-
公开(公告)号：US20190382388A1
公开(公告)日：2019-12-19
申请号：US16535616
申请日：2019-08-08
Applicant: Pfizer Inc.
Inventor： Gary Erik Aspnes , Scott W. Bagley , John M. Curto , David James Edmonds , Mark E. Flanagan , Kentaro Futatsugi , David A. Griffith , Kim Huard , Yajing Lian , Chris Limberakis , Allyn T. Londregan , Alan M. Mathiowetz , David W. Piotrowski , Roger B. Ruggeri
IPC: C07D405/12 , C07D405/14 , C07C53/10 , C07D471/04 , C07C215/40 , C07C53/06 , C07D413/14
Abstract: Provided herein are 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, and 7-aza-benzimidazoles as GLP-1R agonists, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.
-
公开(公告)号：US20190119255A1
公开(公告)日：2019-04-25
申请号：US16220184
申请日：2018-12-14
Applicant: Pfizer Inc.
Inventor： Gary Erik Aspnes , Scott W. Bagley , John M. Curto , Matthew S. Dowling , David Edmonds , Mark E. Flanagan , Kentaro Futatsugi , David A. Griffith , Kim Huard , Gajendra Ingle , Wenhua Jiao , Chris Limberakis , Alan M. Mathiowetz , David W. Piotrowski , Roger B. Ruggeri
IPC: C07D401/14 , A61K31/4545 , A61P43/00 , A61P1/16 , A61P25/02 , A61P3/04 , A61P19/02 , A61P3/10 , A61P13/12 , A61P25/18 , A61P1/00 , A61P15/00 , A61P25/16 , C07D405/14 , C07D471/04 , A61P15/10 , A61P3/00 , C07D487/04 , C07D413/14 , A61P17/06 , A61P9/10 , A61P19/06 , A61P25/28 , A61P25/30 , A61K31/496
Abstract: Provided herein are 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, 7-aza- and 4,7-diaza-benzimidazoles as GLP-1R agonists, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.
-
公开(公告)号：US09340493B2
公开(公告)日：2016-05-17
申请号：US14223061
申请日：2014-03-24
Applicant: Pfizer Inc.
Inventor： Matthew Frank Brown , Charles Francis Donovan , Edmund Lee Ellsworth , Denton Wade Hoyer , Timothy Allan Johnson , Manjinder Singh Lall , Chris Limberakis , Sean Timothy Murphy , Debra Ann Sherry , Clarke Bentley Taylor , Joseph Scott Warmus
IPC: A61K31/685 , A61K31/19 , A61K31/415 , A61K31/44 , A61K31/34 , A61K31/42 , A61K31/425 , A61K31/535 , C07D233/64 , C07D213/55 , C07D307/54 , C07C259/06 , C07D207/267 , C07D213/30 , C07D213/38 , C07D231/12 , C07D237/04 , C07D239/26 , C07D249/04 , C07D249/08 , C07D257/04 , C07D261/08 , C07D261/10 , C07D263/32 , C07D271/06 , C07D277/24 , C07D277/28 , C07D285/06 , C07D307/14 , C07D307/42 , C07D309/10 , C07D413/04 , C07D413/12 , C07D471/04 , C07F9/653 , C07D277/30
CPC classification number: C07C259/06 , C07C2601/04 , C07D207/267 , C07D213/30 , C07D213/38 , C07D213/55 , C07D231/12 , C07D233/64 , C07D237/04 , C07D239/26 , C07D249/04 , C07D249/08 , C07D257/04 , C07D261/08 , C07D261/10 , C07D263/32 , C07D271/06 , C07D277/24 , C07D277/28 , C07D277/30 , C07D285/06 , C07D307/14 , C07D307/42 , C07D307/54 , C07D309/10 , C07D413/04 , C07D413/12 , C07D471/04 , C07F9/653
Abstract: The invention relates to a compound of formula (I): or a pharmaceutically acceptable salt thereof, thereof, wherein: G is a group of formula (II): and pharmaceutically acceptable salts, prodrugs, hydrates, or solvates, thereof, wherein A, B, L1-L4, A, B, R1-R4, and m are as defined herein. The invention also relates to pharmaceutical compositions comprising the compounds of formula (I) and their use in treating a bacterial infection.
Abstract translation: 本发明涉及式（I）化合物或其药学上可接受的盐，其中：G为式（II）的基团：及其药学上可接受的盐，前体药物，水合物或溶剂合物，其中A， B，L1-L4，A，B，R1-R4和m如本文所定义。 本发明还涉及包含式（I）化合物及其在治疗细菌感染中的用途的药物组合物。
-
公开(公告)号：US20240132483A1
公开(公告)日：2024-04-25
申请号：US18513752
申请日：2023-11-20
Applicant: Pfizer Inc.
Inventor： Gary Erik Aspnes , Scott W. Bagley , Edward L. Conn , John M. Curto , David J. Edmonds , Mark E. Flanagan , Kentaro Futatsugi , David A. Griffith , Kim Huard , Chris Limberakis , Alan M. Mathiowetz , David W. Piotrowski , Roger B. Ruggeri
IPC: C07D405/14 , C07D401/14 , C07D403/14 , C07D413/14 , C07D471/04
CPC classification number: C07D405/14 , C07D401/14 , C07D403/14 , C07D413/14 , C07D471/04
Abstract: Provided herein are 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, and 7-aza-benzimidazoles as GLP-1R agonists, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.
-
公开(公告)号：US20230124938A1
公开(公告)日：2023-04-20
申请号：US18049052
申请日：2022-10-24
Applicant: Pfizer Inc.
Inventor： Gary Erik Aspnes , Scott W. Bagley , John M. Curto , Matthew S. Dowling , David Edmonds , Mark E. Flanagan , Kentaro Futatsugi , David A. Griffith , Kim Huard , Gajendra Ingle , Wenhua Jiao , Chris Limberakis , Alan M. Mathiowetz , David W. Piotrowski , Roger B. Ruggeri
IPC: C07D401/14 , A61K31/496 , A61K31/4545 , C07D487/04 , A61P3/00 , A61P15/10 , A61P17/06 , A61P9/10 , A61P19/06 , A61P25/28 , A61P25/30 , A61P43/00 , A61P1/16 , A61P25/02 , A61P3/04 , A61P19/02 , A61P3/10 , A61P13/12 , A61P25/18 , A61P1/00 , A61P15/00 , A61P25/16 , C07D405/14 , C07D413/14 , C07D471/04
Abstract: Provided herein are 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, 7-aza- and 4,7-diaza-benzimidazoles as GLP-1R agonists, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.
-
Patent Agency Ranking
![Solid Forms of 2-((4-((S)-2-(5-Chloropyridin-2-yl)-2-methylbenzo[d][1,3]dioxol-4-yl)piperidin-1-yl)methyl)-1-(((S)-oxetan-2-yl)methyl)-1H-benzo[d]imidazole-6-carboxylic acid, 1,3-Dihydroxy-2-(hydroxymethyl)propan-2-amine Salt](/abs-image/US/2023/02/09/US20230045419A1/abs.jpg.150x150.jpg)
公开(公告)号：US20230045419A1
公开(公告)日：2023-02-09
申请号：US17782478
申请日：2020-12-07
Applicant: Pfizer Inc.
Inventor： Gary E. Aspnes , Scott W. Bagley , Wesley Dewitt Clark , John M. Curto , David James Edmonds , Mark E. Flanagan , Kentaro Futatsugi , David Andrew Griffith , Kim Huard , Yajing Lian , Chris Limberakis , Allyn T. Londregan , Alan M. Mathiowetz , David Walter Piotrowski , Roger B. Ruggeri
IPC: C07D405/14
Abstract: The invention provides solid forms of 2-((4-((S)-2-(5-chloropyridin-2-yl)-2-methylbenzo[d][1,3]dioxol-4-yl)piperidin-1-yl)methyl)-1-(((S)-oxetan-2-yl)methyl)-1H-benzo[d]imidazole-6-carboxylic acid, 1,3-dihydroxy-2-(hydroxymethyl)propan-2-amine salt for example, a hydrate (e.g. a monohydrate) crystalline form (e.g. Form 2 or Form 3) or an amorphous form; as well as pharmaceutical compositions, and the uses thereof in treating diseases, conditions or disorders modulated by GLP-1R in a mammal, such as a human.
-
公开(公告)号：US20210163455A1
公开(公告)日：2021-06-03
申请号：US17171385
申请日：2021-02-09
Applicant: Pfizer Inc.
Inventor： Gary Erik Aspnes , Scott W. Bagley , John M. Curto , David James Edmonds , Mark E. Flanagan , Kentaro Futatsugi , David A. Griffith , Kim Huard , Yajing Lian , Chris Limberakis , Allyn T. Londregan , Alan M. Mathiowetz , David W. Piotrowski , Roger B. Ruggeri
IPC: C07D405/12 , C07C53/06 , C07C53/10 , C07C215/40 , C07D405/14 , C07D413/14 , C07D471/04
Abstract: Provided herein are 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, and 7-aza-benzimidazoles as GLP-1R agonists, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.
-
公开(公告)号：US20200255406A1
公开(公告)日：2020-08-13
申请号：US16861646
申请日：2020-04-29
Applicant: Pfizer Inc.
Inventor： Gary Erik Aspnes , Scott W. Bagley , John M. Curto , Matthew S. Dowling , David Edmonds , Mark E. Flanagan , Kentaro Futatsugi , David A. Griffith , Kim Huard , Gajendra Ingle , Wenhua Jiao , Chris Limberakis , Alan M. Mathiowetz , David W. Piotrowski , Roger B. Ruggeri
IPC: C07D401/14 , A61K31/496 , A61K31/4545 , C07D487/04 , A61P3/00 , A61P15/10 , A61P17/06 , A61P9/10 , A61P19/06 , A61P25/28 , A61P25/30 , A61P43/00 , A61P1/16 , A61P25/02 , A61P3/04 , A61P19/02 , A61P3/10 , A61P13/12 , A61P25/18 , A61P1/00 , A61P15/00 , A61P25/16 , C07D405/14 , C07D413/14 , C07D471/04
Abstract: Provided herein are 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, 7-aza- and 4,7-diaza-benzimidazoles as GLP-1R agonists, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.
-
公开(公告)号：US10676465B2
公开(公告)日：2020-06-09
申请号：US16535616
申请日：2019-08-08
Applicant: Pfizer Inc.
Inventor： Gary Erik Aspnes , Scott W. Bagley , John M. Curto , David James Edmonds , Mark E. Flanagan , Kentaro Futatsugi , David A. Griffith , Kim Huard , Yajing Lian , Chris Limberakis , Allyn T. Londregan , Alan M. Mathiowetz , David W. Piotrowski , Roger B. Ruggeri
IPC: C07D405/12 , C07D405/14 , C07D471/04 , C07C53/06 , C07C53/10 , C07C215/40 , C07D413/14
Abstract: Provided herein are 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, and 7-aza-benzimidazoles as GLP-1R agonists, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.
-
公开(公告)号：US10669259B2
公开(公告)日：2020-06-02
申请号：US16220184
申请日：2018-12-14
Applicant: Pfizer Inc.
Inventor： Gary Erik Aspnes , Scott W. Bagley , John M. Curto , Matthew S. Dowling , David Edmonds , Mark E. Flanagan , Kentaro Futatsugi , David A. Griffith , Kim Huard , Gajendra Ingle , Wenhua Jiao , Chris Limberakis , Alan M. Mathiowetz , David W. Piotrowski , Roger B. Ruggeri
IPC: A61K31/496 , A61K31/4545 , C07D401/14 , C07D487/04 , A61P3/00 , A61P15/10 , A61P17/06 , A61P9/10 , A61P19/06 , A61P25/28 , A61P25/30 , A61P43/00 , A61P1/16 , A61P25/02 , A61P3/04 , A61P19/02 , A61P3/10 , A61P13/12 , A61P25/18 , A61P1/00 , A61P15/00 , A61P25/16 , C07D405/14 , C07D413/14 , C07D471/04
Abstract: Provided herein are 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, 7-aza- and 4,7-diaza-benzimidazoles as GLP-1R agonists, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.
-
-
-
-
-
-
-
-
-
Search Results
26
records
(took 0.022 seconds)
