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    Stent deployment device including splittable sleeve containing the stent
    11.
    发明授权
    Stent deployment device including splittable sleeve containing the stent 失效
    支架展开装置，包括含支架的可拆卸套筒

    公开(公告)号：US06447540B1

    公开(公告)日：2002-09-10

    申请号：US08971113

    申请日：1997-11-14

    申请人： Arthur B. Fontaine ,  Susan DosPassos ,  Brian L. Bates ,  Scott E. Boatman ,  Michael C. Hoffa ,  Thomas A. Osborne

    发明人： Arthur B. Fontaine ,  Susan DosPassos ,  Brian L. Bates ,  Scott E. Boatman ,  Michael C. Hoffa ,  Thomas A. Osborne

    IPC分类号： A61F206

    CPC分类号： A61F2/97 ,  A61F2/95 ,  A61F2/958 ,  A61F2002/9511 ,  A61F2002/9583 ,  A61M25/0668 ,  A61M25/10

    摘要： A stent deployment device (10) includes a catheter (12), a stent (14) positioned on the catheter (12), and a sleeve (16) carried on the catheter (12). The sleeve (16) has a portion (18) extending fully over and containing the stent (14). The stent deployment device (10) also includes a mechanism (20) for splitting at least the portion (18) of the sleeve (16) extending over the stent (14) and, preferably, for splitting the entire sleeve (16). Splitting of the sleeve portion (18) permits expansion of the stent (14). The mechanism (20) can include an inflatable, nondistending balloon (22) carried on the catheter (12), the stent (14) and the sleeve portion (18) being positioned over the balloon (22). The stent (14) can be self-expanding or can be expanded by the balloon (22) itself. Alternatively, the mechanism (20) can include a bulbous end (24) on the catheter (12). Longitudinal movement of the bulbous catheter end (24) with respect to the sleeve (16) splits at least the sleeve portion (18), permitting expansion of the stent (14). As further alternatives, the mechanism (20) can include a garrote (66) connected to the sleeve or a partial segment (62) of the sleeve (16) folded back alongside the stent (14). The sleeve (16) can be the same length as the catheter (12) or can be shorter than the catheter (12). In the former case, the mechanism (20) can include a pair of graspable wings (56) for splitting the full length of the sleeve (16). It is preferred that at least the portion (18) of the sleeve (16) extending over the stent (14) includes a longitudinally extending structure 46 for ensuring that the sleeve portion (18) will in fact split upon operation of the mechanism (20).

    摘要翻译： 支架展开装置（10）包括导管（12），定位在导管（12）上的支架（14）和承载在导管（12）上的套筒（16）。 套筒（16）具有完全延伸并且容纳支架（14）的部分（18）。 支架展开装置（10）还包括一个机构（20），用于至少分开延伸在支架（14）上的套筒（16）的部分（18），并且优选地用于分割整个套筒（16）。 套筒部分（18）的分裂允许支架（14）膨胀。 机构（20）可以包括承载在导管（12）上的可膨胀的非重排球囊（22），支架（14）和套筒部分（18）定位在球囊（22）上方。 支架（14）可以是自膨胀的，或者可以由气囊（22）自身扩张。 或者，机构（20）可以包括在导管（12）上的球根端（24）。 球根导管端部（24）相对于套筒（16）的纵向移动至少分开套筒部分（18），从而允许支架（14）的膨胀。 作为另外的替代方案，机构（20）可以包括连接到套筒的衣壳（66）或套管（16）的沿着支架（14）折回的部分段（62）。 套筒（16）可以与导管（12）的长度相同，或者可以比导管（12）短。 在前一种情况下，机构（20）可以包括用于分离套筒（16）的全长的一对可抓握翼（56）。 优选地，延伸在支架（14）上的套筒（16）的至少部分（18）包括纵向延伸的结构46，用于确保套筒部分（18）实际上将在

    Medical device for and a method of endoscopic surgery
    13.
    发明授权
    Medical device for and a method of endoscopic surgery 失效
    内镜手术方法及其手术方法

    公开(公告)号：US5112308A

    公开(公告)日：1992-05-12

    申请号：US592676

    申请日：1990-10-03

    申请人： Douglas O. Olsen ,  Brian L. Bates ,  Thomas A. Osborne

    发明人： Douglas O. Olsen ,  Brian L. Bates ,  Thomas A. Osborne

    IPC分类号： A61B1/00 ,  A61B17/22 ,  A61B17/34 ,  A61M25/01 ,  A61M29/00

    CPC分类号： A61B17/3417 ,  A61M29/00

    摘要： A medical device for endoscopic access of a body cavity and a method of percutaneously placing inner and outer access sheaths of the device into the body cavity. The medical device includes inner and outer access sheaths and a dilator which is inserted into the outer sheath and has a shoulder or a shoulder piece for abutting against the proximal end of the outer sheath. The device also includes a wire guide that is percutaneously inserted into the body cavity via an introducer needle. The dilator and outer sheath are placed over the wire guide to dilate the puncture site and introduce the dilator and outer sheath into the body cavity. The dilator comprises an elongated cylindrical member having a passageway opening distally from the conically-shaped distal end and from an outside lateral wall of the dilator about the proximal end. The dilator also includes an end cap which is utilized to force the dilator and the outer sheath through the puncture site and into the body cavity. After positioning in the body cavity, the dilator and wire guide are removed through the outer sheath. The inner sheath is then inserted through the outer sheath into the body cavity. The proximal ends of both the inner and outer sheaths include seals for maintaining insufflation of the body cavity. The inner sheath includes a shoulder piece having a chamber and a side port for connection to an insufflation gas line.

    Silver implantable medical device
    15.
    发明授权
    Silver implantable medical device 失效
    银植入式医疗器械

    公开(公告)号：US06530951B1

    公开(公告)日：2003-03-11

    申请号：US08956715

    申请日：1997-10-23

    申请人： Brian L. Bates ,  Neal E. Fearnot ,  Thomas G. Kozma ,  Thomas A. Osborne ,  Anthony O. Ragheb ,  Joseph W. Roberts ,  William D. Voorhees, III

    发明人： Brian L. Bates ,  Neal E. Fearnot ,  Thomas G. Kozma ,  Thomas A. Osborne ,  Anthony O. Ragheb ,  Joseph W. Roberts ,  William D. Voorhees, III

    IPC分类号： A61F206

    CPC分类号： A61L29/16 ,  A61L27/306 ,  A61L27/54 ,  A61L29/106 ,  A61L31/088 ,  A61L31/16 ,  A61L2300/102 ,  A61L2300/104 ,  A61L2300/404 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2300/61

    摘要： A silver implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one layer 18 of a bioactive material posited on one surface of structure 12; and at least one porous layer 20 posited over the bioactive material layer 18 posited on one surface of structure 12 and the bioactive-material-free surface. Also included is a layer or impregnation of silver 45. Preferably, the structure 12 is a coronary stent. The porous layer 20 is comprised of a polymer applied preferably by vapor or plasma deposition and provides a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, merely by condensation of a monomer vapor. Silver is included as a base material, coating or included in a carrier, drug, medicament material utilized with the implantable stent.

    摘要翻译： 银可植入医疗装置10包括适于引入血管系统，食道，气管，结肠，胆道或尿道的结构12; 至少一层生物活性材料层18位于结构12的一个表面上; 并且位于结构12的一个表面上的生物活性材料层18上的至少一个多孔层20和不含生物活性材料的表面。 还包括银层45或浸渍。优选地，结构12是冠状动脉支架。 多孔层20由优选通过蒸气或等离子体沉积施加的聚合物组成，并提供生物活性材料的受控释放。 特别优选的是，聚合物是聚酰胺，聚对二甲苯或聚对二甲苯衍生物，其仅通过单体蒸气的冷凝就不经溶剂，热或催化剂沉积。 银包含作为基材，涂层或包含在与可植入支架一起使用的载体，药物，药物材料中。

    Multiple wire guide introducer system
    17.
    发明授权
    Multiple wire guide introducer system 有权
    多导线导引系统

    公开(公告)号：US07896888B2

    公开(公告)日：2011-03-01

    申请号：US11971364

    申请日：2008-01-09

    申请人： Thomas A. Osborne ,  Brian L. Bates

    发明人： Thomas A. Osborne ,  Brian L. Bates

    IPC分类号： A61F11/00

    CPC分类号： A61M25/0662 ,  A61M25/0172

    摘要： An introducer system for introducing a plurality of wire guides into a vessel of a patient includes first and second wire guides, and a catheter. The first wire guide has a curved proximal end, and a distal end sufficiently flexible for passage through the vessel to a target site for the procedure. The catheter has proximal and distal open ends, and a lumen extending therebetween. At least the distal end of the catheter has sufficient flexibility for passage over the first wire guide to the target site, and has an inwardly curved portion between the proximal and distal open ends. The catheter further has a side port proximally positioned along the inwardly curved portion. The side port is sized and arranged such that the curve of the first wire guide proximal end is passable therethrough when the catheter is passed over the first wire guide. The second wire guide is sized for passage through the lumen when the first wire guide is positioned in the lumen. The second wire guide has a stiffness greater than the stiffness of the first wire guide.

    摘要翻译： 用于将多个线导引器引入患者的容器中的导引器系统包括第一和第二线引导件和导管。 第一线引导件具有弯曲的近端，并且远端具有足够的柔性，用于通过血管到达该过程的目标部位。 导管具有近端和远端开口端，以及在其间延伸的腔。 至少导管的远端具有足够的柔性，用于在第一线导向件上通过到目标部位，并且在近端和远端开口端之间具有向内弯曲的部分。 导管还具有沿着向内弯曲的部分向近侧定位的侧端口。 侧端口的尺寸和布置使得当导管穿过第一导线器时，第一导线器近端的曲线可以穿过其中。 当第一线引导件定位在内腔中时，第二线引导件的尺寸适于通过内腔。 第二导线器的刚度大于第一导线器的刚度。

    Coated implantable medical device
    18.
    发明授权
    Coated implantable medical device 失效
    涂层可植入医疗器械

    公开(公告)号：US07611533B2

    公开(公告)日：2009-11-03

    申请号：US10223415

    申请日：2002-08-19

    申请人： Brian L. Bates ,  Anthony O. Ragheb ,  Neal E. Fearnot ,  Thomas G. Kozma ,  William D. Voorhees, III ,  Thomas A. Osborne

    发明人： Brian L. Bates ,  Anthony O. Ragheb ,  Neal E. Fearnot ,  Thomas G. Kozma ,  William D. Voorhees, III ,  Thomas A. Osborne

    IPC分类号： A61F2/06

    CPC分类号： A61K51/1282 ,  A61F2/24 ,  A61F2/82 ,  A61F2250/0068 ,  A61L27/306 ,  A61L27/54 ,  A61L29/085 ,  A61L29/106 ,  A61L29/16 ,  A61L31/088 ,  A61L31/10 ,  A61L31/16 ,  A61L33/022 ,  A61L2300/256 ,  A61L2300/416 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2300/608 ,  A61L2420/08 ,  A61N5/1002 ,  C08L65/04

    摘要： A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract, and at least one layer 18 of an immunosuppressive agent posited over at least one surface of the structure 12. Optionally, the device 10 can include at least one porous, preferably polymeric layer 20 posited over the layer 18 of immunosuppressive agent, and can alternatively or additionally include at least one coating layer 16 posited on one surface of the structure 12, the at least one layer 18 of immunosuppessive agent being posited in turn on at least a portion of the coating layer 16. The porous layer 20 and the coating layer 16 each provide for the controlled release of the bioactive material from the device 10. The structure 12 is preferably configured as a coronary stent. The polymer of the porous layer 20 is preferably applied by vapor or plasma deposition. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative which is deposited without solvents, heat or catalysts, but rather by condensation of a monomer vapor.

    摘要翻译： 涂覆的可植入医疗装置10包括适于引入到血管系统，食管，气管，结肠，胆管或尿道中的结构12，以及至少一个位于结构的至少一个表面上的免疫抑制剂层18 任选地，装置10可以包括位于免疫抑制剂的层18上的至少一个多孔的，优选的聚合物层20，并且可以替代地或另外包括至少一个涂覆层16，该涂层16位于结构12的一个表面上， 至少一层18的免疫抑制剂依次放置在涂层16的至少一部分上。多孔层20和涂层16各自提供生物活性材料从装置10的受控释放。结构12是 优选构造为冠状动脉支架。 多孔层20的聚合物优选通过蒸气或等离子体沉积来施加。 特别优选的是聚合物是聚酰胺，聚对二甲苯或聚对二甲苯衍生物，它们不用溶剂，加热或催化剂沉积，而是通过单体蒸气的冷凝而沉积。