公开(公告)号：US5572124A

公开(公告)日：1996-11-05

申请号：US361664

申请日：1994-12-22

申请人： Yoshitaka Bito ,  Satoshi Hirata ,  Takayuki Nabeshima ,  Etsuji Yamamoto

发明人： Yoshitaka Bito ,  Satoshi Hirata ,  Takayuki Nabeshima ,  Etsuji Yamamoto

IPC分类号： A61B5/055 ,  G01R33/48 ,  G01R33/54 ,  G01R33/563 ,  G01R33/00 ,  G01V3/00

CPC分类号： G01R33/4828 ,  G01R33/56341

摘要： In an inspection method which generates a static magnetic field, a gradient magnetic field and a radio frequency magnetic field, detects nuclear magnetic resonance signals from an inspection object, computes and processes the nuclear magnetic resonance signals so detected and outputs the result of computation processing, a gradient magnetic field for generating signal attenuation by diffusion and an oscillating gradient magnetic field for generating chemical shift information and spatial information of the materials contained in the inspection object are applied, separation and acquisition of spatial information of each material contained in the inspection object are simultaneously conducted, and a measurement time is shortened.

摘要翻译： 在产生静磁场，梯度磁场和射频磁场的检查方法中，检测来自检查对象的核磁共振信号，对所检测的核磁共振信号进行计算处理，并输出计算处理结果， 应用用于通过扩散产生信号衰减的梯度磁场和用于产生检测对象中包含的材料的化学位移信息和空间信息的振荡梯度磁场，检测对象中包含的每种材料的空间信息的分离和获取是 同时进行，缩短测定时间。

公开(公告)号：US5528145A

公开(公告)日：1996-06-18

申请号：US275348

申请日：1994-07-15

申请人： Satoshi Hirata ,  Yoshitaka Bito ,  Etsuji Yamamoto

发明人： Satoshi Hirata ,  Yoshitaka Bito ,  Etsuji Yamamoto

IPC分类号： G01R33/561 ,  G01R33/565 ,  G01R33/20

CPC分类号： G01R33/5615 ,  G01R33/5616 ,  G01R33/56527 ,  G01R33/56554

摘要： A high-speed magnetic resonance spectroscopic imaging method for obtaining information relating to an object placed in a space by irradiating the object placed in the space applied with a static magnetic field and field gradients in three different directions so as to excite a nuclear spin in the object. At least one of the field gradients is applied while inverting a sign thereof periodically and a magnetic resonance signal generated by excitation of the nuclear spin is measured. A Fourier transform is applied to the measured magnetic resonance signal thereby to obtain a chemical shift image and a measurement spectral bandwidth is set to a value not larger than a frequency difference between two different chemical shifts having frequencies remotest from each other among a plurality of chemical shifts intended to be measured, the measurement spectral bandwidth being determined by a reciprocal of an inversion period of the field gradient which is applied while inverting a sign thereof periodically. The method enables setting of spatial resolution and spectral bandwidth independently.

摘要翻译： 一种高速磁共振光谱成像方法，用于通过照射放置在施加有三个不同方向的静磁场和场梯度的空间中的物体来获得与放置在空间中的物体相关的信息，以便激发在 目的。 应用场梯度中的至少一个，同时周期性地反转其符号，并且测量由核自旋的激发产生的磁共振信号。 对所测量的磁共振信号进行傅里叶变换，从而获得化学位移图像，并且将测量谱带宽设定为不同于多个化学物质中具有彼此偏离的频率的两个不同化学位移之间的频率差的值 测量频谱带宽由周期性地反转其符号时施加的场梯度的反转周期的倒数确定。 该方法可以独立设置空间分辨率和光谱带宽。

公开(公告)号：US20130214785A1

公开(公告)日：2013-08-22

申请号：US13881739

申请日：2011-10-26

申请人： Toru Shirai ,  Yoshitaka Bito ,  Satoshi Hirata ,  Yoshihisa Soutome ,  Yo Taniguchi

发明人： Toru Shirai ,  Yoshitaka Bito ,  Satoshi Hirata ,  Yoshihisa Soutome ,  Yo Taniguchi

IPC分类号： G01R33/36

CPC分类号： G01R33/3621 ,  A61B5/055 ,  G01R33/465 ,  G01R33/4828 ,  G01R33/485 ,  G01R33/5611

摘要： Images of two or more kinds of substances showing different chemical shifts, such as water image and metabolite image, are obtained without extending measurement time. For example, images of two or more kinds of desired substances showing different chemical shifts, such as water image and metabolite image, are obtained by one time of execution of an imaging sequence. In this execution, a pre-pulse is applied so that signals of the substances to be separated shift on the image, and magnetic resonance signals are received with receiver RF coils in a number not smaller than the number of types of the substances to be separated. An image reconstructed from the magnetic resonance signals is separated into images of the individual substances using sensitivity maps of the receiver RF coils. Then, correction is performed for returning the shifted image to the original position. Further, residual signals induced by errors generated in the measurement and the separation processing are eliminated by using spectroscopic images obtained after the separation.

摘要翻译： 在不延长测量时间的情况下，获得显示不同化学位移的两种或更多种物质的图像，例如水图像和代谢物图像。 例如，通过一次执行成像序列，可以获得显示不同化学位移的两种或更多种所需物质的图像，例如水图像和代谢物图像。 在该执行中，施加预脉冲，使得要分离的物质的信号在图像上移动，并且用接收器RF线圈​​接收不少于待分离物质的数量的数量的磁共振信号 。 使用接收机RF线圈的灵敏度图将从磁共振信号重构的图像分离成各个物质的图像。 然后，执行用于将移动的图像返回到原始位置的校正。 此外，通过使用分离后获得的分光图像来消除由测量和分离处理中产生的误差引起的残留信号。

公开(公告)号：US09678187B2

公开(公告)日：2017-06-13

申请号：US14240171

申请日：2012-07-27

申请人： Toru Shirai ,  Yoshitaka Bito ,  Satoshi Hirata ,  Yoshihisa Soutome

发明人： Toru Shirai ,  Yoshitaka Bito ,  Satoshi Hirata ,  Yoshihisa Soutome

IPC分类号： G01R33/46 ,  G01R33/485 ,  G01R33/565 ,  A61B5/055

CPC分类号： G01R33/4625 ,  A61B5/055 ,  G01R33/485 ,  G01R33/56518

摘要： An object of the present invention is to suppress artifacts generated by correction of spectral distortion induced by eddy currents in MRI devices with a simple method, and thereby improve accuracy of the correction.

公开(公告)号：US09091744B2

公开(公告)日：2015-07-28

申请号：US13697122

申请日：2011-05-02

申请人： Satoshi Hirata ,  Yoshitaka Bito

发明人： Satoshi Hirata ,  Yoshitaka Bito

IPC分类号： G01V3/00 ,  G01R33/485 ,  G01R33/483 ,  G01R33/56 ,  G01R33/561

CPC分类号： G01R33/485 ,  G01R33/4833 ,  G01R33/5607 ,  G01R33/5617

摘要： An object of the present invention is to provide a measuring technique which allows in the MRS measurement to suppress with a high degree of precision, incorporation of a signal of unwanted compounds which hinders measurement of a measurement object signal, independent of an imaging object region and the measurement object signal, thereby obtaining a stable and favorable signal spectrum. In the MRS measuring sequence, a spectrum selective inversion RF pulse, having a narrow band characteristic for selectively inverting only a signal peak of a compounds to be suppressed, and phase dispersion-refocusing GC pulses are applied at least one of before and after a region selective RF pulse. This MRS measuring sequence is repeated while changing the echo time TE at predetermined intervals, and nuclear magnetic resonance signals being obtained by the repetition are integrated. The amount of the spectrum selective inversion RF pulse to be applied may be changed according to the echo time TE.

摘要翻译： 本发明的目的是提供一种测量技术，其允许在MRS测量中以高精确度抑制，不依赖于成像对象区域而引入妨碍测量对象信号的测量的不想要的化合物的信号，以及 测量对象信号，从而获得稳定和有利的信号频谱。 在MRS测量序列中，具有用于选择性地仅反转待抑制的化合物的信号峰的窄带特性和相位色散重新聚焦GC脉冲的频谱选择性反转RF脉冲施加在区域之前和之后的至少一个 选择性RF脉冲。 在以预定间隔改变回波时间TE的同时重复该MRS测量序列，并且通过重复获得的核磁共振信号被积分。 可以根据回波时间TE改变要施加的频谱选择性反转RF脉冲的量。

公开(公告)号：US08547101B2

公开(公告)日：2013-10-01

申请号：US13123299

申请日：2009-07-22

申请人： Satoshi Hirata ,  Yoshitaka Bito

发明人： Satoshi Hirata ,  Yoshitaka Bito

IPC分类号： G01V3/00

CPC分类号： G01R33/485 ,  G01R33/4833 ,  G01R33/5617

摘要： In MRS measurement using magnetic resonance highly precise results are efficiently obtained with coincidence of axes with axes in positioning image. In measurement according to the PRESS method for a plurality of regions each localized (specified) with a set of perpendicularly intersecting three slices, wherein one or two slices are common to the sets of three slices localizing the regions, and slices not common do not intersect, a slice not common to those of a region to be selectively excited is excited with a radio frequency magnetic field of which phase is different by 180 degrees from that of a radio frequency magnetic field used for exciting the region to be selectively excited a number of times equal to the number of common slices, and during the measurement of the region to be selectively excited, a group of regions other than the region to be selectively excited are thermally equilibrated.

摘要翻译： 在使用磁共振的MRS测量中，通过定位图像中的轴与轴的重合而有效地获得高精度结果。 在根据PRESS方法对多个区域进行测量，每个区域具有一组垂直相交的三个片段（指定），其中一个或两个切片对于定位该区域的三个切片的组是共同的，并且不共同的切片不相交 与被选择性地激励的区域不共同的切片被与用于激励该区域的射频磁场的相位相差180度的射频磁场激发，以选择性地激发多个 时间等于公共切片的数量，并且在要选择性激发的区域的测量期间，除了要选择性激发的区域之外的一组区域被热平衡。

公开(公告)号：US20110196225A1

公开(公告)日：2011-08-11

申请号：US13123299

申请日：2009-07-22

申请人： Satoshi Hirata ,  Yoshitaka Bito

发明人： Satoshi Hirata ,  Yoshitaka Bito

IPC分类号： A61B5/055

CPC分类号： G01R33/485 ,  G01R33/4833 ,  G01R33/5617

摘要： In the MRS measurement using magnetic resonance for performing measurement of two regions in the same section, highly precise results are efficiently obtained with coincidence of axes with axes in positioning image. In measurement according to the PRESS method for a plurality of regions each localized (specified) with a set of perpendicularly intersecting three slices, wherein one or two slices are common to the sets of three slices localizing the regions, and slices not common do not intersect, a slice not common to those of a region to be selectively excited is excited with a radio frequency magnetic field of which phase is different by 180 degrees from that of a radio frequency magnetic field used for exciting the region to be selectively excited a number of times equal to the number of common slices, and during the measurement of the region to be selectively excited, a group of regions other than the region to be selectively excited are thermally equilibrated.

摘要翻译： 在使用磁共振进行MRS测量的同一部分中的两个区域的测量中，通过定位图像中的轴与轴的一致性有效地获得高精度的结果。 在根据PRESS方法对多个区域进行测量，每个区域具有一组垂直相交的三个片段（指定），其中一个或两个切片对于定位该区域的三个切片的组是共同的，并且不共同的切片不相交 与被选择性地激励的区域不共同的切片被与用于激励该区域的射频磁场的相位相差180度的射频磁场激发，以选择性地激发多个 时间等于公共切片的数量，并且在要选择性激发的区域的测量期间，除了要选择性激发的区域之外的一组区域被热平衡。

公开(公告)号：US20100272337A1

公开(公告)日：2010-10-28

申请号：US12741086

申请日：2008-07-07

申请人： Toru Shirai ,  Yoshitaka Bito ,  Yukari Yamamoto ,  Satoshi Hirata

发明人： Toru Shirai ,  Yoshitaka Bito ,  Yukari Yamamoto ,  Satoshi Hirata

IPC分类号： G06K9/00

CPC分类号： G01R33/56518 ,  G01R33/485 ,  G01R33/5618

摘要： While removing signals unnecessary for measuring signals from a metabolite, data required for eddy current correction are obtained in a short period of time. Signals from an unnecessary substance which is not an object of the measurement are removed, and phase data for correcting spectral distortion caused by an eddy current are obtained by a single measurement. Two kinds of frequency-selective pulses of which intensities are adjusted so that the signals from the unnecessary substance should have the same absolute values of intensities and opposite polarities are applied with changing intensities for every phase encoding for at least one axis, and the obtained signals are arranged in a k-space. By removing aliasing of image data obtained from the k-space data, signals from an unnecessary substance are removed, and phase data for eddy current correction are calculated by using a part of the k-space data.

摘要翻译： 在消除从代谢物测量信号所不必要的信号的同时，在短时间内获得涡流校正所需的数据。 除去不是测量对象的不必要物质的信号，并且通过单次测量获得用于校正由涡流引起的光谱失真的相位数据。 调整强度的两种频率选择脉冲，使得来自不需要的物质的信号应具有相同的强度绝对值和相反的极性，对于至少一个轴的每个相位编码的变化强度，并且获得的信号 被布置在k空间中。 通过去除从k空间数据获得的图像数据的混叠，去除来自不需要的物质的信号，并且通过使用k空间数据的一部分来计算用于涡流校正的相位数据。

公开(公告)号：US09389289B2

公开(公告)日：2016-07-12

申请号：US13881739

申请日：2011-10-26

申请人： Toru Shirai ,  Yoshitaka Bito ,  Satoshi Hirata ,  Yoshihisa Soutome ,  Yo Taniguchi

发明人： Toru Shirai ,  Yoshitaka Bito ,  Satoshi Hirata ,  Yoshihisa Soutome ,  Yo Taniguchi

IPC分类号： G01R33/36 ,  A61B5/055 ,  G01R33/465 ,  G01R33/48 ,  G01R33/485 ,  G01R33/561

CPC分类号： G01R33/3621 ,  A61B5/055 ,  G01R33/465 ,  G01R33/4828 ,  G01R33/485 ,  G01R33/5611

摘要： Images of two or more kinds of substances showing different chemical shifts, such as water image and metabolite image, are obtained without extending measurement time. For example, images of two or more kinds of desired substances showing different chemical shifts, such as water image and metabolite image, are obtained by one time of execution of an imaging sequence. In this execution, a pre-pulse is applied so that signals of the substances to be separated shift on the image, and magnetic resonance signals are received with receiver RF coils in a number not smaller than the number of types of the substances to be separated. An image reconstructed from the magnetic resonance signals is separated into images of the individual substances using sensitivity maps of the receiver RF coils. Then, correction is performed for returning the shifted image to the original position. Further, residual signals induced by errors generated in the measurement and the separation processing are eliminated by using spectroscopic images obtained after the separation.

摘要翻译： 在不延长测量时间的情况下，获得显示不同化学位移的两种或更多种物质的图像，例如水图像和代谢物图像。 例如，通过一次执行成像序列，可以获得显示不同化学位移的两种或更多种所需物质的图像，例如水图像和代谢物图像。 在该执行中，施加预脉冲，使得要分离的物质的信号在图像上移动，并且用接收器RF线圈​​接收不少于待分离物质的数量的数量的磁共振信号 。 使用接收机RF线圈的灵敏度图将从磁共振信号重构的图像分离成各个物质的图像。 然后，执行用于将移动的图像返回到原始位置的校正。 此外，通过使用分离后获得的分光图像来消除由测量和分离处理中产生的误差引起的残留信号。

公开(公告)号：US20120049845A1

公开(公告)日：2012-03-01

申请号：US13140484

申请日：2010-02-03

申请人： Yoshitaka Bito ,  Satoshi Hirata ,  Hisaaki Ochi ,  Koji Hirata ,  Toru Shirai ,  Yosuke Otake

发明人： Yoshitaka Bito ,  Satoshi Hirata ,  Hisaaki Ochi ,  Koji Hirata ,  Toru Shirai ,  Yosuke Otake

IPC分类号： G01R33/32

CPC分类号： G01R33/485 ,  G01R33/56341

摘要： In the diffusion spectroscopic imaging, in which intensity of molecular diffusion is imaged with separating chemical substances, with suppressing artifacts resulting from object motion of an object, spatial resolution, spectral band and SNR are maintained, and measurement accuracy is enhanced. A measurement for acquiring diffusion SI data is repeated a plurality of times with changing acquisition timing, phase variation of each measurement result is corrected, and a diffusion SI image is reconstructed from the corrected measurement results. In addition, the phase variation is calculated for every point in the space from the diffusion SI data acquired by each measurement or navigation data obtained by each measurement. The phase correction is independently performed for every point in the space.

摘要翻译： 在通过分离化学物质成像分子扩散强度的扩散光谱成像中，通过抑制由物体的物体运动产生的伪影，保持了空间分辨率，光谱带和SNR，并且提高了测量精度。 通过改变获取定时多次重复获取扩散SI数据的测量，校正每个测量结果的相位变化，并从校正的测量结果重建扩散SI图像。 此外，根据通过各测量获得的扩散SI数据或通过每次测量获得的导航数据，计算空间中的每个点的相位变化。 对于空间中的每一个点都独立执行相位校正。