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    Steroidal glycolipids as host resistance stimulators against viral infection
    14.
    发明授权
    Steroidal glycolipids as host resistance stimulators against viral infection 失效
    甾体糖脂作为抗病毒感染的宿主抗性刺激物

    公开(公告)号：US5019568A

    公开(公告)日：1991-05-28

    申请号：US370058

    申请日：1989-06-21

    申请人： Philippe L. Durette ,  William K. Hagmann ,  Mitree M. Ponpipom

    发明人： Philippe L. Durette ,  William K. Hagmann ,  Mitree M. Ponpipom

    IPC分类号： A61K33/24 ,  A61K35/54

    CPC分类号： A61K31/704 ,  A61K31/70 ,  A61K33/24

    摘要： Disclosed are pharmaceutical compositions for enhancing human host resistance against opportunistic infection in an individual immunocompromised by an AIDS-related virus, consisting essentially of an anti-viral, anti-AIDS drug selected from the group consisting of ansamycin, ribavirin, dideoxycitidine, HPA-23, AL-721, foscarnet, and azidothymidine and a glycolipid compound consisting essentially of the formula: ##STR1## where: R.sup.1 is .alpha. or .beta.-D-1-thiomannopyranoside, .alpha. or .beta.-L-1-thiofucopyranoside.

    摘要翻译： 公开了用于增强人宿主对由艾滋病相关病毒免疫受损的个体的机体感染抵抗力的药物组合物，其基本上由选自安莎霉素，利巴韦林，双脱氧胞苷，HPA-23的抗病毒，抗艾滋病药物组成 ，AL-721，膦甲酸和叠氮胸苷和基本上由下式组成的糖脂化合物：其中：R1是α或β-D-1-硫代吗喃吡喃糖苷，α或β-L1-硫代吡喃葡萄糖苷。

    Fluorinated Pyrrolo[2,3-D]Pyrimidine Nucleosides for the Treatment of Rna-Dependent Rna Viral Infection
    15.
    发明申请
    Fluorinated Pyrrolo[2,3-D]Pyrimidine Nucleosides for the Treatment of Rna-Dependent Rna Viral Infection 审中-公开
    用于治疗Rna依赖性Rna病毒感染的氟化吡咯并[2,3-D]嘧啶核苷

    公开(公告)号：US20080280842A1

    公开(公告)日：2008-11-13

    申请号：US11664564

    申请日：2005-10-17

    申请人： Malcolm MacCoss ,  David B. Olsen ,  Joseph Leone ,  Philippe L. Durette

    发明人： Malcolm MacCoss ,  David B. Olsen ,  Joseph Leone ,  Philippe L. Durette

    IPC分类号： A61K31/7064 ,  C07H19/04 ,  A61P31/12

    CPC分类号： C07H19/14

    摘要： The present invention provides fluorinated pyrrolo[2,3,d]pyrimidine nucleoside compounds which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as precursors to inhibitors of hepatitis C virus (HCV) NS5B polymerase, as precursors to inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such fluorinated pyrrolo[2,3-d]pyrimidine nucleoside alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the fluorinated pyrrolo[2,3-d]pyrimidine nucleoside of the present invention.

    摘要翻译： 本发明提供了作为RNA依赖性RNA病毒聚合酶抑制剂的氟化吡咯并[2,3，d]嘧啶核苷化合物。 这些化合物是RNA依赖性RNA病毒复制的抑制剂，可用于治疗RNA依赖性RNA病毒感染。 它们特别可用作丙型肝炎病毒（HCV）NS5B聚合酶抑制剂的前体，作为HCV复制抑制剂的前体和/或治疗丙型肝炎感染。 本发明还描述了含有这种氟化吡咯并[2,3-d]嘧啶核苷的药物组合物，或者与其它对RNA依赖性RNA病毒感染，特别是HCV感染有活性的试剂组合。 还公开了本发明的氟化吡咯并[2,3-d]嘧啶核苷抑制RNA依赖性RNA聚合酶，抑制RNA依赖性RNA病毒复制和/或治疗RNA依赖性RNA病毒感染的方法。