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公开(公告)号：US20250003932A1
公开(公告)日：2025-01-02
申请号：US18294945
申请日：2022-08-01
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Ruediger Laubender , Stefan Quint , Marius Wagner
Abstract: A computer implemented method (140) for determining lifetime of at least one chromatography column (116) of at least one chromatography device (110), wherein the method (140) comprises the following steps: i) receiving model input chromatography data via at least one communication interface (128); ii) determining at least one state variable indicative of lifetime of the chromatography column (116) using at least one data driven model based on the model input chromatography data using at least one processing device (130); iii) evaluating the determined state variable thereby determining information about lifetime by using the processing device (130), wherein the evaluation comprises comparing the determined state variable to at least one threshold. Further, a test system (112), a computer program and a method for operating a chromatography column (116) are disclosed.
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公开(公告)号：US11581178B2
公开(公告)日：2023-02-14
申请号：US17453683
申请日：2021-11-05
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Robert Lang , Stefan Quint , Gabriele Punzmann
Abstract: A mass spectrometry (MS) apparatus is provided. The MS apparatus includes a mass spectrometer, an ionization source coupled to the mass spectrometer, and a flow injection system (FIS) coupled to the ionization source. The ionization source is configured to provide an ionized gas flow of an analyte towards an entrance of the mass spectrometer. The ionization source is further configured to provide a second gas flow of a second gas. The MS apparatus is configured to measure a mass spectrometer (MS) signal of the analyte. The MS apparatus is further configured to analyze a dependency of the MS signal of the analyte versus a parameter of the second gas flow or a state of the second gas flow and to determine a condition of the apparatus based on the analyzed dependency.
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13.发明申请公开(公告)号：US20230037141A1
公开(公告)日：2023-02-02
申请号：US17965290
申请日：2022-10-13
Inventor： Stefan Quint , Tibor Toth , Aart Pieter Van Doorn , Yuichiro Hashimoto
Abstract: The present disclosure is related to an analytical system comprising a liquid chromatographic (LC) system comprising a plurality of fluidic streams alternately connectable to a common detector via a stream-selection valve connected to the detector via a valve-to-detector conduit. The analytical system further comprises a wash pump fluidically connected to the stream-selection valve and configured to connect to the valve-to-detector conduit between two consecutive fluidic streams in order to wash liquid from a previous fluidic stream out of the valve-to-detector conduit before liquid from a subsequent fluidic stream enters the valve-to-detector conduit. An analytical method comprising switching between the fluidic streams and washing in between is also disclosed.
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14.发明申请公开(公告)号：US20220246412A1
公开(公告)日：2022-08-04
申请号：US17653539
申请日：2022-03-04
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Stefan Quint , Florian Schweinberger
IPC: H01J49/00
Abstract: A method for checking a validity of a mass axis calibration of a mass spectrometer (MS) of an analyzer system, comprising obtaining a mass axis check sample spanning a predetermined m/z measurement range of the MS and automatically processing the sample, performing multiple full scan mode MS measurements of different types using the MS for the at least two mass axis points to obtain measurement data, wherein the different types include at least a first full scan MS measurement in a positive mode and a second measurement in a negative mode, or at least a first full scan measurement for a first mass filter and a second full scan measurement for a second mass filter; comparing the measurement data for each of the at least two mass axis points with respective reference data and determining if a condition is out of specification based on a result of the comparing steps.
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公开(公告)号：US20210181166A1
公开(公告)日：2021-06-17
申请号：US17113164
申请日：2020-12-07
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Stefan Quint , Marian Roetzer , Florian Schweinberger , Benjamin Tiemann , Marius Wagner , Ralf Zimmermann
Abstract: An analytical system including a mass spectrometer (MS) coupled to liquid chromatography (LC) via an ionization source (IS), and an automated method of maintaining the analytical system in a QC-compliant status are described. The method comprises determining a deviation of the analytical system from a QC-compliant status by determining a deviation of one or more predetermined parameters in an m/z spectrum above one or more predetermined thresholds, triggering an IS and/or MS maintenance procedure upon determining a deviation from the QC-compliant status, determining a return or a failed return to the QC-compliant status during and/or after the IS and/or MS maintenance procedure by determining a return or a failed return respectively of the one or more predetermined parameters in an m/z spectrum below the one or more predetermined thresholds, triggering another IS and/or MS maintenance procedure upon determining a failed return to the QC-compliant status.
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Patent Agency Ranking
公开(公告)号：US12123857B2
公开(公告)日：2024-10-22
申请号：US16996225
申请日：2020-08-18
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Marc Kaminski , Stefan Quint , Benjamin Tiemann
CPC classification number: G01N30/88 , G01N30/20 , G06F16/285 , G01N2030/027 , G01N2030/202 , G01N2030/8804
Abstract: A method of monitoring a state of a liquid chromatography (LC) stream of an automated analyzer is provided including automatically monitoring a system pressure of an injection assembly of the liquid chromatography stream to generate a time series of system pressures, classifying the time series in one of two or more predetermined classes indicating different states of the LC stream and triggering a response based on the classification result.
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公开(公告)号：US11530943B2
公开(公告)日：2022-12-20
申请号：US17066692
申请日：2020-10-09
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Stefan Quint , Dieter Kempken
Abstract: An automated method for detecting and/or monitoring a state of a degasser of an analyzer is provided, the degasser including a container configured to be evacuated. The method includes obtaining a time series of values indicative of pressures inside the container. The time series spans a period during which the container is evacuated or pressurized. The method further includes determining a liquid level state of the degasser which is determined by an amount of liquid present in the container based on the time series.
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公开(公告)号：US20220128531A1
公开(公告)日：2022-04-28
申请号：US17448063
申请日：2021-09-20
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Benjamin Tiemann , Stefan Quint , Florian Schweinberger
Abstract: A liquid chromatography-mass spectrometry (LC-MS) apparatus including an ionization source coupled to a mass spectrometer and a liquid chromatographic (LC) system coupled to the ionization source. The LC system comprises multiple fluidic streams alternately connectable to the ionization source, thereby assigning a detection time window to each fluidic stream from the multiple fluidic streams when connected to the ionization source. The LC-MS apparatus further comprises a controller configured to carry out steps of monitoring an ionization current of the ionization source for the multiple fluidic streams and identifying differences in flow conditions between the multiple fluidic streams based on the monitored ionization current. The controller is further configured to carry out adjusting detection conditions of one or more of the multiple fluidic streams responsive to the identified differences, thereby enabling eluates of interest from each fluidic stream to be detected by the mass spectrometer in the respective detection time window.
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公开(公告)号：US11287402B2
公开(公告)日：2022-03-29
申请号：US17113164
申请日：2020-12-07
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Stefan Quint , Marian Roetzer , Florian Schweinberger , Benjamin Tiemann , Marius Wagner , Ralf Zimmermann
Abstract: An analytical system including a mass spectrometer (MS) coupled to liquid chromatography (LC) via an ionization source (IS), and an automated method of maintaining the analytical system in a QC-compliant status are described. The method comprises determining a deviation of the analytical system from a QC-compliant status by determining a deviation of one or more predetermined parameters in an m/z spectrum above one or more predetermined thresholds, triggering an IS and/or MS maintenance procedure upon determining a deviation from the QC-compliant status, determining a return or a failed return to the QC-compliant status during and/or after the IS and/or MS maintenance procedure by determining a return or a failed return respectively of the one or more predetermined parameters in an m/z spectrum below the one or more predetermined thresholds, triggering another IS and/or MS maintenance procedure upon determining a failed return to the QC-compliant status.
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公开(公告)号：US11249059B2
公开(公告)日：2022-02-15
申请号：US16994118
申请日：2020-08-14
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Stefan Quint , Benjamin Tiemann , Florian Schweinberger , Martin Stingl
IPC: G01N30/72 , G01N30/86 , H01J49/00 , H01J49/16 , G01N35/10 , H01J49/04 , G01N30/62 , G01N15/12 , G01N30/04
Abstract: An automated method of monitoring a state of an analyzer is provided including a mass spectrometer (MS) with an electrospray ionization (ESI) source coupled to a liquid chromatography (LC) stream, including monitoring an electrospray ionization current of the ESI source and identifying a condition of multiple conditions of the analyzer based on the monitored ionization current of the ESI source, one of the conditions being a presence of a dead volume in a liquid chromatography stream of the analyzer downstream of an LC column of the LC stream.
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