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公开(公告)号：US20160101032A1
公开(公告)日：2016-04-14
申请号：US14780122
申请日：2014-03-27
Applicant: OSAKA UNIVERSITY
Inventor： Hironori Nakagami , Ryuichi Morishita , Hideki Tomioka , Akiko Tenma
CPC classification number: A61K8/64 , A23L33/18 , A61K38/10 , A61K2800/78 , A61Q19/08 , C07K7/06 , C07K7/08
Abstract: An object of the present invention to discover a short peptide having an anti-aging effect and to provide a novel anti-aging agent comprising the peptide as an active ingredient. The inventors have discovered that a peptide consisting of an amino acid sequence ELKLIFLHRLKRLRKRLKRK (SEQ ID NO: 1) or a partial sequence thereof and having one or more effects selected from the group consisting of promoting fibroblast growth, promoting hyaluronic acid production and contracting a collagen gel, or a derivative or salt of the peptide is useful as an active ingredient of an anti-aging agent.
Abstract translation: 本发明的目的是发现具有抗衰老作用的短肽，并提供包含该肽作为活性成分的新型抗衰老剂。 本发明人已经发现，由氨基酸序列ELKLIFLHRLKRLRKRLKRK（SEQ ID NO：1）或其部分序列组成的肽具有选自促进成纤维细胞生长，促进透明质酸产生和收缩胶原的一种或多种作用 凝胶或肽的衍生物或盐可用作抗老化剂的活性成分。
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公开(公告)号：US20180110713A1
公开(公告)日：2018-04-26
申请号：US15834889
申请日：2017-12-07
Applicant: Osaka University
Inventor： Hironori Nakagami , Ryuichi Morishita , Hideki Tomioka , Akiko Tenma
CPC classification number: A61K8/64 , A23L33/18 , A61K38/10 , A61K2800/78 , A61Q19/08 , C07K7/06 , C07K7/08
Abstract: An object of the present invention to discover a short peptide having an anti-aging effect and to provide a novel anti-aging agent comprising the peptide as an active ingredient. The inventors have discovered that a peptide consisting of an amino acid sequence ELKLIFLHRLKRLRKRLKRK (SEQ ID NO: 1) or a partial sequence thereof and having one or more effects selected from the group consisting of promoting fibroblast growth, promoting hyaluronic acid production and contracting a collagen gel, or a derivative or salt of the peptide is useful as an active ingredient of an anti-aging agent.
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Patent Agency Ranking
公开(公告)号：US10695420B2
公开(公告)日：2020-06-30
申请号：US15528502
申请日：2015-11-20
Applicant: ANGES, INC. , OSAKA UNIVERSITY , DS PHARMA ANIMAL HEALTH CO., LTD.
Inventor： Hironori Nakagami , Ryuichi Morishita , Hiroshi Koriyama , Hideki Tomioka , Kenji Naohara
Abstract: The present invention provides a combination preparation for inducing a specific immune response to an antigenic peptide, which contains (I) the antigenic peptide, and (II) an expression vector encoding a chimeric hepatitis B virus core antigen polypeptide, into which the antigenic peptide has been inserted or added, wherein said antigenic peptide is inserted in a region of amino acid residues 74-87 or 130-138 of the hepatitis B virus core antigen polypeptide, or added to the N-terminal or C-terminal of the hepatitis B virus core antigen polypeptide, wherein the antigenic peptide of (I) and the expression vector of (II) are substantially simultaneously administered to a subject.
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公开(公告)号：US10463592B2
公开(公告)日：2019-11-05
申请号：US15834889
申请日：2017-12-07
Applicant: Osaka University
Inventor： Hironori Nakagami , Ryuichi Morishita , Hideki Tomioka , Akiko Tenma
Abstract: An object of the present invention to discover a short peptide having an anti-aging effect and to provide a novel anti-aging agent comprising the peptide as an active ingredient. The inventors have discovered that a peptide consisting of an amino acid sequence ELKLIFLHRLKRLRKRLKRK (SEQ ID NO: 1) or a partial sequence thereof and having one or more effects selected from the group consisting of promoting fibroblast growth, promoting hyaluronic acid production and contracting a collagen gel, or a derivative or salt of the peptide is useful as an active ingredient of an anti-aging agent.
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5.发明申请DNA VACCINE CONTAINING VEGF-SPECIFIC EPITOPE AND/OR ANGIOPOIETIN-2-SPECIFIC EPITOPE 审中-公开含有VEGF特异性抗原决定簇和/或抗血清素-2特异性抗原决定簇的DNA疫苗公开(公告)号：US20150202271A1
公开(公告)日：2015-07-23
申请号：US14424937
申请日：2013-08-28
Applicant: OSAKA UNIVERSITY , ANGES MG, INC.
Inventor： Hironori Nakagami , Mariko Kyutoku , Ryuichi Morishita , Hideki Tomioka
CPC classification number: A61K39/0011 , A61K2039/5256 , A61K2039/53 , A61K2039/545 , C12N7/00 , C12N2730/10134 , C12N2730/10143
Abstract: The present invention provides a therapeutic or prophylactic agent for cancer, containing an expression vector encoding a chimeric Hepatitis B virus core antigen polypeptide inserted with an amino acid sequence containing a specific epitope of VEGF and/or a specific epitope of angiopoietin-2, wherein the amino acid sequence containing the specific epitope is inserted between the amino acid residues 80 and 81 of the hepatitis B virus core antigen polypeptide.
Abstract translation: 本发明提供一种癌症治疗或预防剂，其含有编码嵌合乙型肝炎病毒核心抗原多肽的表达载体，其插入含有VEGF特异性表位的氨基酸序列和/或血管生成素-2的特异性表位，其中， 含有特异性表位的氨基酸序列插入到乙型肝炎病毒核心抗原多肽的氨基酸残基80和81之间。
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公开(公告)号：US10543261B2
公开(公告)日：2020-01-28
申请号：US14424937
申请日：2013-08-28
Applicant: OSAKA UNIVERSITY , ANGES, INC.
Inventor： Hironori Nakagami , Mariko Kyutoku , Ryuichi Morishita , Hideki Tomioka
Abstract: The present invention provides a therapeutic or prophylactic agent for cancer, containing an expression vector encoding a chimeric Hepatitis B virus core antigen polypeptide inserted with an amino acid sequence containing a specific epitope of VEGF and/or a specific epitope of angiopoietin-2, wherein the amino acid sequence containing the specific epitope is inserted between the amino acid residues 80 and 81 of the hepatitis B virus core antigen polypeptide.
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公开(公告)号：US09872825B2
公开(公告)日：2018-01-23
申请号：US14780122
申请日：2014-03-27
Applicant: OSAKA UNIVERSITY
Inventor： Hironori Nakagami , Ryuichi Morishita , Hideki Tomioka , Akiko Tenma
CPC classification number: A61K8/64 , A23L33/18 , A61K38/10 , A61K2800/78 , A61Q19/08 , C07K7/06 , C07K7/08
Abstract: An object of the present invention to discover a short peptide having an anti-aging effect and to provide a novel anti-aging agent comprising the peptide as an active ingredient. The inventors have discovered that a peptide consisting of an amino acid sequence ELKLIFLHRLKRLRKRLKRK (SEQ ID NO: 1) or a partial sequence thereof and having one or more effects selected from the group consisting of promoting fibroblast growth, promoting hyaluronic acid production and contracting a collagen gel, or a derivative or salt of the peptide is useful as an active ingredient of an anti-aging agent.
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