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公开(公告)号：US20190309091A1
公开(公告)日：2019-10-10
申请号：US16450186
申请日：2019-06-24
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Michael Gerg , Lars Hillringhaus , Klaus Hirzel , Caroline Dorothea Hojer , Hans-Peter Josel , Christoph Seidel , Michael Schraeml , Leopold Von Proff
IPC: C07K16/44 , G01N33/543
Abstract: The present invention relates to a monoclonal antibody capable of binding to biotin. In one embodiment the monoclonal antibody according to the invention also does not bind to a biotin moiety on a biotinylated molecule, wherein the biotin moiety is attached to the molecule via the carbon atom of the carboxyl function of the valeric acid moiety of biotin. Also disclosed is a method for generation of an antibody as disclosed herein. The monoclonal antibody according to the invention is of specific use in a method for measuring an analyte in a sample, wherein a (strept)avidin/biotin pair is used to bind a biotinylated analyte specific binding agent to a (strept)avidin coated solid phase.
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公开(公告)号：US20190293615A1
公开(公告)日：2019-09-26
申请号：US16438787
申请日：2019-06-12
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Dieter Heindl , Uwe Kobold , Martin Rempt , Christoph Seidel
Abstract: A method for tracking a sample identity during a process in an analysis system is disclosed. The analysis system comprises a liquid chromatograph and a mass spectrometer. The method comprises providing a sample, adding a composition of different chemical substances to the sample with a concentration being above a detection level of the mass spectrometer, processing the sample together with the composition with the analysis system, detecting and measuring a component and/or components of the sample with the mass spectrometer, detecting and measuring the composition or parts of the composition of different chemical substances with the mass spectrometer, and identifying the sample based on a detection of a substance detection signal pattern of the mass spectrometer including substance detection signals representing the composition of chemical substances.
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公开(公告)号：US09416150B2
公开(公告)日：2016-08-16
申请号：US14609649
申请日：2015-01-30
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Frank Bergmann , Robert Cysewski , Luisa de Cola , Sebastian Dziadek , Jesus Miguel Fernandez Hernandez , Hans-Peter Josel , Christoph Seidel
CPC classification number: C07F15/0033 , C09K11/06 , C09K11/07 , C09K2211/1007 , C09K2211/1029 , C09K2211/14 , C09K2211/1408 , C09K2211/1416 , C09K2211/1425 , C09K2211/1441 , C09K2211/1466 , C09K2211/185 , G01N33/582
Abstract: The present invention relates to novel iridium-based Ir(III) luminescent complexes, conjugates comprising these complexes as a label and their application, e.g. in the electrochemiluminescence based detection of an analyte.
Abstract translation: 本发明涉及新型的基于铱的Ir（III）发光复合物，包含这些络合物作为标记的缀合物及其应用，例如， 在基于电化学发光的分析物检测中。
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公开(公告)号：US09403859B2
公开(公告)日：2016-08-02
申请号：US14610372
申请日：2015-01-30
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Frank Bergmann , Robert Cysewski , Luisa de Cola , Sebastian Dziadek , Jesus Miguel Fernandez Hernandez , Hans-Peter Josel , Christoph Seidel
CPC classification number: C07F15/0033 , C09K11/06 , C09K2211/1007 , C09K2211/1011 , C09K2211/1029 , C09K2211/14 , C09K2211/1408 , C09K2211/1416 , C09K2211/1425 , C09K2211/1441 , C09K2211/1466 , C09K2211/185 , G01N33/582
Abstract: The present invention relates to novel iridium-based Ir(III) luminescent complexes, conjugates comprising these complexes as a label and their application, e.g. in the electrochemiluminescence based detection of an analyte.
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公开(公告)号：US20230127289A1
公开(公告)日：2023-04-27
申请号：US17990714
申请日：2022-11-20
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Robert Hahn , Dieter Heindl , Thomas Hoffmann , Hans-Peter Josel , Uwe Kobold , Hannes Kuchelmeister , Simon Ferdinand Loibl , Daniela Mazzier , Jelena Milic , Giuseppe Prencipe , Martin Rempt , Christoph Seidel
IPC: C07D213/56 , C07D401/04 , C07D213/74 , C07D213/30 , H01J49/00
Abstract: The present invention relates to compounds which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said compounds.
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Patent Agency Ranking
公开(公告)号：US20190293612A1
公开(公告)日：2019-09-26
申请号：US16438797
申请日：2019-06-12
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Dieter Heindl , Thomas Heinemeyer , Uwe Kobold , Martin Rempt , Christoph Seidel
Abstract: A method for identifying a reagent during a process in an analysis system is disclosed. The analysis system comprises a liquid chromatograph and a mass spectrometer. The method comprises providing a reagent, adding at least one chemical substance to the reagent with a concentration being above a detection level of the mass spectrometer, processing the reagent together with the chemical substance with the analysis system, and identifying the reagent based on a detection of a substance detection signal of the mass spectrometer representing the chemical substance.
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公开(公告)号：US20190293611A1
公开(公告)日：2019-09-26
申请号：US16438775
申请日：2019-06-12
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Dieter Heindl , Uwe Kobold , Christoph Seidel , Martin Rempt
Abstract: A method for identifying a reagent during a process in an analysis system is disclosed. The analysis system comprises a liquid chromatograph and a mass spectrometer. The method comprises providing a reagent, adding at least one chemical substance to the reagent with a concentration being below a detection level of the mass spectrometer, enriching the chemical substance within the liquid chromatograph to a concentration above the detection level of the mass spectrometer, processing the reagent together with the enriched chemical substance by means of the analysis system, and identifying the reagent based on a detection of a substance detection signal of the mass spectrometer representing the chemical substance.
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公开(公告)号：US09399654B2
公开(公告)日：2016-07-26
申请号：US14609552
申请日：2015-01-30
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Frank Bergmann , Robert Cysewski , Luisa de Cola , Sebastian Dziadek , Jesus Miguel Fernandez Hernandez , Hans-Peter Josel , Christoph Seidel
CPC classification number: C07F15/0033 , C09K11/06 , C09K11/07 , C09K2211/1003 , C09K2211/1007 , C09K2211/1011 , C09K2211/1029 , C09K2211/1059 , C09K2211/1074 , C09K2211/14 , C09K2211/185 , G01N33/582
Abstract: The present invention relates to novel iridium-based Ir(III) luminescent complexes, conjugates comprising these complexes as a label and their application, e.g. in the electrochemiluminescence based detection of an analyte.
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公开(公告)号：US20150147751A1
公开(公告)日：2015-05-28
申请号：US14609649
申请日：2015-01-30
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Frank Bergmann , Robert Cysewski , Luisa de Cola , Sebastian Dziadek , Jesus Miguel Fernandez Hernandez , Hans-Peter Josel , Christoph Seidel
CPC classification number: C07F15/0033 , C09K11/06 , C09K11/07 , C09K2211/1007 , C09K2211/1029 , C09K2211/14 , C09K2211/1408 , C09K2211/1416 , C09K2211/1425 , C09K2211/1441 , C09K2211/1466 , C09K2211/185 , G01N33/582
Abstract: The present invention relates to novel iridium-based Ir(III) luminescent complexes, conjugates comprising these complexes as a label and their application, e.g. in the electrochemiluminescence based detection of an analyte.
Abstract translation: 本发明涉及新型的基于铱的Ir（III）发光复合物，包含这些络合物作为标记的缀合物及其应用，例如， 在基于电化学发光的分析物检测中。
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公开(公告)号：US20150140682A1
公开(公告)日：2015-05-21
申请号：US14610372
申请日：2015-01-30
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Frank Bergmann , Robert Cysewski , Luisa de Cola , Sebastian Dziadek , Jesus Miguel Fernandez Hernandez , Hans-Peter Josel , Christoph Seidel
CPC classification number: C07F15/0033 , C09K11/06 , C09K2211/1007 , C09K2211/1011 , C09K2211/1029 , C09K2211/14 , C09K2211/1408 , C09K2211/1416 , C09K2211/1425 , C09K2211/1441 , C09K2211/1466 , C09K2211/185 , G01N33/582
Abstract: The present invention relates to novel iridium-based Ir(III) luminescent complexes, conjugates comprising these complexes as a label and their application, e.g. in the electrochemiluminescence based detection of an analyte.
Abstract translation: 本发明涉及新型的基于铱的Ir（III）发光复合物，包含这些络合物作为标记的缀合物及其应用，例如， 在基于电化学发光的分析物检测中。
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