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公开(公告)号：US20120238441A1
公开(公告)日：2012-09-20
申请号：US13506875
申请日：2012-05-22
CPC分类号： B01J20/267 , A61M1/3679 , B01D15/34 , B01J20/261 , B01J20/262 , B01J20/28069 , B01J20/28078 , B01J20/2808 , B01J20/28083 , B01J20/28085 , B01J20/28088 , B01J20/3208 , B01J20/327 , B01J20/3272
摘要： A size-selective hemocompatible porous polymeric adsorbent system is provided, the polymer system comprises at least one crosslinking agent and at least one dispersing agent, and the polymer has a plurality of pores with diameters in the range from about 17 to about 40,000 Angstroms
摘要翻译： 提供了尺寸选择性的血液相容性多孔聚合物吸附剂系统，该聚合物体系包含至少一种交联剂和至少一种分散剂，并且该聚合物具有多个直径在约17至约40,000埃范围内的孔
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公开(公告)号：US08211310B2
公开(公告)日：2012-07-03
申请号：US12807597
申请日：2010-09-09
CPC分类号： B01J20/26 , A61M1/3679 , B01D15/34 , B01J20/261 , B01J20/262 , B01J20/28083 , B01J20/28085 , Y10T428/249987 , Y10T428/249991
摘要： A size-selective hemocompatible porous polymeric adsorbent system is provided, the polymer system comprises at least one polymer with a plurality of pores, and the polymer has at least one transport pore with a diameter from about 250 Angstroms to about 2000 Angstroms, and the polymer has a transport pore volume greater than about 1.8% to about 78% of a capacity pore of volume of the polymer.
摘要翻译： 提供尺寸选择性的血液相容性多孔聚合物吸附剂体系，聚合物体系包含至少一种具有多个孔的聚合物，并且该聚合物具有至少一个直径约为250埃至约2000埃的输送孔，聚合物 具有大于聚合物体积容量孔的约1.8％至约78％的运输孔体积。
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公开(公告)号：US20110070424A1
公开(公告)日：2011-03-24
申请号：US12807597
申请日：2010-09-09
CPC分类号： B01J20/26 , A61M1/3679 , B01D15/34 , B01J20/261 , B01J20/262 , B01J20/28083 , B01J20/28085 , Y10T428/249987 , Y10T428/249991
摘要： A size-selective hemocompatible porous polymeric adsorbent system is provided, the polymer system comprises at least one polymer with a plurality of pores, and the polymer has at least one transport pore with a diameter from about 250 Angstroms to about 2000 Angstroms, and the polymer has a transport pore volume greater than about 1.8% to about 78% of a capacity pore of volume of the polymer.
摘要翻译： 提供尺寸选择性的血液相容性多孔聚合物吸附剂体系，聚合物体系包含至少一种具有多个孔的聚合物，并且该聚合物具有至少一个直径约为250埃至约2000埃的输送孔，聚合物 具有大于聚合物体积容量孔的约1.8％至约78％的运输孔体积。
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公开(公告)号：US07875182B2
公开(公告)日：2011-01-25
申请号：US11601931
申请日：2006-11-20
CPC分类号： B01J20/267 , A61M1/3679 , B01D15/34 , B01J20/261 , B01J20/262 , B01J20/28019 , B01J20/28083
摘要： Size-selective hemocompatible porous polymeric adsorbents are provided with a pore structure capable of excluding molecules larger than 50,000 Daltons, but with a pore system that allows good ingress and egress of molecules smaller than 35,000 Daltons. The pore system in these porous polymeric adsorbents is controlled by the method of synthesis so that 98% of the total pore volume is located in pores smaller than 300 Angstroms (Å) in diameter with a working pore size range within 100 to 300 Å in diameter. The porous polymeric adsorbents of this invention are very selective for extracting midsize proteins, such as cytokines and β2-microglobulin, from blood and other physiologic fluids while keeping the components required for good health such as cells, platelets, albumin, hemoglobin, fibrinogen, and other serum proteins intact.
摘要翻译： 尺寸选择性血液相容性多孔聚合物吸附剂具有能够排除大于50,000道尔顿分子的孔结构，但具有允许良好的进入和流出小于35,000道尔顿的分子的孔系统。 这些多孔聚合物吸附剂中的孔隙体系通过合成方法控制，使得总孔体积的98％位于直径小于300埃（孔）的孔中，其工作孔径范围在100至300埃范围内 。 本发明的多孔聚合物吸附剂对于从血液和其他生理液中提取中等蛋白质，例如细胞因子和β-微球蛋白是非常有选择性的，同时保持良好健康所需的组分，例如细胞，血小板，白蛋白，血红蛋白，纤维蛋白原 ，和其他血清蛋白完整。
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公开(公告)号：US20080119576A1
公开(公告)日：2008-05-22
申请号：US11601931
申请日：2006-11-20
IPC分类号： B01D15/34
CPC分类号： B01J20/267 , A61M1/3679 , B01D15/34 , B01J20/261 , B01J20/262 , B01J20/28019 , B01J20/28083
摘要： Size-selective hemocompatible porous polymeric adsorbents are provided with a pore structure capable of excluding molecules larger than 50,000 Daltons, but with a pore system that allows good ingress and egress of molecules smaller than 35,000 Daltons. The pore system in these porous polymeric adsorbents is controlled by the method of synthesis so that 98% of the total pore volume is located in pores smaller than 300 Angstroms (Å) in diameter with a working pore size range within 100 to 300 Å in diameter. The porous polymeric adsorbents of this invention are very selective for extracting midsize proteins, such as cytokines and β2-microglobulin, from blood and other physiologic fluids while keeping the components required for good health such as cells, platelets, albumin, hemoglobin, fibrinogen, and other serum proteins intact.
摘要翻译： 尺寸选择性血液相容性多孔聚合物吸附剂具有能够排除大于50,000道尔顿分子的孔结构，但具有允许良好的进入和流出小于35,000道尔顿的分子的孔系统。 这些多孔聚合物吸附剂中的孔隙体系通过合成方法控制，使得总孔体积的98％位于直径小于300埃（孔）的孔中，其工作孔径范围在100至300埃范围内 。 本发明的多孔聚合物吸附剂对于从血液和其它生理液中提取中等蛋白质，例如细胞因子和β2 - 微球蛋白是非常有选择性的，同时保持良好健康所需的组分如细胞，血小板 ，白蛋白，血红蛋白，纤维蛋白原等完整的血清蛋白。
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公开(公告)号：US4968792A
公开(公告)日：1990-11-06
申请号：US412256
申请日：1989-09-25
IPC分类号： C07D417/12
CPC分类号： C07D417/12
摘要： Disclosed herein are novel benzisothiazole derivatives having pharmacological activity, to a process for preparing them, to pharmaceutical compositions containing them, and to their use in the treatment of a variety of central nervous system disorders.
摘要翻译： 本文公开了具有药理活性的新的苯并异噻唑衍生物，其制备方法，含有它们的药物组合物及其在治疗各种中枢神经系统疾病中的用途。
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公开(公告)号：US4797488A
公开(公告)日：1989-01-10
申请号：US34820
申请日：1987-04-03
IPC分类号： C07D221/22 , A61K31/495 , A61K31/535 , A61P25/18 , C07C61/125 , C07D221/24 , C07D313/06 , C07D401/00 , C07D401/06 , C07D401/12 , C07D491/00 , C07D491/18 , C07D498/00 , C07D498/08 , C07D513/00 , C07D513/08 , C07D513/22 , C07D401/14 , C07D403/14 , C07D413/14 , C07D417/14
CPC分类号： C07C61/125 , C07D221/24 , C07D313/06 , C07D401/12
摘要： Substituted imides of the following formula are antipsychotic, anxiolytic agents with very little extrapyramidal side effects: ##STR1## in which X is --O--, --S--, --SO--, --SO.sub.2 --, --CR.sub.3 R.sub.4 -- where R.sub.3 and R.sub.4, independently, are hydrogen, alkyl of 1 to 4 carbon atoms or, taken together with the carbon atom to which they are attached, R.sub.3 and R.sub.4 form a cycloalkyl group of of 3 to 5 carbon atoms; n is one of the integers 2, 3, 4 or 5; R is phenyl, halophenyl, trifluoromethylphenyl, alkoxyphenyl in which the alkoxy substituent contains 1 to 3 carbon atoms, 2-pyrimidinyl, halopyrimidin-2-yl, 2-pyrazinyl, halopyrazin-2-yl, 2-pyridinyl, cyanopyridin-2-yl, halopyridin-2-yl, quinolyl, or haloquinolyl; R.sub.1 and R.sub.2, taken together, are alkylene of 3 to 5 carbon atoms or alkenylene of 3 to 5 carbon atoms, or taken with the carbon atoms to which they are attached, R.sub.1 and R.sub.2 complete a benzene ring, or a group of the formula: ##STR2## where Y is --CH.sub.2 --, --CH.sub.2 --CH.sub.2 --, --O-- or --S-- and the dotted line represents optional unsaturation; or a pharmaceutically acceptable salt thereof. In addition, the intermediate b3-dicarboxylic and the corresponding anhydrides - 2,3,3a,3b,4,5,6,6a,7,7a-decahydro-4,6,7-metheno-1H-cyclopenta[a]pentalene-1,3-dicarboxylic acid and octahydro-1,5-methano-6,8,9-metheneopentaleno[1,2-d]oxepin-2,4(1H,5H)-dione represent especially significant aspects of the invention.
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