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    NUCLEIC ACID COMPOUNDS FOR INHIBITING PLK1 GENE EXPRESSION AND USES THEREOF
    4.
    发明申请
    NUCLEIC ACID COMPOUNDS FOR INHIBITING PLK1 GENE EXPRESSION AND USES THEREOF 审中-公开
    用于抑制PLK1基因表达的核酸化合物及其用途

    公开(公告)号：US20110136233A1

    公开(公告)日：2011-06-09

    申请号：US13057743

    申请日：2009-08-05

    申请人： Steven C. Quay ,  Narendra K. Vaish ,  Kathy L. Fosnaugh ,  Shaguna Seth

    发明人： Steven C. Quay ,  Narendra K. Vaish ,  Kathy L. Fosnaugh ,  Shaguna Seth

    IPC分类号： C12N5/00 ,  C07H21/02

    CPC分类号： C12N15/1137 ,  C12N2310/14 ,  C12N2310/32 ,  C12N2310/533

    摘要： The present disclosure provides RNA molecules, for example, meroduplex ribonucleic acid molecules (mdRNA), capable of decreasing or silencing gene expression of PLK1 gene. An mdRNA of this disclosure comprises at least three strands that combine to form at least two non-overlapping double-stranded regions separated by a nick or gap wherein one strand is complementary to a PLK1 mRNA. Also provided are methods of decreasing expression of a PLK1 gene in a cell or in a subject to treat a PLK family member-related disease.

    摘要翻译： 本公开提供了能够降低或沉默PLK1基因的基因表达的RNA分子，例如meroduplex核糖核酸分子（mdRNA）。 本公开的mdRNA包含至少三条链，其组合形成由切口或间隙分开的至少两个不重叠的双链区域，其中一条链与PLK1mRNA互补。 还提供减少细胞或受试者中PLK1基因表达以治疗PLK家族成员相关疾病的方法。

    Compositions for enhanced epithelial permeation of neuropeptide Y for treating obesity
    5.
    发明授权
    Compositions for enhanced epithelial permeation of neuropeptide Y for treating obesity 失效
    用于增强神经肽Y上皮渗透以治疗肥胖症的组合物

    公开(公告)号：US07863245B2

    公开(公告)日：2011-01-04

    申请号：US12234547

    申请日：2008-09-19

    申请人： Steven C. Quay

    发明人： Steven C. Quay

    IPC分类号： A61K38/22 ,  A61K38/17 ,  C07K14/435 ,  C07C217/28

    CPC分类号： A61K9/0043 ,  A61K38/1709

    摘要： Pharmaceutical compositions comprising PYY(3-36) or Neuropeptide Y (NPY), a cyclodextrin, and a compound selected from phosphatidylcholine or diglyceride, wherein the PYY(3-36) or Neuropeptide Y (NPY) is present in an amount effective to alleviate one or more symptom(s) of obesity in a subject, and the cyclodextrin and the compound selected from phosphatidylcholine or diglyceride are present in an amount sufficient to enhance epithelial permeation.

    摘要翻译： 包含PYY（3-36）或神经肽Y（NPY），环糊精和选自磷脂酰胆碱或甘油二酯的化合物的药物组合物，其中PYY（3-36）或神经肽Y（NPY）以有效缓解的量存在 受试者中一种或多种肥胖症状，以及环糊精和选自磷脂酰胆碱或甘油二酯的化合物以足以增加上皮渗透的量存在。

    NUCLEIC ACID COMPOUNDS FOR INHIBITING MYC GENE EXPRESSION AND USES THEREOF
    6.
    发明申请
    NUCLEIC ACID COMPOUNDS FOR INHIBITING MYC GENE EXPRESSION AND USES THEREOF 审中-公开
    用于抑制MYC基因表达的核酸化合物及其用途

    公开(公告)号：US20100055782A1

    公开(公告)日：2010-03-04

    申请号：US12529138

    申请日：2008-03-03

    申请人： Steven C. Quay ,  James McSwiggen ,  Narendra K. Vaish ,  Mohammad Ahmadian

    发明人： Steven C. Quay ,  James McSwiggen ,  Narendra K. Vaish ,  Mohammad Ahmadian

    IPC分类号： C12N5/071 ,  C07H21/02 ,  C12N5/02

    CPC分类号： C12N15/1135 ,  C12N2310/14

    摘要： The present disclosure provides meroduplex ribonucleic acid molecules (mdRNA) capable of decreasing or silencing MYC gene expression. An mdRNA of this disclosure comprises at least three strands that combine to form at least two non-over-lapping double-stranded regions separated by a nick or gap wherein one strand is complementary to a MYC mRNA. In addition, the meroduplex may have at least one uridine substituted with a 5-methyluridine, a nucleoside replaced with a locked nucleic acid, or optionally other modifications, and any combination thereof. Also provided are methods of decreasing expression of a MYC gene in a cell or in a subject to treat a MYC-related disease.

    摘要翻译： 本公开提供能够降低或沉默MYC基因表达的meroduplex核糖核酸分子（mdRNA）。 本公开的mdRNA包含至少三条链，其组合形成由切口或间隙分开的至少两个非重叠双链区域，其中一条链与MYC mRNA互补。 此外，meroduplex可以具有至少一个用5-甲基尿苷取代的尿苷，被锁定的核酸替代的核苷，或任选的其它修饰，以及它们的任何组合。 还提供减少细胞或受试者中MYC基因表达以治疗MYC相关疾病的方法。

    NUCLEIC ACID COMPOUNDS FOR INHIBITING BCL2 GENE EXPRESSION AND USES THEREOF
    7.
    发明申请
    NUCLEIC ACID COMPOUNDS FOR INHIBITING BCL2 GENE EXPRESSION AND USES THEREOF 审中-公开
    用于抑制BCL2基因表达的核酸化合物及其用途

    公开(公告)号：US20100041140A1

    公开(公告)日：2010-02-18

    申请号：US12529011

    申请日：2008-02-29

    申请人： Steven C. Quay ,  James McSwiggen ,  Narendra K. Vaish ,  Mohammad Ahmadian

    发明人： Steven C. Quay ,  James McSwiggen ,  Narendra K. Vaish ,  Mohammad Ahmadian

    IPC分类号： C12N5/07 ,  C07H21/02

    CPC分类号： C12N15/1135 ,  C12N2310/14 ,  C12N2310/53

    摘要： The present disclosure provides meroduplex ribonucleic acid molecules (mdRNA) capable of decreasing or silencing BCL2 gene expression. An mdRNA of this disclosure comprises at least three strands that combine to form at least two non-over-lapping double-stranded regions separated by a nick or gap wherein one strand is complementary to a BCL2 mRNA. In addition, the meroduplex may have at least one uridine is a 5-methyluridine, a nucleoside is a locked nucleic acid, or optionally other modifications, and any combination thereof. Also provided are methods of decreasing expression of a BCL2 gene in a cell or in a subject to treat a BCL2-related disease.

    摘要翻译： 本公开提供能够降低或沉默BCL2基因表达的meroduplex核糖核酸分子（mdRNA）。 本公开的mdRNA包含至少三条链，其组合形成由切口或间隙分开的至少两个非重叠双链区域，其中一条链与BCL2 mRNA互补。 此外，meroduplex可以具有至少一个尿苷是5-甲基尿苷，核苷是锁定的核酸或任选的其它修饰，以及它们的任何组合。 还提供减少细胞或受试者中BCL2基因表达以治疗BCL2相关疾病的方法。

    RIBONUCLEIC ACIDS WITH NON-STANDARD BASES AND USES THEREOF
    8.
    发明申请
    RIBONUCLEIC ACIDS WITH NON-STANDARD BASES AND USES THEREOF 审中-公开
    具有非标准基础的RIBONUCLEIC ACIDS及其用途

    公开(公告)号：US20100015708A1

    公开(公告)日：2010-01-21

    申请号：US12486889

    申请日：2009-06-18

    申请人： Steven C. Quay ,  Narendra K. Vaish

    发明人： Steven C. Quay ,  Narendra K. Vaish

    IPC分类号： C12N5/06 ,  C07H21/02

    CPC分类号： C07H21/02

    摘要： The present disclosure provides a ribonucleic acid comprising a double-stranded region having at least one base pair comprising a 5-methyluridine base paired with a 2,6-diaminopurine and methods for preparing the same. Also provided are methods for treating or preventing a disease or disorder by inducing RNAi.

    摘要翻译： 本公开内容提供了包含具有至少一个碱基对的双链区域的核糖核酸，所述碱基对包含与2,6-二氨基嘌呤配对的5-甲基尿苷碱基及其制备方法。 还提供了通过诱导RNAi治疗或预防疾病或病症的方法。

    COMPOSITIONS FOR ENHANCED EPITHELIAL PERMEATION OF PEPTIDE YY FOR TREATING OBESITY
    9.
    发明申请
    COMPOSITIONS FOR ENHANCED EPITHELIAL PERMEATION OF PEPTIDE YY FOR TREATING OBESITY 失效
    用于治疗肥胖的肽增强上皮组合物

    公开(公告)号：US20090118158A1

    公开(公告)日：2009-05-07

    申请号：US12234547

    申请日：2008-09-19

    申请人： Steven C. Quay

    发明人： Steven C. Quay

    IPC分类号： A61K38/00 ,  A61P3/04

    CPC分类号： A61K9/0043 ,  A61K38/1709

    摘要： Pharmaceutical compositions comprising PYY(3-36), a cyclodextrin, and a compound selected from phosphatidylcholine or diglyceride, wherein the PYY(3-36) is present in an amount effective to alleviate one or more symptom(s) of obesity in a subject, and the cyclodextrin and the compound selected from phosphatidylcholine or diglyceride are present in an amount sufficient to enhance epithelial permeation.

    摘要翻译： 包含PYY（3-36），环糊精和选自磷脂酰胆碱或甘油二酯的化合物的药物组合物，其中PYY（3-36）以有效减轻受试者的一种或多种肥胖症状的量存在 ，并且环糊精和选自磷脂酰胆碱或甘油二酯的化合物以足以增加上皮渗透的量存在。