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公开(公告)号：US10675086B2
公开(公告)日：2020-06-09
申请号：US14934698
申请日：2015-11-06
Inventor： Valtino X. Afonso , Lubomir V. Dragnev , Sarah E. Cumming , Yitzhak I. Shai , Saurav Paul
IPC: A61B18/12 , A61B18/14 , A61B5/0402 , A61B5/042 , A61B18/24 , A61B17/00 , A61B18/00 , A61B18/02 , A61N7/02 , A61B5/00 , A61B34/20 , A61B34/10 , A61B34/30 , A61B34/00 , A61B90/00
Abstract: A method and system for presenting information representative of lesion formation is provided. The system comprises an electronic control unit (ECU). The ECU is configured to acquire a value for an ablation description parameter and/or a position signal metric, wherein the value corresponds to a location in the tissue. The ECU is further configured to evaluate the value, assign it a visual indicator of a visualization scheme associated with the parameter/metric corresponding to the value, and generate a marker comprising the visual indicator such that the marker is indicative of the acquired value. The method comprises acquiring a value for the parameter/metric, and evaluating the value. The method further includes assigning a visual indicator of a visualization scheme associated with the parameter/metric corresponding to the value, and generating a marker comprising the visual indicator.
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公开(公告)号：US20190053848A1
公开(公告)日：2019-02-21
申请号：US16117706
申请日：2018-08-30
Inventor： Hong Cao , Riki Thao , Saurav Paul
Abstract: A catheter assembly for assessing contact between the catheter assembly and tissue is disclosed. The assembly includes a catheter shaft and a pressure sensitive conductive composite member whose electrical resistance varies with pressure applied to the catheter assembly. The assembly also includes at least one measurement terminal to permit the measurement of changes in the electrical characteristics of the pressure sensitive conductive composite member. The assembly may optionally include a measurement device to measure resistance, impedance and/or other electrical characteristics. The assembly may utilize a reference electrode secured to the patient's tissue, which permits the measurement device to measure changes between the reference electrode and the at least one measurement terminal. Optionally, the assembly may include a conductive outer layer. Also disclosed are sensor assemblies, contact sensor, methods of contact sensing, and methods of manufacturing relating to the use of pressure sensitive conductive composites.
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公开(公告)号：US20160157919A1
公开(公告)日：2016-06-09
申请号：US14948687
申请日：2015-11-23
Inventor： Saurav Paul , Todd R. Stangenes , Riki Thao
IPC: A61B18/14
CPC classification number: A61B18/1402 , A61B5/01 , A61B5/015 , A61B5/053 , A61B5/6852 , A61B5/6885 , A61B2562/0271
Abstract: A medical device utilizing temperature sensing to identify or assess anatomical bodies or structures includes an elongate tubular member, at least one electrode, a thermal sensor, and a temperature response assessment system or component. The at least one electrode may be connected to the distal portion of the elongate tubular member, and the one or more electrode can be configured to provide energy or heat to a portion of an anatomical body or structure. The thermal sensor may be configured to measure the thermal response of the portion of an anatomical body or structure, e.g., tissue or blood pools. The temperature response assessment system or component can be coupled to the thermal sensor. In embodiments, the device may include a lumen and port opening, which may accommodate a tool, such as a needle. Methods for using temperature sensing to identify an anatomical body or structure are also disclosed.
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14.发明申请公开(公告)号：US20150164424A1
公开(公告)日：2015-06-18
申请号：US14568046
申请日：2014-12-11
Inventor： Israel A. Byrd , Saurav Paul , Dale E. Just , Jamie Skoglund , Paul McDowall
CPC classification number: A61B5/6859 , A61B1/07 , A61B5/0044 , A61B5/0071 , A61B5/0084 , A61B5/4839 , A61B5/6858 , A61B5/7278 , A61B2562/0233 , A61B2562/046 , A61B2576/023 , A61M5/007 , A61M25/007 , A61M25/0147
Abstract: A photodynamic mapping device includes a shaft with a proximal end and a distal end, at least one optical electrode at the distal end of the shaft, and at least one optical fiber positioned inside the shaft. In embodiments, the at least one optical fiber extends from the distal end of the shaft and is coupled to the at least one optical electrode provided at or about an outer surface of the device. In an embodiment, at least one optical fiber is coupled, at or about the proximal end of the shaft, to a light source coupled and an optical sensor. An analyzer can be coupled to the optical sensor. Embodiments of such devices can be configured to deliver substances, such as photodynamic therapeutic substances.
Abstract translation: 光动力测绘装置包括具有近端和远端的轴，在轴的远端处的至少一个光电极和位于轴内部的至少一个光纤。 在实施例中，至少一个光纤从轴的远端延伸并且耦合到设置在设备的外表面处或周围的至少一个光电极。 在一个实施例中，至少一个光纤在轴的近端处或周围耦合到耦合的光源和光学传感器。 分析仪可以耦合到光学传感器。 这种装置的实施例可以被配置为递送物质，例如光动力学治疗物质。
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公开(公告)号：US20140243813A1
公开(公告)日：2014-08-28
申请号：US14254324
申请日：2014-04-16
Inventor： Saurav Paul , Hong Cao
IPC: A61B18/12
CPC classification number: A61B18/1233 , A61B18/1206 , A61B18/1492 , A61B2018/00678 , A61B2018/00702 , A61B2018/00779 , A61B2018/00791 , A61B2018/00827 , A61B2018/00869 , A61B2018/00892 , A61B2090/065
Abstract: Disclosed herein are ablation systems and methods for providing feedback on lesion formation in real-time. The methods and systems assess absorptivity of tissue based on a degree of electric coupling or contact between an ablation electrode and the tissue. The absorptivity can then be used, along with other information, including, power levels and activation times, to provide real-time feedback on the lesions being created. Feedback may be provided, for example, in the form of estimated lesion volumes and other lesion characteristics. The methods and systems can provide estimated treatment times to achieve a desired lesion characteristic for a given degree of contact, as well as depth of a lesion being created. The degree of contact may be measured using different techniques, including the phase angle techniques and a coupling index.
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Patent Agency Ranking
公开(公告)号：US20130226169A1
公开(公告)日：2013-08-29
申请号：US13850060
申请日：2013-03-25
Inventor： Stephan P. Miller , Don Curtis Deno , Saurav Paul , Liane R. Teplitsky
IPC: A61B18/12
CPC classification number: A61B18/1492 , A61B18/1233 , A61B18/14 , A61B2018/00178 , A61B2018/00577 , A61B2018/00648 , A61B2018/00696 , A61B2018/00773 , A61B2018/00791 , A61B2018/00863 , A61B2018/00875 , A61B2090/065
Abstract: A method and system for assessing lesion formation in tissue is provided. The system includes an electronic control unit (ECU). The ECU is configured to acquire values for first and second components of a complex impedance between the electrode and the tissue, and to calculate an index responsive to the first and second values. The ECU is further configured to process the ECI to assess lesion formation in the tissue.
Abstract translation: 提供了一种用于评估组织中病变形成的方法和系统。 该系统包括电子控制单元（ECU）。 ECU被配置为获取电极和组织之间的复阻抗的第一和第二分量的值，并且响应于第一和第二值来计算索引。 ECU还被配置为处理ECI以评估组织中的病变形成。
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17.发明申请公开(公告)号：US20130138099A1
公开(公告)日：2013-05-30
申请号：US13745162
申请日：2013-01-18
Inventor： Saurav Paul , Hong Cao
IPC: A61B18/14
CPC classification number: A61B18/1206 , A61B18/1492 , A61B34/20 , A61B2018/00303 , A61B2018/00357 , A61B2018/00577 , A61B2018/00642 , A61B2018/00666 , A61B2018/00702 , A61B2018/0075 , A61B2018/00755 , A61B2018/00869 , A61B2018/00875 , A61B2090/064 , A61B2090/065
Abstract: An electrode coupling output system associated with an electrode catheter that provides indication to the physician via the navigation system, concerning the electrical coupling of an electrode, such as an ablative or mapping electrode, with a patient. The indication may be provided by changing the color or other display characteristics of the electrode on the navigation system display or by way of providing a waveform indicating the electrode coupling. In this manner, electrode coupling information is provided to a physician in a manner that minimizes physician distraction.
Abstract translation: 与电极导管相关联的电极耦合输出系统，其通过导航系统向医生提供关于电极（例如烧蚀或映射电极）与患者的电耦合的指示。 可以通过改变导航系统显示器上的电极的颜色或其他显示特性或通过提供指示电极耦合的波形来提供指示。 以这种方式，电极耦合信息以最小化医师分心的方式提供给医师。
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公开(公告)号：US20240342469A1
公开(公告)日：2024-10-17
申请号：US18754711
申请日：2024-06-26
Inventor： Saurav Paul , Troy T. Tegg , Israel A. Byrd , Riki Thao , Harry A. Puryear , Linda Nemec
CPC classification number: A61N1/327 , A61B18/14 , A61B2018/0016
Abstract: Catheter systems include direction-sensitive, multi-polar tip electrode assemblies for electroporation-mediated therapy, electroporation-induced primary necrosis therapy and electric field-induced apoptosis therapy, including configurations for producing narrow, linear lesions as well as distributed, wide area lesions. A monitoring system for electroporation therapy includes a mechanism for delivering electrochromic dyes to a tissue site as well as a fiber optic arrangement to optically monitor the progress of the therapy as well as to confirm success post-therapy. A fiber optic temperature sensing electrode catheter includes a tip electrode having a cavity whose inner surface is impregnated or coated with thermochromic/thermotropic material that changes color with changes in temperature. An optic fiber/detector arrangement monitors the thermochromic or thermotropic materials, acquiring a light signal and generating an output signal indicative of the spectrum of the light signal. An analyzer determines an electrode temperature based on the detector output and predetermined spectrum versus temperature calibration data.
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公开(公告)号：US11839424B2
公开(公告)日：2023-12-12
申请号：US15911908
申请日：2018-03-05
Inventor： Reed R. Heimbecher , Saurav Paul , John M. Berns , Jeffrey A. Schweitzer
CPC classification number: A61B18/1492 , A61B34/30 , A61B90/04 , A61B18/18 , A61B2018/0022 , A61B2018/00285 , A61B2018/00642 , A61B2018/00696 , A61B2018/00714 , A61B2018/00779 , A61B2018/00869 , A61B2018/00875 , A61B2018/00898 , A61B2018/00904 , A61B2034/301
Abstract: A monitoring, managing and protecting system is provided that includes a monitoring probe working in conjunction with an ablating device. The probe is configured to be positioned in close proximity to a region of non-targeted tissue proximate an ablation site of targeted tissue and to be operatively connected to an electrical response assessment system or component. The probe includes an elongate shaft having proximal and distal ends, with a handle disposed at the proximal end thereof and a tissue monitoring and protecting apparatus disposed at the distal end thereof. The ablating device includes an elongate shaft having proximal and distal ends, with a handle mounted at the proximal end thereof and an ablation element mounted at the distal end thereof. The monitoring probe measures electrical characteristics of the non-targeted tissue and/or of the tissue between the monitoring electrode and the ablation electrode. The electrical response assessment system determines whether the tissue is being damaged based on the electrical measurements. The monitoring, managing and protecting system can notify a practitioner based on the determination, or modify or stop the ablation procedure.
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公开(公告)号：US10799176B2
公开(公告)日：2020-10-13
申请号：US14151273
申请日：2014-01-09
Inventor： Riki Thao , Saurav Paul
Abstract: Systems and methods are disclosed for assessing tissue contact, e.g., for mapping, tissue ablation, or other procedures. An exemplary tissue contact sensing system comprises a flexible tip device. At least one piezoelectric sensor is housed within the flexible tip device. The at least one piezoelectric sensor is responsive to contact stress of the flexible tip device by generating electrical signals corresponding to the amount of contact stress. An output device is electrically connected to the at least one piezoelectric sensor. The output device receives the electrical signals for assessing tissue contact by the flexible tip device. Methods for assembling and using the flexible tip device are also disclosed.
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