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公开(公告)号：US10227396B2
公开(公告)日：2019-03-12
申请号：US14772122
申请日：2014-03-06
Applicant: OSAKA UNIVERSITY
Inventor： Yoshiaki Taniyama , Ryuichi Morishita , Junya Azuma , Fumihiro Sanada , Naruto Katsuragi
Abstract: The present invention provides a drug for preventing or treating inflammation-associated diseases in which a periostin isoform having cell adhesion activity is involved, and also provides an inhibitor of a periostin isoform having cell adhesion activity.
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公开(公告)号：US09872825B2
公开(公告)日：2018-01-23
申请号：US14780122
申请日：2014-03-27
Applicant: OSAKA UNIVERSITY
Inventor： Hironori Nakagami , Ryuichi Morishita , Hideki Tomioka , Akiko Tenma
CPC classification number: A61K8/64 , A23L33/18 , A61K38/10 , A61K2800/78 , A61Q19/08 , C07K7/06 , C07K7/08
Abstract: An object of the present invention to discover a short peptide having an anti-aging effect and to provide a novel anti-aging agent comprising the peptide as an active ingredient. The inventors have discovered that a peptide consisting of an amino acid sequence ELKLIFLHRLKRLRKRLKRK (SEQ ID NO: 1) or a partial sequence thereof and having one or more effects selected from the group consisting of promoting fibroblast growth, promoting hyaluronic acid production and contracting a collagen gel, or a derivative or salt of the peptide is useful as an active ingredient of an anti-aging agent.
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公开(公告)号：US12227743B2
公开(公告)日：2025-02-18
申请号：US16963476
申请日：2019-01-23
Applicant: Osaka University
Inventor： Fumihiro Sanada , Yoshiaki Taniyama , Ryuichi Morishita
IPC: C12N15/113 , A61K35/76 , A61K48/00 , A61P35/04
Abstract: Provided is a pharmaceutical composition for the treatment of a disease associated with upregulated periostin expression or periostin splice variant switching, which pharmaceutical composition comprises, as an active ingredient, a nucleic acid capable of inducing skipping of exon 17 in periostin gene transcription and/or a nucleic acid capable of inducing skipping of exon 21 in periostin gene transcription. The pharmaceutical composition of the present invention can treat a disease associated with upregulated periostin expression or periostin splice variant switching, while preventing complete inhibition of the functions of periostin.
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公开(公告)号：US11583221B2
公开(公告)日：2023-02-21
申请号：US16763829
申请日：2018-11-13
Applicant: OSAKA UNIVERSITY
Inventor： Shuko Takeda , Ryuichi Morishita , Akane Oyama , Tsuneo Nakajima
Abstract: A cognitive impairment diagnostic apparatus includes: a display which displays a video for diagnosis of cognitive impairment on a display surface; an imaging unit which captures images of an eye of a subject; a detection unit which detects viewpoints of the subject on the display surface in time series based on the images captured by the imaging unit; a creation unit which creates a distribution map representing a distribution of the viewpoints detected by the detection unit; a storage unit which stores case characteristic data indicating a characteristic of a viewpoint distribution corresponding to a typical case in cognitive impairment; and a diagnostic unit which diagnoses cognitive impairment of the subject by determining whether the distribution map has the characteristic indicated by the case characteristic data.
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公开(公告)号：US10980876B2
公开(公告)日：2021-04-20
申请号：US16087799
申请日：2017-03-24
Applicant: OSAKA UNIVERSITY , FUNPEP CO., LTD.
Inventor： Hironori Nakagami , Ryuichi Morishita , Akiko Tenma
IPC: A61K39/395 , A61K39/39 , A61K39/00 , A61P37/04
Abstract: The present invention provides a vaccine containing a complex of a peptide consisting of the amino acid sequence of SEQ ID NO: 1 and an epitope of a disease-causing biological protein such as DPP4, IL-17A, IgE, S100A9 or PCSK9, which vaccine uses a less antigenic carrier protein and is capable of inducing antibody production to serve as an effective vaccine.
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Patent Agency Ranking
公开(公告)号：US20210047642A1
公开(公告)日：2021-02-18
申请号：US16963476
申请日：2019-01-23
Applicant: Osaka University
Inventor： Fumihiro Sanada , Yoshiaki Taniyama , Ryuichi Morishita
IPC: C12N15/113 , A61K35/76 , A61P35/04
Abstract: Provided is a pharmaceutical composition for the treatment of a disease associated with upregulated periostin expression or periostin splice variant switching, which pharmaceutical composition comprises, as an active ingredient, a nucleic acid capable of inducing skipping of exon 17 in periostin gene transcription and/or a nucleic acid capable of inducing skipping of exon 21 in periostin gene transcription. The pharmaceutical composition of the present invention can treat a disease associated with upregulated periostin expression or periostin splice variant switching, while preventing complete inhibition of the functions of periostin.
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公开(公告)号：US10695420B2
公开(公告)日：2020-06-30
申请号：US15528502
申请日：2015-11-20
Applicant: ANGES, INC. , OSAKA UNIVERSITY , DS PHARMA ANIMAL HEALTH CO., LTD.
Inventor： Hironori Nakagami , Ryuichi Morishita , Hiroshi Koriyama , Hideki Tomioka , Kenji Naohara
Abstract: The present invention provides a combination preparation for inducing a specific immune response to an antigenic peptide, which contains (I) the antigenic peptide, and (II) an expression vector encoding a chimeric hepatitis B virus core antigen polypeptide, into which the antigenic peptide has been inserted or added, wherein said antigenic peptide is inserted in a region of amino acid residues 74-87 or 130-138 of the hepatitis B virus core antigen polypeptide, or added to the N-terminal or C-terminal of the hepatitis B virus core antigen polypeptide, wherein the antigenic peptide of (I) and the expression vector of (II) are substantially simultaneously administered to a subject.
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公开(公告)号：US10463592B2
公开(公告)日：2019-11-05
申请号：US15834889
申请日：2017-12-07
Applicant: Osaka University
Inventor： Hironori Nakagami , Ryuichi Morishita , Hideki Tomioka , Akiko Tenma
Abstract: An object of the present invention to discover a short peptide having an anti-aging effect and to provide a novel anti-aging agent comprising the peptide as an active ingredient. The inventors have discovered that a peptide consisting of an amino acid sequence ELKLIFLHRLKRLRKRLKRK (SEQ ID NO: 1) or a partial sequence thereof and having one or more effects selected from the group consisting of promoting fibroblast growth, promoting hyaluronic acid production and contracting a collagen gel, or a derivative or salt of the peptide is useful as an active ingredient of an anti-aging agent.
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公开(公告)号：US10233215B2
公开(公告)日：2019-03-19
申请号：US16134153
申请日：2018-09-18
Applicant: OSAKA UNIVERSITY
Inventor： Hironori Nakagami , Ryuichi Morishita , Hiroshi Koriyama , Akiko Tenma
Abstract: The invention provides a peptide and an immunostimulant or hair grower containing the peptide as an active ingredient, as well as a method for hair growth or regrowth promotion by administering an effective amount of the peptide to a mammal. The peptide has 23 or less amino acids and includes the amino acid sequence LHRLKRLRKRL (SEQ ID NO: 1), preferably the amino acid sequence LHRLKRLRKRLK (SEQ ID NO: 9).
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公开(公告)号：US10112978B2
公开(公告)日：2018-10-30
申请号：US15514310
申请日：2015-09-25
Applicant: OSAKA UNIVERSITY
Inventor： Hironori Nakagami , Ryuichi Morishita , Hiroshi Koriyama , Akiko Tenma
Abstract: An object of the present invention is to provide a novel peptide and a novel immunostimulant or hair grower containing the peptide as an active ingredient. The present invention provides a peptide of 23 or less amino acids comprising the amino acid sequence LHRLKRLRKRL (SEQ ID NO: 1), preferably the amino acid sequence LHRLKRLRKRLK (SEQ ID NO: 9), and also provides an immunostimulant containing the peptide, a vaccine adjuvant containing the peptide, a vaccine composition containing the peptide, and a hair grower containing the peptide.
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