Prodrugs based on gemcitabine structure and synthetic methods and applications thereof
    11.
    发明授权
    Prodrugs based on gemcitabine structure and synthetic methods and applications thereof 失效
    基于吉西他滨结构的前体药物及其合成方法及应用

    公开(公告)号:US08653048B2

    公开(公告)日:2014-02-18

    申请号:US13265335

    申请日:2010-03-25

    IPC分类号: A61K31/70 C07H19/00

    CPC分类号: C07H19/06 A61K31/7068

    摘要: Prodrugs based on gemcitabine structure shown in formula (I) as well as their synthetic method and application are disclosed in the present invention, wherein the definitions for the groups of a, b, c, d, E, Z and V are described in the specification. By modifying the N4 group, the solubility, the bioavailability and the organ specificity of the prodrugs are improved. Therefore, the fast metabolism problem is overcome for the produced prodrugs compounds. Intestinal toxicity induced by gemcitabine is decreased. Thereby, the prodrugs can be delivered by oral administration in clinics and further improve their anti-tumor, anti-cancer, anti-infection and diffusion preventing capability, and can also specifically act on liver or colon. The synthetic method is simple and adapted to industrial production.

    摘要翻译: 基于式(I)所示的吉西他滨结构的前药以及它们的合成方法和应用在本发明中公开,其中a,b,c,d,E,Z和V组的定义描述于 规范。 通过改变N4基团,前药的溶解度,生物利用度和器官特异性得到改善。 因此,所制备的前药化合物克服了快速代谢问题。 吉西他滨引起的肠毒性降低。 因此,前药可以通过口服给药在临床中进一步提高其抗肿瘤,抗癌,抗感染和扩散防止能力,并且还可以特异性地作用于肝脏或结肠。 合成方法简单,适应工业生产。

    Method and device of session control
    12.
    发明授权
    Method and device of session control 有权
    会话控制的方法和设备

    公开(公告)号:US08549153B2

    公开(公告)日:2013-10-01

    申请号:US13002288

    申请日:2009-06-24

    IPC分类号: G06F15/16

    摘要: A method and device of session control are used to resolve the problem that when there is a failure in the session control function bound with the user, the UE can not re-login in time or the session can not be continued. In the flow of the user initial login, an address information of P-CSCF bound with the user in HSS is saved, so that when the user is called, an available S-CSCF can get the address information of P-CSCF bound with the called user from the HSS, and inform the user to do re-initial login according to the address information of P-CSCF or complete the session continuation; further, the address information of the user in D-HSS is saved, so that when the user is called, an available A-CSCF can get the address information of the called user from the D-HSS, and inform the user to do re-initial login according to the address information of the called user or complete the session continuation.

    摘要翻译: 使用会话控制的方法和装置来解决当与用户绑定的会话控制功能发生故障时,UE不能及时重新登录或不能继续进行会话。 在用户初始登录的流程中,保存与HSS中的用户绑定的P-CSCF的地址信息,使得当用户被叫时,可用的S-CSCF可以获得与 从HSS中呼叫用户,并根据P-CSCF的地址信息通知用户重新登录,或完成会话继续; 此外,D-HSS中的用户的地址信息被保存,使得当用户被叫时,可用的A-CSCF可以从D-HSS获取被叫用户的地址信息,并通知用户做re - 根据被叫用户的地址信息初始登录或完成会话继续。

    Method and system for payment through mobile devices
    14.
    发明授权
    Method and system for payment through mobile devices 有权
    通过移动设备支付的方法和系统

    公开(公告)号:US08503993B2

    公开(公告)日:2013-08-06

    申请号:US12802280

    申请日:2010-06-02

    申请人: Gang Li

    发明人: Gang Li

    IPC分类号: H04M3/42

    摘要: Processing payment through a mobile device includes: receiving a command; using an upper layer application program on the mobile device to generate a payment request based on the command and send the payment request to localhost address of the mobile device via a predetermined port; using a lower layer payment program on the mobile device to monitor the payment request sent from the localhost address of the mobile device via the predetermined port; in response to the payment request, using the lower layer payment program to provide an input interface for payment information in and receive the input payment information; using the lower layer payment program to connect with a payment server and pass the payment information over a network to the payment server; and using the lower layer payment program to transfer a payment processing result received from the payment server, to the upper layer application program.

    摘要翻译: 通过移动设备处理支付包括:接收命令; 在所述移动设备上使用上层应用程序,基于所述命令生成支付请求,并经由预定端口向所述移动设备的本地主机地址发送所述支付请求; 在所述移动设备上使用较低层支付程序来监视经由所述预定端口从所述移动设备的本地主机地址发送的支付请求; 响应于支付请求,使用较低层支付程序为支付信息提供输入接口并接收输入的支付信息; 使用下层支付程序与支付服务器连接并通过网络将支付信息传递到支付服务器; 并且使用较低层支付程序将从支付服务器接收到的支付处理结果传送到上层应用程序。

    Package for micro-electro-mechanical acoustic transducer with improved double side mountable electrodes
    15.
    发明授权
    Package for micro-electro-mechanical acoustic transducer with improved double side mountable electrodes 有权
    用于具有改进的双面安装电极的微机电声换能器的封装

    公开(公告)号:US08472647B2

    公开(公告)日:2013-06-25

    申请号:US12416186

    申请日:2009-04-01

    申请人: Jia-Xin Mei Gang Li

    发明人: Jia-Xin Mei Gang Li

    IPC分类号: H04R25/00 H01L29/84

    摘要: A surface mountable package includes a base and a cover with a cavity defined thereby, and an acoustic transducer unit received in the cavity. The cover includes a first metal ring to enclose the acoustic transducer unit. The base includes a second metal ring to press against the first metal ring in order to form a metal shielding area. First and second metal connecting paths are formed electrically connected to the metal shielding area and the acoustic transducer unit, respectively. Besides, two pairs of first and second surface mountable metal electrodes are electrically connected to the first and the second metal connecting paths, respectively. As a result, the package can be selectively double surface mountable to a user's circuit board via the metal electrodes of the base or the metal electrodes of the cover.

    摘要翻译: 表面可安装的包装包括底座和由其限定的空腔的盖,以及容纳在空腔中的声学换能器单元。 盖包括用于封闭声换能器单元的第一金属环。 底座包括第二金属环,以压靠第一金属环以形成金属屏蔽区域。 第一和第二金属连接路径分别形成为电连接到金属屏蔽区域和声学换能器单元。 此外,两对第一和第二可表面安装的金属电极分别电连接到第一和第二金属连接路径。 结果,封装可以通过基座的金属电极或盖的金属电极选择性地双面表面安装到用户的电路板。

    HOUGH TRANSFORM APPROACH TO GAP MEASUREMENT IN BLADE INSPECTION
    16.
    发明申请
    HOUGH TRANSFORM APPROACH TO GAP MEASUREMENT IN BLADE INSPECTION 有权
    叶片检查中的GAP测量的粗糙变换方法

    公开(公告)号:US20130088587A1

    公开(公告)日:2013-04-11

    申请号:US13617416

    申请日:2012-09-14

    IPC分类号: H04N5/33

    摘要: Two adjacent objects with a gap between the objects rotate in a hot atmosphere with a temperature greater than 300 F in a gas turbine. Automatic and accurate contactless measurement of the gap is performed by taking images of the gap. An image, preferably an infra-red image is taken from the gap, a processor extracts the two edges from the image of the gap. The processor also determines a line through the pixels of an edge by applying a Hough transform on the pixels. The edges are substantially parallel. A line substantially perpendicular to the lines is also determined. Using the substantially parallel lines and the line substantially perpendicular to the substantially parallel lines the processor determines a width of the gap.

    摘要翻译: 在燃气轮机中,具有物体之间的间隙的两个相邻物体在温度大于300°F的热气氛中旋转。 通过拍摄间隙的图像来进行间隙的自动和准确的非接触式测量。 从间隙中取出图像,优选地是红外图像,处理器从间隙的图像中提取两个边缘。 处理器还通过在像素上应用霍夫变换来确定穿过边缘的像素的线。 边缘基本上平行。 还确定了基本上垂直于线的线。 使用基本平行的线和基本上垂直于基本上平行的线的线,处理器确定间隙的宽度。

    REFRIGERATOR
    17.
    发明申请
    REFRIGERATOR 有权
    冰箱

    公开(公告)号:US20120227433A1

    公开(公告)日:2012-09-13

    申请号:US13510851

    申请日:2010-10-18

    IPC分类号: F25D23/00 F25D23/12 F25C1/00

    CPC分类号: F25D23/126 F25C5/22 F25D11/02

    摘要: A refrigerator includes a cabinet defining a refrigerating chamber and a freezing chamber, an ice making device and an ice making water supply device. A variable temperature drawer is disposed in lower part of the refrigerating chamber. The ice making water supply device includes a water tank disposed above the variable temperature drawer, a water pump connected with the water tank, and a water pipe connected with the water tank and the ice making device for introducing the water in the water tank into the ice making device. With the refrigerator according to embodiments, the water quality is ensured and the preservation effect is improved. Because the temperature of the variable temperature drawer is generally in the range of −3° C. to 8° C., the water in the water tank is not easy to be frozen, and can be supplied to the ice making device continuously.

    摘要翻译: 冰箱包括限定冷藏室和冷冻室的柜体,制冰装置和制冰供水装置。 可变温度抽屉布置在冷藏室的下部。 制冰供水装置包括设置在可变温度抽屉上方的水箱,与水箱连接的水泵,以及与水箱连接的水管和制冰装置,用于将水箱中的水引入 制冰装置 根据实施方式的冰箱,能够确保水质,提高保存效果。 因为可变温度抽屉的温度通常在-3℃至8℃的范围内,水箱中的水不容易冷冻,并且可以连续供应给制冰装置。

    TRANSMITTER, BASE STATION DEVICE, AND METHOD FOR ALIGNING SIGNAL OUTPUT FROM TRANSMITTER
    18.
    发明申请
    TRANSMITTER, BASE STATION DEVICE, AND METHOD FOR ALIGNING SIGNAL OUTPUT FROM TRANSMITTER 有权
    发射机,基站装置以及用于从信号发射器调制信号输出的方法

    公开(公告)号:US20120202442A1

    公开(公告)日:2012-08-09

    申请号:US13503179

    申请日:2009-10-22

    申请人: Gang Li

    发明人: Gang Li

    IPC分类号: H04W24/00 H04B17/00

    CPC分类号: H04W56/001 H04W24/06

    摘要: A transmitter, a base station device, and a method for aligning a signal output from a transmitter are provided. The transmitter is connected to a first antenna, and the first antenna detects a second test signal transmitted by a second antenna that is connected to another transmitter. The transmitter includes: a signal generating unit, which generates a first test signal; a directional coupler, which receives the first test signal and the second test signal; and a signal processing unit, which measures a timing difference between the first test signal and the second test signal, and uses the measured timing difference to control signal generation, so as to align a signal transmission delay between the two transmitters. Thus, closed-loop detection and an adaptive rectification mechanism for transmission signals of multiple transmitters can be implemented, and accuracy of aligning a signal at each transmitting antenna is improved.

    摘要翻译: 提供了一种发射机,基站装置和用于对准从发射机输出的信号的方法。 发射机连接到第一天线,第一天线检测由连接到另一发射机的第二天线发射的第二测试信号。 发射机包括:信号产生单元,产生第一测试信号; 定向耦合器,其接收第一测试信号和第二测试信号; 以及信号处理单元,其测量第一测试信号和第二测试信号之间的定时差,并且使用测量的定时差来控制信号生成,以便对准两个发射机之间的信号传输延迟。 因此,可以实现用于多个发射机的发射信号的闭环检测和自适应整流机制,并且改善每个发射天线处的信号对准精度。

    Electrical connector with stacked ports
    20.
    发明申请
    Electrical connector with stacked ports 审中-公开
    具有堆叠端口的电气连接器

    公开(公告)号:US20090170369A1

    公开(公告)日:2009-07-02

    申请号:US12317862

    申请日:2008-12-29

    申请人: Hung-Chi Yu Gang Li

    发明人: Hung-Chi Yu Gang Li

    IPC分类号: H01R13/66 H01R13/40

    CPC分类号: H01R27/02 H01R12/712

    摘要: An electrical connector adapted for mounting on a printed circuit board (PCB) includes a first, a second and third mating port. The first and second mating ports are of horizontal types relative to the PCB and the third mating port is of vertical type. The first and second mating ports are stacked one over another and the third mating port is located at one side of the first mating port and the second mating port.

    摘要翻译: 适于安装在印刷电路板(PCB)上的电连接器包括第一,第二和第三配合端口。 第一和第二配合端口是相对于PCB的水平类型,并且第三配合端口是垂直型的。 第一和第二配合端口彼此堆叠,并且第三配合端口位于第一配合端口和第二配合端口的一侧。