公开(公告)号：US09097778B2

公开(公告)日：2015-08-04

申请号：US13140484

申请日：2010-02-03

申请人： Yoshitaka Bito ,  Satoshi Hirata ,  Hisaaki Ochi ,  Koji Hirata ,  Toru Shirai ,  Yosuke Otake

发明人： Yoshitaka Bito ,  Satoshi Hirata ,  Hisaaki Ochi ,  Koji Hirata ,  Toru Shirai ,  Yosuke Otake

IPC分类号： G01R33/485 ,  G01R33/563

CPC分类号： G01R33/485 ,  G01R33/56341

摘要： In the diffusion spectroscopic imaging, in which intensity of molecular diffusion is imaged with separating chemical substances, with suppressing artifacts resulting from object motion of an object, spatial resolution, spectral band and SNR are maintained, and measurement accuracy is enhanced. A measurement for acquiring diffusion SI data is repeated a plurality of times with changing acquisition timing, phase variation of each measurement result is corrected, and a diffusion SI image is reconstructed from the corrected measurement results. In addition, the phase variation is calculated for every point in the space from the diffusion SI data acquired by each measurement or navigation data obtained by each measurement. The phase correction is independently performed for every point in the space.

摘要翻译： 在通过分离化学物质成像分子扩散强度的扩散光谱成像中，通过抑制由物体的物体运动产生的伪影，保持了空间分辨率，光谱带和SNR，并且提高了测量精度。 通过改变获取定时多次重复获取扩散SI数据的测量，校正每个测量结果的相位变化，并从校正的测量结果重建扩散SI图像。 此外，根据通过各测量获得的扩散SI数据或通过每次测量获得的导航数据，计算空间中每个点的相位变化。 对于空间中的每一个点都独立执行相位校正。

公开(公告)号：US20130057285A1

公开(公告)日：2013-03-07

申请号：US13697122

申请日：2011-05-02

申请人： Satoshi Hirata ,  Yoshitaka Bito

发明人： Satoshi Hirata ,  Yoshitaka Bito

IPC分类号： G01R33/38

CPC分类号： G01R33/485 ,  G01R33/4833 ,  G01R33/5607 ,  G01R33/5617

摘要： An object of the present invention is to provide a measuring technique which allows in the MRS measurement to suppress with a high degree of precision, incorporation of a signal of unwanted compounds which hinders measurement of a measurement object signal, independent of an imaging object region and the measurement object signal, thereby obtaining a stable and favorable signal spectrum. In the MRS measuring sequence, a spectrum selective inversion RF pulse, having a narrow band characteristic for selectively inverting only a signal peak of a compounds to be suppressed, and phase dispersion-refocusing GC pulses are applied at least one of before and after a region selective RF pulse. This MRS measuring sequence is repeated while changing the echo time TE at predetermined intervals, and nuclear magnetic resonance signals being obtained by the repetition are integrated. The amount of the spectrum selective inversion RF pulse to be applied may be changed according to the echo time TE.

摘要翻译： 本发明的目的是提供一种测量技术，其允许在MRS测量中以高精确度抑制，不依赖于成像对象区域而引入妨碍测量对象信号的测量的不想要的化合物的信号，以及 测量对象信号，从而获得稳定和有利的信号频谱。 在MRS测量序列中，具有用于选择性地仅反转待抑制的化合物的信号峰的窄带特性和相位色散重新聚焦GC脉冲的频谱选择性反转RF脉冲施加在区域之前和之后的至少一个 选择性RF脉冲。 在以预定间隔改变回波时间TE的同时重复该MRS测量序列，并且通过重复获得的核磁共振信号被积分。 可以根据回波时间TE改变要施加的频谱选择性反转RF脉冲的量。

公开(公告)号：US08258785B2

公开(公告)日：2012-09-04

申请号：US12523259

申请日：2007-12-17

申请人： Satoshi Hirata ,  Yoshitaka Bito ,  Kiyoharu Tanaka

发明人： Satoshi Hirata ,  Yoshitaka Bito ,  Kiyoharu Tanaka

IPC分类号： G01V3/00

CPC分类号： A61B5/055 ,  A61B5/7257

摘要： An object of the invention is to obtain a magnetic resonance spectroscopic image to which the MAC summation is applied with high accuracy and in short time, even though a phase characteristic distribution of the MAC has a spatial non-uniformity, in the MRSI measurement using a magnetic resonance imaging apparatus provided with a MAC. Using a non-water-suppressed image signal with high SNR, obtained in the non-water-suppressed measurement (a reference measurement) without water suppression, a correction value for correcting the phase distortion for the MAC summation is calculated on each pixel in each coil. After correcting a phase on each pixel in each coil of a main-scan image signal measured under suppressing water (water-suppressed image signal) using the corrective value, signal adding operation (summation) is performed. Then, a phase correction in a spectrum-axis is to be performed on the summed spectrum signal.

摘要翻译： 本发明的目的在于，即使在MAC的相位特性分布具有空间不均匀性的情况下，也能够在短时间内以高精度和短时间获得应用了MAC求和的磁共振分光图像， 具有MAC的磁共振成像装置。 使用在没有水分抑制的非水抑制测量（参考测量）中获得的具有高SNR的非水分抑制图像信号，针对每个像素计算用于校正MAC求和的相位失真的校正值 线圈 在使用校正值校正在用抑制水（水分抑制图像信号）测量的主扫描图像信号的每个线圈中的每个像素上的相位之后，执行信号相加操作（求和）。 然后，对相加的频谱信号进行频谱轴的相位校正。

公开(公告)号：US08030924B2

公开(公告)日：2011-10-04

申请号：US11797878

申请日：2007-05-08

申请人： Yoshitaka Bito ,  Hisaaki Ochi ,  Yo Taniguchi ,  Satoshi Hirata ,  Toru Shirai

发明人： Yoshitaka Bito ,  Hisaaki Ochi ,  Yo Taniguchi ,  Satoshi Hirata ,  Toru Shirai

IPC分类号： G01V3/00

CPC分类号： G01R33/485 ,  G01R33/5608

摘要： A magnetic resonance imaging system capable of conducting spectroscopic imaging with an improved SNR without degrading the spatial resolution includes edge-preserving filter processing means for spectroscopic imaging. The edge-preserving filter processing means executes processing including the steps of calculating spectral similarity in spatial neighborhoods (spatially neighboring voxels) at each voxel in spectroscopic imaging data, calculating a spectral weight according to the spectral similarity, and conducting weighted smoothing for compounding spectra of spatial neighborhoods (spatially neighboring voxels) according to the spectral weight.

摘要翻译： 能够在不降低空间分辨率的情况下以改善的SNR进行光谱成像的磁共振成像系统包括用于分光成像的边缘保留滤波处理装置。 边缘保留滤波处理装置执行处理，其包括以下步骤：计算分光成像数据中的每个体素的空间邻域（空间相邻体素）中的频谱相似度，根据频谱相似度计算频谱权重，以及进行加权平滑化， 根据光谱权重的空间邻域（空间相邻体素）。

公开(公告)号：US20100013481A1

公开(公告)日：2010-01-21

申请号：US12523259

申请日：2007-12-17

申请人： Satoshi Hirata ,  Yoshitaka Bito ,  Kiyoharu Tanaka

发明人： Satoshi Hirata ,  Yoshitaka Bito ,  Kiyoharu Tanaka

IPC分类号： G01R33/48 ,  G01R33/44

CPC分类号： A61B5/055 ,  A61B5/7257

摘要： An object of the invention is to obtain a magnetic resonance spectroscopic image to which the MAC summation is applied with high accuracy and in short time, even though a phase characteristic distribution of the MAC has a spatial non-uniformity, in the MRSI measurement using a magnetic resonance imaging apparatus provided with a MAC.Using a non-water-suppressed image signal with high SNR, obtained in the non-water-suppressed measurement (a reference measurement) without water suppression, a correction value for correcting the phase distortion for the MAC summation is calculated on each pixel in each coil.After correcting a phase on each pixel in each coil of a main-scan image signal measured under suppressing water (water-suppressed image signal) using the corrective value, signal adding operation (summation) is performed.Then, a phase correction in a spectrum-axis is to be performed on the summed spectrum signal.

摘要翻译： 本发明的目的在于，即使在MAC的相位特性分布具有空间不均匀性的情况下，也能够在短时间内以高精度和短时间获得应用了MAC求和的磁共振分光图像， 具有MAC的磁共振成像装置。 使用在没有水分抑制的非水抑制测量（参考测量）中获得的具有高SNR的非水分抑制图像信号，针对每个像素计算用于校正MAC求和的相位失真的校正值 线圈 在使用校正值校正在用抑制水（水分抑制图像信号）测量的主扫描图像信号的每个线圈中的每个像素上的相位之后，执行信号相加操作（求和）。 然后，对相加的频谱信号进行频谱轴的相位校正。

公开(公告)号：US09389289B2

公开(公告)日：2016-07-12

申请号：US13881739

申请日：2011-10-26

申请人： Toru Shirai ,  Yoshitaka Bito ,  Satoshi Hirata ,  Yoshihisa Soutome ,  Yo Taniguchi

发明人： Toru Shirai ,  Yoshitaka Bito ,  Satoshi Hirata ,  Yoshihisa Soutome ,  Yo Taniguchi

IPC分类号： G01R33/36 ,  A61B5/055 ,  G01R33/465 ,  G01R33/48 ,  G01R33/485 ,  G01R33/561

CPC分类号： G01R33/3621 ,  A61B5/055 ,  G01R33/465 ,  G01R33/4828 ,  G01R33/485 ,  G01R33/5611

摘要： Images of two or more kinds of substances showing different chemical shifts, such as water image and metabolite image, are obtained without extending measurement time. For example, images of two or more kinds of desired substances showing different chemical shifts, such as water image and metabolite image, are obtained by one time of execution of an imaging sequence. In this execution, a pre-pulse is applied so that signals of the substances to be separated shift on the image, and magnetic resonance signals are received with receiver RF coils in a number not smaller than the number of types of the substances to be separated. An image reconstructed from the magnetic resonance signals is separated into images of the individual substances using sensitivity maps of the receiver RF coils. Then, correction is performed for returning the shifted image to the original position. Further, residual signals induced by errors generated in the measurement and the separation processing are eliminated by using spectroscopic images obtained after the separation.

摘要翻译： 在不延长测量时间的情况下，获得显示不同化学位移的两种或更多种物质的图像，例如水图像和代谢物图像。 例如，通过一次执行成像序列，可以获得显示不同化学位移的两种或更多种所需物质的图像，例如水图像和代谢物图像。 在该执行中，施加预脉冲，使得要分离的物质的信号在图像上移动，并且用接收器RF线圈​​接收不少于待分离物质的数量的数量的磁共振信号 。 使用接收机RF线圈的灵敏度图将从磁共振信号重构的图像分离成各个物质的图像。 然后，执行用于将移动的图像返回到原始位置的校正。 此外，通过使用分离后获得的分光图像来消除由测量和分离处理中产生的误差引起的残留信号。

公开(公告)号：US20120049845A1

公开(公告)日：2012-03-01

申请号：US13140484

申请日：2010-02-03

申请人： Yoshitaka Bito ,  Satoshi Hirata ,  Hisaaki Ochi ,  Koji Hirata ,  Toru Shirai ,  Yosuke Otake

发明人： Yoshitaka Bito ,  Satoshi Hirata ,  Hisaaki Ochi ,  Koji Hirata ,  Toru Shirai ,  Yosuke Otake

IPC分类号： G01R33/32

CPC分类号： G01R33/485 ,  G01R33/56341

摘要： In the diffusion spectroscopic imaging, in which intensity of molecular diffusion is imaged with separating chemical substances, with suppressing artifacts resulting from object motion of an object, spatial resolution, spectral band and SNR are maintained, and measurement accuracy is enhanced. A measurement for acquiring diffusion SI data is repeated a plurality of times with changing acquisition timing, phase variation of each measurement result is corrected, and a diffusion SI image is reconstructed from the corrected measurement results. In addition, the phase variation is calculated for every point in the space from the diffusion SI data acquired by each measurement or navigation data obtained by each measurement. The phase correction is independently performed for every point in the space.

摘要翻译： 在通过分离化学物质成像分子扩散强度的扩散光谱成像中，通过抑制由物体的物体运动产生的伪影，保持了空间分辨率，光谱带和SNR，并且提高了测量精度。 通过改变获取定时多次重复获取扩散SI数据的测量，校正每个测量结果的相位变化，并从校正的测量结果重建扩散SI图像。 此外，根据通过各测量获得的扩散SI数据或通过每次测量获得的导航数据，计算空间中的每个点的相位变化。 对于空间中的每一个点都独立执行相位校正。

公开(公告)号：US20100097062A1

公开(公告)日：2010-04-22

申请号：US12519197

申请日：2007-06-29

申请人： Toru Shirai ,  Yoshitaka Bito ,  Yo Taniguchi ,  Satoshi Hirata

发明人： Toru Shirai ,  Yoshitaka Bito ,  Yo Taniguchi ,  Satoshi Hirata

IPC分类号： G01V3/14

CPC分类号： G01R33/485 ,  G01R33/483 ,  G01R33/5602 ,  G01R33/5607

摘要： A method for obtaining the most appropriate amplitude of signal suppression pulse, which suppresses unnecessary signals from the substance not subjected to measurement, highly accurately, swiftly and stably, and an MRI apparatus that enables the optimization are provided.A pulse amplitude adjusting means equipped in the MRI apparatus acquires signals while changing the amplitude of signal suppression pulse and calculates signal absolute values and phase values, and computes reference signals, which are polarized signal absolute values, based on the changes in signal phase values. This reference signals are subjected to polynomial fitting. A value which makes this fitting curve is 0 or closes to 0 is set as the optimal pulse amplitude.

摘要翻译： 提供了一种用于获得信号抑制脉冲的最适当振幅的方法，其能够高度准确，快速且稳定地抑制不被测量的物质的不必要的信号，并且提供能够进行优化的MRI装置。 装备在MRI装置中的脉冲幅度调整装置在改变信号抑制脉冲的振幅的同时获取信号，并且计算信号绝对值和相位值，并且基于信号相位值的变化来计算作为极化信号绝对值的参考信号。 该参考信号经过多项式拟合。 使该拟合曲线为0或接近0的值被设定为最佳脉冲幅度。

公开(公告)号：US5572124A

公开(公告)日：1996-11-05

申请号：US361664

申请日：1994-12-22

申请人： Yoshitaka Bito ,  Satoshi Hirata ,  Takayuki Nabeshima ,  Etsuji Yamamoto

发明人： Yoshitaka Bito ,  Satoshi Hirata ,  Takayuki Nabeshima ,  Etsuji Yamamoto

IPC分类号： A61B5/055 ,  G01R33/48 ,  G01R33/54 ,  G01R33/563 ,  G01R33/00 ,  G01V3/00

CPC分类号： G01R33/4828 ,  G01R33/56341

摘要： In an inspection method which generates a static magnetic field, a gradient magnetic field and a radio frequency magnetic field, detects nuclear magnetic resonance signals from an inspection object, computes and processes the nuclear magnetic resonance signals so detected and outputs the result of computation processing, a gradient magnetic field for generating signal attenuation by diffusion and an oscillating gradient magnetic field for generating chemical shift information and spatial information of the materials contained in the inspection object are applied, separation and acquisition of spatial information of each material contained in the inspection object are simultaneously conducted, and a measurement time is shortened.

摘要翻译： 在产生静磁场，梯度磁场和射频磁场的检查方法中，检测来自检查对象的核磁共振信号，对所检测的核磁共振信号进行计算处理，并输出计算处理结果， 应用用于通过扩散产生信号衰减的梯度磁场和用于产生检测对象中包含的材料的化学位移信息和空间信息的振荡梯度磁场，检测对象中包含的每种材料的空间信息的分离和获取是 同时进行，缩短测定时间。

公开(公告)号：US10267879B2

公开(公告)日：2019-04-23

申请号：US14240441

申请日：2012-07-27

申请人： Suguru Yokosawa ,  Yo Taniguchi ,  Yoshitaka Bito ,  Yoshihisa Soutome

发明人： Suguru Yokosawa ,  Yo Taniguchi ,  Yoshitaka Bito ,  Yoshihisa Soutome

IPC分类号： G01R33/54 ,  G01R33/483 ,  A61B5/055 ,  A61B5/00

摘要： A technique in a medical imaging apparatus being capable of setting any plane in three-dimensional space as an imaging slice is provided, allowing an automatically-set imaging slice to be configured to suit user's preferences, and determine a position of the imaging slice being configured, with respect to an imaging target subject automatically with a high degree of accuracy. Reference information for specifying the imaging slice, set by the user for each imaging site, is associated with the anatomical feature of the imaging site, so as to generate an imaging slice parameter. Upon actual imaging, the imaging slice parameter and the anatomical feature of the imaging target subject obtained by scout imaging are used to determine the imaging slice position of the imaging target subject.