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公开(公告)号：US07456180B2
公开(公告)日：2008-11-25
申请号：US10567009
申请日：2004-07-29
申请人： Serguei Sviridov , Vishnumurthy Kodumuru , Shifeng Liu , Melwyn Abreo , Michael D. Winther , Heinz W. Gschwend , Rajender Kamboj , Shaoyi Sun , Mark W. Holladay , Wenbao Li , Chi Tu
发明人： Serguei Sviridov , Vishnumurthy Kodumuru , Shifeng Liu , Melwyn Abreo , Michael D. Winther , Heinz W. Gschwend , Rajender Kamboj , Shaoyi Sun , Mark W. Holladay , Wenbao Li , Chi Tu
IPC分类号： A61K31/497 , C07D241/02
CPC分类号： A61K31/551 , A61K31/00 , A61K31/501 , C07D237/20 , C07D403/08 , C07D405/08 , C07D409/12 , C07D413/08
摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where G, J, L, M, x, y, W, V, R2, R3, R4, R5, R6, R7, R8, R8a, R9, R9a, R10, R10a, R11 and R11a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
摘要翻译： 公开了在哺乳动物，优选人中治疗SCD介导的疾病或病症的方法，其中所述方法包括向有需要的哺乳动物施用式（I）化合物：其中G，J，L，M，x ，y，W，V，R 2，R 3，R 4，R 5，R SUP > 6，R 7，R 8，R 8a，R 9，R SUP， > 9a，R 10，R 10a，R 11和R 11是本文定义的 。 还公开了包含式（I）化合物的药物组合物。
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12.发明授权Piperazine derivatives as stearoyl-coa desaturase inhibitors and their use as therapeutic agents 有权哌嗪衍生物作为硬脂酰辅酶A去饱和酶抑制剂及其作为治疗剂的用途公开(公告)号：US08030488B2
公开(公告)日：2011-10-04
申请号：US12247792
申请日：2008-10-08
申请人： Serguei Sviridov , Vishnumurthy Kodumuru , Shifeng Liu , Melwyn Abreo , Michael D. Winther , Heinz W. Gschwend , Rajender Kamboj , Shaoyi Sun , Mark W. Holladay , Wenbao Li , Chi Tu
发明人： Serguei Sviridov , Vishnumurthy Kodumuru , Shifeng Liu , Melwyn Abreo , Michael D. Winther , Heinz W. Gschwend , Rajender Kamboj , Shaoyi Sun , Mark W. Holladay , Wenbao Li , Chi Tu
IPC分类号： C07D239/02
CPC分类号： A61K31/551 , A61K31/00 , A61K31/501 , C07D237/20 , C07D403/08 , C07D405/08 , C07D409/12 , C07D413/08
摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where G, J, L, M, x, y, W, V, R2, R3, R4, R5, R6, R7, R8, R8a, R9, R9a, R10, R10a, R11 and R11a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
摘要翻译： 公开了在哺乳动物，优选人中治疗SCD介导的疾病或病症的方法，其中所述方法包括向有需要的哺乳动物施用式（I）化合物：其中G，J，L，M，x ，Y，W，V，R2，R3，R4，R5，R6，R7，R8，R8a，R9，R9a，R10，R10a，R11和R11a。 还公开了包含式（I）化合物的药物组合物。
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公开(公告)号：US20090030008A1
公开(公告)日：2009-01-29
申请号：US12247792
申请日：2008-10-08
申请人： Serguei Sviridov , Vishnumurthy Kodumuru , Shifeng Liu , Melwyn Abreo , Michael D. Winther , Heinz W. Gschwend , Rajender Kamboj , Shaoyi Sun , Mark W. Holladay , Wenbao Li , Chi Tu
发明人： Serguei Sviridov , Vishnumurthy Kodumuru , Shifeng Liu , Melwyn Abreo , Michael D. Winther , Heinz W. Gschwend , Rajender Kamboj , Shaoyi Sun , Mark W. Holladay , Wenbao Li , Chi Tu
IPC分类号： A61K31/496 , C07D403/04 , A61P3/04 , A61P3/10
CPC分类号： A61K31/551 , A61K31/00 , A61K31/501 , C07D237/20 , C07D403/08 , C07D405/08 , C07D409/12 , C07D413/08
摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where G, J, L, M, x, y, W, V, R2, R3, R4, R5, R6, R7, R8, R8a, R9, R9a, R10, R10a, R11 and R11a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
摘要翻译： 公开了在哺乳动物，优选人中治疗SCD介导的疾病或病症的方法，其中所述方法包括向有需要的哺乳动物施用式（I）化合物：其中G，J，L，M，x ，Y，W，V，R2，R3，R4，R5，R6，R7，R8，R8a，R9，R9a，R10，R10a，R11和R11a。 还公开了包含式（I）化合物的药物组合物。
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公开(公告)号：US20060252767A1
公开(公告)日：2006-11-09
申请号：US10567009
申请日：2004-07-29
申请人： Serguei Sviridov , Vishnumurthy Kodumuru , Shifeng Liu , Melwyn Abreo , Michael Winther , Heins Gschwend , Rajender Kamboj , Shaoyi Sun , Mark Holladay , Wenbao Li , Chi Tu
发明人： Serguei Sviridov , Vishnumurthy Kodumuru , Shifeng Liu , Melwyn Abreo , Michael Winther , Heins Gschwend , Rajender Kamboj , Shaoyi Sun , Mark Holladay , Wenbao Li , Chi Tu
IPC分类号： A61K31/497 , C07D403/04
CPC分类号： A61K31/551 , A61K31/00 , A61K31/501 , C07D237/20 , C07D403/08 , C07D405/08 , C07D409/12 , C07D413/08
摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where G, J, L, M, x, y, W, V, R2, R3, R4, R5, R6, R7, R8, R8a, R9, R9a, R10, R10a, R11 and R11a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
摘要翻译： 公开了在哺乳动物，优选人中治疗SCD介导的疾病或病症的方法，其中所述方法包括向有需要的哺乳动物施用式（I）化合物：其中G，J，L，M，x ，Y，W，V，R 2，R 3，R 4，R 5，R SUP > 6，R 7，R 8，R 8a，R 9，R SUP， > 9a，R 10，R 10a，R 11和R 11a在本文中定义。 还公开了包含式（I）化合物的药物组合物。
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15.发明申请公开(公告)号：US20080103304A1
公开(公告)日：2008-05-01
申请号：US11969539
申请日：2008-01-04
申请人： Robert Plourde , Sammy Shaver , James Douglass , Paul Watson , Jose Boyer , Chi Tu , Melwyn Abreo , Lorenzo Alfaro-Lopez , Yangbo Feng , Daniel Harvey , Tatyana Khasonova
发明人： Robert Plourde , Sammy Shaver , James Douglass , Paul Watson , Jose Boyer , Chi Tu , Melwyn Abreo , Lorenzo Alfaro-Lopez , Yangbo Feng , Daniel Harvey , Tatyana Khasonova
IPC分类号： C07D473/00
CPC分类号： C07D519/00 , A61F2250/0067 , A61K31/519 , A61K31/52 , A61K31/522 , A61K31/7076 , A61K31/727 , A61K45/06 , A61K2300/00
摘要： This invention is directed to a method of preventing or treating diseases or conditions associated with platelet aggregation. The method is also directed to a method of treating thrombosis or related disorders. The method comprises administering to a subject a pharmaceutical composition comprising an effective amount of a non-nucleotide compound, preferably a P2Y12 receptor antagonist compound, wherein said amount is effective to inhibit platelet aggregation. The compounds useful for this invention include compounds of general Formulae I and III-XII, or salts, hydrates, and solvates thereof. The present invention also provides novel compounds of Formulae I and III-XII.
摘要翻译： 本发明涉及一种预防或治疗与血小板聚集有关的疾病或病症的方法。 该方法还涉及治疗血栓形成或相关病症的方法。 该方法包括向受试者施用包含有效量的非核苷酸化合物，优选P2Y 12受体拮抗剂化合物的药物组合物，其中所述量有效抑制血小板聚集。 可用于本发明的化合物包括通式I和III-XII的化合物，或其盐，水合物和溶剂合物。 本发明还提供式I和III-XII的新型化合物。
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16.发明申请公开(公告)号：US20050267134A1
公开(公告)日：2005-12-01
申请号：US11124619
申请日：2005-05-05
申请人： Robert Plourde, , Sammy Shaver , James Douglass, , Paul Watson , Jose Boyer , Chi Tu , Melwyn Abreo , Lorenzo Alfaro-Lopez , Yangbo Feng , Daniel Harvey , Tatyana Khasanova
发明人： Robert Plourde, , Sammy Shaver , James Douglass, , Paul Watson , Jose Boyer , Chi Tu , Melwyn Abreo , Lorenzo Alfaro-Lopez , Yangbo Feng , Daniel Harvey , Tatyana Khasanova
IPC分类号： A61K31/519 , A61K31/522 , A61K31/7076 , A61K31/727 , A61K45/06 , C07D473/12 , A61K31/52
CPC分类号： C07D519/00 , A61F2250/0067 , A61K31/519 , A61K31/52 , A61K31/522 , A61K31/7076 , A61K31/727 , A61K45/06 , A61K2300/00
摘要： This invention is directed to a method of preventing or treating diseases or conditions associated with platelet aggregation. The method is also directed to a method of treating thrombosis or related disorders. The method comprises administering to a subject a pharmaceutical composition comprising an effective amount of a non-nucleotide compound, preferably a P2Y12 receptor antagonist compound, wherein said amount is effective to inhibit platelet aggregation, preferably in a reversible manner. The compounds useful for this invention include compounds of general Formulae I and III-XII, or salts, hydrates, and solvates thereof. The present invention also provides novel compounds of Formulae I and III-XII.
摘要翻译： 本发明涉及一种预防或治疗与血小板聚集有关的疾病或病症的方法。 该方法还涉及治疗血栓形成或相关病症的方法。 该方法包括向受试者施用包含有效量的非核苷酸化合物，优选P2Y 12受体拮抗剂化合物的药物组合物，其中所述量有效抑制血小板聚集，优选以可逆的 方式。 可用于本发明的化合物包括通式I和III-XII的化合物，或其盐，水合物和溶剂合物。 本发明还提供式I和III-XII的新型化合物。
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17.发明申请公开(公告)号：US20050159388A1
公开(公告)日：2005-07-21
申请号：US10971766
申请日：2004-10-21
申请人： Robert Plourde , Sammy Shaver , Melwyn Abreo , Lorenzo Alfaro-Lopez , Yangbo Feng , Daniel Harvey , Tatyana Khasanova , Chi Tu
发明人： Robert Plourde , Sammy Shaver , Melwyn Abreo , Lorenzo Alfaro-Lopez , Yangbo Feng , Daniel Harvey , Tatyana Khasanova , Chi Tu
IPC分类号： A61K31/00 , A61K31/519 , A61K31/522 , A61K31/7076 , A61K31/727 , A61K45/06 , C07D471/04 , C07D493/04 , C07D519/00
CPC分类号： C07D471/04 , A61K31/00 , A61K31/519 , A61K31/522 , A61K31/7076 , A61K31/727 , A61K45/06 , C07D493/04 , C07D519/00 , A61K2300/00
摘要： This invention is directed to a method of preventing or treating diseases or conditions associated with platelet aggregation. The method is also directed to a method of treating thrombosis or related disorders. The method comprises administering to a subject a pharmaceutical composition comprising an effective amount of a non-nucleotide compound, preferably a P2Y12 receptor antagonist compound, wherein said amount is effective to inhibit platelet aggregation. The compounds useful for this invention include compounds of general Formulae I and III-XI, or salts, hydrates, and solvates thereof. The present invention also provides novel compounds according to Formulae I and III-XI.
摘要翻译： 本发明涉及一种预防或治疗与血小板聚集有关的疾病或病症的方法。 该方法还涉及治疗血栓形成或相关病症的方法。 该方法包括向受试者施用包含有效量的非核苷酸化合物，优选P2Y 12受体拮抗剂化合物的药物组合物，其中所述量有效抑制血小板聚集。 可用于本发明的化合物包括通式I和III-XI的化合物，或其盐，水合物和溶剂合物。 本发明还提供了根据式I和III-XI的新化合物。
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公开(公告)号：US20100197913A1
公开(公告)日：2010-08-05
申请号：US12552465
申请日：2009-09-02
申请人： Robert Plourde, JR. , Sammy R. Shaver , James G. Douglass, III , Paul S. Watson , José L. Boyer , Chi Tu , Melwyn A. Abreo , Lorenzo J. Alfaro-Lopez , Yangbo Feng , Daniel F. Harvey , Tatyana V. Khasonova
发明人： Robert Plourde, JR. , Sammy R. Shaver , James G. Douglass, III , Paul S. Watson , José L. Boyer , Chi Tu , Melwyn A. Abreo , Lorenzo J. Alfaro-Lopez , Yangbo Feng , Daniel F. Harvey , Tatyana V. Khasonova
IPC分类号： C07D473/34
CPC分类号： C07D519/00 , A61F2250/0067 , A61K31/519 , A61K31/52 , A61K31/522 , A61K31/7076 , A61K31/727 , A61K45/06 , A61K2300/00
摘要： This invention is directed to a method of preventing or treating diseases or conditions associated with platelet aggregation. The method is also directed to a method of treating thrombosis or related disorders. The method comprises administering to a subject a pharmaceutical composition comprising an effective amount of a non-nucleotide compound, preferably a P2Y12 receptor antagonist compound, wherein said amount is effective to inhibit platelet aggregation. The compounds useful for this invention include compounds of general Formulae I and III-XII, or salts, hydrates, and solvates thereof. The present invention also provides novel compounds of Formulae I and III-XII.
摘要翻译： 本发明涉及一种预防或治疗与血小板聚集有关的疾病或病症的方法。 该方法还涉及治疗血栓形成或相关病症的方法。 该方法包括向受试者施用包含有效量的非核苷酸化合物，优选P2Y12受体拮抗剂化合物的药物组合物，其中所述量有效抑制血小板聚集。 可用于本发明的化合物包括通式I和III-XII的化合物，或其盐，水合物和溶剂合物。 本发明还提供式I和III-XII的新型化合物。
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19.发明授权公开(公告)号：US07368438B2
公开(公告)日：2008-05-06
申请号：US10971766
申请日：2004-10-21
申请人： Robert Plourde, Jr. , Sammy R. Shaver , José L. Boyer , Melwyn A. Abreo , Lorenzo J. Alfaro-Lopez , Yangbo Feng , Daniel F. Harvey , Tatyana V. Khasonova , Chi Tu
发明人： Robert Plourde, Jr. , Sammy R. Shaver , José L. Boyer , Melwyn A. Abreo , Lorenzo J. Alfaro-Lopez , Yangbo Feng , Daniel F. Harvey , Tatyana V. Khasonova , Chi Tu
CPC分类号： C07D471/04 , A61K31/00 , A61K31/519 , A61K31/522 , A61K31/7076 , A61K31/727 , A61K45/06 , C07D493/04 , C07D519/00 , A61K2300/00
摘要： This invention is directed to a method of preventing or treating diseases or conditions associated with platelet aggregation. The method is also directed to a method of treating thrombosis or related disorders. The method comprises administering to a subject a pharmaceutical composition comprising an effective amount of a non-nucleotide compound, preferably a P2Y12 receptor antagonist compound, wherein said amount is effective to inhibit platelet aggregation. The compounds useful for this invention include compounds of general Formula I and III-XI, or salts, hydrates, and solvates thereof. The present invention also provides novel compounds according to Formula I and III-XI.
摘要翻译： 本发明涉及一种预防或治疗血小板聚集相关疾病或病症的方法。 该方法还涉及治疗血栓形成或相关病症的方法。 该方法包括向受试者施用包含有效量的非核苷酸化合物，优选P2Y 12受体拮抗剂化合物的药物组合物，其中所述量有效抑制血小板聚集。 可用于本发明的化合物包括通式I和III-XI的化合物，或其盐，水合物和溶剂合物。 本发明还提供了根据式I和III-XI的新化合物。
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公开(公告)号：US07943760B2
公开(公告)日：2011-05-17
申请号：US12552465
申请日：2009-09-02
申请人： Robert Plourde, Jr. , Sammy R. Shaver , James G. Douglass, III , Paul S. Watson , José L. Boyer , Chi Tu , Melwyn A. Abreo , Lorenzo J. Alfaro-Lopez , Yangbo Feng , Daniel F. Harvey , Tatyana V. Khasonova
发明人： Robert Plourde, Jr. , Sammy R. Shaver , James G. Douglass, III , Paul S. Watson , José L. Boyer , Chi Tu , Melwyn A. Abreo , Lorenzo J. Alfaro-Lopez , Yangbo Feng , Daniel F. Harvey , Tatyana V. Khasonova
CPC分类号： C07D519/00 , A61F2250/0067 , A61K31/519 , A61K31/52 , A61K31/522 , A61K31/7076 , A61K31/727 , A61K45/06 , A61K2300/00
摘要： This invention is directed to a method of preventing or treating diseases or conditions associated with platelet aggregation. The method is also directed to a method of treating thrombosis or related disorders. The method comprises administering to a subject a pharmaceutical composition comprising an effective amount of a non-nucleotide compound, preferably a P2Y12 receptor antagonist compound, wherein said amount is effective to inhibit platelet aggregation. The compounds useful for this invention include compounds of general Formulae I and III-XII, or salts, hydrates, and solvates thereof. The present invention also provides novel compounds of Formulae I and III-XII.
摘要翻译： 本发明涉及一种预防或治疗与血小板聚集有关的疾病或病症的方法。 该方法还涉及治疗血栓形成或相关病症的方法。 该方法包括向受试者施用包含有效量的非核苷酸化合物，优选P2Y12受体拮抗剂化合物的药物组合物，其中所述量有效抑制血小板聚集。 可用于本发明的化合物包括通式I和III-XII的化合物，或其盐，水合物和溶剂合物。 本发明还提供式I和III-XII的新型化合物。
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