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公开(公告)号：US08759374B2
公开(公告)日：2014-06-24
申请号：US13308287
申请日：2011-11-30
申请人： Xiangping Qian , Chihyuan (Grace) Chuang , Pu-Ping Lu , Bing Yao , Qing (Kevin) Lu , Hong Jiang , Wenyue Wang , Bradley P. Morgan , David J. Morgans, Jr.
发明人： Xiangping Qian , Chihyuan (Grace) Chuang , Pu-Ping Lu , Bing Yao , Qing (Kevin) Lu , Hong Jiang , Wenyue Wang , Bradley P. Morgan , David J. Morgans, Jr.
IPC分类号： C07D217/22 , A61K31/44
CPC分类号： C07H21/04 , C07D213/75 , C07D217/22 , C07D261/14 , C07D277/82 , C07D401/12 , C07D471/04 , C07D487/04
摘要： Chemical entities that modulate smooth muscle myosin and/or non-muscle myosin, pharmaceutical compositions and methods of treatment of diseases and conditions associated with smooth muscle myosin and/or non-muscle myosin are described.
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公开(公告)号：US08071625B2
公开(公告)日：2011-12-06
申请号：US11888892
申请日：2007-08-01
申请人： Xiangping Qian , Pu-Ping Lu , Chihyuan (Grace) Chuang , Bradley P. Morgan , David J. Morgans, Jr.
发明人： Xiangping Qian , Pu-Ping Lu , Chihyuan (Grace) Chuang , Bradley P. Morgan , David J. Morgans, Jr.
IPC分类号： A61K31/445 , C07D211/06 , C07D309/02
CPC分类号： C07C275/24 , C07C271/28 , C07D207/09 , C07D211/06
摘要： Chemical entities that modulate smooth muscle myosin and/or non-muscle myosin, pharmaceutical compositions and methods of treatment of diseases and conditions associated with smooth muscle myosin and/or non-muscle myosin are described.
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公开(公告)号：US20080132548A1
公开(公告)日：2008-06-05
申请号：US11888903
申请日：2007-08-01
申请人： Xiangping Qian , Jeffrey T. Finer , Pu-Ping Lu , Chihyuan (Grace) Chuang , Bradley P. Morgan , David J. Morgans
发明人： Xiangping Qian , Jeffrey T. Finer , Pu-Ping Lu , Chihyuan (Grace) Chuang , Bradley P. Morgan , David J. Morgans
IPC分类号： A61K31/41 , C07D257/04 , A61K31/4439 , C07D401/12 , C07D413/12 , A61K31/422 , A61P21/00
CPC分类号： C07D257/04 , C07D403/10
摘要： Chemical entities that modulate smooth muscle myosin and/or non-muscle myosin, pharmaceutical compositions and methods of treatment of diseases and conditions associated with smooth muscle myosin and/or non-muscle myosin are described.
摘要翻译： 描述了调节平滑肌肌球蛋白和/或非肌肉肌球蛋白的化学实体，治疗与平滑肌肌球蛋白和/或非肌肉肌球蛋白相关的疾病和病症的药物组合物和方法。
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公开(公告)号：US20080146619A1
公开(公告)日：2008-06-19
申请号：US11888655
申请日：2007-07-31
申请人： Pu-Ping Lu , Xiangping Qian , Jeffrey T. Finer , Chihyuan (Grace) Chuang , Bradley P. Morgan , David J. Morgans
发明人： Pu-Ping Lu , Xiangping Qian , Jeffrey T. Finer , Chihyuan (Grace) Chuang , Bradley P. Morgan , David J. Morgans
IPC分类号： A61K31/44 , A61P21/00 , C07D421/02
CPC分类号： A61K31/44 , C07D213/82
摘要： Chemical entities that modulate smooth muscle myosin and/or non-muscle myosin, and chemical entities, pharmaceutical compositions and methods of treatment of diseases and conditions associated with smooth muscle myosin and/or non-muscle myosin are described.
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公开(公告)号：US20080139575A1
公开(公告)日：2008-06-12
申请号：US11888672
申请日：2007-07-31
IPC分类号： A61K31/497 , C07D211/82 , C07D401/14 , C07D401/04 , A61P21/00 , A61K31/4545 , A61K31/444 , A61K31/4439
CPC分类号： C07D401/14 , C07D401/04 , C07D405/14 , C07D413/14
摘要： Chemical entities that modulate smooth muscle myosin and/or non-muscle myosin, and chemical entities, pharmaceutical compositions and methods of treatment of diseases and conditions associated with smooth muscle myosin and/or non-muscle myosin are described.
摘要翻译： 描述了调节平滑肌肌球蛋白和/或非肌肉肌球蛋白的化学实体以及与平滑肌肌球蛋白和/或非肌肉肌球蛋白相关的疾病和病症的化学实体，药物组合物和治疗方法。
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公开(公告)号：US20080194633A1
公开(公告)日：2008-08-14
申请号：US11888892
申请日：2007-08-01
IPC分类号： C07C271/28 , C07C275/18 , C07D211/06 , A61K31/445 , A61K31/27 , A61K31/17 , C07D207/09 , A61K31/40 , A61P1/00 , A61P9/00 , A61P11/00 , A61P13/00 , A61P21/00
CPC分类号： C07C275/24 , C07C271/28 , C07D207/09 , C07D211/06
摘要： Chemical entities that modulate smooth muscle myosin and/or non-muscle myosin, pharmaceutical compositions and methods of treatment of diseases and conditions associated with smooth muscle myosin and/or non-muscle myosin are described.
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公开(公告)号：US20080132545A1
公开(公告)日：2008-06-05
申请号：US11888647
申请日：2007-07-31
IPC分类号： A61K31/444 , C07D401/14 , C07D401/12 , C07D213/80 , A61K31/44 , C07D213/85 , A61P21/00
CPC分类号： C07D213/82 , C07D213/80 , C07D213/85 , C07D401/14
摘要： Chemical entities that modulate smooth muscle myosin and/or non-muscle myosin, and chemical entities, pharmaceutical compositions and methods of treatment of diseases and conditions associated with smooth muscle myosin and/or non-muscle myosin are described.
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公开(公告)号：US07605164B2
公开(公告)日：2009-10-20
申请号：US11353252
申请日：2006-02-14
申请人： Fady Malik , Adam Lewis Tomasi , Bainian Feng , Erica Anne Kraynack , Kathleen A. Elias , Pu-Ping Lu , Whitney Walter Smith , Xiangping Qian , David J. Morgans, Jr.
发明人： Fady Malik , Adam Lewis Tomasi , Bainian Feng , Erica Anne Kraynack , Kathleen A. Elias , Pu-Ping Lu , Whitney Walter Smith , Xiangping Qian , David J. Morgans, Jr.
IPC分类号： A61K31/497 , A61K31/381 , A61K31/4409 , A61K31/4406 , A61K31/4402 , A61K31/42 , A61P9/04 , C07D401/10 , C07D403/10 , C07D213/643 , C07D213/65 , C07D213/68 , C07D261/18 , C07D333/22
CPC分类号： C07D401/12 , A61K31/4412 , A61K31/444 , A61K31/513 , C07D213/65 , C07D261/18 , C07D333/38 , C07D409/12 , C07D413/12
摘要： Certain substituted benzamide derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
摘要翻译： 某些取代的苯甲酰胺衍生物选择性地调节心脏肌节，例如通过增强心肌肌球蛋白，并且可用于治疗包括充血性心力衰竭的收缩性心力衰竭。
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公开(公告)号：US07399866B2
公开(公告)日：2008-07-15
申请号：US10541596
申请日：2004-01-14
申请人： Bradley Paul Morgan , Kathleen A. Elias , Erica Anne Kraynack , Pu-Ping Lu , Fady Malik , Alex Muci , Xiangping Qian , Whitney Walter Smith , Todd Tochimoto , Adam Lewis Tomasi , David J. Morgans, Jr.
发明人： Bradley Paul Morgan , Kathleen A. Elias , Erica Anne Kraynack , Pu-Ping Lu , Fady Malik , Alex Muci , Xiangping Qian , Whitney Walter Smith , Todd Tochimoto , Adam Lewis Tomasi , David J. Morgans, Jr.
IPC分类号： C07D211/68 , C07D401/04 , C07D401/14
CPC分类号： A61K31/44 , A61K31/17 , C07C275/30 , C07C275/34 , C07C275/36 , C07C275/40 , C07D207/12 , C07D211/42 , C07D213/65 , C07D213/70 , C07D213/75 , C07D217/04 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D498/04 , C07D513/04
摘要： Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, are useful in the treatment of systolic heart failure including congestive heart failure.
摘要翻译： 某些取代的脲衍生物选择性调节心脏肌节，例如通过增强心肌肌球蛋白，可用于治疗包括充血性心力衰竭的收缩性心力衰竭。
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公开(公告)号：US07053094B2
公开(公告)日：2006-05-30
申请号：US11040478
申请日：2005-01-20
申请人： Fady Malik , Adam Lewis Tomasi , Bainian Feng , Erica Anne Kraynack , Kathleen A. Elias , Pu-Ping Lu , Whitney Walter Smith , Xiangping Qian , David J. Morgans, Jr.
发明人： Fady Malik , Adam Lewis Tomasi , Bainian Feng , Erica Anne Kraynack , Kathleen A. Elias , Pu-Ping Lu , Whitney Walter Smith , Xiangping Qian , David J. Morgans, Jr.
IPC分类号： A61K31/4965 , A61K31/44 , A61K31/42 , A01N43/40 , A01N43/80
CPC分类号： C07D401/12 , A61K31/4412 , A61K31/444 , A61K31/513 , C07D213/65 , C07D261/18 , C07D333/38 , C07D409/12 , C07D413/12
摘要： Certain substituted benzamide derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
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