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11.发明授权公开(公告)号：US08496975B2
公开(公告)日：2013-07-30
申请号：US12988870
申请日：2009-04-06
申请人： Ezio Bombardelli , Gabriele Fontana , Andrea Giori , Paolo Morazzoni , Antonella Riva , Massimo Ronchi
发明人： Ezio Bombardelli , Gabriele Fontana , Andrea Giori , Paolo Morazzoni , Antonella Riva , Massimo Ronchi
IPC分类号： A61K9/68 , A61K31/4355 , A61K8/49 , A61P1/02
CPC分类号： A61K45/06 , A61K31/343 , A61K31/473 , A61K2300/00
摘要： The present invention relates to compositions comprising benzophenanthridine alkaloids, benzofuran compounds and catechin polyphenols, which are useful in the treatment and prevention of infections of the oral cavity.
摘要翻译： 本发明涉及可用于治疗和预防口腔感染的苯并菲啶生物碱，苯并呋喃化合物和儿茶素多酚的组合物。
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12.发明授权Formulations with sanguinarine, chelerythrine or chelidonine for the treatment of warts, verrucas and psoriatic plaques 有权配有血根碱，螯合剂或螯合剂的治疗疣，verrucas和银屑病斑块的制剂公开(公告)号：US08226994B2
公开(公告)日：2012-07-24
申请号：US12921476
申请日：2009-03-09
IPC分类号： A61K36/28 , A61K31/435 , A61P17/12
CPC分类号： A61K36/66 , A61K31/4741 , A61K36/75 , Y10S514/863
摘要： The invention provides formulations containing sanguinarine, chelerythrine or chelidonine or their salts or extracts containing them, mixed with suitable vehicles and/or excipients, for the treatment of common skin warts and verrucas, anal and vulvar warts and psoriatic plaques.
摘要翻译： 本发明提供含有血根碱，螯合物或螯合物或其含有它们的盐或提取物的配方，与合适的载体和/或赋形剂混合，用于治疗常见的皮肤疣和疣状，肛门和外阴疣以及牛皮癣斑块。
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13.发明申请ANTITUMORAL AGENTS WITH A BENZOPHENANTHRIDINE STRUCTURE AND FORMULATIONS CONTAINING THEM 有权具有苯并噻嗪结构和含有它们的制剂的抗菌剂公开(公告)号：US20100331525A1
公开(公告)日：2010-12-30
申请号：US12918453
申请日：2009-02-16
IPC分类号： C07K14/76 , C07D471/14 , C07D471/04
CPC分类号： A61K31/473
摘要： The use of benzophenanthridine alkaloids and the salts thereof for the preparation of medicaments for the treatment of tumors is disclosed.
摘要翻译： 公开了苯并菲啶生物碱及其盐在制备用于治疗肿瘤的药物中的用途。
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14.发明申请Hyperforin halogenated derivatives, the use thereof and formulations containing them 失效Hyperforin卤化衍生物，其使用和含有它们的制剂公开(公告)号：US20050222274A1
公开(公告)日：2005-10-06
申请号：US10511894
申请日：2003-04-15
IPC分类号： A61K36/18 , A61K31/122 , A61P25/24 , A61P25/28 , C07C45/51 , C07C45/62 , C07C45/63 , C07C45/78 , C07C49/477 , C07C49/507 , C07C49/513 , C07C49/693 , C07C49/713 , C07C49/743 , C07C49/293 , A61K31/12
CPC分类号： C07C49/743 , C07C45/512 , C07C45/62 , C07C45/63 , C07C45/78 , C07C49/477 , C07C49/513 , C07C49/693 , C07C49/713
摘要： Hyperforin and adhyperforin halogenated derivatives of general formula (I) in which X, R and R1 have the meanings as defined in the disclosure, the process for the preparation thereof and the use thereof in the pharmaceutical and/or nutritional field, in particular in the treatment of depression, and Alzheimer's disease.
摘要翻译： 其中X，R和R 1具有如本公开内容中所定义的含义的通式（I）的高效蛋白和高效皂化衍生物，其制备方法及其在药物和/ 或营养场，特别是治疗抑郁症和阿尔茨海默病。
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公开(公告)号：US20050220905A1
公开(公告)日：2005-10-06
申请号：US10513730
申请日：2003-04-30
IPC分类号： A61K36/00 , A61K20060101 , A61K31/197 , A61K31/198 , A61K31/215 , A61K36/16 , A61K36/18 , A61K36/54 , A61P15/00 , A61P15/10 , A61K35/78
CPC分类号： A61K36/16 , A61K31/197 , A61K31/215 , A61K36/185 , A61K36/54 , A61K2300/00
摘要： Disclosed are pharmaceutical compositions containing: extracts of Tribulus terrestris, Turnera diffusa and Cinnamon cassia in tile weight ratio of 1.5-3.5:1-2:0.1-0.4 respectively; Ginkgo biloba extract, and optionally arginine or a physiologically equivalent esters salts or precursor thereof. The compositions according to the invention are useful in the treatment of male and female sexual dysfunctions.
摘要翻译： 公开了药物组合物，其分别含有：枸杞提取物，苦参和肉桂桂，重量比分别为1.5-3.5：1-2：0.1-0.4; 银杏提取物，以及任选的精氨酸或其生理学上等同的酯盐或其前体。 根据本发明的组合物可用于治疗男性和女性性功能障碍。
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16.发明授权Cloning, yeast expression, purification and biological activity of the extension region of the soybean 7S globulin alfa' subunit involved in HEP G2 cell cholesterol homeostasis 有权参与HEP G2细胞胆固醇体内平衡的大豆7S球蛋白α亚基的延伸区域的克隆，酵母表达，纯化和生物活性公开(公告)号：US08569455B2
公开(公告)日：2013-10-29
申请号：US13378605
申请日：2010-06-16
申请人： Paolo Morazzoni , Antonella Riva , Cesare Ponzone , Davide Berlanda , Marcello Duranti , Alessandro Consonni
发明人： Paolo Morazzoni , Antonella Riva , Cesare Ponzone , Davide Berlanda , Marcello Duranti , Alessandro Consonni
IPC分类号： C07K14/415 , C12P21/04 , A61K38/16
CPC分类号： C07K14/415
摘要： A truncated form of α′ chain (eα′), the soybean 7S globulin, active in controlling the cholesterol and triglyceride homeostasis in in vitro and in vivo models, was cloned and expressed in the yeast Pichia pastoris. The recombinant polypeptide spanned 142 amino acid residues from the N-terminal side and included the N-terminal extension region of the soybean alpha′ subunit. The eα′ polypeptide was purified by conventional biochemical techniques and its potential to modulate the activity of the LDL-receptor was evaluated in a human hepatoma cell line (Hep G2) by monitoring the uptake and degradation of labeled LDL.
摘要翻译： 在酵母巴斯德毕赤酵母中克隆并表达了在体外和体内模型中有效控制胆固醇和甘油三酯体内平衡的α'链（ealpha'）的截短形式，大豆7S球蛋白。 重组多肽跨越了N末端侧的142个氨基酸残基并且包括大豆α'亚基的N末端延伸区。 通过常规生物化学技术纯化ealpha多肽，并通过监测标记的LDL的摄取和降解，在人肝癌细胞系（Hep G2）中评价其调节LDL-受体活性的潜力。
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公开(公告)号：US07438934B2
公开(公告)日：2008-10-21
申请号：US12036522
申请日：2008-02-25
CPC分类号： A61K31/198 , A61K31/11 , A61K31/192 , A61K31/70 , A61K36/185 , A61K36/296 , A61K36/54 , A61K2300/00
摘要： Pharmaceutical compositions containing: extracts of Tribulus terrestris, Epimedium koreanum, Cinnamon cassia in the weight ratio of 1.5-3.5:1-2:0.1-0.4 respectively; and optionally arginine or a physiologically equivalent ester, salt or precursor thereof. The compositions are useful in the treatment of male and female sexual dysfunctions. A method of treatment using the pharmaceutical compositions is also described.
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18.发明授权Hyperforin halogenated derivatives, the use thereof and formulations containing them 失效Hyperforin卤化衍生物，其使用和含有它们的制剂公开(公告)号：US07057078B2
公开(公告)日：2006-06-06
申请号：US10511894
申请日：2003-04-15
CPC分类号： C07C49/743 , C07C45/512 , C07C45/62 , C07C45/63 , C07C45/78 , C07C49/477 , C07C49/513 , C07C49/693 , C07C49/713
摘要： Hyperforin and adhyperforin halogenated derivatives of general formula (I) in which X, R and R1 have the meanings as defined in the disclosure, the process for the preparation thereof and the use thereof in the pharmaceutical and/or nutritional field, in particular in the treatment of depression, and Alzheimer's disease.
摘要翻译： 其中X，R和R 1具有如本公开内容中所定义的含义的通式（I）的高效蛋白和高效皂化衍生物，其制备方法及其在药物和/ 或营养场，特别是治疗抑郁症和阿尔茨海默病。
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公开(公告)号：US20050175722A1
公开(公告)日：2005-08-11
申请号：US10513819
申请日：2003-05-02
IPC分类号： A61K31/352 , A61K31/11 , A61K31/198 , A61K31/704 , A61K36/00 , A61K36/10 , A61K36/18 , A61K36/185 , A61K36/29 , A61K36/296 , A61K36/54 , A61P15/00 , A61P15/10 , A61K35/78
CPC分类号： A61K31/198 , A61K31/11 , A61K31/192 , A61K31/70 , A61K36/185 , A61K36/296 , A61K36/54 , A61K2300/00
摘要： Pharmaceutical compositions containing: extracts of Tribulus terrestris, Epimedium koreanum, Cinnamon cassia in the weight ratio of 1.5-3.5:1-2:0.1-0.4 respectively; and optionally arginine or a physiologically equivalent ester, salt or precursor thereof. The compositions are useful in the treatment of male and female sexual dysfunctions. A method of treatment using the pharmaceutical compositions is also described.
摘要翻译： 含有：枸杞提取物，韩文淫羊藿，肉桂桂的提取物，重量比分别为1.5-3.5：1-2：0.1-0.4; 和任选的精氨酸或其生理学上等同的酯，盐或其前体。 该组合物可用于治疗男性和女性性功能障碍。 还描述了使用药物组合物的治疗方法。
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20.再颁专利Hyperforin derivatives, the use thereof and formulations containing them 有权Hyperforin衍生物，其使用和含有它们的制剂公开(公告)号：USRE43280E1
公开(公告)日：2012-03-27
申请号：US12896158
申请日：2003-04-18
CPC分类号： C07C69/013 , C07C45/62 , C07C45/64 , C07C45/78 , C07C49/733 , C07C49/743 , C07C2602/46
摘要： The use of the reduction products of hyperforin and adhyperforin, pharmaceutically acceptable salts or esters thereof, in the pharmaceutical and/or nutritional field, in particular in the treatment of depression and Alzheimer's disease.
摘要翻译： 在制药和/或营养领域，特别是治疗抑郁症和阿尔茨海默氏病中，使用高效蛋白和高血压素的还原产物，其药学上可接受的盐或酯。
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