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公开(公告)号：US10228553B2
公开(公告)日：2019-03-12
申请号：US15821605
申请日：2017-11-22
Applicant: OLYMPUS CORPORATION
Inventor： Yoshihiro Shimada
Abstract: A microscope device 100 includes: a sample container holder 7 that is capable of housing a plurality of sample containers 9 and that is supported so as to be attachable, each of the sample containers 9 housing a sample S and a first immersion medium and including a transparent section that transmits light; an illumination optical system 1 that emits illumination light to the sample S via the transparent section; a detection optical system 2 that detects light from the sample S via the transparent section; and a movement mechanism 16 that relatively moves the sample container holder 7, the detection optical system 2, and the illumination optical system 1 in a gravity direction. The sample container holder 7 houses the plurality of sample containers S in the gravity direction.
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公开(公告)号：US10996454B2
公开(公告)日：2021-05-04
申请号：US16370630
申请日：2019-03-29
Applicant: OLYMPUS CORPORATION
Inventor： Yoshihiro Shimada
Abstract: A microscope includes a movable stage supporting wells arranged in an array, a first imaging unit having a low-magnification objective lens, a second imaging unit having a high-magnification objective lens, a computer determining a representative position of a spheroid based on imaging data of the spheroid acquired by the first imaging unit, and a controller causing respective imaging units to sequentially acquire imaging data of the spheroid in each of the wells. The controller causes the first imaging unit to acquire imaging data for the spheroid in one of the wells, and then causes the stage to adjust the representative position to the optical axis of the high-magnification objective lens, and further causes the second imaging unit to acquire imaging data while causing the first imaging unit to acquire imaging data of the spheroid in another of the wells in synchronization with acquisition by the second imaging unit.
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公开(公告)号：US09842393B2
公开(公告)日：2017-12-12
申请号：US15166195
申请日：2016-05-26
Applicant: OLYMPUS CORPORATION
Inventor： Kosuke Takagi , Yoshihiro Shimada
CPC classification number: G06T7/0012 , G01N33/4833 , G06K9/0014 , G06K9/52 , G06T7/66 , G06T7/70 , G06T2200/04 , G06T2207/30004 , G06T2207/30024
Abstract: A cell evaluation method includes: a labeling step of labeling at least some of cells constituting a cell clump with a chemical substance; an image-capturing step of acquiring a plurality of slice images of the labeled cells, for at least part of the cell clump; an evaluating step of evaluating the characteristics of the cells on the basis of the plurality of slice images; a 3D-image creating step of creating a 3D image of at least part of the cell clump by subjecting the plurality of slice images to image processing; a center-of-gravity determining step of determining, from the 3D image, a center-of-gravity position of the cell clump; and an organizing step of organizing evaluation results obtained in the evaluating step, with respect to the distance from the center-of-gravity position.
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公开(公告)号：US09261689B2
公开(公告)日：2016-02-16
申请号：US14298707
申请日：2014-06-06
Applicant: OLYMPUS CORPORATION
Inventor： Yoshihiro Shimada , Makio Ueno , Shingo Tamano , Naoki Hayashi , Eiji Yokoi
CPC classification number: G02B21/0032 , G02B21/002 , G02B21/0036 , G02B21/0096 , G02B21/06 , G02B21/26 , G02B27/4261
Abstract: A scanning optical microscope includes a light source, a light converging optical system, a stage, a scanning unit which displaces an illumination light and the stage relatively, a detecting optical system, and a photodetector. A light modulation element and a relay optical system are disposed on the light converging optical system side of the light source, and a modulated signal having only amplitude changed is input to the light modulation element, and the light modulation element is positioned such that the illumination light emerged from the light modulation element with respect to the modulated signal of a predetermined amplitude coincides with an optical axis of the light converging optical system, and a position of a pupil of the light converging optical system and a position of the light modulation element are conjugate through at least the relay optical system.
Abstract translation: 扫描光学显微镜包括光源，聚光光学系统，舞台，相对地移动照明光和舞台的扫描单元，检测光学系统和光电检测器。 光调制元件和中继光学系统设置在光源的聚光光学系统侧，并且只有振幅改变的调制信号被输入到光调制元件，并且光调制元件被定位成使得照明 相对于预定幅度的调制信号从光调制元件出射的光与会聚光学系统的光轴重合，会聚光学系统的光瞳位置和光调制元件的位置是 通过至少中继光学系统共轭。
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