公开(公告)号：US06770435B1

公开(公告)日：2004-08-03

申请号：US09431384

申请日：1999-11-01

申请人： Patricia A. Billing-Medel ,  Maurice Cohen ,  Tracey L. Colpitts ,  Paula N. Friedman ,  Julian Gordon ,  Edward N. Granados ,  Steven C. Hodges ,  Michael R. Klass ,  Jon D. Kratochvil ,  John C. Russell ,  Christi P. Scheffel ,  Stephen D. Stroupe

发明人： Patricia A. Billing-Medel ,  Maurice Cohen ,  Tracey L. Colpitts ,  Paula N. Friedman ,  Julian Gordon ,  Edward N. Granados ,  Steven C. Hodges ,  Michael R. Klass ,  Jon D. Kratochvil ,  John C. Russell ,  Christi P. Scheffel ,  Stephen D. Stroupe

IPC分类号： C12Q168

CPC分类号： C07K14/47 ,  C12Q1/6886 ,  C12Q2600/136

摘要： A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as BU101 and transcribed from breast tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the breast, such as breast cancer. Also provided are antibodies which specifically bind to BU101-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific BU101 polypeptide, which molecules are useful for the therapeutic treatment of breast diseases, tumors or metastases.

摘要翻译： 描述了一组连续和部分重叠的cDNA序列和由此编码的多肽，命名为BU101并从乳腺组织转录。 这些序列可用于检测，诊断，分期，监测，预后，体内成像，预防或治疗或确定个体对乳腺疾病和病症如乳腺癌的倾向。 还提供了特异性结合BU101编码的多肽或蛋白质的抗体，以及预防组织特异性BU101多肽的作用的激动剂或抑制剂，该分子可用于治疗乳腺疾病，肿瘤或转移瘤。

公开(公告)号：US06660834B2

公开(公告)日：2003-12-09

申请号：US10278547

申请日：2002-10-23

申请人： Patricia A. Billing-Medel ,  Maurice Cohen ,  Tracey L. Colpitts ,  Paula N. Friedman ,  Julian Gordon ,  Edward N. Granados ,  Mark A. Hayden ,  Steven C. Hodges ,  Michael R. Klass ,  Jon D. Kratochvil ,  Lisa Roberts-Rapp ,  John C. Russell ,  Stephen D. Stroupe

发明人： Patricia A. Billing-Medel ,  Maurice Cohen ,  Tracey L. Colpitts ,  Paula N. Friedman ,  Julian Gordon ,  Edward N. Granados ,  Mark A. Hayden ,  Steven C. Hodges ,  Michael R. Klass ,  Jon D. Kratochvil ,  Lisa Roberts-Rapp ,  John C. Russell ,  Stephen D. Stroupe

IPC分类号： C07K1447

CPC分类号： G01N33/6893 ,  C07K14/47 ,  C07K16/3046 ,  C12Q1/6886 ,  C12Q2600/136 ,  G01N2800/06 ,  Y10S435/81 ,  Y10S530/828

摘要： A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as CS198 and transcribed from GI tract tissue, is described. These sequences are useful for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the GI tract, such as GI tract cancer. Also provided are antibodies which specifically bind to CS198-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific CS198 polypeptide, which molecules are useful for the therapeutic treatment of GI tract diseases, tumors or metastases.

摘要翻译： 描述了一组连续和部分重叠的cDNA序列和由此编码的多肽，命名为CS198并从胃肠道组织转录。 这些序列可用于检测，诊断，分期，监测，预后，预防或治疗或确定个体对胃肠道疾病和病症（例如胃肠道癌）的倾向。 还提供了特异性结合CS198编码的多肽或蛋白质的抗体，以及预防组织特异性CS198多肽的作用的激动剂或抑制剂，该分子可用于胃肠道疾病，肿瘤或转移瘤的治疗性治疗。

公开(公告)号：US6130043A

公开(公告)日：2000-10-10

申请号：US071710

申请日：1998-05-01

申请人： Patricia A. Billing-Medel ,  Maurice Cohen ,  Tracey L. Colpitts ,  Paula N. Friedman ,  Julian Gordon ,  Edward N. Granados ,  Steven C. Hodges ,  Michael R. Klass ,  Jon D. Kratochvil ,  Lisa Roberts-Rapp ,  John C. Russell ,  Stephen D. Stroupe ,  Hong Yu

发明人： Patricia A. Billing-Medel ,  Maurice Cohen ,  Tracey L. Colpitts ,  Paula N. Friedman ,  Julian Gordon ,  Edward N. Granados ,  Steven C. Hodges ,  Michael R. Klass ,  Jon D. Kratochvil ,  Lisa Roberts-Rapp ,  John C. Russell ,  Stephen D. Stroupe ,  Hong Yu

IPC分类号： A61K38/00 ,  C07K16/30 ,  C12N15/12 ,  C12Q1/68 ,  G01N33/574 ,  C07H21/04 ,  C12P19/34

CPC分类号： C07K16/3069 ,  C12Q1/6886 ,  G01N33/57434 ,  A61K38/00 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N2500/04

摘要： A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as PS108 and transcribed from prostate tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the prostate, such as prostate cancer. Also provided are antibodies which specifically bind to PS108-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific PS108 polypeptide, which molecules are useful for the therapeutic treatment of prostate diseases, tumors or metastases.

公开(公告)号：US06368792B1

公开(公告)日：2002-04-09

申请号：US09049698

申请日：1998-03-27

申请人： Patricia A. Billing-Medel ,  Maurice Cohen ,  Tracey L. Colpitts ,  Paula N. Friedman ,  Mark Hayden ,  Michael R. Klass ,  Lisa Roberts-Rapp ,  John C. Russell ,  Stephen D. Stroupe

发明人： Patricia A. Billing-Medel ,  Maurice Cohen ,  Tracey L. Colpitts ,  Paula N. Friedman ,  Mark Hayden ,  Michael R. Klass ,  Lisa Roberts-Rapp ,  John C. Russell ,  Stephen D. Stroupe

IPC分类号： C12Q168

CPC分类号： C07K16/3046 ,  C07K2317/34 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136

摘要： A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as CS193 and transcribed from GI tract tissue, are described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the GI tract, such as GI tract cancer. Also provided are antibodies which specifically bind to CS193-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific CS193 polypeptide, which molecules are useful for the therapeutic treatment of GI tract diseases, tumors or metastases.

公开(公告)号：US06465181B2

公开(公告)日：2002-10-15

申请号：US09276600

申请日：1999-03-25

申请人： Patricia A. Billing-Medel ,  Maurice Cohen ,  Tracey L. Colpitts ,  Julian Gordon ,  Edward N. Granados ,  John C. Russell ,  Stephen D. Stroupe

发明人： Patricia A. Billing-Medel ,  Maurice Cohen ,  Tracey L. Colpitts ,  Julian Gordon ,  Edward N. Granados ,  John C. Russell ,  Stephen D. Stroupe

IPC分类号： C12Q168

CPC分类号： G01N33/57434 ,  A61K38/00 ,  C07K14/4748 ,  C07K16/3069 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/136

摘要： A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as PCIGF and transcribed from prostate tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the prostate, such as prostate cancer. Also provided are antibodies which specifically bind to PCIGF-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific PCIGF polypeptide, which molecules are useful for the therapeutic treatment of prostate diseases, tumors or metastases.

摘要翻译： 描述了一组连续和部分重叠的cDNA序列和由此编码的多肽，称为PCIGF并从前列腺组织转录。 这些序列可用于检测，诊断，分期，监测，预后，体内成像，预防或治疗或确定个体对前列腺疾病和病症如前列腺癌的倾向。 还提供了特异性结合PCIGF编码的多肽或蛋白质的抗体，以及预防组织特异性PCIGF多肽的作用的激动剂或抑制剂，该分子可用于治疗前列腺疾病，肿瘤或转移瘤。

公开(公告)号：US06207380B1

公开(公告)日：2001-03-27

申请号：US09153804

申请日：1998-09-15

申请人： Patricia A. Billing-Medel ,  Maurice Cohen ,  Paula N. Friedman ,  Julian Gordon ,  Steven C. Hodges ,  Michael R. Klass ,  Jon D. Kratochvil ,  Eric Russell ,  Stephen D. Stroupe

发明人： Patricia A. Billing-Medel ,  Maurice Cohen ,  Paula N. Friedman ,  Julian Gordon ,  Steven C. Hodges ,  Michael R. Klass ,  Jon D. Kratochvil ,  Eric Russell ,  Stephen D. Stroupe

IPC分类号： C12Q168

CPC分类号： C12Q1/6883 ,  C07K16/18 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158

摘要： Polypeptides and polynucleotides useful for detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the urinary tract, such as urinary cancer, are described. These sequences are derived from keratin/cytokeratin, CAS, or mat-8 polypeptides and polynucleotides. Also provided are antibodies which specifically bind to keratin/cytokeratin, CAS, or mat-8-encoded polypeptides or proteins, which molecules are useful for the therapeutic treatment of urinary tract diseases, tumors or metastases.

摘要翻译： 描述了可用于检测，诊断，分期，监测，预后，体内成像，预防或治疗或确定个体对尿路疾病和状况（例如尿癌）的倾向的多肽和多核苷酸。 这些序列衍生自角蛋白/细胞角蛋白，CAS或mat-8多肽和多核苷酸。 还提供了特异性结合角蛋白/细胞角蛋白，CAS或mat-8编码的多肽或蛋白质的抗体，该分子可用于治疗尿路疾病，肿瘤或转移瘤。