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公开(公告)号：US10570121B2
公开(公告)日：2020-02-25
申请号：US16156304
申请日：2018-10-10
Applicant: Pfizer Inc.
Inventor： Michael Raymond Collins , Robert Steven Kania , Robert Arnold Kumpf , Pei-Pei Kung , Daniel Tyler Richter , Scott Channing Sutton , Martin James Wythes
IPC: C07D401/06 , C07B59/00 , A61K31/4725 , C07D405/14 , C07D401/14 , C07D413/14 , C07D409/14
Abstract: This invention relates to compounds of general formula (I) in which R1, R2, R3, R4, L, X and Z are as defined herein, and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.
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公开(公告)号：US20170348313A1
公开(公告)日：2017-12-07
申请号：US15612030
申请日：2017-06-02
Applicant: Pfizer Inc.
Inventor： John Howard Tatlock , Indrawan James McAlpine , Michelle Bich Tran-Dube , Eugene Yuanjin Rui , Martin James Wythes , Robert Arnold Kumpf , Michele Ann McTigue , Ryan Patman
IPC: A61K31/519 , C07D471/06 , C07D251/16 , A61K31/137 , A61K31/53 , C07D519/00 , C07D237/22 , A61K31/02 , C07C255/34
CPC classification number: A61K31/519 , A61K31/02 , A61K31/137 , A61K31/53 , C07C255/34 , C07D237/22 , C07D239/42 , C07D239/84 , C07D251/16 , C07D251/18 , C07D471/06 , C07D487/04 , C07D491/048 , C07D519/00
Abstract: Compounds of the general formula): processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.
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公开(公告)号：US20150361067A1
公开(公告)日：2015-12-17
申请号：US14740439
申请日：2015-06-16
Applicant: PFIZER INC.
Inventor： Michael Raymond Collins , Robert Steven Kania , Robert Arnold Kumpf , Pei-Pei Kung , Daniel Tyler Richter , Scott Channing Sutton , Martin James Wythes
IPC: C07D401/06 , C07D409/14 , C07D413/14 , C07D405/14 , C07D401/14
CPC classification number: C07D405/14 , C07B59/002 , C07B2200/05 , C07D401/06 , C07D401/14 , C07D409/14 , C07D413/14
Abstract: This invention relates to compounds of general formula (I) in which R1, R2, R3, R4, L, X and Z are as defined herein, and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.
Abstract translation: 本发明涉及其中R1，R2，R3，R4，L，X和Z如本文所定义的通式（I）化合物及其药学上可接受的盐，涉及包含这些化合物和盐的药物组合物，以及方法 使用这些化合物，盐和组合物来治疗异常细胞生长，包括癌症。
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公开(公告)号：US20150239842A1
公开(公告)日：2015-08-27
申请号：US14430799
申请日：2013-09-16
Applicant: PFIZER INC.
Inventor： Martin Paul Edwards , Robert Arnold Kumpf , Pei-Pei Kung , Indrawan James Mcalpine , Eugene Yuanjin Rui , Scott Channing Sutton , John Howard Tatlock , Martin James Wythes
IPC: C07D213/64 , C07D487/08 , C07D491/08 , C07D405/14 , C07D413/14 , C07D401/12 , C07D401/14
CPC classification number: C07D401/14 , C07D213/64 , C07D401/12 , C07D405/14 , C07D407/14 , C07D409/14 , C07D413/14 , C07D487/08 , C07D491/08
Abstract: This invention relates to compounds of general formula (I), in which R1, R2, R6, U, V, W, X, Y and Z are as defined herein, and the pharmaceutically acceptable salts thereof, pharmaceutical compositions containing such compounds and salts, and to methods of using such compounds, salts and compositions.
Abstract translation: 本发明涉及通式（I）的化合物，其中R1，R2，R6，U，V，W，X，Y和Z如本文所定义，及其药学上可接受的盐，含有这些化合物和盐的药物组合物 以及使用这些化合物，盐和组合物的方法。
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公开(公告)号：US10709709B2
公开(公告)日：2020-07-14
申请号：US16224016
申请日：2018-12-18
Applicant: Pfizer Inc.
Inventor： John Howard Tatlock , Indrawan James McAlpine , Michelle Bich Tran-Dube , Eugene Yuanjin Rui , Martin James Wythes , Robert Arnold Kumpf , Michele Ann McTigue , Ryan Patman
IPC: A61K31/519 , A61P35/02 , A61P35/04 , C07D239/42 , C07D239/84 , C07D251/18 , C07D487/04 , C07D491/048 , A61K31/137 , A61K31/53 , C07D237/22 , C07D251/16 , C07D471/06 , C07D519/00 , C07C255/34 , A61K31/02
Abstract: Compounds of the general formula): processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.
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Patent Agency Ranking
公开(公告)号：US10428104B2
公开(公告)日：2019-10-01
申请号：US15045679
申请日：2016-02-17
Applicant: Pfizer Inc.
Inventor： John Howard Tatlock , Indrawan James McAlpine , Michelle Bich Tran-Dube , Eugene Yuanjin Rui , Martin James Wythes , Robert Arnold Kumpf , Michele Ann McTigue
IPC: C07H19/14 , C07H19/23 , A61K31/7064 , C07H19/24 , C07H19/16
Abstract: Compounds such as: processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds to treat neoplasms have been disclosed.
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公开(公告)号：US20190284216A1
公开(公告)日：2019-09-19
申请号：US16297910
申请日：2019-03-11
Applicant: PFIZER INC.
Inventor： Martin James Wythes , Indrawan James McAlpine , Ryan Patman , Eugene Yuanjin Rui , Andrew Fensome , Andreas Maderna , Mehran Jalaie , Ketan S. Gajiwala
IPC: C07F9/6574 , A61P35/00 , A61K47/68
Abstract: Compounds of the general formula (I): or a pharmaceutically acceptable salt thereof, processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.
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公开(公告)号：US20190111060A1
公开(公告)日：2019-04-18
申请号：US16224016
申请日：2018-12-18
Applicant: Pfizer Inc.
Inventor： John Howard Tatlock , Indrawan James McAlpine , Michelle Bich Tran-Dube , Eugene Yuanjin Rui , Martin James Wythes , Robert Arnold Kumpf , Michele Ann McTigue , Ryan Patman
IPC: A61K31/519 , C07D491/048 , C07D487/04 , C07D251/18 , C07D239/84 , C07D239/42 , A61K31/137 , C07D471/06 , A61K31/53 , C07D519/00 , C07D237/22 , C07D251/16
Abstract: Compounds of the general formula): processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.
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公开(公告)号：US20170298048A1
公开(公告)日：2017-10-19
申请号：US15635648
申请日：2017-06-28
Applicant: Pfizer Inc.
Inventor： Michael Raymond Collins , Robert Steven Kania , Robert Arnold Kumpf , Pei-Pei Kung , Daniel Tyler Richter , Scott Channing Sutton , Martin James Wythes
IPC: C07D405/14 , C07D401/06 , C07D401/14 , C07D409/14
CPC classification number: C07D405/14 , C07B59/002 , C07B2200/05 , C07D401/06 , C07D401/14 , C07D409/14 , C07D413/14
Abstract: This invention relates to compounds of general formula (I) in which R1, R2, R3, R4, L, X and Z are as defined herein, and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.
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公开(公告)号：US09040515B2
公开(公告)日：2015-05-26
申请号：US14132567
申请日：2013-12-18
Applicant: Pfizer Inc.
Inventor： Martin Paul Edwards , Robert Arnold Kumpf , Pei-Pei Kung , Indrawan James McAlpine , Sacha Ninkovic , Eugene Yuanjin Rui , Scott Channing Sutton , John Howard Tatlock , Martin James Wythes , Luke Raymond Zehnder
IPC: C07D401/06 , C07D401/14 , C07D403/14 , C07D405/14 , C07D407/14 , C07D413/06 , C07D413/14 , C07D471/04 , C07D487/04
CPC classification number: C07D401/06 , C07D401/14 , C07D403/14 , C07D405/14 , C07D407/14 , C07D413/06 , C07D413/14 , C07D471/04 , C07D487/04
Abstract: This invention relates to compounds of general formula (I) in which R1, R2, U, V, L, M, R5, m, X, Y and Z are as defined herein, and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.
Abstract translation: 本发明涉及通式（I）的化合物，其中R1，R2，U，V，L，M，R5，m，X，Y和Z如本文所定义，及其药学上可接受的盐， 这些化合物和盐，以及使用这些化合物，盐和组合物用于治疗异常细胞生长（包括癌症）的方法。
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