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公开(公告)号：US20220349863A1
公开(公告)日：2022-11-03
申请号：US17659772
申请日：2022-04-19
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Andreas Leinenbach , Aart Pieter van Doom
IPC: G01N30/36
Abstract: A liquid chromatographic (LC) system is herein disclosed, the LC system comprising at least one fluidic stream comprising at least one HPLC column, a downstream valve connected to the at least one fluidic stream and connectable to a detector via a valve-to-detector conduit, wherein the at least one fluidic stream is connectable to the valve-to-detector conduit via the downstream valve, and where the LC system further comprises a downstream pump fluidically connected to the downstream valve and connectable to the at least one fluidic stream via the downstream valve in order to backflush and thereby clean the at least one HPLC column. A respective automated LC method is herein also disclosed.
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公开(公告)号：US20210188788A1
公开(公告)日：2021-06-24
申请号：US17154501
申请日：2021-01-21
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Dieter Heindl , Hans-Peter Josel , Uwe Kobold , Christoph Seidel , Martin Rempt , Andreas Leinenbach , Giuseppe Prencipe , Silvia Baecher , Simon Ferdinand Loibl , Anna-Skrollan Geiermann , Jelena Milic , Robert Hahn , Nicole Pirkl
IPC: C07D257/04 , C07D249/06 , H01J49/00
Abstract: The present invention relates to reagents which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said reagents.
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公开(公告)号：US11730821B2
公开(公告)日：2023-08-22
申请号：US17933906
申请日：2022-09-21
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Hartmut Duefel , Uwe Kobold , Andreas Leinenbach
CPC classification number: A61K47/68 , G01N33/6848 , G01N2030/8868 , G01N2458/00
Abstract: The present disclosure is directed at an antibody conjugate having an antibody and a tag, wherein one or more element(s) present in the antibody exhibit an isotope ratio which differs from the naturally occurring isotope ratio of the one or more element(s), wherein the amount of the isotope which is less-common in nature, is increased to at least 4% of the atoms of the respective element in the antibody, as well as uses thereof.
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Patent Agency Ranking
公开(公告)号：US20230022977A1
公开(公告)日：2023-01-26
申请号：US17933906
申请日：2022-09-21
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Hartmut Duefel , Uwe Kobold , Andreas Leinenbach
Abstract: The present disclosure is directed at an antibody conjugate having an antibody and a tag, wherein one or more element(s) present in the antibody exhibit an isotope ratio which differs from the naturally occurring isotope ratio of the one or more element(s), wherein the amount of the isotope which is less-common in nature, is increased to at least 4% of the atoms of the respective element in the antibody, as well as uses thereof.
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公开(公告)号：US20210198217A1
公开(公告)日：2021-07-01
申请号：US17155020
申请日：2021-01-21
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Dieter Heindl , Hans-Peter Josel , Uwe Kobold , Christoph Seidel , Martin Rempt , Andreas Leinenbach , Giuseppe Prencipe , Silvia Baecher , Simon Ferdinand Loibl , Anna-Skrollan Geiermann , Jelena Milic , Nicole Pirkl
IPC: C07D249/06 , C07D257/04 , C07D203/04 , G01N30/72
Abstract: The present invention relates to reagents which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said reagents.
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公开(公告)号：US20200246476A1
公开(公告)日：2020-08-06
申请号：US16852931
申请日：2020-04-20
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Harmut Duefel , Uwe Kobold , Andreas Leinenbach
Abstract: The present disclosure is directed at an antibody conjugate having an antibody and a tag, wherein one or more element(s) present in the antibody exhibit an isotope ratio which differs from the naturally occurring isotope ratio of the one or more element(s), wherein the amount of the isotope which is less-common in nature, is increased to at least 4% of the atoms of the respective element in the antibody, as well as uses thereof.
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公开(公告)号：US20200041470A1
公开(公告)日：2020-02-06
申请号：US16520696
申请日：2019-07-24
Inventor： Thomas Carell , Uwe Kobold , Dieter Heindl , Silvia Baecher , Andreas Leinenbach , Martin Rempt , Toni Pfaffeneder , Angie Kirchner , Olesea Kosmatchev , Rene Rahimoff , Sarah Schiffers , Markus Muller
IPC: G01N30/72 , H01J49/10 , H01J49/00 , H01J49/06 , C07D249/04
Abstract: The present invention relates to reagents suitable in the mass spectrometric determination of analyte molecules such as carbohydrates as well as adducts of such reagents and analyte molecules and applications of said reagents and adducts. Further, the present invention relates to methods for the mass spectrometric determination of analyte molecules.
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公开(公告)号：US20190250158A1
公开(公告)日：2019-08-15
申请号：US16389066
申请日：2019-04-19
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Uwe Kobold , Robert Lang , Andreas Leinenbach
IPC: G01N33/566 , G01N33/573 , G01N33/68
CPC classification number: G01N33/566 , G01N33/543 , G01N33/573 , G01N33/6848
Abstract: The present disclosure relates to a method for detecting an analyte involving a) contacting the analyte, a capture agent and a solid surface to form a capture complex attached to a solid surface, b) cleaving at least one covalent bond within the analyte and/or within said capture agent in the capture complex and, thereby, releasing the analyte or a fragment thereof from the capture complex, and c) detecting at least one fragment of the analyte and, thereby, detecting the analyte. The present disclosure further relates to a kit having i) a capture agent binding to an analyte; and ii) an agent cleaving at least one covalent bond within the analyte and/or within the capture agent; and to the use of a protease for releasing fragments of an analyte for detecting the analyte, wherein the analyte is bound to a solid surface via a capture agent.
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