公开(公告)号：US3518296A

公开(公告)日：1970-06-30

申请号：US3518296D

申请日：1964-04-22

Applicant: ROUSSEL UCLAF

Inventor： BUCOURT ROBERT ,  PIERDET ANDRE ,  COSTEROUSSE GERMAIN ,  HAINAUT DANIEL ,  JOLY ROBERT ,  WARNANT JULIEN ,  GOFFINET BERNARD

IPC: C07C45/67 ,  C07C69/74

CPC classification number: C07C45/676

公开(公告)号：US3472885A

公开(公告)日：1969-10-14

申请号：US3472885D

申请日：1967-04-25

Applicant: ROUSSEL UCLAF

Inventor： BUCOURT ROBERT ,  NEDELEC LUCIEN ,  GASC JEAN-CLAUDE

IPC: C07B61/00 ,  C07C169/08 ,  C07C167/02

CPC classification number: C07B61/00

公开(公告)号：US3906096A

公开(公告)日：1975-09-16

申请号：US44756174

申请日：1974-03-04

Applicant: ROUSSEL UCLAF

Inventor： BUCOURT ROBERT ,  PIERDET ANDRE ,  SALMON JEAN

IPC: C07J1/00 ,  A61K31/56

CPC classification number: C07J1/0088

Abstract: 11 Beta -ALKOXY- Delta 4-GONENES OF THE FORMULA
WHEREIN R and X are alkyl of 1 to 4 carbon atoms, R1 is a saturated or unsaturated hydrocarbon of 1 to 6 carbon atoms, R2 is selected from the group consisting of hydrogen and acyl of an organic carboxylic acid of 1 to 18 carbon atoms and Y and Y'' are selected from the group consisting of hydrogen and methyl and the enolic esters thereof with an organic carboxylic acid of 1 to 18 carbon atoms which possess anti-androgenic and anti-estrogenic activity, their preparation and novel intermediates.

Abstract translation: 其中R和X为1-4个碳原子的烷基，R1为1至6个碳原子的饱和或不饱和烃基，R2选自氢和酰基 的1至18个碳原子的有机羧酸，Y和Y'选自氢和甲基及其烯醇与具有1至18个碳原子的有机羧酸，其具有抗雄激素和抗 - 雌激素活性，其制备和新型中间体。

公开(公告)号：US3697511A

公开(公告)日：1972-10-10

申请号：US3697511D

申请日：1970-10-20

Applicant: ROUSSEL UCLAF

Inventor： BUCOURT ROBERT ,  NEDELEC LUCIEN

IPC: C07J5/00 ,  C07J75/00 ,  C07C173/00

CPC classification number: C07J5/00 ,  C07J75/00

Abstract: A novel process for introducing a 10-hydrocarbon group into a Delta 9(11)-19-nor-steroid by reacting a 13 Beta -lower alkylDelta 5(10),9(11)-19-nor steroid with a per carboxylic acid to form a mixture of the corresponding 5 Alpha ,10 Alpha - and 5 Beta ,10 Beta -epoxy steroids and reacting the latter with a hydrocarbon magnesium halide to form the corresponding 10hydrocarbon-13 Beta -lower alkyl-5-hydroxy- Delta 9(11)-19-norsteroid and to novel intermediates.

Abstract translation: 通过使13β-低级烷基-DTATA 5（10），9（11）-19-或类固醇与一种或多种甾族化合物反应，将10-烃基引入到DELTA 9（11）-19-去 - 类固醇中的新方法 羧酸形成相应的5α，10α和5β，10β-环氧类固醇的混合物，并使其与烃卤化镁反应形成相应的10-烃-13β-低级烷基-5-羟基 - DELTA 9（11）-19-类固醇和新型中间体。

公开(公告)号：US3637756A

公开(公告)日：1972-01-25

申请号：US3637756D

申请日：1970-02-06

Applicant: ROUSSEL UCLAF

Inventor： BUCOURT ROBERT ,  VIGNAU MICHEL ,  RAYNAL JEAN

IPC: C07D317/72 ,  C07D493/10 ,  C07D13/04

CPC classification number: C07D493/10 ,  C07D317/72

Abstract: THIS INVENTION RELATES TO A CYCLOPENTYLPROPIONYL KETAL OF THE FORMULA

2-R,2-(Y-CH2-CH2-),3,3-(-O-R"-O-)CYCLOPENTANONE

WHEREIN R IS AN ALKYL HAVING 1 TO 3 CARBON ATOMS, Y IS A SUBSTITUENT SELECTED FROM THE GROUP CONSISTING OF -COO-LOWER ALKYL-COOH AND -C=N AND R" IS A LOWER ALKYLENE HAVING 2 TO 4 CARBON ATOMS, WHICH IS USED AS INTERMEDIATES IN THE PREPARATION OF 13-ALKYL GONAPENTAENES.

公开(公告)号：US3637755A

公开(公告)日：1972-01-25

申请号：US3637755D

申请日：1970-01-21

Applicant: ROUSSEL UCLAF

Inventor： BUCOURT ROBERT ,  VIGNAU MICHEL ,  RAYNAL JEAN

IPC: C07D317/72 ,  C07D493/10 ,  C07D15/10

CPC classification number: C07D493/10 ,  C07D317/72

Abstract: THIS INVENTION RELATES TO AN OPTICALLY ACTIVE LACTONE OF THE FORMULA

2-(O=),4A-R,5,5-(-O-R"-O-)-2,3,4,4A,5,6-HEXAHYDRO

CYCLOPENTA(B)PYRAN

WHERE R IS ALKYL HAVING 1 TO 3 CARBON ATOMS, R" IS A LOWER ALKYLENE HAVING 2 TO 4 CARBON ATOMS AND THE WAVY LINE INDICATES EITHER THE A OR B CONFIGURATION, WHICH MAY BE USED IN THE PREPARATION OF 13-ALKYL GONAPENTAENES.

公开(公告)号：US3637754A

公开(公告)日：1972-01-25

申请号：US3637754D

申请日：1970-01-21

Applicant: ROUSSEL UCLAF

Inventor： BUCOURT ROBERT ,  VIGNAU MICHEL ,  RAYNAL JEAN

IPC: C07D317/72 ,  C07D493/10 ,  C07D13/04

CPC classification number: C07D493/10 ,  C07D317/72

Abstract: THIS INVENTION RELATES TO AN OPTICALLY ACITVE SECO-GONATETRAENE OF THE FORMULA

1,1-(-O-R"-O-),4-((2-R4,3-(R3-O-),4-R2,S-R1-PHENYL)-

CH(-R5)-CH(-R6)-),5-(O=),7A-R-5,6,7,7A-TETRAHYDROINDAN

WHERE R IS AN ALKYL HAVING 1 TO 3 CARBON ATOMS, R" IS A LOWER ALKYLENE HAVING 2 TO 4 CARBON ATOMS, R1, R2 AND R4 ARE SUBSTITUENTS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, LOWER ALKYL AND LOWER ALKOXY, R3 IS LOWER ALKYL, R5 AND R6 ARE SUBSTITUENTS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, A-LOWER ALKYL AND B-LOWER ALKYL AND THE WAVY LINE INDICATES EITHER THE A-CONFIGURATION OR THE B-CONFIGURATION, WHICH ARE USED AS INTERMEDIATES IN THE PREPARATION OF OPITCALLY ACTIVE 13-ALKYL GONAPENTAENES.

公开(公告)号：US3579504A

公开(公告)日：1971-05-18

申请号：US3579504D

申请日：1965-04-26

Applicant: ROUSSEL UCLAF

Inventor： NOMINE GERARD ,  BUCOURT ROBERT ,  PIERDET ANDRE

IPC: C07J21/00 ,  C07J75/00 ,  C07C173/00

CPC classification number: C07J21/00 ,  C07J75/00

Abstract: THE PRESENT INVENTION RELATES TO A NEW DERIVATIVE OF $4,9-GONADIENE OF FORMULA I;

3-(O=),13-(CH3-CH2-CH2-),17-(HO-),17-(CL-C*C-)-

GONA-4,9-DIENE

AS WELL AS A PROCESS OF PREPARATION OF THE SAID COMPOUND. THE INVENTION ALSO RELATES TO INTERMEDIATES USEFUL IN THE PRODUCTION OF THE COMPOUND OF FORMULA I.

公开(公告)号：US3506693A

公开(公告)日：1970-04-14

申请号：US3506693D

申请日：1967-08-21

Applicant: ROUSSEL UCLAF

Inventor： BUCOURT ROBERT ,  VIGNAU MICHEL ,  RAYNAL JEAN

IPC: C07D317/72 ,  C07D493/10 ,  C07C167/02

CPC classification number: C07D493/10 ,  C07D317/72

公开(公告)号：US3444297A

公开(公告)日：1969-05-13

申请号：US3444297D

申请日：1962-06-21

Applicant: ROUSSEL UCLAF

Inventor： NOMINE GERARD ,  BUCOURT ROBERT ,  PIERDET ANDRE ,  SNOZZI CANDIDO

IPC: A61K31/567 ,  C07J1/00 ,  C07J21/00 ,  C07J71/00 ,  C07J75/00 ,  A61K17/08 ,  C07C169/22

CPC classification number: A61K31/567 ,  C07J1/00 ,  C07J21/00 ,  C07J71/00 ,  C07J75/00