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公开(公告)号：US20140363452A1
公开(公告)日：2014-12-11
申请号：US14322262
申请日：2014-07-02
Applicant: PFIZER INC.
Inventor： Matthew David DOROSKI , Andreas MADERNA , Christopher John O'DONNELL , Chakrapani SUBRAMANYAM , Beth VETELINO , Russell George DUSHIN , Pavel STROP , Edmund Idris GRAZIANI
CPC classification number: C07K7/06 , A61K38/06 , A61K38/07 , A61K38/08 , A61K47/6803 , A61K47/6811 , A61K47/6851 , A61K47/6855 , A61K47/6863 , A61K47/6889 , C07K5/0205 , C07K5/0808 , C07K7/02 , C07K16/00 , C07K2319/30
Abstract: The present invention is directed to cytotoxic pentapeptides, to antibody drug conjugates thereof, and to methods for using the same to treat cancer.
Abstract translation: 本发明涉及细胞毒性五肽，其抗体药物偶联物及其用于治疗癌症的方法。
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Patent Agency Ranking
公开(公告)号：US20240156977A1
公开(公告)日：2024-05-16
申请号：US18492348
申请日：2023-10-23
Applicant: Pfizer Inc.
Inventor： Andrea Therese HOOPER , Kimberly Ann MARQUETTE , Chakrapani SUBRAMANYAM , Hans-Peter GERBER , Chad Michael MAY
CPC classification number: A61K47/6803 , A61K47/6843 , A61P35/00 , C07K16/18 , A61K38/08 , A61K47/6811
Abstract: The present invention provides antibodies and antibody-drug conjugates that bind to the extra domain B splice variant of fibronectin 1 and methods for preparing and using the same.
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公开(公告)号：US20180362519A1
公开(公告)日：2018-12-20
申请号：US16072291
申请日：2017-01-27
Applicant: PFIZER INC. , CovX Technologies Ireland Limited
Inventor： Chakrapani SUBRAMANYAM , Lawrence N. TUMEY , Longfei XIE , Carolyn LEVERETT , Beth C. VETELINO , Sai Chetan K. SUKURU , Sarah HUDSON , Venkata Ramana DOPPALAPUDI , Abhijit S. BHAT
IPC: C07D417/12 , A61K47/65 , A61K47/68 , A61P35/00 , C07D277/56
Abstract: The present invention is directed to novel cytotoxic tubulysin analogs and derivatives, to antibody drug conjugates thereof, and to methods for using the same to treat medical conditions including cancer.
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公开(公告)号：US20150209445A1
公开(公告)日：2015-07-30
申请号：US14605697
申请日：2015-01-26
Applicant: Pfizer Inc.
Inventor： Andreas MADERNA , Matthew David DOROSKI , Zecheng CHEN , Hud Lawrence RISLEY , Jeffrey Michael CASAVANT , Christopher John O'DONNELL , Alexander M. PORTE , Chakrapani SUBRAMANYAM
IPC: A61K47/48 , A61K31/404 , A61K31/4439 , C07D401/14 , C07D409/14 , A61K31/675 , C07F9/6561 , A61K31/454 , A61K31/7056 , C07H17/02 , C07D417/14 , A61K31/433 , A61K31/407 , C07D487/04 , C07K5/08 , C07K5/06 , C07K9/00 , A61K38/05 , A61K38/06 , C07D405/14
CPC classification number: A61K47/48384 , A61K31/404 , A61K31/407 , A61K31/433 , A61K31/4439 , A61K31/454 , A61K31/675 , A61K31/7056 , A61K38/05 , A61K38/06 , A61K47/6803 , A61K47/6807 , A61K47/6811 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14 , C07D487/04 , C07F9/6561 , C07H17/02 , C07K5/06 , C07K5/08 , C07K9/003
Abstract: Cytotoxic dimers comprising CBI-based and/or CPI-based sub-units, antibody drug conjugates comprising such dimers, and to methods for using the same to treat cancer and other conditions.
Abstract translation: 包含基于CBI和/或CPI的亚单位的细胞毒性二聚体，包含这种二聚体的抗体药物偶联物，以及使用该二聚体治疗癌症和其它病症的方法。
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公开(公告)号：US20140134193A1
公开(公告)日：2014-05-15
申请号：US14069057
申请日：2013-10-31
Applicant: PFIZER INC.
Inventor： Chakrapani SUBRAMANYAM , Frank Erich KOEHN , Kenneth John DIRICO , Alessandra S. EUSTAQUIO , Michael Eric GREEN , Haiyin HE , Min HE , Christopher John O'DONNELL , Sujiet PUTHENVEETIL , Anokha RATNAYAKE , Jesse Alexander TESKE , Hui Yu YANG
IPC: C07D493/10 , A61K47/48 , A61K45/06 , C07D309/14 , C07D405/14
CPC classification number: A61K47/6855 , A61K31/35 , A61K31/351 , A61K31/397 , A61K31/4025 , A61K31/453 , A61K31/496 , A61K31/501 , A61K45/06 , A61K47/6803 , A61K47/6869 , A61K47/6889 , C07D309/10 , C07D309/14 , C07D405/12 , C07D405/14 , C07D493/10 , C07D493/20
Abstract: The present invention is directed to novel cytotoxic spliceostatin analogs and derivatives, to antibody drug conjugates thereof, and to methods for using the same to treat medical conditions including cancer.
Abstract translation: 本发明涉及新颖的细胞毒素剪接抑制物类似物及其衍生物，其抗体药物偶联物及其用于治疗包括癌症在内的医学病症的方法。
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公开(公告)号：US20130129753A1
公开(公告)日：2013-05-23
申请号：US13670612
申请日：2012-11-07
Applicant: PFIZER INC.
Inventor： Matthew David DOROSKI , Andreas MADERNA , Christopher John O'DONNELL , Chakrapani SUBRAMANYAM , Beth VETELINO , Russell George DUSHIN , Pavel STROP , Edmund Idris GRAZIANI
CPC classification number: C07K7/06 , A61K38/06 , A61K38/07 , A61K38/08 , A61K47/6803 , A61K47/6811 , A61K47/6851 , A61K47/6855 , A61K47/6863 , A61K47/6889 , C07K5/0205 , C07K5/0808 , C07K7/02 , C07K16/00 , C07K2319/30
Abstract: The present invention is directed to cytotoxic pentapeptides, to antibody drug conjugates thereof, and to methods for using the same to treat cancer.
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