公开(公告)号：US07307945B2

公开(公告)日：2007-12-11

申请号：US10306511

申请日：2002-11-27

申请人： Mitchell R Gerdisch ,  Harvey Rubin

发明人： Mitchell R Gerdisch ,  Harvey Rubin

IPC分类号： H04L12/28 ,  H04J3/26

CPC分类号： H04L12/1886 ,  H04L12/1836 ,  H04L12/185

摘要： Multi cast techniques are employed to provide host computer elements access to multiple redundant servers of a communication network in such a way that the hosts need not know which of the servers is active. In one embodiment, the servers provide a gateway function between an Ethernet LAN and an external network. The Ethernet LAN comprises one or more hosts connected to one or more switches, the switches connected to corresponding servers defining an active/standby pair. The servers are connected to an external network by corresponding active/standby links. The hosts send messages directed to a multicast address to at least one of the switches. The switches forward the messages on ports according to a multicast routing topology having been determined by performing IGMP “snooping” of messages issued from the servers. Both the active and standby servers receive the messages; and the active server sends the messages to the external network. In case the active server fails or is removed from service, the standby server is promoted to active server and assumes the role of the formerly active server without necessitating any communication to the hosts to inform them of the change in status of the active server.

摘要翻译： 使用多播技术来提供主机计算机元件访问通信网络的多个冗余服务器，使得主机不需要知道哪个服务器是活动的。 在一个实施例中，服务器在以太网LAN和外部网络之间提供网关功能。 以太网LAN包括连接到一个或多个交换机的一个或多个主机，交换机连接到定义主备对的相应服务器。 服务器通过相应的主备链路连接到外部网络。 主机向至少一个交换机发送定向到组播地址的消息。 根据通过对从服务器发出的消息执行IGMP“窥探”确定的组播路由拓扑，交换机转发端口上的消息。 主服务器和备用服务器都接收消息; 活动服务器将消息发送到外部网络。 如果活动服务器发生故障或从服务中删除，则备用服务器将升级为活动服务器，并承担以前活动的服务器的角色，而不需要与主机进行任何通信，以通知他们活动服务器状态的更改。

公开(公告)号：US07161912B1

公开(公告)日：2007-01-09

申请号：US09420275

申请日：1999-10-18

申请人： Miguel Dajer ,  Michael Francis Garyantes ,  Harvey Rubin

发明人： Miguel Dajer ,  Michael Francis Garyantes ,  Harvey Rubin

IPC分类号： H04Q7/20

CPC分类号： H04W88/08

摘要： A wireless communication system base station includes a number of channel unit boards, each including multiple channel elements for providing processing operations for signals assigned to multiple carriers of the system. A given channel unit board includes a multiplexer which is operative to implement multi-carrier/multi-sector channel pooling by assigning a given one of the channel elements of that board to any one of the multiple carriers of the system. For example, the multiplexer in the given channel board may be operative to connect the channel elements of that board to I/Q signal buses associated with different system carriers. The I/Q signal bus for each of the carriers is then combined on the given board with corresponding signals from other boards. The invention allows each of N channel elements of the given channel unit board to be assigned to a particular one of up to N carriers of the system, thereby providing substantially improved flexibility in terms of system configuration.

摘要翻译： 无线通信系统基站包括多个信道单元板，每个信道单元板包括用于为分配给系统的多个载波的信号提供处理操作的多个信道单元。 给定的信道单元板包括多路复用器，其通过将该板的给定一个信道单元分配给系统的多个载波中的任一个来操作来实现多载波/多扇区信道池。 例如，给定通道板中的多路复用器可操作以将该板的通道元件连接到与不同系统载体相关联的I / Q信号总线。 然后，每个载波的I / Q信号总线在给定的板上与来自其他板的相应信号组合。 本发明允许将给定信道单元板的N个信道单元中的每一个分配给系统的多达N个载波中的特定一个，从而在系统配置方面提供显着改进的灵活性。

公开(公告)号：US20060153233A1

公开(公告)日：2006-07-13

申请号：US11035407

申请日：2005-01-13

申请人： Ina Chen ,  Ling Ding ,  Mark Kraml ,  Harvey Rubin ,  Yang Yang

发明人： Ina Chen ,  Ling Ding ,  Mark Kraml ,  Harvey Rubin ,  Yang Yang

IPC分类号： H04J3/16

CPC分类号： H04W28/10 ,  H04L47/10 ,  H04L47/12 ,  H04L47/14 ,  H04L47/2416 ,  H04L47/70 ,  H04L47/746 ,  H04L47/762 ,  H04L47/801 ,  H04L47/822 ,  H04L47/824 ,  H04W28/26

摘要： A wireless communication system (20) includes a wireless network (22) that communicates with a plurality of base stations (24) over a backhaul network (26). A disclosed example includes monitoring an amount of control traffic on the backhaul network (26) and dynamically and automatically adjusting an allocation of the backhaul resource for handling the control traffic. A disclosed example automatically allocates a remaining amount of the backhaul resource for handling bearer traffic.

摘要翻译： 无线通信系统（20）包括通过回程网络（26）与多个基站（24）进行通信的无线网络（22）。 公开的示例包括监视回程网络（26）上的控制业务量，并且动态地并且自动地调整用于处理控制业务的回程资源的分配。 所公开的示例自动分配剩余量的用于处理承载业务的回程资源。

公开(公告)号：US06507572B1

公开(公告)日：2003-01-14

申请号：US09332274

申请日：1999-06-11

申请人： Sarath Kumar ,  Sanjiv Nanda ,  Harvey Rubin ,  Stanislav Vitebskiy

发明人： Sarath Kumar ,  Sanjiv Nanda ,  Harvey Rubin ,  Stanislav Vitebskiy

IPC分类号： H04Q720

CPC分类号： H04W52/143 ,  H04W36/18 ,  H04W52/146 ,  H04W52/40 ,  H04W52/44 ,  H04W52/50

摘要： A back haul architecture enables efficient primary transfer (i.e., transfer of the designation of primary base station from one base station to another). A frame selection/distribution (FSD) function queues packets of forward-link data—to which sequence numbers have been assigned—for packet-mode transmission over the back haul only to one base station—the current primary base station—where the packets are again queued for over-the-air transmission to the mobile unit. If and when it becomes appropriate to transfer the designation of primary base station to another base station, there may still be packets of data queued at the old primary base station awaiting transmission to the mobile unit. The old primary base station sends a message to the new primary base station indicating a particular sequence number that identifies the remaining packets of forward-link data queued at the old primary base station. The new primary base station then sends a message to the FSD function requesting transmission of those packets of forward-link data corresponding to the particular sequence number. The FSD function then transmits those requested packets of forward-link data to the new primary base station, which queues the requested packets for over-the-air transmission to the mobile unit. In this way, transmission of all of the forward-link data to the mobile unit is enabled without having to transmit the remaining queued packets of forward-link data from the old primary base station to the new primary base station over the back haul, thereby providing an efficient mechanism for primary transfer in wireless communications systems that support forward-link data transmissions only in simplex mode.

摘要翻译： 后向架构使得能够有效地进行一次传送（即将主基站的指定从一个基站传送到另一个基站）。 帧选择/分配（FSD）功能将前向链路数据的分组排队到序列号已经被分配的分组模式 - 用于仅在背行上的分组模式传输到一个基站 - 当前主基站 - 其中分组是 再次排队到空中传输到移动单元。 如果当将主基站的指定传送到另一基站变得适当时，仍然可能在旧的主基站处排队等待传输到移动单元的数据分组。 旧的主基站向新的主基站发送消息，指示表示在旧主基站排队的前向链路数据的剩余分组的特定序列号。 然后，新的主基站向FSD功能发送一个请求发送与特定序列号对应的前向链路数据的分组的消息。 然后，FSD功能将所请求的前向链路数据分组发送到新的主基站，该主基站将所请求的分组排队到空中传输到移动单元。 以这种方式，可以使得所有前向链路数据向移动单元的传输得以实现，而无需将后续链路数据的剩余排队分组从旧的主基站传输到新的主基站，从而 提供了一种仅在单工模式下支持前向链路数据传输的无线通信系统中的主要传输的有效机制。

公开(公告)号：US06377572B1

公开(公告)日：2002-04-23

申请号：US09080769

申请日：1998-05-18

申请人： Michael F. Dolan ,  Chung-Zin Liu ,  Harvey Rubin ,  Kenneth Wayne Strom

发明人： Michael F. Dolan ,  Chung-Zin Liu ,  Harvey Rubin ,  Kenneth Wayne Strom

IPC分类号： H04L1258

CPC分类号： H04W28/16 ,  H04W76/10 ,  Y10S370/913

摘要： A system includes a first virtual end point processor (332) operably coupled to a plurality of channel elements (304) and a second virtual end point processor (340) operably coupled to a plurality of frame selectors (314). The system also includes at least one signaling manager (318, 334) that is arranged and constructed to establish a communication path that terminates at the first virtual end point processor (332) and the second virtual end point processor (340) prior to receiving a request for resources for a data call, such that set-up time for the data call through a wireless network is reduced.

摘要翻译： 系统包括可操作地耦合到多个通道元件（304）的第一虚拟终点处理器（332）和可操作地耦合到多个框架选择器（314）的第二虚拟终点处理器（340）。 该系统还包括至少一个信令管理器（318,334），其被布置和构造成在接收到第一虚拟终点处理器之前建立终止于第一虚拟终点处理器（332）和第二虚拟终点处理器（340）的通信路径 请求数据呼叫的资源，从而减少通过无线网络进行数据呼叫的建立时间。

公开(公告)号：US5834279A

公开(公告)日：1998-11-10

申请号：US813940

申请日：1997-03-03

申请人： Harvey Rubin ,  Fude Yang ,  David Avarbock ,  Sean Curran

发明人： Harvey Rubin ,  Fude Yang ,  David Avarbock ,  Sean Curran

IPC分类号： C12N1/21 ,  C12N9/02 ,  C12N9/90 ,  C12N15/31 ,  C12N9/03

CPC分类号： C12N9/0093 ,  C12N9/90 ,  C12Y117/04001 ,  C12Y599/01002 ,  A01K2217/05

摘要： Nucleic acid molecules that encode R2 subunit protein and topoisomerase I protein, fragments thereof, recombinant expression vectors and host cells are disclosed. Oligonucleotide molecules with nucleotide sequences complimentary to a nucleotide sequence encode R2 subunit protein and topoisomerase I protein are disclosed.

摘要翻译： 公开了编码R2亚基蛋白和拓扑异构酶I蛋白的核酸分子，其片段，重组表达载体和宿主细胞。 公开了具有与编码R2亚单位蛋白质和拓扑异构酶I蛋白质的核苷酸序列互补的核苷酸序列的寡核苷酸分子。

公开(公告)号：US5459063A

公开(公告)日：1995-10-17

申请号：US136743

申请日：1993-10-14

申请人： Barry S. Cooperman ,  Harvey Rubin ,  Jerome Salem ,  Alison L. Fisher

发明人： Barry S. Cooperman ,  Harvey Rubin ,  Jerome Salem ,  Alison L. Fisher

IPC分类号： A61K38/00 ,  C07K14/445 ,  C12N9/02 ,  C12N15/53

CPC分类号： C12N9/0093 ,  C07K14/445 ,  A61K38/00

摘要： This invention relates to the ribonucleotide reductase of Plasmodium falciparum (Pf RR), to the subunits of Pf RR (Pf R1 and Pf R2), and to compounds comprising peptides derived from the Pf R2 C-terminus sequence that inhibit the action of protozoal RR. The invention provides a method for the prevention and treatment of malaria caused by P. falciparum by controlling the proliferation of P. falciparum comprising administering to a patient at least one peptide according to the invention. Antimalarial compositions are provided which comprise a pharmaceutically acceptable carrier and at least one peptide according to the invention which inhibits the P. falciparum ribonucleotide reductase reduction of ribonucleotides to 2'-deoxyribonucleotides. Also provided are methods for diagnosing malaria and for screening potential antimalarial agents.

摘要翻译： 本发明涉及恶性疟原虫（Pf RR）对Pf RR（Pf R1和Pf R2）的亚基的核糖核苷酸还原酶，以及包含抑制原生动物RR作用的Pf R2 C-末端序列的肽的化合物 。 本发明提供了通过控制恶性疟原虫的增殖来预防和治疗由恶性疟原虫引起的疟疾的方法，其包括向患者施用至少一种本发明的肽。 提供了抗疟组合物，其包含药学上可接受的载体和根据本发明的至少一种肽，其将核糖核苷酸的恶性疟原虫核糖核苷酸还原酶还原成2'-脱氧核糖核苷酸。 还提供了诊断疟疾和筛选潜在抗疟药物的方法。

公开(公告)号：US4416988A

公开(公告)日：1983-11-22

申请号：US389564

申请日：1982-09-17

申请人： Harvey Rubin

发明人： Harvey Rubin

IPC分类号： C07H21/00 ,  C07K14/665 ,  C12P19/34 ,  C07H21/04

CPC分类号： C07H21/00 ,  C07K14/665 ,  Y10T436/143333

摘要： A synthetic oligodeoxynucleotide complementary to endorphin mRNA and a method of using it to detect and isolate endorphin mRNA and cDNA from human and rabbit pancreas. A unique 15 base oligodeoxynucleotide dCATGAACCCGCCGTA wherein T represents thymine, G represents guanine, A represents adenine, and C represents cytosine and where at least 13 of the 15 nucleotides are as indicated (one of those indicated may be instead one of the other three mentioned nucleotides) has been found to be complementary to endorphin mRNA. To isolate endorphin mRNA, total RNA is first extracted from human brain and A+ is isolated from the total RNA. Other tissues may be used. The A+ RNA is then treated with the oligodeoxynucleotide, and the resulting hybridized RNA is enzymatically converted to endorphin mRNA:cDNA which can then be purified and used in a conventional manner to produce endorphin by cloning techniques.

摘要翻译： 与内啡肽mRNA互补的合成寡脱氧核苷酸及其用于检测和分离来自人和兔胰腺的内啡肽mRNA和cDNA的方法。 独特的15碱基寡脱氧核苷酸dCATGAACCCGCCGTA，其中T表示胸腺嘧啶，G表示鸟嘌呤，A表示腺嘌呤，C表示胞嘧啶，其中15个核苷酸中至少13个如所示（所示的一个可替代其他三个核苷酸之一 ）已被发现与内啡肽mRNA互补。 为了分离内啡肽mRNA，首先从人脑中提取总RNA，并从总RNA中分离A +。 可以使用其他组织。 然后用寡脱氧核苷酸处理A + RNA，并将得到的杂交RNA酶转化为内啡肽mRNA：然后可以将其纯化并以常规方式用克隆技术产生内啡肽。

公开(公告)号：US4401759A

公开(公告)日：1983-08-30

申请号：US366593

申请日：1982-04-08

申请人： Harvey Rubin ,  Richard H. Tullis

发明人： Harvey Rubin ,  Richard H. Tullis

IPC分类号： C07K14/605 ,  C12Q1/68 ,  C12N15/00 ,  C12P19/34 ,  C12P21/00

CPC分类号： C07K14/605 ,  C12Q1/68 ,  C12Q1/6876 ,  Y10T436/143333

摘要： A synthetic oligodeoxynucleotide complementary to glucagon mRNA and a method of using it to detect and isolate glucagon mRNA and cDNA from human and rabbit pancreas. A unique 14 base oligodeoxynucleotide dTTCATCAGCCACTG wherein T represents thymine, G represents guanine, A represents adenine, and C represents cytosine and where at least 13 of the 14 nucleotides are as indicated (one of those indicated may be replaced by one of the other three mentioned nucleotides) has been found to be complementary to glucagon mRNA. To isolate glucagon mRNA, total RNA is first extracted from human or rabbit pancreas and A+ RNA (mRNA-poly A) is isolated from the total RNA. The A+ RNA is then treated with the oligodeoxynucleotide, and the resulting hybridized RNA is enzymatically converted to glucagon mRNA which can then be purified, copied into glucagon cDNA and used in a conventional manner to produce glucagon by cloning technique.

摘要翻译： 与胰高血糖素mRNA互补的合成寡脱氧核苷酸及其用于检测和分离来自人和兔胰腺的胰高血糖素mRNA和cDNA的方法。 独特的14碱基寡脱氧核苷酸dTTCATCAGCCACTG，其中T代表胸腺嘧啶，G代表鸟嘌呤，A代表腺嘌呤，C代表胞嘧啶，其中14个核苷酸中的至少13个如上所述（其中一个可被其他三个之一代替 核苷酸）已被发现与胰高血糖素mRNA互补。 为了分离胰高血糖素mRNA，首先从人或兔胰腺提取总RNA，并从总RNA中分离出A + RNA（mRNA-聚A）。 然后用寡脱氧核苷酸处理A + RNA，将得到的杂交RNA酶转化为胰高血糖素mRNA，然后将其纯化，复制成胰高血糖素cDNA，并以常规方式用克隆技术生产胰高血糖素。

公开(公告)号：US4358586A

公开(公告)日：1982-11-09

申请号：US219435

申请日：1980-12-23

申请人： Harvey Rubin

发明人： Harvey Rubin

IPC分类号： C07H21/00 ,  C07H21/04 ,  C12N15/00

CPC分类号： C07H21/00

摘要： A synthetic oligodeoxynucleotide complementary to endorphin mRNA and a method of using it to detect and isolate endorphin mRNA and cDNA from human and rabbit pancreas. A unique 15 base oligodeoxynucleotide dCATGAACCCGCCGTA wherein T represents thymine, G represents guanine, A represents adenine, and C represents cytosine and where at least 13 of the 15 nucleotides are as indicated (one of those indicated may be instead one of the other three mentioned nucleotides) has been found to be complementary to endorphin mRNA. To isolate endorphin mRNA, total RNA is first extracted from human brain and A+ is isolated from the total RNA. Other tissues may be used. The A+ RNA is then treated with the oligodeoxynucleotide, and the resulting hybridized RNA is enzymatically converted to endorphin mRNA:cDNA which can then be purified and used in a conventional manner to produce endorphin by cloning techniques.

摘要翻译： 与内啡肽mRNA互补的合成寡脱氧核苷酸及其用于检测和分离来自人和兔胰腺的内啡肽mRNA和cDNA的方法。 独特的15碱基寡脱氧核苷酸dCATGAACCCGCCGTA，其中T表示胸腺嘧啶，G表示鸟嘌呤，A表示腺嘌呤，C表示胞嘧啶，其中15个核苷酸中至少13个如所示（所示的一个可替代其他三个核苷酸之一 ）已被发现与内啡肽mRNA互补。 为了分离内啡肽mRNA，首先从人脑中提取总RNA，并从总RNA中分离A +。 可以使用其他组织。 然后用寡脱氧核苷酸处理A + RNA，并将得到的杂交RNA酶转化为内啡肽mRNA：然后可以将其纯化并以常规方式用克隆技术产生内啡肽。