公开(公告)号：US20200079778A9

公开(公告)日：2020-03-12

申请号：US16211338

申请日：2018-12-06

Applicant: SUNOVION PHARMACEUTICALS INC.

Inventor： Michele L.R. Heffernan ,  Larry Wendell Hardy ,  Frank Xinhe Wu ,  Lakshmi D. Saraswat ,  Kerry L. Spear

IPC: C07D487/04 ,  C07D487/10 ,  C07D498/04 ,  C07D491/22 ,  C07D491/20 ,  C07D471/04 ,  C07D487/18 ,  C07D487/14 ,  C07D471/20 ,  C07D471/14 ,  C07D491/147

Abstract: Compounds that modulate GluR5 activity and methods of using the same are disclosed.

公开(公告)号：US09868718B2

公开(公告)日：2018-01-16

申请号：US14502532

申请日：2014-09-30

Applicant: SUNOVION PHARMACEUTICALS INC.

Inventor： Liming Shao ,  Fengjiang Wang ,  Scott Christopher Malcolm ,  Michael Charles Hewitt ,  Larry R. Bush ,  Jianguo Ma ,  Mark A. Varney ,  Una Campbell ,  Sharon Rae Engel ,  Larry Wendell Hardy ,  Patrick Koch ,  John E. Campbell

IPC: C07C13/28 ,  C07D333/20 ,  C07C211/17 ,  C07C211/29 ,  C07C211/40 ,  C07C215/42 ,  C07C215/44 ,  C07C217/52 ,  C07C217/74 ,  C07C323/32 ,  C07D207/06 ,  C07D207/08 ,  C07D211/14 ,  C07D265/14 ,  C07D277/28 ,  C07D295/06 ,  C07D307/52 ,  C07D317/58 ,  C07D317/72 ,  C07D319/06 ,  C07D491/056 ,  C07D211/16

CPC classification number: C07D333/20 ,  C07C211/17 ,  C07C211/29 ,  C07C211/40 ,  C07C215/42 ,  C07C215/44 ,  C07C217/52 ,  C07C217/74 ,  C07C323/32 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/10 ,  C07C2601/14 ,  C07C2601/16 ,  C07C2602/08 ,  C07D207/06 ,  C07D207/08 ,  C07D211/14 ,  C07D211/16 ,  C07D265/14 ,  C07D277/28 ,  C07D295/06 ,  C07D307/52 ,  C07D317/58 ,  C07D317/72 ,  C07D319/06 ,  C07D491/056

Abstract: The invention relates to novel cyclohexylamine derivatives and their use in the treatment and/or prevention of central nervous system (CNS) disorders, such as depression, anxiety, schizophrenia and sleep disorder as well as methods for their synthesis. The invention also relates to pharmaceutical compositions containing the compounds of the invention, as well as methods of inhibiting reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine from the synaptic cleft and methods of modulating one or more monoamine transporter.

公开(公告)号：US20160251359A1

公开(公告)日：2016-09-01

申请号：US15013741

申请日：2016-02-02

Applicant: SUNOVION PHARMACEUTICALS INC.

Inventor： Michele L.R. Heffernan ,  Larry Wendell Hardy ,  Frank Xinhe WU ,  Lakshmi D. Saraswat ,  Kerry L. Spear

IPC: C07D487/04 ,  C07D487/14 ,  C07D491/147 ,  C07D491/22 ,  C07D487/18 ,  C07D491/20 ,  C07D471/14 ,  C07D487/10

CPC classification number: C07D487/04 ,  C07D471/04 ,  C07D471/14 ,  C07D471/20 ,  C07D487/10 ,  C07D487/14 ,  C07D487/18 ,  C07D491/147 ,  C07D491/20 ,  C07D491/22 ,  C07D498/04

Abstract: Compounds that modulate GluR5 activity and methods of using the same are disclosed.

Abstract translation: 公开了调节GluR5活性的化合物及其使用方法。