摘要:
The present invention relates to single nucleotide polymorphisms (SNPs) in the leptin promoter, and to methods for the identification of animals carrying specific alleles of these SNPs that are associated with circulating leptin levels, feed intake, growth rate, body weight, carcass merit and carcass composition. The present invention provides oligonucleotides that can be used as primers and/or probes to amplify and/or detect these SNPs, and provides methods for selecting and grouping animals, in particular bovines, according to genotype.
摘要:
Coating production systems and methods which include ultrasonic dispersion and active cooling. The system includes a mixing reservoir and an ultrasonic disperser for ultrasonically dispersing an additive with another coating component within the mixing reservoir. The system also includes a heat exchanger in communication with the mixing reservoir to receive a mixture of the additive and another coating component from the mixing reservoir. The mixture is cooled by thermal energy transfer from the mixture to the heat exchanger. The cooled mixture is returned to the mixing reservoir.
摘要:
A protection circuit for a multi-cell lithium battery pack is disclosed. The protection circuit monitors and compares the battery pack voltage level and automatically disconnects the battery pack from a charging signal when a turn-off threshold level is reached. Overcharging is eliminated, while maximizing the amount of charge on the battery pack, and thus duration of use.
摘要:
A process for the preparation of a compound of formula (A): ##STR1## wherein X is hydrogen, hydroxy, chloro, C.sub.1-6 alkoxy or phenyl C.sub.1-6 alkoxy and R.sub.a and R.sub.b are hydrogen, including acyl and phosphate derivatives thereof; which process comprises:i) the preparation of a compound of formula (I): ##STR2## wherein R.sub.1 is C.sub.1-6 alkyl, or phenyl C.sub.1-6 alkyl in which the phenyl group is optionally substituted; R.sub.2 is hydrogen, hydroxy, chlorine, C.sub.1-6 alkoxy, phenyl C.sub.1-6 alkoxy or amino; and R.sub.3 is halogen, C.sub.1-6 alkylthio, C.sub.1-6 alkylsulphonyl, azido, an amino group or a protected amino group, which process comprises the reaction of a compound of formula (II): ##STR3## with a compound of formula (VII): ##STR4## wherein Q is a leaving group, J is hydrogen or halo and R.sub.1 is as hereinbefore defined; to give a compound of formula (VIII): ##STR5## followed by reduction of the compound of formula (VIII) to give a compound of formula (I) as hereinbefore defined; and, as necessary or desired, interconverting variables R.sub.1, R.sub.2 and R.sub.3 to further values of R.sub.1, R.sub.2 and R.sub.3 ;(ii) the conversion of the resulting compound of formula (I) to a compound of formula (A) by converting variable R.sub.3, when other than amino, to amino, reducing the ester groups CO.sub.2 R.sub.1 to CH.sub.2 OH and optionally forming acyl or phosphate derivatives thereof, and as necessary or desired converting variable R.sub.2 in the compound of formula (I) to variable X in the compound of formula (A).
摘要:
An improved thrombopoietin mimetic, the bis-(monoethanolamine) salt of 3′-[(2Z)-[1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazino]-2′-hydroxy-[1,1′-biphenyl]-3-carboxylic acid.
摘要:
A certificate server is provided for issuing digital certificates to be used by a network resource and/or a client resource. The certificate server is configured to communicate with the network resource or the client resource to receive a certificate request. Upon receiving the certificate request, the certificate server may automate the process for authenticating the certificate request, validating the terms of the certificate request and digitally signing the certificate request. An authentication appliance may communicate with or be integrated within the certificate server. The certificate server includes a web service server, a certificate authority component, and a database that enable communication with either the network resource, client resource, or the authentication appliance to automate the administration process typically involved in receiving and signing a certificate request. The certificate authority component may sign the certificate request with a trusted root chain associated with the network resource.
摘要:
A method for pricing a trade comprising providing a user input for entering trade data, providing a structure for receiving the trade data and then transmitting the structure to a pricing system. The structure, now populated with both the trade data and the pricing data, is received from the pricing system and the trade data and pricing information is displayed. Advantageously, the structure is encrypted prior to transmitting it to the pricing system and decrypted when received from the pricing system. The pricing system records the data and the pricing information, which may be automatically entered into a trading system if and when the user agrees.
摘要:
The preparation of poly(arylene ether ketones) by Friedel-Crafts polymerization, in the presence of a Lewis acid catalyst and a diluent, is conducted under conditions in which the polymer and/or its complex with the catalyst is suspended in the diluent during at least part of the polyreaction mixture if desired. The dispersant may be a polymer or an organic compound containing at least eight carbon atoms and is preferably a Lewis base. The dispersant preferably contains at least one molecular segment substantially compatible with the poly(arylene ether ketone) or its complex with the Lewis acid and substantially incompatible with the diluent and at least one molecular segment substantially compatible with the diluent and substantially incompatible with the poly(arylene ether ketone) or its complex with the Lewis acid.
摘要:
A method of predicting the phenotype of cattle through the analysis of one or more single nucleotide polymorphisms (SNPs) is described. More particularly, a method for predicting cattle temperament and behavior through the analysis of one or more single nucleotide polymorphisms (SNPs) mapped at specific regions of the bovine genome is described.