the sample or the level of the concentration of substances contained in the sample.

    Abstract translation: 分析方法使用标记的抗原，标记的抗体，示踪剂等，其中放射性同位素，荧光染料，发光染料，酶等与抗体或与蛋白质结合的抗原结合作为分析对象进行 作为样品或样品的血液，血清，血浆或体液的微量物质如激素，肿瘤标志物，感染性病原体标志物，感染性抗体等的测定。 该分析能够在高灵敏度下实现，噪声产生较少，背景较差。 当通过荧光测定或发光测定法在分析方法中基于样品的抗原 - 抗体反应进行测定时，检测或测量非特异性荧光或发光如干涉光，无论样品的性质如何，均可有效地消除或去除 或样品中所含物质的浓度水平。

    Automatic analyzer
    7.
    发明授权
    Automatic analyzer 有权
    自动分析仪

    公开(公告)号：US08741218B2

    公开(公告)日：2014-06-03

    申请号：US13145346

    申请日：2009-12-14

    Applicant: Michihiro Saito

    Inventor： Michihiro Saito

    IPC: G01N33/00

    CPC classification number: G01N21/6428 ,  G01N2021/6439 ,  G01N2035/0097

    Abstract: An analytic method uses a labeled antigen, labeled antibody, tracer, etc. in which a radio isotope, fluorescent dye, luminescent dye, enzyme, etc. is bonded to an antibody or an antigen bonded to a protein as an object of analysis for performing an assay of a trace amount of a substance such as a hormone, tumor marker, infective pathogen marker, infective antibody, etc., for blood, serum, plasma, or body fluid as a sample or specimen. The analysis is enabled at high sensitivity, with less generation of noises and at low background. When an assay is performed based on the antigen-antibody reaction for a sample in an analytic method by fluorometry or luminometry, detection or measurement of non-specific fluorescence or luminescence such as interference light is eliminated or removed effectively irrespective of the property of the sample or the level of the concentration of substances contained in the sample.

    Abstract translation: 分析方法使用标记的抗原，标记的抗体，示踪剂等，其中放射性同位素，荧光染料，发光染料，酶等与抗体或与蛋白质结合的抗原结合作为分析对象进行 作为样品或样品的血液，血清，血浆或体液的微量物质如激素，肿瘤标志物，感染性病原体标志物，感染性抗体等的测定。 该分析能够在高灵敏度下实现，噪声产生较少，背景较差。 当通过荧光测定或发光测定法在分析方法中基于样品的抗原 - 抗体反应进行测定时，检测或测量非特异性荧光或发光如干涉光，无论样品的性质如何，均可有效地消除或去除 或样品中所含物质的浓度水平。

    Chemical analysis apparatus and chemical analysis cartridge
    8.
    发明申请
    Chemical analysis apparatus and chemical analysis cartridge 有权
    化学分析仪和化学分析盒

    公开(公告)号：US20060153735A1

    公开(公告)日：2006-07-13

    申请号：US11319977

    申请日：2005-12-29

    Applicant: Yoshihiro Nagaoka ,  Nobuyuki Maki ,  Noriyo Nishijima ,  Michihiro Saito ,  Hiroki Ihara

    Inventor： Yoshihiro Nagaoka ,  Nobuyuki Maki ,  Noriyo Nishijima ,  Michihiro Saito ,  Hiroki Ihara

    IPC: G01N31/22 ,  G01N35/00

    CPC classification number: G01N21/07 ,  G01N35/025 ,  G01N2035/00148 ,  G01N2035/00495 ,  Y10T436/11 ,  Y10T436/111666 ,  Y10T436/25

    Abstract: A chemical analysis apparatus comprises a motor, a holding disk that can be rotated by the motor, a plurality of examination cartridges arranged on the holding disk, a perforator that perforates the examination cartridges, a heating device, and a detection device. The examination cartridge comprises a substrate including a vessel and a flow channel, which are defined by recesses, and a cover that covers the vessel and the flow channel. A centrifugal force generated by rotation of the holding disk is made use of to move a solution from a vessel on an inner peripheral side relative to an axis of rotation to a vessel on an outer peripheral side relative to the axis of rotation through the flow channel.

    Abstract translation: 化学分析装置包括电动机，可由电动机旋转的保持盘，设置在保持盘上的多个检查盒，对检查筒进行穿孔的穿孔器，加热装置和检测装置。 检查筒包括由凹部限定的容器和流路的基板和覆盖容器和流路的盖。 通过保持盘的旋转而产生的离心力用于将溶液从相对于旋转轴线的内周侧的容器移动到通过流动通道相对于旋转轴线的外周侧上的容器 。

    Immunological analyzing apparatus and immunological analyzing method
    9.
    发明授权
    Immunological analyzing apparatus and immunological analyzing method 有权
    免疫分析仪器及免疫分析方法

    公开(公告)号：US07001730B2

    公开(公告)日：2006-02-21

    申请号：US10092914

    申请日：2002-03-08

    Applicant: Michihiro Saito ,  Kazuhiro Tanaka

    Inventor： Michihiro Saito ,  Kazuhiro Tanaka

    IPC: G01N33/53 ,  G01N21/01 ,  G01N35/02 ,  G01N35/10

    CPC classification number: G01N33/54333 ,  G01N35/025 ,  G01N35/10 ,  G01N35/1004 ,  G01N2035/00534 ,  G01N2035/00564 ,  G01N2035/0441 ,  G01N2035/0443 ,  G01N2035/0444 ,  G01N2035/0453 ,  Y10T436/113332 ,  Y10T436/115831

    Abstract: An immunological analyzing apparatus and method using fine particles bonded with an antigen or an antibody are provided which are capable of obtaining a good analysis result with preferable reproducibility with no effect of carry-over.The immunological apparatus includes plural reagent vessels for containing plural kinds of liquid reagents in which fine particles bonded with an antigen or an antibody are suspended, a stirring vessel for stirring the liquid reagent, a probe for dispensing the liquid reagent, a reaction vessel for mixing and reacting the liquid reagent and a specimen, a measuring device for measuring the reaction in the reaction vessel, and a mechanism for determining as to whether or not the liquid reagent in the reagent vessel is to be stirred prior to dispensing of the liquid reagent in the reagent vessel to the reaction vessel, based on the information regarding the predetermined stirring time interval and the information regarding the carry-over between each of plural kinds of liquid reagents.

    Abstract translation: 提供了使用与抗原或抗体结合的细粒子的免疫学分析装置和方法，其能够以优异的再现性获得良好的分析结果，而没有遗留的影响。

    Automated analyzer and automated analysis
    10.
    发明授权
    Automated analyzer and automated analysis 有权
    自动分析仪和自动分析

    公开(公告)号：US06635488B1

    公开(公告)日：2003-10-21

    申请号：US09598048

    申请日：2000-06-21

    Applicant: Michihiro Saito ,  Koshin Tagami

    Inventor： Michihiro Saito ,  Koshin Tagami

    IPC: G01N3502

    CPC classification number: G01N35/00594 ,  G01N35/00603 ,  G01N2035/00702 ,  G01N2035/0472 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/114998

    Abstract: An automated analyzer which analyzes a sample which might have been affected by carryover, judges the effect of carryover from the analytical value, and indicates the result. The automated analyzer also performs analysis on a specific inspection item necessary for a sample which might have been affected by carryover from its preceding sample and modifies the result of analysis of said sample according to the analytical value.

    Abstract translation: 分析可能受到遗留影响的样本的自动分析仪，从分析值判断结转的影响，并指示结果。 自动分析仪还对可能受到前一样品残留影响的样品所需的特定检查项目进行分析，并根据分析值修改所述样品的分析结果。

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