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公开(公告)号：US20210198217A1
公开(公告)日：2021-07-01
申请号：US17155020
申请日：2021-01-21
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Dieter Heindl , Hans-Peter Josel , Uwe Kobold , Christoph Seidel , Martin Rempt , Andreas Leinenbach , Giuseppe Prencipe , Silvia Baecher , Simon Ferdinand Loibl , Anna-Skrollan Geiermann , Jelena Milic , Nicole Pirkl
IPC: C07D249/06 , C07D257/04 , C07D203/04 , G01N30/72
Abstract: The present invention relates to reagents which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said reagents.
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公开(公告)号：US20240110932A1
公开(公告)日：2024-04-04
申请号：US18541624
申请日：2023-12-15
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Johannes Pflieger , Nicole Pirkl , Martin Rempt , Christoph Zuth
CPC classification number: G01N33/743 , G01N30/7233 , G01N33/6848 , H01J49/0009 , G01N2030/027 , G01N2333/575 , G01N2496/00
Abstract: The present invention relates to a method of determining an analyte in a sample by mass spectrometry (MS), the method comprising (a) admixing a pre-determined amount of internal calibrator to said sample, wherein said internal calibrator comprises at least two non-identical isotopologues of the analyte at predetermined amounts; (b) determining MS signals of ions generated from said analyte (analyte signal) and from said at least two isotopologues (isotopologue signals); (c) providing a calibration based on the analyte signal and the isotopologue signals determined in step (b); and (d) determining said analyte based on the calibration provided in step (c). Further, the present invention relates to devices, systems, and uses related thereto.
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公开(公告)号：US11885818B2
公开(公告)日：2024-01-30
申请号：US17155054
申请日：2021-01-21
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Dieter Heindl , Hans-Peter Josel , Uwe Kobold , Christoph Seidel , Martin Rempt , Andreas Leinenbach , Giuseppe Prencipe , Silvia Baecher , Simon Ferdinand Loibl , Anna-Skrollan Geiermann , Jelena Milic , Nicole Pirkl
IPC: C07D401/06 , C07D413/06 , G01N33/74 , G01N33/58 , C07J43/00
CPC classification number: G01N33/743 , C07D401/06 , C07D413/06 , C07J43/003 , G01N33/58 , G01N2560/00
Abstract: The present invention relates to reagents which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said reagents.
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Patent Agency Ranking
公开(公告)号：US11845733B2
公开(公告)日：2023-12-19
申请号：US17155020
申请日：2021-01-21
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Dieter Heindl , Hans-Peter Josel , Uwe Kobold , Christoph Seidel , Martin Rempt , Andreas Leinenbach , Giuseppe Prencipe , Silvia Baecher , Simon Ferdinand Loibl , Anna-Skrollan Geiermann , Jelena Milic , Nicole Pirkl
IPC: C07D249/04 , C07D257/04 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/06 , C07D471/04 , C07D249/06 , C07D203/04 , G01N30/72
CPC classification number: C07D249/06 , C07D203/04 , C07D249/04 , C07D257/04 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/06 , C07D471/04 , G01N30/72
Abstract: The present invention relates to reagents which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said reagents.
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公开(公告)号：US20210140983A1
公开(公告)日：2021-05-13
申请号：US17155054
申请日：2021-01-21
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Dieter Heindl , Hans-Peter Josel , Uwe Kobold , Christoph Seidel , Martin Rempt , Andreas Leinenbach , Giuseppe Prencipe , Silvia Baecher , Simon Ferdinand Loibl , Anna-Skrollan Geiermann , Jelena Milic , Nicole Pirkl
IPC: G01N33/74 , C07D401/06 , G01N33/58
Abstract: The present invention relates to reagents which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said reagents.
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公开(公告)号：US20240092742A1
公开(公告)日：2024-03-21
申请号：US18500149
申请日：2023-11-02
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Dieter Heindl , Hans-Peter Josel , Uwe Kobold , Christoph Seidel , Martin Rempt , Andreas Leinenbach , Giuseppe Prencipe , Silvia Baecher , Simon Ferdinand Loibl , Anna-Skrollan Geiermann , Jelena Milic , Nicole Pirkl
IPC: C07D249/06 , C07D203/04 , C07D249/04 , C07D257/04 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/06 , C07D471/04
CPC classification number: C07D249/06 , C07D203/04 , C07D249/04 , C07D257/04 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/06 , C07D471/04 , G01N30/72
Abstract: The present invention relates to reagents which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said reagents.
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公开(公告)号：US20230314444A1
公开(公告)日：2023-10-05
申请号：US18328104
申请日：2023-06-02
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Samir Karaca , Nicole Pirkl , Martin Rempt
CPC classification number: G01N33/6848 , H01J49/165 , G01N33/743
Abstract: The present invention relates to a method, a diagnostic system, a dopand and the use thereof for the enhancement of detection of an analyte of interest by Cross Spray ESI mass spectrometry.
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公开(公告)号：US20210188788A1
公开(公告)日：2021-06-24
申请号：US17154501
申请日：2021-01-21
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Dieter Heindl , Hans-Peter Josel , Uwe Kobold , Christoph Seidel , Martin Rempt , Andreas Leinenbach , Giuseppe Prencipe , Silvia Baecher , Simon Ferdinand Loibl , Anna-Skrollan Geiermann , Jelena Milic , Robert Hahn , Nicole Pirkl
IPC: C07D257/04 , C07D249/06 , H01J49/00
Abstract: The present invention relates to reagents which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said reagents.
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