公开(公告)号：US20130214785A1

公开(公告)日：2013-08-22

申请号：US13881739

申请日：2011-10-26

申请人： Toru Shirai ,  Yoshitaka Bito ,  Satoshi Hirata ,  Yoshihisa Soutome ,  Yo Taniguchi

发明人： Toru Shirai ,  Yoshitaka Bito ,  Satoshi Hirata ,  Yoshihisa Soutome ,  Yo Taniguchi

IPC分类号： G01R33/36

CPC分类号： G01R33/3621 ,  A61B5/055 ,  G01R33/465 ,  G01R33/4828 ,  G01R33/485 ,  G01R33/5611

摘要： Images of two or more kinds of substances showing different chemical shifts, such as water image and metabolite image, are obtained without extending measurement time. For example, images of two or more kinds of desired substances showing different chemical shifts, such as water image and metabolite image, are obtained by one time of execution of an imaging sequence. In this execution, a pre-pulse is applied so that signals of the substances to be separated shift on the image, and magnetic resonance signals are received with receiver RF coils in a number not smaller than the number of types of the substances to be separated. An image reconstructed from the magnetic resonance signals is separated into images of the individual substances using sensitivity maps of the receiver RF coils. Then, correction is performed for returning the shifted image to the original position. Further, residual signals induced by errors generated in the measurement and the separation processing are eliminated by using spectroscopic images obtained after the separation.

摘要翻译： 在不延长测量时间的情况下，获得显示不同化学位移的两种或更多种物质的图像，例如水图像和代谢物图像。 例如，通过一次执行成像序列，可以获得显示不同化学位移的两种或更多种所需物质的图像，例如水图像和代谢物图像。 在该执行中，施加预脉冲，使得要分离的物质的信号在图像上移动，并且用接收器RF线圈​​接收不少于待分离物质的数量的数量的磁共振信号 。 使用接收机RF线圈的灵敏度图将从磁共振信号重构的图像分离成各个物质的图像。 然后，执行用于将移动的图像返回到原始位置的校正。 此外，通过使用分离后获得的分光图像来消除由测量和分离处理中产生的误差引起的残留信号。

公开(公告)号：US20140306703A1

公开(公告)日：2014-10-16

申请号：US14240171

申请日：2012-07-27

申请人： Toru Shirai ,  Yoshitaka Bito ,  Satoshi Hirata ,  Yoshihisa Soutome

发明人： Toru Shirai ,  Yoshitaka Bito ,  Satoshi Hirata ,  Yoshihisa Soutome

IPC分类号： G01R33/46

CPC分类号： G01R33/4625 ,  A61B5/055 ,  G01R33/485 ,  G01R33/56518

摘要： An object of the present invention is to suppress artifacts generated by correction of spectral distortion induced by eddy currents in MRI devices with a simple method, and thereby improve accuracy of the correction. In the eddy current correction processing for correcting spectral distortion caused by an eddy current using phase values of FID signals of a substance showing higher signal intensities compared with a metabolite as an object of measurement, phase jumps of the phase values used for the correction are corrected beforehand. In the correction of the phase jumps, small phase change amount points are identified by using primary time differential values of the phase values, and the other points are identified as a phase jump generation region. Then, the primary time differential values corresponding to the identified phase jump generation regions are excluded. The phase jump generation regions are identified as regions where the primary time differential value changes in an amount not smaller than a threshold value defined beforehand within a range defined beforehand.

摘要翻译： 本发明的目的是通过简单的方法来抑制由MRI装置中的涡流引起的光谱失真校正而产生的伪影，从而提高校正精度。 在使用与作为测量对象的代谢物相比显示较高信号强度的物质的FID信号的相位值来校正由涡流引起的光谱失真的涡流校正处理中，校正用于校正的相位值的相位跳变 预先。 在相位跳变的校正中，通过使用相位值的一次时间差分值来识别小的相位变化量点，并且将其他点识别为相位跳跃产生区域。 然后，排除与所识别的相位跳跃发生区域对应的主要时间差值。 相位跳变产生区域被识别为主要时间差值在不小于预先定义的范围内预先定义的阈值的量的变化的区域。

公开(公告)号：US08188739B2

公开(公告)日：2012-05-29

申请号：US12519197

申请日：2007-06-29

申请人： Toru Shirai ,  Yoshitaka Bito ,  Yo Taniguchi ,  Satoshi Hirata

发明人： Toru Shirai ,  Yoshitaka Bito ,  Yo Taniguchi ,  Satoshi Hirata

IPC分类号： G01V3/00

CPC分类号： G01R33/485 ,  G01R33/483 ,  G01R33/5602 ,  G01R33/5607

摘要： A method for obtaining the most appropriate amplitude of signal suppression pulse, which suppresses unnecessary signals from the substance not subjected to measurement, highly accurately, swiftly and stably, and an MRI apparatus that enables the optimization are provided.A pulse amplitude adjusting means equipped in the MRI apparatus acquires signals while changing the amplitude of signal suppression pulse and calculates signal absolute values and phase values, and computes reference signals, which are polarized signal absolute values, based on the changes in signal phase values. This reference signals are subjected to polynomial fitting. A value which makes this fitting curve is 0 or closes to 0 is set as the optimal pulse amplitude.

摘要翻译： 提供了一种用于获得信号抑制脉冲的最适当振幅的方法，其能够高度准确，快速且稳定地抑制不被测量的物质的不必要的信号，并且提供能够进行优化的MRI装置。 装备在MRI装置中的脉冲幅度调整装置在改变信号抑制脉冲的振幅的同时获取信号，并且计算信号绝对值和相位值，并且基于信号相位值的变化来计算作为极化信号绝对值的参考信号。 该参考信号经过多项式拟合。 使该拟合曲线为0或接近0的值被设定为最佳脉冲幅度。

公开(公告)号：US20080009703A1

公开(公告)日：2008-01-10

申请号：US11797878

申请日：2007-05-08

申请人： Yoshitaka Bito ,  Hisaaki Ochi ,  Yo Taniguchi ,  Satoshi Hirata ,  Toru Shirai

发明人： Yoshitaka Bito ,  Hisaaki Ochi ,  Yo Taniguchi ,  Satoshi Hirata ,  Toru Shirai

IPC分类号： A61B5/05

CPC分类号： G01R33/485 ,  G01R33/5608

摘要： A magnetic resonance imaging system capable of conducting spectroscopic imaging with an improved SNR without degrading the spatial resolution includes edge-preserving filter processing means for spectroscopic imaging. The edge-preserving filter processing means executes processing including the steps of calculating spectral similarity in spatial neighborhoods (spatially neighboring voxels) at each voxel in spectroscopic imaging data, calculating a spectral weight according to the spectral similarity, and conducting weighted smoothing for compounding spectra of spatial neighborhoods (spatially neighboring voxels) according to the spectral weight.

摘要翻译： 能够在不降低空间分辨率的情况下以改善的SNR进行光谱成像的磁共振成像系统包括用于分光成像的边缘保留滤波处理装置。 边缘保留滤波处理装置执行处理，其包括以下步骤：计算分光成像数据中的每个体素的空间邻域（空间相邻体素）中的频谱相似度，根据频谱相似度计算频谱权重，以及进行加权平滑化， 根据光谱权重的空间邻域（空间相邻体素）。

公开(公告)号：US09678187B2

公开(公告)日：2017-06-13

申请号：US14240171

申请日：2012-07-27

申请人： Toru Shirai ,  Yoshitaka Bito ,  Satoshi Hirata ,  Yoshihisa Soutome

发明人： Toru Shirai ,  Yoshitaka Bito ,  Satoshi Hirata ,  Yoshihisa Soutome

IPC分类号： G01R33/46 ,  G01R33/485 ,  G01R33/565 ,  A61B5/055

CPC分类号： G01R33/4625 ,  A61B5/055 ,  G01R33/485 ,  G01R33/56518

摘要： An object of the present invention is to suppress artifacts generated by correction of spectral distortion induced by eddy currents in MRI devices with a simple method, and thereby improve accuracy of the correction.

公开(公告)号：US09091744B2

公开(公告)日：2015-07-28

申请号：US13697122

申请日：2011-05-02

申请人： Satoshi Hirata ,  Yoshitaka Bito

发明人： Satoshi Hirata ,  Yoshitaka Bito

IPC分类号： G01V3/00 ,  G01R33/485 ,  G01R33/483 ,  G01R33/56 ,  G01R33/561

CPC分类号： G01R33/485 ,  G01R33/4833 ,  G01R33/5607 ,  G01R33/5617

摘要： An object of the present invention is to provide a measuring technique which allows in the MRS measurement to suppress with a high degree of precision, incorporation of a signal of unwanted compounds which hinders measurement of a measurement object signal, independent of an imaging object region and the measurement object signal, thereby obtaining a stable and favorable signal spectrum. In the MRS measuring sequence, a spectrum selective inversion RF pulse, having a narrow band characteristic for selectively inverting only a signal peak of a compounds to be suppressed, and phase dispersion-refocusing GC pulses are applied at least one of before and after a region selective RF pulse. This MRS measuring sequence is repeated while changing the echo time TE at predetermined intervals, and nuclear magnetic resonance signals being obtained by the repetition are integrated. The amount of the spectrum selective inversion RF pulse to be applied may be changed according to the echo time TE.

摘要翻译： 本发明的目的是提供一种测量技术，其允许在MRS测量中以高精确度抑制，不依赖于成像对象区域而引入妨碍测量对象信号的测量的不想要的化合物的信号，以及 测量对象信号，从而获得稳定和有利的信号频谱。 在MRS测量序列中，具有用于选择性地仅反转待抑制的化合物的信号峰的窄带特性和相位色散重新聚焦GC脉冲的频谱选择性反转RF脉冲施加在区域之前和之后的至少一个 选择性RF脉冲。 在以预定间隔改变回波时间TE的同时重复该MRS测量序列，并且通过重复获得的核磁共振信号被积分。 可以根据回波时间TE改变要施加的频谱选择性反转RF脉冲的量。

公开(公告)号：US08547101B2

公开(公告)日：2013-10-01

申请号：US13123299

申请日：2009-07-22

申请人： Satoshi Hirata ,  Yoshitaka Bito

发明人： Satoshi Hirata ,  Yoshitaka Bito

IPC分类号： G01V3/00

CPC分类号： G01R33/485 ,  G01R33/4833 ,  G01R33/5617

摘要： In MRS measurement using magnetic resonance highly precise results are efficiently obtained with coincidence of axes with axes in positioning image. In measurement according to the PRESS method for a plurality of regions each localized (specified) with a set of perpendicularly intersecting three slices, wherein one or two slices are common to the sets of three slices localizing the regions, and slices not common do not intersect, a slice not common to those of a region to be selectively excited is excited with a radio frequency magnetic field of which phase is different by 180 degrees from that of a radio frequency magnetic field used for exciting the region to be selectively excited a number of times equal to the number of common slices, and during the measurement of the region to be selectively excited, a group of regions other than the region to be selectively excited are thermally equilibrated.

摘要翻译： 在使用磁共振的MRS测量中，通过定位图像中的轴与轴的重合而有效地获得高精度结果。 在根据PRESS方法对多个区域进行测量，每个区域具有一组垂直相交的三个片段（指定），其中一个或两个切片对于定位该区域的三个切片的组是共同的，并且不共同的切片不相交 与被选择性地激励的区域不共同的切片被与用于激励该区域的射频磁场的相位相差180度的射频磁场激发，以选择性地激发多个 时间等于公共切片的数量，并且在要选择性激发的区域的测量期间，除了要选择性激发的区域之外的一组区域被热平衡。

公开(公告)号：US20110196225A1

公开(公告)日：2011-08-11

申请号：US13123299

申请日：2009-07-22

申请人： Satoshi Hirata ,  Yoshitaka Bito

发明人： Satoshi Hirata ,  Yoshitaka Bito

IPC分类号： A61B5/055

CPC分类号： G01R33/485 ,  G01R33/4833 ,  G01R33/5617

摘要： In the MRS measurement using magnetic resonance for performing measurement of two regions in the same section, highly precise results are efficiently obtained with coincidence of axes with axes in positioning image. In measurement according to the PRESS method for a plurality of regions each localized (specified) with a set of perpendicularly intersecting three slices, wherein one or two slices are common to the sets of three slices localizing the regions, and slices not common do not intersect, a slice not common to those of a region to be selectively excited is excited with a radio frequency magnetic field of which phase is different by 180 degrees from that of a radio frequency magnetic field used for exciting the region to be selectively excited a number of times equal to the number of common slices, and during the measurement of the region to be selectively excited, a group of regions other than the region to be selectively excited are thermally equilibrated.

摘要翻译： 在使用磁共振进行MRS测量的同一部分中的两个区域的测量中，通过定位图像中的轴与轴的一致性有效地获得高精度的结果。 在根据PRESS方法对多个区域进行测量，每个区域具有一组垂直相交的三个片段（指定），其中一个或两个切片对于定位该区域的三个切片的组是共同的，并且不共同的切片不相交 与被选择性地激励的区域不共同的切片被与用于激励该区域的射频磁场的相位相差180度的射频磁场激发，以选择性地激发多个 时间等于公共切片的数量，并且在要选择性激发的区域的测量期间，除了要选择性激发的区域之外的一组区域被热平衡。

公开(公告)号：US20100272337A1

公开(公告)日：2010-10-28

申请号：US12741086

申请日：2008-07-07

申请人： Toru Shirai ,  Yoshitaka Bito ,  Yukari Yamamoto ,  Satoshi Hirata

发明人： Toru Shirai ,  Yoshitaka Bito ,  Yukari Yamamoto ,  Satoshi Hirata

IPC分类号： G06K9/00

CPC分类号： G01R33/56518 ,  G01R33/485 ,  G01R33/5618

摘要： While removing signals unnecessary for measuring signals from a metabolite, data required for eddy current correction are obtained in a short period of time. Signals from an unnecessary substance which is not an object of the measurement are removed, and phase data for correcting spectral distortion caused by an eddy current are obtained by a single measurement. Two kinds of frequency-selective pulses of which intensities are adjusted so that the signals from the unnecessary substance should have the same absolute values of intensities and opposite polarities are applied with changing intensities for every phase encoding for at least one axis, and the obtained signals are arranged in a k-space. By removing aliasing of image data obtained from the k-space data, signals from an unnecessary substance are removed, and phase data for eddy current correction are calculated by using a part of the k-space data.

摘要翻译： 在消除从代谢物测量信号所不必要的信号的同时，在短时间内获得涡流校正所需的数据。 除去不是测量对象的不必要物质的信号，并且通过单次测量获得用于校正由涡流引起的光谱失真的相位数据。 调整强度的两种频率选择脉冲，使得来自不需要的物质的信号应具有相同的强度绝对值和相反的极性，对于至少一个轴的每个相位编码的变化强度，并且获得的信号 被布置在k空间中。 通过去除从k空间数据获得的图像数据的混叠，去除来自不需要的物质的信号，并且通过使用k空间数据的一部分来计算用于涡流校正的相位数据。

公开(公告)号：US5528145A

公开(公告)日：1996-06-18

申请号：US275348

申请日：1994-07-15

申请人： Satoshi Hirata ,  Yoshitaka Bito ,  Etsuji Yamamoto

发明人： Satoshi Hirata ,  Yoshitaka Bito ,  Etsuji Yamamoto

IPC分类号： G01R33/561 ,  G01R33/565 ,  G01R33/20

CPC分类号： G01R33/5615 ,  G01R33/5616 ,  G01R33/56527 ,  G01R33/56554

摘要： A high-speed magnetic resonance spectroscopic imaging method for obtaining information relating to an object placed in a space by irradiating the object placed in the space applied with a static magnetic field and field gradients in three different directions so as to excite a nuclear spin in the object. At least one of the field gradients is applied while inverting a sign thereof periodically and a magnetic resonance signal generated by excitation of the nuclear spin is measured. A Fourier transform is applied to the measured magnetic resonance signal thereby to obtain a chemical shift image and a measurement spectral bandwidth is set to a value not larger than a frequency difference between two different chemical shifts having frequencies remotest from each other among a plurality of chemical shifts intended to be measured, the measurement spectral bandwidth being determined by a reciprocal of an inversion period of the field gradient which is applied while inverting a sign thereof periodically. The method enables setting of spatial resolution and spectral bandwidth independently.

摘要翻译： 一种高速磁共振光谱成像方法，用于通过照射放置在施加有三个不同方向的静磁场和场梯度的空间中的物体来获得与放置在空间中的物体相关的信息，以便激发在 目的。 应用场梯度中的至少一个，同时周期性地反转其符号，并且测量由核自旋的激发产生的磁共振信号。 对所测量的磁共振信号进行傅里叶变换，从而获得化学位移图像，并且将测量谱带宽设定为不同于多个化学物质中具有彼此偏离的频率的两个不同化学位移之间的频率差的值 测量频谱带宽由周期性地反转其符号时施加的场梯度的反转周期的倒数确定。 该方法可以独立设置空间分辨率和光谱带宽。