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1.发明申请公开(公告)号：US20080103304A1
公开(公告)日：2008-05-01
申请号：US11969539
申请日：2008-01-04
申请人： Robert Plourde , Sammy Shaver , James Douglass , Paul Watson , Jose Boyer , Chi Tu , Melwyn Abreo , Lorenzo Alfaro-Lopez , Yangbo Feng , Daniel Harvey , Tatyana Khasonova
发明人： Robert Plourde , Sammy Shaver , James Douglass , Paul Watson , Jose Boyer , Chi Tu , Melwyn Abreo , Lorenzo Alfaro-Lopez , Yangbo Feng , Daniel Harvey , Tatyana Khasonova
IPC分类号： C07D473/00
CPC分类号： C07D519/00 , A61F2250/0067 , A61K31/519 , A61K31/52 , A61K31/522 , A61K31/7076 , A61K31/727 , A61K45/06 , A61K2300/00
摘要： This invention is directed to a method of preventing or treating diseases or conditions associated with platelet aggregation. The method is also directed to a method of treating thrombosis or related disorders. The method comprises administering to a subject a pharmaceutical composition comprising an effective amount of a non-nucleotide compound, preferably a P2Y12 receptor antagonist compound, wherein said amount is effective to inhibit platelet aggregation. The compounds useful for this invention include compounds of general Formulae I and III-XII, or salts, hydrates, and solvates thereof. The present invention also provides novel compounds of Formulae I and III-XII.
摘要翻译： 本发明涉及一种预防或治疗与血小板聚集有关的疾病或病症的方法。 该方法还涉及治疗血栓形成或相关病症的方法。 该方法包括向受试者施用包含有效量的非核苷酸化合物，优选P2Y 12受体拮抗剂化合物的药物组合物，其中所述量有效抑制血小板聚集。 可用于本发明的化合物包括通式I和III-XII的化合物，或其盐，水合物和溶剂合物。 本发明还提供式I和III-XII的新型化合物。
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2.发明申请公开(公告)号：US20050267134A1
公开(公告)日：2005-12-01
申请号：US11124619
申请日：2005-05-05
申请人： Robert Plourde, , Sammy Shaver , James Douglass, , Paul Watson , Jose Boyer , Chi Tu , Melwyn Abreo , Lorenzo Alfaro-Lopez , Yangbo Feng , Daniel Harvey , Tatyana Khasanova
发明人： Robert Plourde, , Sammy Shaver , James Douglass, , Paul Watson , Jose Boyer , Chi Tu , Melwyn Abreo , Lorenzo Alfaro-Lopez , Yangbo Feng , Daniel Harvey , Tatyana Khasanova
IPC分类号： A61K31/519 , A61K31/522 , A61K31/7076 , A61K31/727 , A61K45/06 , C07D473/12 , A61K31/52
CPC分类号： C07D519/00 , A61F2250/0067 , A61K31/519 , A61K31/52 , A61K31/522 , A61K31/7076 , A61K31/727 , A61K45/06 , A61K2300/00
摘要： This invention is directed to a method of preventing or treating diseases or conditions associated with platelet aggregation. The method is also directed to a method of treating thrombosis or related disorders. The method comprises administering to a subject a pharmaceutical composition comprising an effective amount of a non-nucleotide compound, preferably a P2Y12 receptor antagonist compound, wherein said amount is effective to inhibit platelet aggregation, preferably in a reversible manner. The compounds useful for this invention include compounds of general Formulae I and III-XII, or salts, hydrates, and solvates thereof. The present invention also provides novel compounds of Formulae I and III-XII.
摘要翻译： 本发明涉及一种预防或治疗与血小板聚集有关的疾病或病症的方法。 该方法还涉及治疗血栓形成或相关病症的方法。 该方法包括向受试者施用包含有效量的非核苷酸化合物，优选P2Y 12受体拮抗剂化合物的药物组合物，其中所述量有效抑制血小板聚集，优选以可逆的 方式。 可用于本发明的化合物包括通式I和III-XII的化合物，或其盐，水合物和溶剂合物。 本发明还提供式I和III-XII的新型化合物。
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3.发明申请公开(公告)号：US20050159388A1
公开(公告)日：2005-07-21
申请号：US10971766
申请日：2004-10-21
申请人： Robert Plourde , Sammy Shaver , Melwyn Abreo , Lorenzo Alfaro-Lopez , Yangbo Feng , Daniel Harvey , Tatyana Khasanova , Chi Tu
发明人： Robert Plourde , Sammy Shaver , Melwyn Abreo , Lorenzo Alfaro-Lopez , Yangbo Feng , Daniel Harvey , Tatyana Khasanova , Chi Tu
IPC分类号： A61K31/00 , A61K31/519 , A61K31/522 , A61K31/7076 , A61K31/727 , A61K45/06 , C07D471/04 , C07D493/04 , C07D519/00
CPC分类号： C07D471/04 , A61K31/00 , A61K31/519 , A61K31/522 , A61K31/7076 , A61K31/727 , A61K45/06 , C07D493/04 , C07D519/00 , A61K2300/00
摘要： This invention is directed to a method of preventing or treating diseases or conditions associated with platelet aggregation. The method is also directed to a method of treating thrombosis or related disorders. The method comprises administering to a subject a pharmaceutical composition comprising an effective amount of a non-nucleotide compound, preferably a P2Y12 receptor antagonist compound, wherein said amount is effective to inhibit platelet aggregation. The compounds useful for this invention include compounds of general Formulae I and III-XI, or salts, hydrates, and solvates thereof. The present invention also provides novel compounds according to Formulae I and III-XI.
摘要翻译： 本发明涉及一种预防或治疗与血小板聚集有关的疾病或病症的方法。 该方法还涉及治疗血栓形成或相关病症的方法。 该方法包括向受试者施用包含有效量的非核苷酸化合物，优选P2Y 12受体拮抗剂化合物的药物组合物，其中所述量有效抑制血小板聚集。 可用于本发明的化合物包括通式I和III-XI的化合物，或其盐，水合物和溶剂合物。 本发明还提供了根据式I和III-XI的新化合物。
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4.发明授权公开(公告)号：US07335648B2
公开(公告)日：2008-02-26
申请号：US11124619
申请日：2005-05-05
申请人： Robert Plourde, Jr. , Sammy R. Shaver , James G. Douglass, III , Paul S. Watson , José L. Boyer , Chi Tu , Melwyn A. Abreo , Lorenzo J. Alfaro-Lopez , Yangbo Feng , Daniel F. Harvey , Tatyana V. Khasonova
发明人： Robert Plourde, Jr. , Sammy R. Shaver , James G. Douglass, III , Paul S. Watson , José L. Boyer , Chi Tu , Melwyn A. Abreo , Lorenzo J. Alfaro-Lopez , Yangbo Feng , Daniel F. Harvey , Tatyana V. Khasonova
CPC分类号： C07D519/00 , A61F2250/0067 , A61K31/519 , A61K31/52 , A61K31/522 , A61K31/7076 , A61K31/727 , A61K45/06 , A61K2300/00
摘要： This invention is directed to a method of preventing or treating diseases or conditions associated with platelet aggregation. The method is also directed to a method of treating thrombosis or related disorders. The method comprises administering to a compounds useful for this invention include compounds of general Formulae I and III-XII, or salts, hydrates, and solvates thereof. The present invention also provides novel compounds of Formulae I and III-XII.
摘要翻译： 本发明涉及一种预防或治疗与血小板聚集有关的疾病或病症的方法。 该方法还涉及治疗血栓形成或相关病症的方法。 该方法包括对可用于本发明的化合物施用包括通式I和III-XII的化合物，或其盐，水合物和溶剂化物。 本发明还提供式I和III-XII的新型化合物。
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公开(公告)号：US20100197913A1
公开(公告)日：2010-08-05
申请号：US12552465
申请日：2009-09-02
申请人： Robert Plourde, JR. , Sammy R. Shaver , James G. Douglass, III , Paul S. Watson , José L. Boyer , Chi Tu , Melwyn A. Abreo , Lorenzo J. Alfaro-Lopez , Yangbo Feng , Daniel F. Harvey , Tatyana V. Khasonova
发明人： Robert Plourde, JR. , Sammy R. Shaver , James G. Douglass, III , Paul S. Watson , José L. Boyer , Chi Tu , Melwyn A. Abreo , Lorenzo J. Alfaro-Lopez , Yangbo Feng , Daniel F. Harvey , Tatyana V. Khasonova
IPC分类号： C07D473/34
CPC分类号： C07D519/00 , A61F2250/0067 , A61K31/519 , A61K31/52 , A61K31/522 , A61K31/7076 , A61K31/727 , A61K45/06 , A61K2300/00
摘要： This invention is directed to a method of preventing or treating diseases or conditions associated with platelet aggregation. The method is also directed to a method of treating thrombosis or related disorders. The method comprises administering to a subject a pharmaceutical composition comprising an effective amount of a non-nucleotide compound, preferably a P2Y12 receptor antagonist compound, wherein said amount is effective to inhibit platelet aggregation. The compounds useful for this invention include compounds of general Formulae I and III-XII, or salts, hydrates, and solvates thereof. The present invention also provides novel compounds of Formulae I and III-XII.
摘要翻译： 本发明涉及一种预防或治疗与血小板聚集有关的疾病或病症的方法。 该方法还涉及治疗血栓形成或相关病症的方法。 该方法包括向受试者施用包含有效量的非核苷酸化合物，优选P2Y12受体拮抗剂化合物的药物组合物，其中所述量有效抑制血小板聚集。 可用于本发明的化合物包括通式I和III-XII的化合物，或其盐，水合物和溶剂合物。 本发明还提供式I和III-XII的新型化合物。
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公开(公告)号：US07943760B2
公开(公告)日：2011-05-17
申请号：US12552465
申请日：2009-09-02
申请人： Robert Plourde, Jr. , Sammy R. Shaver , James G. Douglass, III , Paul S. Watson , José L. Boyer , Chi Tu , Melwyn A. Abreo , Lorenzo J. Alfaro-Lopez , Yangbo Feng , Daniel F. Harvey , Tatyana V. Khasonova
发明人： Robert Plourde, Jr. , Sammy R. Shaver , James G. Douglass, III , Paul S. Watson , José L. Boyer , Chi Tu , Melwyn A. Abreo , Lorenzo J. Alfaro-Lopez , Yangbo Feng , Daniel F. Harvey , Tatyana V. Khasonova
CPC分类号： C07D519/00 , A61F2250/0067 , A61K31/519 , A61K31/52 , A61K31/522 , A61K31/7076 , A61K31/727 , A61K45/06 , A61K2300/00
摘要： This invention is directed to a method of preventing or treating diseases or conditions associated with platelet aggregation. The method is also directed to a method of treating thrombosis or related disorders. The method comprises administering to a subject a pharmaceutical composition comprising an effective amount of a non-nucleotide compound, preferably a P2Y12 receptor antagonist compound, wherein said amount is effective to inhibit platelet aggregation. The compounds useful for this invention include compounds of general Formulae I and III-XII, or salts, hydrates, and solvates thereof. The present invention also provides novel compounds of Formulae I and III-XII.
摘要翻译： 本发明涉及一种预防或治疗与血小板聚集有关的疾病或病症的方法。 该方法还涉及治疗血栓形成或相关病症的方法。 该方法包括向受试者施用包含有效量的非核苷酸化合物，优选P2Y12受体拮抗剂化合物的药物组合物，其中所述量有效抑制血小板聚集。 可用于本发明的化合物包括通式I和III-XII的化合物，或其盐，水合物和溶剂合物。 本发明还提供式I和III-XII的新型化合物。
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7.发明授权公开(公告)号：US07592445B2
公开(公告)日：2009-09-22
申请号：US11969539
申请日：2008-01-04
申请人： Robert Plourde, Jr. , Sammy R. Shaver , James G. Douglass, III , Paul S. Watson , José L. Boyer , Chi Tu , Melwyn A. Abreo , Lorenzo J. Alfaro-Lopez , Yangbo Feng , Daniel F. Harvey , Tatyana V. Khasonova
发明人： Robert Plourde, Jr. , Sammy R. Shaver , James G. Douglass, III , Paul S. Watson , José L. Boyer , Chi Tu , Melwyn A. Abreo , Lorenzo J. Alfaro-Lopez , Yangbo Feng , Daniel F. Harvey , Tatyana V. Khasonova
CPC分类号： C07D519/00 , A61F2250/0067 , A61K31/519 , A61K31/52 , A61K31/522 , A61K31/7076 , A61K31/727 , A61K45/06 , A61K2300/00
摘要： This invention is directed to compounds of Formulae III and V, useful for treating diseases or conditions associated with platelet aggregation.
摘要翻译： 本发明涉及式III和V的化合物，其可用于治疗与血小板聚集有关的疾病或病症。
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8.发明授权公开(公告)号：US07368438B2
公开(公告)日：2008-05-06
申请号：US10971766
申请日：2004-10-21
申请人： Robert Plourde, Jr. , Sammy R. Shaver , José L. Boyer , Melwyn A. Abreo , Lorenzo J. Alfaro-Lopez , Yangbo Feng , Daniel F. Harvey , Tatyana V. Khasonova , Chi Tu
发明人： Robert Plourde, Jr. , Sammy R. Shaver , José L. Boyer , Melwyn A. Abreo , Lorenzo J. Alfaro-Lopez , Yangbo Feng , Daniel F. Harvey , Tatyana V. Khasonova , Chi Tu
CPC分类号： C07D471/04 , A61K31/00 , A61K31/519 , A61K31/522 , A61K31/7076 , A61K31/727 , A61K45/06 , C07D493/04 , C07D519/00 , A61K2300/00
摘要： This invention is directed to a method of preventing or treating diseases or conditions associated with platelet aggregation. The method is also directed to a method of treating thrombosis or related disorders. The method comprises administering to a subject a pharmaceutical composition comprising an effective amount of a non-nucleotide compound, preferably a P2Y12 receptor antagonist compound, wherein said amount is effective to inhibit platelet aggregation. The compounds useful for this invention include compounds of general Formula I and III-XI, or salts, hydrates, and solvates thereof. The present invention also provides novel compounds according to Formula I and III-XI.
摘要翻译： 本发明涉及一种预防或治疗血小板聚集相关疾病或病症的方法。 该方法还涉及治疗血栓形成或相关病症的方法。 该方法包括向受试者施用包含有效量的非核苷酸化合物，优选P2Y 12受体拮抗剂化合物的药物组合物，其中所述量有效抑制血小板聚集。 可用于本发明的化合物包括通式I和III-XI的化合物，或其盐，水合物和溶剂合物。 本发明还提供了根据式I和III-XI的新化合物。
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公开(公告)号：US07749980B2
公开(公告)日：2010-07-06
申请号：US10576859
申请日：2004-10-21
申请人： Robert Plourde, Jr. , Sammy R. Shaver , Melwyn Anthony Abreo , Lorenzo Josue Alfaro-Lopez , Yangbo Feng , Tatyana V. Khasanova , Mark W. Holladay , Christopher S. Crean
发明人： Robert Plourde, Jr. , Sammy R. Shaver , Melwyn Anthony Abreo , Lorenzo Josue Alfaro-Lopez , Yangbo Feng , Tatyana V. Khasanova , Mark W. Holladay , Christopher S. Crean
CPC分类号： A61K31/519 , A61K31/52
摘要： The present invention is directed to a method of treating pain. The method comprises administering to a subject a pharmaceutical composition comprising an effective amount of a P2X receptor antagonist. The methods of the present invention are useful in reducing pain, such as traumatic pain, neuropathic pain, organ pain and/or pain associated with diseases. The P2X receptor antagonists useful for this invention are non-nucleotide compounds of general Formula I. Compounds of Formula I can be used alone to treat pain. Compounds of Formula I can also be used in conjunction with other therapeutic agents or adjunctive therapies commonly used to treat pain, thus enhancing the therapeutic effect of pain reduction.
摘要翻译： 本发明涉及治疗疼痛的方法。 该方法包括向受试者施用包含有效量的P2X受体拮抗剂的药物组合物。 本发明的方法可用于减少疼痛，例如创伤性疼痛，神经性疼痛，器官疼痛和/或与疾病相关的疼痛。 可用于本发明的P2X受体拮抗剂是通式I的非核苷酸化合物。式I化合物可单独用于治疗疼痛。 式I化合物也可以与通常用于治疗疼痛的其它治疗剂或辅助疗法结合使用，从而增强疼痛减轻的治疗效果。
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公开(公告)号：US20110052562A1
公开(公告)日：2011-03-03
申请号：US12745357
申请日：2008-12-18
申请人： Yangbo Feng , Philip LoGrasso , Thomas Bannister , Thomas Schroeter , Hampton Sessions , Lei Yao , Bo Wang , Michael P. Smolinski , Yen Ting Chen , Yan Yin , Bozena Frackowiak-Wojtasek , Sarwat Chowdhury
发明人： Yangbo Feng , Philip LoGrasso , Thomas Bannister , Thomas Schroeter , Hampton Sessions , Lei Yao , Bo Wang , Michael P. Smolinski , Yen Ting Chen , Yan Yin , Bozena Frackowiak-Wojtasek , Sarwat Chowdhury
IPC分类号： A61K38/49 , C07D405/04 , A61K31/4184 , A61P9/10 , A61P9/12 , A61P25/28 , A61P25/16 , A61P11/06 , A61P19/02 , A61P19/10 , A61P17/06 , A61P27/06 , A61P3/10 , A61P13/00 , A61P31/12 , C07D405/14 , A61K31/4439 , C07D471/04 , A61K31/437 , C07D487/04 , A61K31/519 , A61K31/506 , A61K31/5377 , C07D413/14
CPC分类号： C07D405/12 , C07D405/14 , C07D409/14 , C07D471/04 , C07D487/04
摘要： Compounds useful as Rho kinase inhibitors according to formula IA or IB: wherein A, B, D, E, R1, R2 and Ar1 are as defined herein, and any tautomer, salt, stereoisomer, hydrate, solvent, or prodrug thereof, pharmaceutical compositions, methods of treatment, and synthetic methods are provided.
摘要翻译： 用作根据式IA或IB的Rho激酶抑制剂的化合物：其中A，B，D，E，R 1，R 2和Ar 1如本文所定义，以及其任何互变异构体，盐，立体异构体，水合物，溶剂或前药，药物组合物 ，治疗方法和合成方法。
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