公开(公告)号：US20190153061A1

公开(公告)日：2019-05-23

申请号：US16197565

申请日：2018-11-21

Applicant: Novartis AG ,  The Trustees of the University of Pennsylvania

Inventor： Jennifer Brogdon ,  Eugene Choi ,  Hilmar Erhard Ebersbach ,  David Jonathan Glass ,  Heather Huet ,  Carl H. June ,  Joan Mannick ,  Michael C. Milone ,  Leon Murphy ,  Gabriela Plesa ,  Celeste Richardson ,  Marco Ruella ,  Reshma Singh ,  Yongqiang Wang ,  Qilong Wu

IPC: C07K14/705 ,  C07K16/28 ,  C07H21/04 ,  C12N15/63 ,  C12N5/00 ,  A61K35/12 ,  A61K38/17

Abstract: The invention provides compositions and methods for treating diseases associated with expression of BCMA. The invention also relates to chimeric antigen receptor (CAR) specific to BCMA vectors encoding the same, and recombinant T cells comprising the BCMA CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a BCMA binding domain.

公开(公告)号：US10174095B2

公开(公告)日：2019-01-08

申请号：US14805193

申请日：2015-07-21

Applicant: Novartis AG ,  The Trustees of the University of Pennsylvania

Inventor： Jennifer Brogdon ,  Eugene Choi ,  Hilmar Erhard Ebersbach ,  David Glass ,  Heather Huet ,  Carl H. June ,  Joan Mannick ,  Michael C. Milone ,  Leon Murphy ,  Gabriela Plesa ,  Celeste Richardson ,  Marco Ruella ,  Reshma Singh ,  Yongqiang Wang ,  Qilong Wu

IPC: C07H21/04 ,  C12N15/63 ,  C12N5/00 ,  C07K16/28 ,  C07K14/705 ,  A61K35/12 ,  A61K38/17 ,  C07K14/715 ,  C07K19/00 ,  A61K39/395 ,  A61P35/00

Abstract: The invention provides compositions and methods for treating diseases associated with expression of BCMA. The invention also relates to chimeric antigen receptor (CAR) specific to BCMA vectors encoding the same, and recombinant T cells comprising the BCMA CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a BCMA binding domain.

公开(公告)号：US11639378B2

公开(公告)日：2023-05-02

申请号：US17502910

申请日：2021-10-15

Applicant: Novartis AG

Inventor： Johanna Abend ,  Zorica Dragic ,  Adam Lloyd Feire ,  Mark Knapp ,  Steven Kovacs ,  Elisabetta Traggiai ,  Lichun Wang ,  Yongqiang Wang ,  Danqing Wu ,  Qilong Wu ,  Fangmin Xu

IPC: A61K39/395 ,  C07K16/08 ,  A61K39/42 ,  A61K45/06 ,  A61K9/19

Abstract: The present invention relates to anti-VP1 antibodies, antibody fragments, and their uses for the prevention and treatment of polyoma virus infection and associated diseases.

公开(公告)号：US11459390B2

公开(公告)日：2022-10-04

申请号：US15543688

申请日：2016-01-15

Applicant: Novartis AG ,  The Trustees of the University of Pennsylvania

Inventor： Jennifer Brogdon ,  Hilmar Erhard Ebersbach ,  David Glass ,  Thomas Huber ,  Julia Jascur ,  Carl H. June ,  Jihyun Lee ,  Joan Mannick ,  Michael C. Milone ,  Leon Murphy ,  Avery D. Posey ,  Huijuan Song ,  Yongqiang Wang ,  Lai Wei ,  Qilong Wu ,  Qiumei Yang ,  Jiquan Zhang

IPC: C07K16/28 ,  C07K14/705 ,  C07K14/725 ,  A61K35/17 ,  C07K16/30 ,  A61P35/00 ,  A61P35/02 ,  A61K48/00 ,  C12N15/86 ,  A61K35/12

Abstract: The invention provides compositions and methods for treating diseases associated with expression of a tumor antigen as described herein. The invention also relates to nucleic acids comprising a truncated PGK promoter operably linked to a chimeric antigen receptor (CAR) specific to a tumor antigen as described herein, vectors encoding the same, and recombinant T cells comprising the CARs of the present invention. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises an antigen binding domain that binds to a tumor antigen as described herein.

公开(公告)号：US11161894B2

公开(公告)日：2021-11-02

申请号：US16657855

申请日：2019-10-18

Applicant: Novartis AG

Inventor： Johanna Abend ,  Zorica Dragic ,  Adam Lloyd Feire ,  Mark Knapp ,  Steven Kovacs ,  Elisabetta Traggiai ,  Lichun Wang ,  Yongqiang Wang ,  Danqing Wu ,  Qilong Wu ,  Fangmin Xu

IPC: A61K39/42 ,  A61K45/06 ,  A61K9/19 ,  C07K16/08

Abstract: The present invention relates to anti-VP1 antibodies, antibody fragments, and their uses for the prevention and treatment of polyoma virus infection and associated diseases.

公开(公告)号：US10703819B2

公开(公告)日：2020-07-07

申请号：US15726703

申请日：2017-10-06

Applicant: Novartis AG ,  The Trustees of the University of Pennsylvania

Inventor： Jennifer Brogdon ,  Saar Gill ,  David Jonathan Glass ,  Saad Kenderian ,  Andreas Loew ,  Joan Mannick ,  Michael Milone ,  Leon Murphy ,  David L. Porter ,  Marco Ruella ,  Yongqiang Wang ,  Qilong Wu ,  Jiquan Zhang

IPC: C07K16/28 ,  A61K39/00 ,  C07K16/24 ,  C12N5/0783

Abstract: The invention provides compositions and methods for treating diseases associated with expression of CD123. The invention also relates to chimeric antigen receptor (CAR) specific to CD123, vectors encoding the same, and recombinant cells comprising the CD123 CAR. The invention also includes methods of administering a genetically modified cell expressing a CAR that comprises a CD123 binding domain.

公开(公告)号：US10654914B2

公开(公告)日：2020-05-19

申请号：US16183262

申请日：2018-11-07

Applicant: Novartis AG

Inventor： Johanna Abend ,  Zorica Dragic ,  Adam Lloyd Feire ,  Mark Knapp ,  Steven Kovacs ,  Elisabetta Traggiai ,  Lichun Wang ,  Yongqiang Wang ,  Danqing Wu ,  Qilong Wu ,  Fangmin Xu

IPC: A61K9/19 ,  A61K39/42 ,  C07K16/08 ,  A61K45/06

Abstract: The present invention relates to anti-VP1 antibodies, antibody fragments, and their uses for the prevention and treatment of polyoma virus infection and associated diseases.

公开(公告)号：US10450366B2

公开(公告)日：2019-10-22

申请号：US15758491

申请日：2016-09-08

Applicant: Novartis AG

Inventor： Johanna Abend ,  Zorica Dragic ,  Adam Lloyd Feire ,  Mark Knapp ,  Steven Kovacs ,  Elisabetta Traggiai ,  Lichun Wang ,  Yongqiang Wang ,  Danqing Wu ,  Qilong Wu ,  Fangmin Xu

IPC: A61K39/00 ,  A61K39/42 ,  C07K16/00 ,  C07K16/08 ,  A61K45/06 ,  A61K9/19

Abstract: The present disclosure is directed to anti-VP1 antibodies, antibody fragments, and their uses for the reducing the likelihood or treatment of polyoma virus infection.