公开(公告)号：US20060257879A1

公开(公告)日：2006-11-16

申请号：US10566792

申请日：2004-08-02

Applicant: Stuart Wilson ,  Christopher Stanley ,  Sharon Banin

Inventor： Stuart Wilson ,  Christopher Stanley ,  Sharon Banin

IPC: C12Q1/68 ,  C12Q1/34

CPC classification number: C12Q1/42 ,  C12Q1/6806 ,  G01N33/573 ,  G01N33/57434

Abstract: The present invention provides a method of detecting an enzyme in a sample wherein the enzyme is capable of adding or removing a chemical moiety to or from a nucleic acid molecule, which thereby confers altered sensitivity of the nucleic acid molecule in a subsequent process. The invention also relates to diagnostic methods which take advantage of the method of the invention and kits which are useful for carrying out the method of the invention.

Abstract translation: 本发明提供了一种检测样品中的酶的方法，其中酶能够向或从核酸分子添加或除去化学部分，从而赋予核酸分子在随后的方法中更高的敏感性。 本发明还涉及利用本发明方法和可用于实施本发明方法的试剂盒的诊断方法。

公开(公告)号：US20050256142A1

公开(公告)日：2005-11-17

申请号：US11033692

申请日：2005-01-11

Applicant: Peter Fischer ,  Michael Jarman ,  Edward McDonald ,  Bernard Nutley ,  Florence Raynaud ,  Stuart Wilson ,  Paul Workman

Inventor： Peter Fischer ,  Michael Jarman ,  Edward McDonald ,  Bernard Nutley ,  Florence Raynaud ,  Stuart Wilson ,  Paul Workman

IPC: A61K31/52 ,  A61P3/10 ,  A61P9/00 ,  A61P17/06 ,  A61P17/14 ,  A61P25/28 ,  A61P31/12 ,  A61P35/00 ,  C07D473/16 ,  C07D473/12

CPC classification number: C07D473/16 ,  A61K31/52 ,  Y02A50/411

Abstract: The present invention relates to compounds of formula 1 or pharmaceutically acceptable salts thereof, wherein one of R1 and R2 is methyl, ethyl or isopropyl, and the other is H; R3 and R4 are each independently H, branched or unbranched C1-C6 alkyl, or aryl, and wherein at least one of R3 and R4 is other than H; R5 is a branched or unbranched C1-C5 alkyl group or a C1-C6 cycloalkyl group, each of which may be optionally substituted with one or more OH groups; R6, R7, R8 and R9 are each independently H, halogen, NO2, OH, OMe, CN, NH2, COOH, CONH2, or SO2NH2. A further aspect of the invention relates to pharmaceutical compositions comprising compounds of formula 1, and the use of said compounds in treating proliferative disorders, viral disorders, CNS disorders, diabetes, stroke, alopecia or neurodegenerative disorders.

Abstract translation: 本发明涉及式1化合物或其药学上可接受的盐，其中R 1和R 2之一是甲基，乙基或异丙基，另一个是H; R 3和R 4各自独立地为H，支链或非支链C 1 -C 6烷基或芳基 并且其中R 3和R 4中的至少一个不是H; R 5是支链或非支链C 1 -C 5烷基或C 1 -C 3亚烷基 其中每一个可以任选地被一个或多个OH基团取代; R 6，R 7，R 8和R 9各自独立地为H，卤素，NO 3， 2，OH，OMe，CN，NH 2，COOH，CONH 2或SO 2 NH 2， / SUB>。 本发明的另一方面涉及包含式1化合物的药物组合物，以及所述化合物在治疗增殖性疾病，病毒性疾病，中枢神经系统疾病，糖尿病，中风，脱发或神经变性疾病中的用途。

公开(公告)号：US06407843B1

公开(公告)日：2002-06-18

申请号：US09728376

申请日：2000-11-28

Applicant: Michael W. Rowan ,  Peter Chang ,  James F. Coward ,  Roger R. Taur ,  Stuart Wilson ,  Ting K. Yee

Inventor： Michael W. Rowan ,  Peter Chang ,  James F. Coward ,  Roger R. Taur ,  Stuart Wilson ,  Ting K. Yee

IPC: H04B1000

CPC classification number: H04J14/0298 ,  H04L1/0057 ,  H04L1/006 ,  H04L1/0065 ,  H04L1/0071 ,  H04L5/06 ,  H04L27/34 ,  H04L27/36 ,  H04L27/38 ,  H04L2001/0096

Abstract: A system transmits digital data over an optical fiber at high aggregate data rates and high bandwidth efficiencies. The system includes a modulation stage, a frequency division multiplexer, and an optical modulator. The modulation stage QAM-modulates a plurality of incoming digital data channels. The frequency division multiplexer combines the QAM-modulated signals by frequency division multiplexing them into an RF signal. The optical modulator uses the RF signal to modulate an optical carrier for transmission over an optical fiber.

Abstract translation: 系统以高聚合数据速率和高带宽效率通过光纤传输数字数据。 该系统包括调制级，频分多路复用器和光调制器。 调制级QAM调制多个输入数字数据通道。 分频多路复用器将QAM调制信号通过频率分频复用为RF信号进行组合。 光调制器使用RF信号来调制光载波以在光纤上传输。

公开(公告)号：US09096884B2

公开(公告)日：2015-08-04

申请号：US13264177

申请日：2010-04-19

Applicant: Stuart Wilson ,  William Mullen

Inventor： Stuart Wilson ,  William Mullen

IPC: C12Q1/04 ,  C12Q1/68

CPC classification number: C12Q1/04 ,  C12Q1/68 ,  C12Q1/689 ,  C12Q1/6895 ,  C12Q2521/501 ,  C12Q2527/119 ,  C12Q2533/10 ,  C12Q2537/149 ,  G01N2333/9015

Abstract: A method of detecting a ligase expressing micro-organism in a sample comprises steps of treating the sample under conditions that inhibit the activity of ATP-dependent ligase from mammalian cells but which do not inhibit the activity of the microbial ligases, contacting the sample or a portion of the sample with a nucleic acid molecule which acts as a substrate for ligase activity in the sample, incubating the thus contacted sample under conditions suitable for ligase activity; and specifically determining the presence and/or the amount of a ligated nucleic acid molecule resulting from the action of the ligase on the substrate nucleic acid molecule to indicate the presence of the ligase expressing micro-organism. The micro-organism may be a fungus or a bacterium or both. High pH conditions may be employed to inactivate mammalian ligases. Related kits are described.

Abstract translation: 检测样品中连接酶表达微生物的方法包括以下步骤：在抑制ATP依赖性连接酶从哺乳动物细胞的活性但不抑制微生物连接酶的活性，接触样品或 样品的一部分与核酸分子起作用，作为样品中连接酶活性的底物，在适合连接酶活性的条件下孵育由此接触的样品; 并且具体地确定由连接酶对底物核酸分子的作用产生的连接的核酸分子的存在和/或量，以指示表达微生物的连接酶的存在。 微生物可以是真菌或细菌或两者。 可以使用高pH条件来灭活哺乳动物连接酶。 描述相关工具包。

公开(公告)号：US08080375B2

公开(公告)日：2011-12-20

申请号：US11914697

申请日：2006-05-18

Applicant: Stuart Wilson ,  John Christopher Stanley ,  Sharon Banin

Inventor： Stuart Wilson ,  John Christopher Stanley ,  Sharon Banin

IPC: C12Q1/68

CPC classification number: G01N33/57434 ,  C12Q1/42 ,  C12Q1/682 ,  G01N33/573 ,  C12Q2563/179 ,  C12Q2521/525

Abstract: An improved method of detecting an enzyme in a sample, which enzyme is capable of adding or removing a chemical moiety to or from a nucleic acid molecule, thereby conferring the nucleic acid molecule with the ability to be extended to generate a novel detectable nucleic acid molecule, comprises the steps of allowing the sample to be tested for the presence of the enzyme to interact with the nucleic acid molecule; and testing for interaction of the enzyme with the nucleic acid molecule by detecting the novel nucleic acid molecule generated only in the presence of the enzyme. The preferred enzyme is a phosphatase. The methods have a number of applications, for example in enhancing the sensitivity of immunoassays, for detecting pathogen associated phosphatase, for diagnosing certain conditions and for detecting specific contaminants in a sample.

Abstract translation: 一种检测样品中酶的改进方法，该酶能够向或从核酸分子添加或除去化学部分，从而赋予具有延伸以产生新的可检测核酸分子的能力的核酸分子 包括以下步骤：使样品测试酶的存在与核酸分子相互作用; 并通过检测仅在酶存在下产生的新的核酸分子来测试酶与核酸分子的相互作用。 优选的酶是磷酸酶。 该方法具有许多应用，例如增强免疫测定的灵敏度，用于检测病原体相关磷酸酶，用于诊断某些条件并检测样品中的特定污染物。

公开(公告)号：US07612079B2

公开(公告)日：2009-11-03

申请号：US10742237

申请日：2003-12-18

Applicant: Peter Martin Fischer ,  Mike Jarman ,  Ted McDonald ,  Bernard Nutley ,  Florence Raynaud ,  Stuart Wilson ,  Paul Workman

Inventor： Peter Martin Fischer ,  Mike Jarman ,  Ted McDonald ,  Bernard Nutley ,  Florence Raynaud ,  Stuart Wilson ,  Paul Workman

IPC: C07D473/16 ,  A61K31/52 ,  A61P35/00 ,  C07C215/08 ,  A61P17/06 ,  A61P35/02

CPC classification number: C07D473/16

Abstract: The present invention relates to compounds of formula I or a pharmaceutically acceptable salt thereof wherein R2 is 2-hydroxymethylpyrrolidin-1-yl, or NHCH(R4)CH(R3)OH, wherein R3 is hydrogen or methyl and R4 is methyl, ethyl or isopropyl; R6 is 3-nitrophenylamino, 3,4-dimethoxybenzylamino, 3-iodobenzyl-amino, pyrid-2-yl-methylamino, pyrid-4-yl-methylamino or indan-5-amino; R9 is isopropyl or cyclopentanyl. In a further aspect, the invention relates to pharmaceutical compositions comprising said compounds, and the use thereof in treating antiproliferative disorders and or viral disorders.

Abstract translation: 本发明涉及式I化合物或其药学上可接受的盐，其中R2是2-羟甲基吡咯烷-1-基或NHCH（R4）CH（R3）OH，其中R3是氢或甲基，R4是甲基，乙基或 异丙基 R6是3-硝基苯基氨基，3,4-二甲氧基苄基氨基，3-碘苄基 - 氨基，吡啶-2-基 - 甲基氨基，吡啶-4-基 - 甲基氨基或茚满-5-氨基; R9是异丙基或环戊基。 在另一方面，本发明涉及包含所述化合物的药物组合物及其在治疗抗增生性疾病和/或病毒性疾病中的用途。

公开(公告)号：US07582642B2

公开(公告)日：2009-09-01

申请号：US11033692

申请日：2005-01-11

Applicant: Peter Martin Fischer ,  Michael Jarman ,  Edward McDonald ,  Bernard Nutley ,  Florence Raynaud ,  Stuart Wilson ,  Paul Workman

Inventor： Peter Martin Fischer ,  Michael Jarman ,  Edward McDonald ,  Bernard Nutley ,  Florence Raynaud ,  Stuart Wilson ,  Paul Workman

IPC: C07D473/16 ,  A61K31/52 ,  A61P35/00 ,  A61P31/14 ,  A61P31/20 ,  C07D473/40

CPC classification number: C07D473/16 ,  A61K31/52 ,  Y02A50/411

Abstract: The present invention relates to compounds of formula 1 or pharmaceutically acceptable salts thereof, wherein one of R1 and R2 is methyl, ethyl or isopropyl, and the other is H; R3 and R4 are each independently H, branched or unbranched C1-C6 alkyl, or aryl, and wherein at least one of R3 and R4 is other than H; R5 is a branched or unbranched C1-C5 alkyl group or a C1-C6 cycloalkyl group, each of which may be optionally substituted with one or more OH groups; R6, R7, R8 and R9 are each independently H, halogen, NO2, OH, OMe, CN, NH2, COOH, CONH2, or SO2NH2. A further aspect of the invention relates to pharmaceutical compositions comprising compounds of formula 1, and the use of said compounds in treating proliferative disorders, viral disorders, stroke, alopecia, CNS disorders, neurodegenerative disorders, or diabetes.

Abstract translation: 本发明涉及式1化合物或其药学上可接受的盐，其中R 1和R 2之一是甲基，乙基或异丙基，另一个是H; R 3和R 4各自独立地为H，支链或非支链的C 1 -C 6烷基或芳基，并且其中R 3和R 4中的至少一个不是H; R5是支链或非支链C 1 -C 5烷基或C 1 -C 6环烷基，其各自可以任选被一个或多个OH基取代; R6，R7，R8和R9各自独立地为H，卤素，NO2，OH，OMe，CN，NH2，COOH，CONH2或SO2NH2。 本发明的另一方面涉及包含式1化合物的药物组合物，以及所述化合物在治疗增殖性疾病，病毒性疾病，中风，脱发，中枢神经系统疾病，神经变性疾病或糖尿病中的用途。

公开(公告)号：US20090215047A1

公开(公告)日：2009-08-27

申请号：US11993986

申请日：2006-07-03

Applicant: Stuart Wilson ,  Sharon Banin

Inventor： Stuart Wilson ,  Sharon Banin

IPC: C12Q1/68

CPC classification number: C12Q1/25 ,  C12Q1/68 ,  C12Q1/6844 ,  Y02A50/52 ,  C12Q2563/143 ,  C12Q2561/125 ,  C12Q2521/543

Abstract: A method of detecting a molecule associated with viability of one or more cells or organisms in a sample comprises the initial step of contacting the sample with an enzyme, which enzyme is capable of adding or removing a chemical moiety to or from a nucleic acid molecule in the presence of the molecule associated with viability of the of the one or more cells or organisms. This thereby generates a novel detectable nucleic acid molecule. The next step involves detecting the presence of the molecule associated with viability of the one or more cells or organisms by detecting the novel nucleic acid molecule generated only in the presence of the molecule associated with viability of the one or more cells or organisms. A most preferred molecule associated with viability is ATP, although NAD may also be detected. A preferred enzyme for use in the methods is ligase. The method has numerous applications, in particular in monitoring viability of cells, toxicology testing and determining whether there is contamination in a sample or on a surface. Kits are also provided for carrying out the methods.

Abstract translation: 检测与样品中一种或多种细胞或生物体的活力相关的分子的方法包括使样品与酶接触的初始步骤，该酶能够在或从其中的核酸分子中加入或除去化学部分 与一种或多种细胞或生物的活力相关的分子的存在。 由此产生新的可检测的核酸分子。 下一步涉及通过检测仅在与一种或多种细胞或生物体的活力相关的分子的存在下产生的新的核酸分子来检测与一种或多种细胞或生物体的存活力相关的分子的存在。 与活力相关的最优选的分子是ATP，尽管也可以检测到NAD。 用于该方法的优选酶是连接酶。 该方法具有许多应用，特别是在监测细胞的活力，毒理学测试和确定样品或表面是否存在污染。 还提供工具包来执行这些方法。

公开(公告)号：US20060183760A1

公开(公告)日：2006-08-17

申请号：US11238533

申请日：2005-09-28

Applicant: Peter Fischer ,  Michael Jarman ,  Edward McDonald ,  Bernard Nutley ,  Florence Raynaud ,  Stuart Wilson ,  Paul Workman

Inventor： Peter Fischer ,  Michael Jarman ,  Edward McDonald ,  Bernard Nutley ,  Florence Raynaud ,  Stuart Wilson ,  Paul Workman

IPC: A61K31/52 ,  C07D473/12

CPC classification number: C07D473/16

Abstract: The present invention relates to compounds of formula I or pharmaceutically acceptable salts thereof, wherein one of R1 and R2 is methyl, ethyl or isopropyl, and the other is H; R3 and R4 are each independently H, branched or un branched C1-C6 alkyl, or aryl, and wherein at least one of R3 and R4 is other than H; R5 is a branched or unbranched C1-C5 alkyl group or a C1-C6 cycloalkyl group, each of which may be optionally substituted with one or more OH groups; R6, R7, R8 and R9 are each independently H, halogen, NO2, OH, OMe, CN, NH2, COOH, CONH2, or SO2NH2. A further aspect of the invention relates to pharmaceutical compositions comprising compounds of formula 1, and the use of said compounds in treating proliferative disorders, viral disorders, CNS disorders, diabetes, stroke, alopecia or neurodegenerative disorders.

Abstract translation: 本发明涉及式I化合物或其药学上可接受的盐，其中R 1和R 2中的一个为甲基，乙基或异丙基，另一个为H; R 3和R 4各自独立地为H，支链或非支链C 1 -C 6烷基，或 芳基，并且其中R 3和R 4中的至少一个不是H; R 5是支链或非支链C 1 -C 5烷基或C 1 -C 3亚烷基 其中每一个可以任选地被一个或多个OH基团取代; R 6，R 7，R 8和R 9各自独立地为H，卤素，NO 3， 2，OH，OMe，CN，NH 2，COOH，CONH 2或SO 2 NH 2， / SUB>。 本发明的另一方面涉及包含式1化合物的药物组合物，以及所述化合物在治疗增殖性疾病，病毒性疾病，中枢神经系统疾病，糖尿病，中风，脱发或神经变性疾病中的用途。

公开(公告)号：US20060139210A1

公开(公告)日：2006-06-29

申请号：US11025397

申请日：2004-12-29

Applicant: Andy Stavros ,  Ming Tsai ,  Stuart Wilson

Inventor： Andy Stavros ,  Ming Tsai ,  Stuart Wilson

IPC: H01Q1/38

CPC classification number: H01Q9/285 ,  H01Q21/0025

Abstract: A phased antenna array is disclosed. The phased antenna array is composed of one or more modules and has a plurality of antenna. The array has a plurality of antenna configured to operate as an array and each module has at least one antenna. The modules have a substrate that supports the antenna, a microelectronic device for sending signals to or receiving signals from said antenna and conductive traces that connect that antenna to the microelectronic device. In those embodiments where the phased antenna array has more than one module, a common substrate supports the one or more modules. A combination of circuitry and interconnects achieves the desired electrical interconnection between the modules.