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公开(公告)号：US20120244609A1
公开(公告)日：2012-09-27
申请号：US13385100
申请日：2012-02-02
Applicant: Mark Selker , Barbara Paldus , Timothy Johnston
Inventor： Mark Selker , Barbara Paldus , Timothy Johnston
CPC classification number: C12M27/14 , C12M23/00 , C12M29/00 , C12M29/06 , G01N21/359 , G01N21/552 , G01N21/65 , G01N21/8507
Abstract: A composite sensor assembly for monitoring bio-processes which is suitable for use with a polymeric bioprocess vessel or with downstream equipment, and comprises: i) a port comprising a high surface tension thermoplastic having a hollow tubular portion and a base plate portion, the base plate portion being fusibly sealable to the bioreactor vessel at a hole in the wall thereof; ii) a generally opaque polymeric monitoring sensor assembly including electrical, and/or optical measurement components. The sensor assembly fits inside the bore of the hollow tubular portion of the port, and is adhesively retained therein.
Abstract translation: 一种用于监测适用于聚合物生物过程容器或与下游设备的生物过程的复合传感器组件，包括：i）包含具有中空管状部分和底板部分的高表面张力热塑性塑料的端口， 板部分在其壁的孔处易于密封到生物反应器容器; ii）包括电和/或光学测量部件的通常不透明的聚合物监测传感器组件。 传感器组件装配在端口的中空管状部分的孔内，并且粘合地保持在其中。
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公开(公告)号：US20090273447A1
公开(公告)日：2009-11-05
申请号：US12321657
申请日：2009-01-22
Applicant: Mark Selker , Charles Kamas , Barbara Paldus
Inventor： Mark Selker , Charles Kamas , Barbara Paldus
IPC: H04Q5/22
CPC classification number: A61L2/24 , A61L2/0035 , A61L2/081 , A61L2202/14 , G06K7/10366
Abstract: A data management system for a biological process, comprising: a. a single-use component, b. a tag assembly, including a non-volatile memory storage component, that is associated with the single-use component, c. the memory storage component including a unique identification and a memory, and at least one data element that describes a key performance, calibration or control parameter of the single-use component d. a memory reader useable to obtain the identification from the memory storage component
Abstract translation: 一种用于生物过程的数据管理系统，包括：a。 一次性使用的组件，b。 与单次使用组件相关联的标签组件，包括非易失性存储器存储组件，c。 所述存储器存储组件包括唯一标识和存储器，以及描述所述一次性组件d的关键性能，校准或控制参数的至少一个数据元素。 可用于从存储器存储组件获得标识的存储器读取器
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公开(公告)号：US07580128B2
公开(公告)日：2009-08-25
申请号：US11893033
申请日：2007-08-14
Applicant: Mark Selker
Inventor： Mark Selker
IPC: G01N21/00
CPC classification number: G01N21/51 , G01N21/75 , G01N21/84 , G01N2021/4707 , G01N2021/4709 , G01N2021/7783
Abstract: An optical loss probe utilized as a bioreactor process monitor manifesting a substantially linear response in optical loss vs. concentration of scatterers present in an aqueous medium in the range of between about 0 AU and about 4.0 AU, said probe comprising: i) a light source, ii) an optical detector, and iii) an optical gap between said light source and said optical detector, said optical detector having a receiving aperture configured such that the solid angle of acceptance of the light passing through said optical gap and impinging on said optical detector is less than π/50 radians.
Abstract translation: 一种用作生物反应器过程监测器的光学损耗探针，其表现出在水介质中存在于约0A0至约4.0AU范围内的散射体的光学损耗与散射体的基本线性响应，所述探针包括：i）光源 ，ii）光学检测器，以及iii）所述光源和所述光学检测器之间的光学间隙，所述光学检测器具有接收孔，所述接收孔被配置为使得通过所述光学间隙的光的入射角接近所述光学 检测器小于pi / 50弧度。
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14.发明申请System and method for gas analysis using doubly resonant photoacoustic spectroscopy 有权使用双共振光声光谱法进行气体分析的系统和方法公开(公告)号：US20060123884A1
公开(公告)日：2006-06-15
申请号：US11245748
申请日：2005-10-07
Applicant: Mark Selker , Alfred Riddle , Barbara Paldus
Inventor： Mark Selker , Alfred Riddle , Barbara Paldus
IPC: G01N21/00
CPC classification number: G01N21/1702 , G01N2021/1704
Abstract: A method for analyzing gas concentration using doubly resonant photoacoustic spectroscopy, and a doubly resonant photaoacoustic gas detector comprising: i) a continuous wave light beam whose wavelength coincides with an absorption wavelength of a gaseous analyte; ii) a closed path optical cavity having at least two reflective surfaces; iii) an acoustic resonator chamber contained within said optical cavity, and comprising an acoustic sensor for detecting sound waves generated by a gaseous analyte present within said chamber, the light beam passing sequentially into, through and out of said chamber, and being repeatedly reflected back and forth through said chamber, and being modulated at a frequency which is equal to or equal to one-half of an acoustic resonance frequency of said acoustic resonator chamber.
Abstract translation: 一种使用双共振光声光谱分析气体浓度的方法，以及双谐振光声气体检测器，包括：i）连续波光束，其波长与气态分析物的吸收波长一致; ii）具有至少两个反射表面的封闭路径光腔; iii）包含在所述光学腔内的声学谐振腔，并且包括用于检测由所述室内存在的气态分析物产生的声波的声学传感器，所述光束顺序地通过，通过和离开所述腔室，并被反复反射回 并通过所述腔室进行调制，并以等于或等于所述声谐振腔的声共振频率的二分之一的频率进行调制。
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公开(公告)号：US10101209B2
公开(公告)日：2018-10-16
申请号：US13506585
申请日：2012-04-30
Applicant: Mark Selker , Barbara Paldus
Inventor： Mark Selker , Barbara Paldus
Abstract: A multi-analyte sensor system based on hollow core photonic bandgap fiber and Raman anti-Stokes spectroscopy. The system includes: i) an inlet to introduce an analyte sample into an analyzer chamber which analyzer includes; ii) a measurement system to derive the anti-Stokes spectral peaks and/or spectra of the sample; iii) a set of reference calibrants corresponding to the analytes of which the sample is primarily comprised; iv) a second inlet to introduce said calibrants into the analyzer chamber; v) a second measurement system to derive the anti-Stokes spectral peaks and/or spectra of the calibrants vi) an outlet through which the sample and calibrants are expelled from the analyzer chamber.
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Patent Agency Ranking
公开(公告)号：US09921576B2
公开(公告)日：2018-03-20
申请号：US12151254
申请日：2008-05-05
Applicant: Mark Selker , Barbara Paldus
Inventor： Mark Selker , Barbara Paldus
CPC classification number: G05B23/0221 , C12M41/48
Abstract: A bioreactor monitoring and/or control system utilizing only non-dedicated user input and information display devices, a digital controller and software, which system comprises: i) at least one diagnostic probe for measuring operating conditions in a bioreactor; ii) signal conditioning and communication electronics which supply operating current and/or voltage to the probe and which convert the diagnostic signal into a format accessible by a digital controller which directly receives the format converted signal and transmits it to software which enables the display device to show the converted signal, and also instruct the controller to implement changes in the operating conditions in the reactor, and iii) a software-based virtual transmitter which substantially replicates the keyboard, display, menu-tree and response of a physical sensor transmitter.
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公开(公告)号：US09868095B2
公开(公告)日：2018-01-16
申请号：US12008447
申请日：2008-01-10
Applicant: Mark Selker , Barbara Paldus
Inventor： Mark Selker , Barbara Paldus
CPC classification number: B01F11/0025 , B01F3/04248 , B01F11/0014 , B01F11/0017 , B01F15/00831 , B01F15/0085 , B01F15/00876 , B01F15/00883 , C12M23/02 , C12M23/28 , C12M27/10 , C12M27/16 , C12M27/20
Abstract: A cylindrical or annular polymeric bioreactor is disclosed which provides enhanced mixing and aeration of the growth medium while simultaneously offering reduced mechanical shear force.
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公开(公告)号：US20090027670A1
公开(公告)日：2009-01-29
申请号：US11893033
申请日：2007-08-14
Applicant: Mark Selker
Inventor： Mark Selker
IPC: G01N21/49
CPC classification number: G01N21/51 , G01N21/75 , G01N21/84 , G01N2021/4707 , G01N2021/4709 , G01N2021/7783
Abstract: An optical loss probe utilized as a bioreactor process monitor manifesting a substantially linear response in optical loss vs. concentration of scatterers present in an aqueous medium in the range of between about 1 AU and about 4.0 AU, said probe comprising: i) a light source, ii) an optical detector, and iii) an optical gap between said light source and said optical detector, said optical detector having a receiving aperture configured such that the solid angle of acceptance of the light passing through said optical gap and impinging on said optical detector is less than π/50 radians.
Abstract translation: 一种用作生物反应器过程监测器的光损耗探针，其表现出在水介质中存在于约1 AU至约4.0 AU范围内的散射体的光学损耗与散射体的浓度之间的基本线性响应，所述探针包括：i）光源 ，ii）光学检测器，以及iii）所述光源和所述光学检测器之间的光学间隙，所述光学检测器具有接收孔，所述接收孔被配置为使得通过所述光学间隙的光的入射角接近所述光学 检测器小于pi / 50弧度。
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公开(公告)号：US10227555B2
公开(公告)日：2019-03-12
申请号：US13134157
申请日：2011-05-31
Applicant: Mark Selker , Barbara Paldus , Timothy Johnston
Inventor： Mark Selker , Barbara Paldus , Timothy Johnston
IPC: C12M1/34 , C12M1/00 , C12M3/06 , G01N21/359 , G01N21/552 , G01N21/65 , G01N21/78 , G01N21/80 , G01N21/77
Abstract: A composite sensor assembly for monitoring bio-processes which is suitable for use with a polymeric bioprocess vessel or with downstream equipment, and comprises: i) a port comprising a high surface tension thermoplastic having a hollow tubular portion and a base plate portion, the base plate being fusibly sealable to the bioreactor vessel at a hole in the wall thereof; ii) a generally opaque polymeric monitoring sensor assembly including electrical, and/or optical measurement components. The sensor assembly fits inside the bore of the hollow tubular portion of the port, and is adhesively retained therein.
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公开(公告)号：US09050379B2
公开(公告)日：2015-06-09
申请号：US12321657
申请日：2009-01-22
Applicant: Mark Selker , Charles Kamas , Barbara Paldus
Inventor： Mark Selker , Charles Kamas , Barbara Paldus
CPC classification number: A61L2/24 , A61L2/0035 , A61L2/081 , A61L2202/14 , G06K7/10366
Abstract: A data management system for a biological process, comprising: a. a single-use component, b. a tag assembly, including a non-volatile memory storage component, that is associated with the single-use component, c. the memory storage component including a unique identification and a memory, and at least one data element that describes a key performance, calibration or control parameter of the single-use component d. a memory reader useable to obtain the identification from the memory storage component.
Abstract translation: 一种用于生物过程的数据管理系统，包括：a。 一次性使用的组件，b。 与单次使用组件相关联的标签组件，包括非易失性存储器存储组件，c。 所述存储器存储组件包括唯一标识和存储器，以及描述所述一次性组件d的关键性能，校准或控制参数的至少一个数据元素。 可用于从存储器存储组件获得标识的存储器读取器。
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