RIBONUCLEIC ACIDS WITH NON-STANDARD BASES AND USES THEREOF
    11.
    发明申请
    RIBONUCLEIC ACIDS WITH NON-STANDARD BASES AND USES THEREOF 审中-公开
    具有非标准基础的RIBONUCLEIC ACIDS及其用途

    公开(公告)号:US20100015708A1

    公开(公告)日:2010-01-21

    申请号:US12486889

    申请日:2009-06-18

    IPC分类号: C12N5/06 C07H21/02

    CPC分类号: C07H21/02

    摘要: The present disclosure provides a ribonucleic acid comprising a double-stranded region having at least one base pair comprising a 5-methyluridine base paired with a 2,6-diaminopurine and methods for preparing the same. Also provided are methods for treating or preventing a disease or disorder by inducing RNAi.

    摘要翻译: 本公开内容提供了包含具有至少一个碱基对的双链区域的核糖核酸,所述碱基对包含与2,6-二氨基嘌呤配对的5-甲基尿苷碱基及其制备方法。 还提供了通过诱导RNAi治疗或预防疾病或病症的方法。

    COMPOSITIONS FOR ENHANCED EPITHELIAL PERMEATION OF PEPTIDE YY FOR TREATING OBESITY
    12.
    发明申请
    COMPOSITIONS FOR ENHANCED EPITHELIAL PERMEATION OF PEPTIDE YY FOR TREATING OBESITY 失效
    用于治疗肥胖的肽增强上皮组合物

    公开(公告)号:US20090118158A1

    公开(公告)日:2009-05-07

    申请号:US12234547

    申请日:2008-09-19

    申请人: Steven C. Quay

    发明人: Steven C. Quay

    IPC分类号: A61K38/00 A61P3/04

    CPC分类号: A61K9/0043 A61K38/1709

    摘要: Pharmaceutical compositions comprising PYY(3-36), a cyclodextrin, and a compound selected from phosphatidylcholine or diglyceride, wherein the PYY(3-36) is present in an amount effective to alleviate one or more symptom(s) of obesity in a subject, and the cyclodextrin and the compound selected from phosphatidylcholine or diglyceride are present in an amount sufficient to enhance epithelial permeation.

    摘要翻译: 包含PYY(3-36),环糊精和选自磷脂酰胆碱或甘油二酯的化合物的药物组合物,其中PYY(3-36)以有效减轻受试者的一种或多种肥胖症状的量存在 ,并且环糊精和选自磷脂酰胆碱或甘油二酯的化合物以足以增加上皮渗透的量存在。

    Cyanocobalamin low viscosity aqueous formulations for intranasal delivery
    16.
    发明授权
    Cyanocobalamin low viscosity aqueous formulations for intranasal delivery 有权
    用于鼻内给药的氰钴胺素低粘度含水制剂

    公开(公告)号:US07229636B1

    公开(公告)日:2007-06-12

    申请号:US10787385

    申请日:2004-02-26

    IPC分类号: A61F13/00

    摘要: A stable pharmaceutical mercury-free aqueous solution of cyanocobalamin comprised of cyanocobalamin and water wherein said solution of cyanocobalamin is suitable for intranasal administration, has a viscosity less than about 1000 cPs, and wherein said solution of cyanocobalamin has a bioavailability of cyanocobalamin when administered intranasally of at least about 7% relative to an intramuscular injection of cyanocobalamin with the proviso that the solution is essentially free of mercury and mercury-containing compounds. The present invention is also directed towards a method for elevating the vitamin B12 levels in the cerebral spinal fluid (CSF) comprising administering intranasally a sufficient amount of a mercury-free cyanocobalamin solution so as to increase the average ratio of vitamin B12 in the CSF to that in the blood serum (B12 CSF/B12 Serum×100) to at least about 1.1 comprising intranasally administering an aqueous solution of a cyanocobalamin, wherein said solution of cyanocobalamin has a bioavailability of at least 7% relative to an intramuscular injection of a cyanocobalamin.

    摘要翻译: 一种由氰钴胺素和水组成的稳定的药用无汞水溶液,其中所述氰钴胺溶液适合于鼻内给药,其粘度小于约1000cPs,其中所述氰钴胺溶液在鼻内给药时具有氰钴胺素的生物利用度 相对于肌内注射氰钴胺素至少约7%,条件是溶液基本上不含汞和含汞化合物。 本发明还涉及提高脑脊髓液(CSF)中维生素B12水平的方法,其包括向鼻内施用足够量的无汞氰钴胺溶液,以增加CSF中维生素B12的平均比例 在血清中(B12 CSF / B12 Serumx100)至少约1.1,包括鼻内施用氰钴胺水溶液,其中所述氰钴胺溶液相对于肌内注射氰钴胺素具有至少7%的生物利用度。

    Emulsion vehicle for poorly soluble drugs
    18.
    发明授权
    Emulsion vehicle for poorly soluble drugs 失效
    用于难溶性药物的乳剂

    公开(公告)号:US07030155B2

    公开(公告)日:2006-04-18

    申请号:US10151066

    申请日:2002-05-17

    IPC分类号: A61K43/16

    摘要: A method of making an emulsion of tocopherol incorporating a co-solvent and, stabilized by biocompatible surfactants, as a vehicle or carrier for therapeutic drugs, which is substantially ethanol free and which can be administered to animals or humans by various routes, is disclosed. Also included in the emulsion is PEGylated vitamin E. PEGylated α-tocopherol includes polyethylene glycol subunits attached by a succinic acid diester at the ring hydroxyl of vitamin E and serves as a primary surfactant, stabilizer and a secondary solvent in emulsions of α-tocopherol.

    摘要翻译: 公开了一种生产含有助溶剂并通过生物相容性表面活性剂稳定化的生育酚乳液作为治疗药物的载体或载体的方法,所述载体或载体基本上不含有乙醇,并且可通过各种途径施用于动物或人类。 乳液中还包含聚乙二醇化维生素E.聚乙二醇化α-生育酚包括在维生素E的环羟基处由琥珀酸二酯连接的聚乙二醇亚单位,并且用作α-生育酚乳液中的主要表面活性剂,稳定剂和第二溶剂。

    Methods and devices for obtaining and assaying mammary fluid samples for evaluating breast diseases, including cancer
    20.
    发明授权
    Methods and devices for obtaining and assaying mammary fluid samples for evaluating breast diseases, including cancer 失效
    用于获得和测定乳腺液样品以评估乳腺疾病(包括癌症)的方法和装置

    公开(公告)号:US06287521B1

    公开(公告)日:2001-09-11

    申请号:US09027362

    申请日:1998-02-20

    IPC分类号: G01N3348

    摘要: Non-invasive methods are provided for obtaining biological samples of mammary fluid or mammary fluid components by administering oxytocin to a patient to stimulate expression of mammary fluid. During or after mammary fluid expression, a biological sample is collected in the form of whole mammary fluid, whole cells or cellular components, other selected liquid or solid fractions of the mammary fluid, purified or bulk proteins, glycoproteins, peptides, nucleotides or other desired Constituents of mammary fluid. Methods and kits are also provided for determining the presence or amount of a breast disease marker in biological samples of mammary fluid or mammary fluid components obtained according to the above sample collection methods. Also provided within the invention are novel breast pump and breast pump adapter devices which incorporate a solid phase sample collection medium integrated within the breast pump or adapter or otherwise fluidly connected therewith. These devices collect a sample of expressed breast fluid by contacting the fluid with a solid phase sample collection medium while the pump or adapter is applied to the breast.

    摘要翻译: 提供非侵入性方法用于通过向患者施用催产素以刺激乳腺液的表达来获得乳液或乳液成分的生物样品。 在乳腺液表达期间或之后,以整个乳腺液,全细胞或细胞组分,乳液的其它选择的液体或固体部分,纯化或体蛋白,糖蛋白,肽,核苷酸或其他所需的形式收集生物样品 乳液成分。 还提供了方法和试剂盒,用于确定根据上述样品收集方法获得的乳腺液或乳腺液成分的生物样品中乳腺疾病标志物的存在或数量。 本发明还提供了新颖的吸乳器和吸奶器适配器装置,其包括集成在吸乳器或适配器内或以其它方式流体连接的固相样品收集介质。 这些装置通过在将泵或适配器应用于乳房的同时将流体与固相样品收集介质接触来收集表达乳腺液的样品。