公开(公告)号：US20150233074A1

公开(公告)日：2015-08-20

申请号：US14383443

申请日：2013-12-24

Applicant: Pei YU

Inventor： Pei Yu

IPC: E02D5/28 ,  B22D13/02 ,  E02D27/12 ,  C21D8/10 ,  C21D9/08 ,  C22C37/10 ,  C21D5/00

CPC classification number: E02D5/285 ,  B22D13/02 ,  C21D5/00 ,  C21D8/105 ,  C21D9/08 ,  C22C28/00 ,  C22C33/08 ,  C22C37/04 ,  C22C37/10 ,  E02D5/66 ,  E02D27/12

Abstract: The present invention provides a nodular cast iron foundation pile pipe and a method for preparing same, including following steps: (1) preparation before pipe casting: including molten iron preparation, spheroidization and coating spraying on an inner wall of a pipe mold; (2) pipe casting process: including centrifugal casting and pipe drawing; (3) annealing process; (4) finishing process. The present invention further provides the foundation pile pipe manufactured with the above-mentioned method wherein the flange and the foundation pile pipe are integrally cast or welded. In the present invention, the nodular cast iron is used as the material of the foundation pile pipe instead of Q345 steel used in the prior art. As a result, the overall strength is enhanced. The present invention possesses advantages such as corrosion resistance, long service life, low manufacturing cost, low labor intensity, short construction period and being suitable for mechanized construction.

Abstract translation: 本发明提供一种球墨铸铁基础桩管及其制备方法，包括以下步骤：（1）管道铸造前的准备：包括铁水制备，球化和喷涂在管模内壁上; （2）管道铸造工艺：包括离心铸造和管道拉拔; （3）退火工艺; （4）整理过程。 本发明还提供了一种用上述方法制造的地基桩管，其中法兰和地桩桩整体铸造或焊接。 在本发明中，代替现有技术中使用的Q345钢，将球墨铸铁用作基桩管的材料。 结果，综合实力得到提高。 本发明具有耐腐蚀，使用寿命长，制造成本低，劳动强度低，施工周期短，适用于机械化施工等优点。

公开(公告)号：US20060228761A1

公开(公告)日：2006-10-12

申请号：US11295841

申请日：2005-12-06

Applicant: Ying Luo ,  Pei Yu ,  Mary Shen ,  Betty Huang

Inventor： Ying Luo ,  Pei Yu ,  Mary Shen ,  Betty Huang

IPC: G01N33/574 ,  C07H21/04 ,  C12P21/06 ,  C40B30/06 ,  C07K14/82 ,  C07K16/30

CPC classification number: C12N9/1205 ,  C07K14/4738 ,  C07K16/18

Abstract: The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.

公开(公告)号：US20110077295A1

公开(公告)日：2011-03-31

申请号：US12672476

申请日：2008-08-07

Applicant: Yuqiang Wang ,  Xiaojian Jiang ,  Jie Jiang ,  Zaijun Zhang ,  Zhaoqi Yang ,  Pei Yu

Inventor： Yuqiang Wang ,  Xiaojian Jiang ,  Jie Jiang ,  Zaijun Zhang ,  Zhaoqi Yang ,  Pei Yu

IPC: A61K31/341 ,  C07D307/60 ,  A61P35/00 ,  A61P3/10 ,  A61P35/02

CPC classification number: C07D307/58 ,  C07D307/60 ,  C07D409/12

Abstract: The present invention relates to an andrographolide derivative of the formula (I), wherein R1, R2 and R3 are same or different substituents selected from hydrogen, substituted or unsubstituted organic acid radicals, inorganic acid radicals, alkyl, aryl or heteroaryl, and at least one of R1, R2 and R3 is R-lipoic acid, S-lipoic acid or a mixture thereof, or corresponding dihydrolipoic acids thereof, or N-acetylcysteine radical. The derivative has good antitumor effect, can induce apoptosis of tumor cells, can directly kill Gram-positive bacteria (staphylococcus aureus) and drug resistance bacteria (MRSA5676 and MRSA5677), can inhibit the QS-system of Gram-negative bacteria (Pseudomonas aeruginosa), can inhibit and destroy the formation of biofilm of Pseudomonas aeruginosa; and exhibits significant hypoglycemic effect, so that it can be used in manufacture of medicaments for treatment of cancers, inflammation, diabetes, and bacterial and viral infections.

Abstract translation: 本发明涉及式（I）的穿心莲内酯衍生物，其中R 1，R 2和R 3是相同或不同的选自氢，取代或未取代的有机酸基，无机酸基，烷基，芳基或杂芳基的取代基，至少 R1，R2和R3之一是R-硫辛酸，S-硫辛酸或其混合物，或其相应的二氢硫辛酸或N-乙酰半胱氨酸碱基。 该衍生物具有良好的抗肿瘤作用，可诱导肿瘤细胞凋亡，可直接杀死革兰氏阳性菌（金黄色葡萄球菌）和耐药细菌（MRSA5676和MRSA5677），可抑制革兰氏阴性菌（绿脓假单胞菌）的QS系统， ，可以抑制和破坏铜绿假单胞菌生物膜的形成; 并显示出显着的降血糖作用，因此可用于制造用于治疗癌症，炎症，糖尿病以及细菌和病毒感染的药物。