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公开(公告)号：US5318890A
公开(公告)日：1994-06-07
申请号：US695805
申请日：1991-05-06
申请人： Steven Rosen , Mark Singer , Yasuyuki Imai , Ted Yednock
发明人： Steven Rosen , Mark Singer , Yasuyuki Imai , Ted Yednock
IPC分类号： A61K38/00 , A61P29/00 , C07K14/47 , C07K14/705 , C07K16/28 , C12N15/12 , C12Q1/02 , G01N33/53 , G01N33/566 , C12Q1/00
CPC分类号： C07K14/4727 , C07K14/70564 , C07K14/70596 , C07K16/28 , C07K16/2854 , A61K38/00 , C07K2317/34 , C07K2319/00 , C07K2319/33
摘要： The present invention provides novel assays for determining the ability of a test compound to inhibit intercellular adhesion mediated by a selectin receptor, such as the LHR. The assays involve contacting the test compound with the receptor and an isolated receptor-binding agent. The receptor-binding agent is a sulfated polysaccharide, a sulfated glycolipid, or a compound comprising the extracellular region of an endothelial cell surface glycoprotein. Also provided are compositions comprising a compound comprising the extracellular region of an endothelial cell surface protein, which is specifically recognized by lymphocyte homing receptors.
摘要翻译： 本发明提供了用于测定测试化合物抑制由选择素受体（例如LHR）介导的细胞间粘附的能力的新型测定法。 测定包括使测试化合物与受体和分离的受体结合剂接触。 受体结合剂是硫酸化多糖，硫酸化糖脂或包含内皮细胞表面糖蛋白的胞外区的化合物。 还提供了包含由淋巴细胞归巢受体特异性识别的内皮细胞表面蛋白的细胞外区的化合物的组合物。
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公开(公告)号：US20190109477A1
公开(公告)日：2019-04-11
申请号：US16151424
申请日：2018-10-04
IPC分类号： H02J7/00 , H01M10/613 , H01M10/615 , H01M10/659 , H02J7/35
摘要： Systems and methods for managing and utilizing heat associated with battery charge and/or discharge cycles are described herein. A system as described herein includes a battery array comprising one or more batteries, a heat collector physically coupled to respective batteries of the battery array that captures heat associated with at least one of charge cycles or discharge cycles of the respective batteries of the battery array, and a routing controller communicatively coupled to the heat collector that initiates transference of the heat captured by the heat collector as an energy source to one or more subsystems that are distinct from the heat collector.
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公开(公告)号：US20190102730A1
公开(公告)日：2019-04-04
申请号：US16151412
申请日：2018-10-04
摘要： Techniques that facilitate drone delivery and landing, particularly with respect to home and commercial package delivery, are provided. In one example, a computer-implemented method comprises: detecting, by a system comprising a processor, presence of a drone device within a defined vicinity of a protected area, wherein the protected area is accessible via an opening that is blocked by a physical barrier. The method further comprises controlling, by the system, access by the drone device to the protected area to drop off or pick up a package by controlling removal of the physical barrier based in part on detection of the drone device within the defined vicinity of the protected area.
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公开(公告)号：US20190101306A1
公开(公告)日：2019-04-04
申请号：US16151387
申请日：2018-10-04
摘要： Facilitating structure automation functionality by automatically modifying a condition of an environment based on implementing a parameter adjustment at a remote device within the structure is provided herein. A method can comprise facilitating a communication link between a controller device, a first auxiliary device, and a second auxiliary device. Facilitating the communication link comprises defining a communication standard that controls a communication between the first auxiliary device and the second auxiliary device. The method can also comprise implementing a first change at the first auxiliary device based on a first determination that a first condition within an environment of the first auxiliary device is to be changed. Further, the method can comprise implementing a second change at the second auxiliary device based on a second determination that a second condition within the environment of the second auxiliary device is to be changed.
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公开(公告)号：US11233782B2
公开(公告)日：2022-01-25
申请号：US16151391
申请日：2018-10-04
IPC分类号： H04L29/06 , H04L9/32 , H04W12/08 , H04W12/63 , H04W12/069 , H04L29/08 , H04W4/02 , H04W4/70 , H04W4/021
摘要： Facilitating single node network connectivity for structure automation functionality is provided herein. A system can comprise a memory that stores executable components and a processor, operatively coupled to the memory, that executes the executable components. The executable components can comprise a management component that facilitates a communication with electronic devices within a structure and an initialization component that enables a streamlined security process based on an indication that the at least one electronic device is to be registered with the management component. Further, the executable components can comprise a negotiation component that performs a certificate authentication for the at least one electronic device. The certificate authentication can be automatically performed with a certificate authority during a backend process.
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公开(公告)号：US10707804B2
公开(公告)日：2020-07-07
申请号：US16206320
申请日：2018-11-30
IPC分类号： H02S20/25 , H02S50/10 , H02S40/38 , E04D1/30 , G05B19/048 , F24S20/69 , H02S40/32 , E04D1/12 , H02S50/00 , H01L35/30
摘要： At least one shingle is integrated with logic circuitry and various other components which enable high-level functionality and automated system diagnostics. Each shingle can automatically determine its absolute position on a rooftop and/or its position relative to other shingles in the smart shingle system. Each shingle can also detect various changes in its own power generation, efficiency, and/or operating conditions, as well as those of neighboring shingles. Each shingle can then leverage this information to conduct system diagnostics and possibly to generate and/or execute recommended solutions. In another embodiment, each shingle can be coupled to a centralized controller which can perform the same automapping and diagnostic functions. The controller can also monitor the power usage of the building to help optimize the power generation of the smart shingle system. In some embodiments, the smart shingle system can be outfitted with heating components and/or actuators to help automate the process of keeping the smart shingles clear of debris.
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公开(公告)号：US20190165718A1
公开(公告)日：2019-05-30
申请号：US16206320
申请日：2018-11-30
摘要： At least one shingle is integrated with logic circuitry and various other components which enable high-level functionality and automated system diagnostics. Each shingle can automatically determine its absolute position on a rooftop and/or its position relative to other shingles in the smart shingle system. Each shingle can also detect various changes in its own power generation, efficiency, and/or operating conditions, as well as those of neighboring shingles. Each shingle can then leverage this information to conduct system diagnostics and possibly to generate and/or execute recommended solutions. In another embodiment, each shingle can be coupled to a centralized controller which can perform the same automapping and diagnostic functions. The controller can also monitor the power usage of the building to help optimize the power generation of the smart shingle system. In some embodiments, the smart shingle system can be outfitted with heating components and/or actuators to help automate the process of keeping the smart shingles clear of debris.
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公开(公告)号：US20190104119A1
公开(公告)日：2019-04-04
申请号：US16151391
申请日：2018-10-04
摘要： Facilitating single node network connectivity for structure automation functionality is provided herein. A system can comprise a memory that stores executable components and a processor, operatively coupled to the memory, that executes the executable components. The executable components can comprise a management component that facilitates a communication with electronic devices within a structure and an initialization component that enables a streamlined security process based on an indication that the at least one electronic device is to be registered with the management component. Further, the executable components can comprise a negotiation component that performs a certificate authentication for the at least one electronic device. The certificate authentication can be automatically performed with a certificate authority during a backend process.
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公开(公告)号：US20060229435A1
公开(公告)日：2006-10-12
申请号：US11327164
申请日：2006-01-05
申请人： Laurence Lasky , Scott Stachel , Steven Rosen , Mark Singer , Ted Yednock
发明人： Laurence Lasky , Scott Stachel , Steven Rosen , Mark Singer , Ted Yednock
CPC分类号： C07K14/705 , A61K38/00 , C07K2319/02 , C07K2319/32 , C07K2319/33 , C07K2319/705
摘要： DNA isolates coding for the lymphocyte homing receptor and methods of obtaining such DNA are provided, together with expression systems for recombinant production of the lymphocyte homing receptor useful in therapeutic or diagnostic compositions.
摘要翻译： 提供了编码淋巴细胞归巢受体的DNA分离物和获得这种DNA的方法，以及可用于治疗或诊断组合物的淋巴细胞归巢受体重组产生的表达系统。
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公开(公告)号：US20050222011A1
公开(公告)日：2005-10-06
申请号：US10934272
申请日：2004-09-03
申请人： Steven Rosen , Christopher Sassetti
发明人： Steven Rosen , Christopher Sassetti
IPC分类号： C12N15/09 , A61K38/00 , A61K38/17 , A61K39/395 , A61P29/00 , A61P43/00 , C07K14/47 , C07K14/705 , C07K16/18 , C07K16/28 , C12P21/02 , C12P21/08
CPC分类号： C07K16/28 , A01K2217/05 , A61K38/00 , C07K14/705 , C07K2319/30
摘要： Podocalyxin like proteins (e.g. PCLP and PCLP-2) having selectin ligand activity are provided. Also provided are nucleic acid compositions encoding novel PCLP-2 proteins. The subject polypeptide and nucleic acid compositions find use in a variety of applications, including research, diagnostic, and therapeutic agent screening applications, as well as in treatment therapies for disease conditions associated with podocalyxin like protein activity. In particular, methods of treating diseases associated with podocalyxin like protein selectin binding activity and/or chemokine presenting activity are provided, where such diseases include inflammation and the like.
摘要翻译： 提供了具有选择蛋白配体活性的磷霉素样蛋白（例如PCLP和PCLP-2）。 还提供了编码新型PCLP-2蛋白质的核酸组合物。 主题多肽和核酸组合物可用于各种应用，包括研究，诊断和治疗剂筛选应用，以及用于与足胶质细胞样蛋白活性相关的疾病状况的治疗疗法。 特别地，提供了治疗与足胶质相关疾病如蛋白质选择蛋白结合活性和/或趋化因子呈递活性的方法，其中这些疾病包括炎症等。
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