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公开(公告)号：US10562878B2
公开(公告)日：2020-02-18
申请号：US15836261
申请日：2017-12-08
发明人： Liming Shao , Fengjiang Wang , Scott Christopher Malcolm , Michael Charles Hewitt , Larry R. Bush , Jianguo Ma , Mark A. Varney , Una Campbell , Sharon Rae Engel , Larry Wendell Hardy , Patrick Koch , John E. Campell
IPC分类号： C07D333/20 , C07C211/17 , C07C211/40 , C07C215/42 , C07C215/44 , C07C217/52 , C07C217/74 , C07C323/32 , C07D207/06 , C07D207/08 , C07D211/14 , C07D265/14 , C07D277/28 , C07D295/06 , C07D307/52 , C07D317/58 , C07D317/72 , C07D319/06 , C07D491/056 , C07C211/29 , C07D211/16
摘要： The invention relates to novel cyclohexylamine derivatives and their use in the treatment and/or prevention of central nervous system (CNS) disorders, such as depression, anxiety, schizophrenia and sleep disorder as well as methods for their synthesis. The invention also relates to pharmaceutical compositions containing the compounds of the invention, as well as methods of inhibiting reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine from the synaptic cleft and methods of modulating one or more monoamine transporter.
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公开(公告)号：US10189825B2
公开(公告)日：2019-01-29
申请号：US14377673
申请日：2013-02-08
IPC分类号： C07D409/04 , C07D405/04 , C07D495/04 , C07D491/048 , C07D409/14
摘要： Provided herein are thiophene compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.
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公开(公告)号：US11332462B2
公开(公告)日：2022-05-17
申请号：US16722048
申请日：2019-12-20
IPC分类号： C07D409/04 , C07D409/14 , C07D491/048 , C07D495/04 , C07D405/04
摘要： Provided herein are thiophene compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.
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公开(公告)号：US09884844B2
公开(公告)日：2018-02-06
申请号：US14758681
申请日：2013-12-31
发明人： Qun Kevin Fang , Una Campbell , Kerry L. Spear
IPC分类号： C07D401/04 , C07D491/113 , G01N33/50 , C07D401/14 , C07D413/14 , C07D487/10 , C07D498/10
CPC分类号： C07D401/04 , C07D401/14 , C07D413/14 , C07D487/10 , C07D491/113 , C07D498/10 , G01N33/5038
摘要： Provided herein are heterocyclyl compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.
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公开(公告)号：US09351954B2
公开(公告)日：2016-05-31
申请号：US14205859
申请日：2014-03-12
发明人： Liming Shao , John Emmerson Campbell , Michael Charles Hewitt , Una Campbell , Taleen G. Hanania
IPC分类号： C07D495/02 , C07D233/00 , C07D403/02 , C07D403/14 , C07D231/00 , C07D487/00 , C07D487/02 , C07D405/00 , C07D409/00 , C07D411/00 , A61K31/415 , A61K31/40 , A61K31/48 , A61K31/381 , C07D277/60 , C07D333/54 , C07D333/76 , C07D333/78 , C07D495/04 , C07D495/20 , A61K31/435 , A61K31/55 , A61K45/06
CPC分类号： A61K31/381 , A61K31/435 , A61K31/55 , A61K45/06 , C07D277/60 , C07D333/54 , C07D333/76 , C07D333/78 , C07D495/04 , C07D495/20
摘要： Provided herein are multicyclic compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. For example, disclosed herein are compounds having formula (IIa) shown below, or a pharmaceutically acceptable salt or stereoisomer thereof, wherein the variables are defined herein. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.
摘要翻译： 本文提供多环化合物，其合成方法，包含该化合物的药物组合物及其使用方法。 例如，本文公开的是具有下面所示的式（IIa）的化合物或其药学上可接受的盐或立体异构体，其中变量在本文中定义。 本文提供的化合物可用于治疗，预防和/或治疗各种神经障碍，包括但不限于精神病和精神分裂症。
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![IMIDAZO[1,2-a]PYRIDINE COMPOUNDS](/abs-image/US/2013/10/31/US20130289013A1/abs.jpg.150x150.jpg)
公开(公告)号：US20130289013A1
公开(公告)日：2013-10-31
申请号：US13925108
申请日：2013-06-24
发明人： Qun Kevin FANG , Frank Xinhe Wu , Paul T. Grover , Seth C. Hopkins , Una Campbell , Milan Chytil , Kerry L. Spear
IPC分类号： C07D471/04 , C07D487/04
CPC分类号： C07D471/04 , C07D487/04
摘要： Imidazo[1,2-a]pyridines are disclosed. Compounds of the invention are useful therapeutic agents and their inclusion in pharmaceutical formulations and use in methods of treatment are disclosed.
摘要翻译： 公开了咪唑并[1,2-a]吡啶。 本发明的化合物是有用的治疗剂，并且它们包括在药物制剂中并用于治疗方法。
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公开(公告)号：US10556890B2
公开(公告)日：2020-02-11
申请号：US15851836
申请日：2017-12-22
IPC分类号： C07D409/04 , C07D409/14 , C07D491/048 , C07D495/04 , C07D405/04
摘要： Provided herein are thiophene compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.
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公开(公告)号：US10085968B2
公开(公告)日：2018-10-02
申请号：US14950834
申请日：2015-11-24
发明人： Liming Shao , John Emmerson Campbell , Michael Charles Hewitt , Una Campbell , Taleen G. Hanania
IPC分类号： C07D233/00 , C07D403/02 , C07D403/14 , C07D231/00 , C07D487/02 , C07D487/00 , C07D405/00 , C07D409/00 , C07D495/02 , A61K31/415 , A61K31/40 , C07D277/22 , A61K31/381 , C07D277/60 , C07D333/54 , C07D333/76 , C07D333/78 , C07D495/04 , C07D495/20 , A61K31/435 , A61K31/55 , A61K45/06
摘要： Provided herein are multicyclic compounds of formula (IVa), shown below, wherein R1, R2, R3, R4, R5, R6, R7, m, and n are defined herein elsewhere, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.
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公开(公告)号：US09868718B2
公开(公告)日：2018-01-16
申请号：US14502532
申请日：2014-09-30
发明人： Liming Shao , Fengjiang Wang , Scott Christopher Malcolm , Michael Charles Hewitt , Larry R. Bush , Jianguo Ma , Mark A. Varney , Una Campbell , Sharon Rae Engel , Larry Wendell Hardy , Patrick Koch , John E. Campbell
IPC分类号： C07C13/28 , C07D333/20 , C07C211/17 , C07C211/29 , C07C211/40 , C07C215/42 , C07C215/44 , C07C217/52 , C07C217/74 , C07C323/32 , C07D207/06 , C07D207/08 , C07D211/14 , C07D265/14 , C07D277/28 , C07D295/06 , C07D307/52 , C07D317/58 , C07D317/72 , C07D319/06 , C07D491/056 , C07D211/16
CPC分类号： C07D333/20 , C07C211/17 , C07C211/29 , C07C211/40 , C07C215/42 , C07C215/44 , C07C217/52 , C07C217/74 , C07C323/32 , C07C2601/02 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07C2602/08 , C07D207/06 , C07D207/08 , C07D211/14 , C07D211/16 , C07D265/14 , C07D277/28 , C07D295/06 , C07D307/52 , C07D317/58 , C07D317/72 , C07D319/06 , C07D491/056
摘要： The invention relates to novel cyclohexylamine derivatives and their use in the treatment and/or prevention of central nervous system (CNS) disorders, such as depression, anxiety, schizophrenia and sleep disorder as well as methods for their synthesis. The invention also relates to pharmaceutical compositions containing the compounds of the invention, as well as methods of inhibiting reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine from the synaptic cleft and methods of modulating one or more monoamine transporter.
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公开(公告)号：US10894033B2
公开(公告)日：2021-01-19
申请号：US16791118
申请日：2020-02-14
发明人： Liming Shao , John Emmerson Campbell , Michael Charles Hewitt , Una Campbell , Taleen G. Hanania
IPC分类号： A61K31/381 , C07D277/60 , C07D333/54 , C07D333/76 , A61K45/06 , C07D495/04 , C07D495/20 , A61K31/435 , A61K31/55 , C07D333/78
摘要： Provided herein are multicyclic compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.
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