公开(公告)号：US20050137633A1

公开(公告)日：2005-06-23

申请号：US10744952

申请日：2003-12-22

申请人： Rodney Salo ,  Bruce KenKnight ,  Joseph Pastore ,  Steven Girouard

发明人： Rodney Salo ,  Bruce KenKnight ,  Joseph Pastore ,  Steven Girouard

IPC分类号： A61N1/362 ,  A61N1/368

CPC分类号： A61N1/3627 ,  A61N1/3684

摘要： An implantable device for delivering cardiac pacing therapy in order to improve cardiac function is programmed to allow some amount of intrinsic activity to occur without otherwise the disturbing the pacing algorithm used to deliver therapy. Intrinsic cardiac cycles utilize the heart's native conduction system and thus serve to prevent the atrophy which may otherwise result from continuous pacing.

摘要翻译： 用于递送心脏起搏治疗以改善心脏功能的可植入装置被编程为允许发生一定量的内在活动，而无需另外打扰用于递送治疗的起搏算法。 内在心脏周期利用心脏的天然传导系统，从而用于预防由连续起搏引起的萎缩。

公开(公告)号：US07725185B2

公开(公告)日：2010-05-25

申请号：US12070080

申请日：2008-02-15

申请人： Lili Liu ,  Rodney Salo

发明人： Lili Liu ,  Rodney Salo

IPC分类号： A61N1/365 ,  A61N1/05

CPC分类号： A61N1/368 ,  A61N1/3627 ,  A61N1/3684

摘要： An apparatus and method for reversing ventricular remodeling with electro-stimulatory therapy. A ventricle is paced by delivering one or more stimulatory pulses in a manner such that a stressed region of the myocardium is pre-excited relative to other regions in order to subject the stressed region to a lessened preload and afterload during systole. The unloading of the stressed myocardium over time effects reversal of undesirable ventricular remodeling.

摘要翻译： 用电刺激治疗逆转心室重构的装置和方法。 通过递送一个或多个刺激脉冲以使得相对于其它区域预激励心肌的应激区域以使受压区域在收缩期间减轻预负荷和后负荷来起搏心室。 随着时间的推移，应力心肌的卸载会影响不良心室重构的逆转。

公开(公告)号：US20070100383A1

公开(公告)日：2007-05-03

申请号：US11261202

申请日：2005-10-28

申请人： Joseph Pastore ,  Rodney Salo ,  Ronald Heil ,  Randy Westlund

发明人： Joseph Pastore ,  Rodney Salo ,  Ronald Heil ,  Randy Westlund

IPC分类号： A61N1/36

CPC分类号： A61N1/0587 ,  A61N1/059 ,  A61N1/3627

摘要： A method includes mounting an anchor member to a surface of a heart, the anchor member having a tension member coupled to the anchor member, advancing a lead body along the tension member, the lead body including a plurality of electrodes disposed along the lead body, identifying an MI region of the heart, positioning the plurality of electrodes at or near the MI region, affixing the tension member to the lead body to hold the electrodes in position, and delivering pulses through the plurality of electrodes to the heart.

摘要翻译： 一种方法包括将锚定构件安装到心脏的表面，所述锚定构件具有联接到所述锚定构件的张紧构件，使所述引线体沿着所述张紧构件前进，所述引线主体包括沿着所述引线主体设置的多个电极， 识别心脏的MI区域，将多个电极定位在MI区域处或附近，将张紧构件固定到引线体以将电极保持在适当位置，并且将脉冲通过多个电极传递到心脏。

公开(公告)号：US20060293714A1

公开(公告)日：2006-12-28

申请号：US11168024

申请日：2005-06-28

申请人： Rodney Salo ,  Joseph Pastore ,  Andrew Kramer ,  Jeffrey Stahmann ,  Jesse Hartley

发明人： Rodney Salo ,  Joseph Pastore ,  Andrew Kramer ,  Jeffrey Stahmann ,  Jesse Hartley

IPC分类号： A61N1/36

CPC分类号： A61N1/3627 ,  A61M5/14276 ,  A61N1/36521 ,  A61N1/36585 ,  A61N1/3756

摘要： Devices and methods for therapy control based on electromechanical timing involve detecting electrical activation of a patient's heart, and detecting mechanical cardiac activity resulting from the electrical activation. A timing relationship is determined between the electrical activation and the mechanical activity. A therapy is controlled based on the timing relationship. The therapy may improve intraventricular dyssynchrony of the patient's heart, or treat at least one of diastolic and systolic dysfunction and/or dyssynchrony of the patient's heart, for example. Electrical activation may be detected by sensing delivery of an electrical stimulation pulse to the heart or sensing intrinsic depolarization of the patient's heart. Mechanical activity may be detected by sensing heart sounds, a change in one or more of left ventricular impedance, ventricular pressure, right ventricular pressure, left atrial pressure, right atrial pressure, systemic arterial pressure and pulmonary artery pressure.

摘要翻译： 基于机电定时的治疗控制的装置和方法涉及检测患者心脏的电激活，以及检测由电激活引起的机械心脏活动。 在电激活和机械活动之间确定时序关系。 基于时间关系控制治疗。 该治疗可以改善患者心脏的心室内不同步，或治疗患者心脏的舒张期和收缩功能障碍和/或不同步中的至少一种。 可以通过感测向心脏传递电刺激脉冲或感测患者心脏的固有去极化来检测电激活。 可以通过感测心脏声音，左心室阻抗，心室压力，右心室压力，左心房压力，右心房压力，全身动脉压力和肺动脉压力中的一个或多个的变化来检测机械活动。

公开(公告)号：US20060173504A1

公开(公告)日：2006-08-03

申请号：US11046215

申请日：2005-01-28

申请人： Qingsheng Zhu ,  Joseph Pastore ,  Allan Shuros ,  Rodney Salo

发明人： Qingsheng Zhu ,  Joseph Pastore ,  Allan Shuros ,  Rodney Salo

IPC分类号： A61N1/362

CPC分类号： A61N1/3627 ,  A61N1/3682 ,  A61N1/3684

摘要： A method and apparatus are disclosed for treating mitral or tricuspid regurgitation with electrical stimulation. By providing pacing stimulation to a selected region of the left ventricle, such as one in proximity to the mitral valve apparatus in a manner which pre-excites the region during early ventricular systole, a beneficial effect is obtained which can prevent or reduce the extent of mitral regurgitation.

摘要翻译： 公开了一种用于用电刺激治疗二尖瓣或三尖瓣反流的方法和装置。 通过以在早期心室收缩期间预激活该区域的方式向左心室的选定区域（例如二尖瓣装置附近的一个）提供起搏刺激，可获得有益效果，其可以防止或减少 二尖瓣反流。

公开(公告)号：US20060161210A1

公开(公告)日：2006-07-20

申请号：US11037723

申请日：2005-01-18

申请人： Joseph Pastore ,  Rodney Salo ,  Gerrard Carlson ,  Andrew Kramer ,  Jiang Ding ,  Yinghong Yu

发明人： Joseph Pastore ,  Rodney Salo ,  Gerrard Carlson ,  Andrew Kramer ,  Jiang Ding ,  Yinghong Yu

IPC分类号： A61N1/362

CPC分类号： A61B5/02405 ,  A61B5/4035 ,  A61N1/36114 ,  A61N1/36592 ,  A61N1/368

摘要： A cardiac rhythm management system modulates the delivery of pacing and/or autonomic neurostimulation pulses based on heart rate variability (HRV). An HRV parameter being a measure of the HRV is produced to indicate a patient's cardiac condition, based on which the delivery of pacing and/or autonomic neurostimulation pulses is started, stopped, adjusted, or optimized. In one embodiment, the HRV parameter is used to adjust a maximum tracking rate in an atrial tracking pacing mode.

公开(公告)号：US20060030810A1

公开(公告)日：2006-02-09

申请号：US11244016

申请日：2005-10-05

申请人： Evgenia Mandrusov ,  Paul Consigny ,  Rodney Salo

发明人： Evgenia Mandrusov ,  Paul Consigny ,  Rodney Salo

IPC分类号： A61N1/30

CPC分类号： A61N1/0568 ,  A61N1/056 ,  A61N1/306 ,  A61N1/326 ,  A61N2001/0585

摘要： A device that includes an electrical output channel adapted to deliver a sub-threshold voltage, a lead that includes a proximal end adapted to be electrically connected to the electrical output channel and a distal end adapted to be placed in the blood conduit where the distal end of the lead is adapted to deliver a treatment agent that stimulates therapeutic angiogenesis, and at least one electrode on the distal end of the first lead.

摘要翻译： 一种包括适于递送亚阈值电压的电输出通道的装置，包括适于电连接到电输出通道的近端的引线和适于放置在血管中的远端，其中远端 的铅适于递送刺激治疗性血管生成的治疗剂，以及至少一个电极在第一引线的远端。

公开(公告)号：US20050177195A1

公开(公告)日：2005-08-11

申请号：US11025847

申请日：2004-12-29

申请人： Rodney Salo

发明人： Rodney Salo

IPC分类号： A61N1/05 ,  A61N1/362 ,  A61N1/368 ,  A61B17/52 ,  A61N1/22 ,  A61N1/26 ,  A61N1/40

CPC分类号： A61N1/3627 ,  A61N1/0587 ,  A61N1/3684

摘要： A cardiac rhythm management device for in which pre-excitation pacing is applied to one or more sites in proximity to an infarcted region of the ventricular myocardium. Such pacing servers to either prevent or minimize post-infarct remodeling.

摘要翻译： 一种心律管理装置，其中预激发起搏应用于心室心肌梗塞区域附近的一个或多个部位。 这种起搏服务器可以预防或最小化梗死后重塑。

公开(公告)号：US07742815B2

公开(公告)日：2010-06-22

申请号：US11223398

申请日：2005-09-09

申请人： Rodney Salo ,  Abhijeet Chavan

发明人： Rodney Salo ,  Abhijeet Chavan

IPC分类号： A61N1/36

CPC分类号： A61N1/36564 ,  A61N1/3621 ,  A61N1/3925

摘要： A system and method for administering a therapeutic treatment to the heart, includes a pressure sensor positioned in the pulmonary artery, an implantable medical device located remotely from the sensor, and communication means for communicating pressure data from the pressure sensor to the implantable medical device. The system includes a control module operatively coupled to the implantable medical device. The control module is adapted for comparing the pulmonary arterial pressure data to a pre-programmed value, adjusting an operating parameter of the implantable medical device based on the relationship of the pulmonary arterial pressure to the pre-programmed value, and repeating this process until the relationship between the pulmonary arterial pressure data and the pre-programmed value is such that no adjustment is necessary.

摘要翻译： 用于向心脏施用治疗性治疗的系统和方法包括定位在肺动脉中的压力传感器，远离传感器定位的可植入医疗装置以及用于将压力数据从压力传感器传送到可植入医疗装置的连通装置。 该系统包括可操作地耦合到可植入医疗装置的控制模块。 控制模块适于将肺动脉压数据与预编程值进行比较，基于肺动脉压与预编程值的关系来调整可植入医疗装置的操作参数，并重复该过程直到 肺动脉压数据与预编程值之间的关系使得不需要调整。

公开(公告)号：US20070112388A1

公开(公告)日：2007-05-17

申请号：US11651311

申请日：2007-01-09

申请人： Rodney Salo

发明人： Rodney Salo

IPC分类号： A61N1/365

CPC分类号： A61N1/056 ,  A61N1/3627 ,  A61N1/3655 ,  A61N1/36571 ,  A61N2001/0585

摘要： Methods of cardiac pacing involve sensing left ventricular electrical rhythms, sensing left ventricular blood flow rate, and sensing a coronary vein blood temperature. The methods further involve modifying delivery of synchronized electrical signals to the patient's heart based at least in part on the sensed coronary vein blood temperature and sensed left ventricular flow rate.

摘要翻译： 心脏起搏方法涉及感测左心室电节律，感测左心室血流速度，以及感测冠状静脉血液温度。 所述方法还包括至少部分地基于感测的冠状静脉血液温度和感测的左心室流率来修改同步电信号到患者心脏的传送。