公开(公告)号：US20210277030A1

公开(公告)日：2021-09-09

申请号：US17316185

申请日：2021-05-10

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Satoshi Yamamoto ,  Junya Shirai ,  Mitsunori Kono ,  Yoshihide Tomata ,  Ayumu Sato ,  Atsuko Ochida ,  Yoshiyuki Fukase ,  Shoji Fukumoto ,  Tsuneo Oda ,  Hidekazu Tokuhara ,  Naoki Ishii ,  Yusuke Sasaki

IPC: C07F7/08 ,  C07D205/04 ,  C07D207/12 ,  C07K5/065 ,  C07D239/36 ,  C07D213/64 ,  C07D309/06 ,  C07D333/38 ,  C07F7/10 ,  C07D403/06 ,  C07D271/10 ,  C07C237/22 ,  C07D295/14 ,  C07D207/26 ,  C07D413/12 ,  C07F7/30 ,  C07D233/72 ,  C07D309/08 ,  C07D231/56 ,  C07D261/08 ,  C07D209/18 ,  C07D405/12 ,  C07D261/12 ,  C07D239/54 ,  C07D211/62 ,  C07D237/14 ,  C07D231/12 ,  C07D487/04 ,  A61P43/00 ,  A61P29/00 ,  A61P25/00 ,  A61P19/02 ,  A61P17/06 ,  A61P1/04 ,  C07K5/087

Abstract: The present invention relates to compound (I) or a salt thereof which has a RORγt inhibitory action. In the formula (I), each symbol is as defined in the specification.

公开(公告)号：US20210106607A1

公开(公告)日：2021-04-15

申请号：US17065242

申请日：2020-10-07

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： MASATO YOSHIKAWA ,  Morihisa Saitoh ,  Taisuke Kato ,  Yayoi Nakayama ,  Tomohiro Seki ,  Yasuo Nakagawa ,  Yusuke Tominari ,  Masaki Seto ,  Yusuke Sasaki ,  Masanori Okaniwa ,  Tsuneo Oda ,  Akito Shibuya ,  Kosuke Hidaka ,  Zenyu Shiokawa ,  Shumpei Murata ,  Atsutoshi Okabe ,  Yoshihisa Nakada ,  Michiyo Mochizuki ,  Brian Scott Freeze ,  Taisuke Tawaraishi ,  Yasufumi Wada ,  Paul D. Greenspan

IPC: A61K31/7084 ,  A61P35/00 ,  C07H21/00 ,  C07H21/02 ,  A61K47/68 ,  A61K31/7076

Abstract: The present disclosure provides a compound having a STING agonistic activity, which may be expected to be useful as an agent for the prophylaxis or treatment of STING-related diseases.
The present disclosure relates to a compound represented by the formula (I): wherein each symbol is as defined in the description, or a salt thereof.

公开(公告)号：US20200010487A1

公开(公告)日：2020-01-09

申请号：US16576293

申请日：2019-09-19

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Satoshi Yamamoto ,  Junya Shirai ,  Mitsunori Kono ,  Yoshihide Tomata ,  Ayumu Sato ,  Atsuko Ochida ,  Yoshiyuki Fukase ,  Shoji Fukumoto ,  Tsuneo Oda ,  Hidekazu Tokuhara ,  Naoki Ishii ,  Yusuke Sasaki

IPC: C07F7/08 ,  C07D205/04 ,  C07D207/12 ,  C07K5/065 ,  C07K5/087

Abstract: The present invention relates to compound (I) or a salt thereof which has a RORγt inhibitory action. In the formula (I), each symbol is as defined in the specification.

公开(公告)号：US20190192549A1

公开(公告)日：2019-06-27

申请号：US16185258

申请日：2018-11-09

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： MASATO YOSHIKAWA ,  Morihisa Saitoh ,  Taisuke Kato ,  Yayoi Yoshitomi ,  Tomohiro Seki ,  Yasuo Nakagawa ,  Yusuke Tominari ,  Masaki Seto ,  Yusuke Sasaki ,  Masanori Okaniwa ,  Tsuneo Oda ,  Akito Shibuya ,  Kosuke Hidaka ,  Zenyu Shiokawa ,  Shumpei Murata ,  Atsutoshi Okabe ,  Yoshihisa Nakada ,  Michiyo Mochizuki ,  Brian Scott Freeze ,  Taisuke Tawaraishi ,  Yasufumi Wada ,  Paul D. Greenspan

IPC: A61K31/7084 ,  A61P35/00 ,  A61K47/68 ,  A61K31/7076

CPC classification number: A61K31/7084 ,  A61K31/7076 ,  A61K47/6807 ,  A61P35/00 ,  C07H21/00 ,  C07H21/02

Abstract: The present disclosure provides a compound having a STING agonistic activity, which may be expected to be useful as an agent for the prophylaxis or treatment of STING-related diseases.The present disclosure relates to a compound represented by the formula (I): wherein each symbol is as defined in the description, or a salt thereof.

公开(公告)号：US20170107240A1

公开(公告)日：2017-04-20

申请号：US14902388

申请日：2014-07-02

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Satoshi Yamamoto ,  Junya Shirai ,  Mitsunori Kono ,  Yoshihide Tomata ,  Ayumu Sato ,  Atsuko Ochida ,  Yoshiyuki Fukase ,  Shoji Fukumoto ,  Tsuneo Oda ,  Hidekazu Tokuhara ,  Naoki Ishii ,  Yusuke Sasaki

IPC: C07F7/08 ,  C07D205/04 ,  C07D207/12 ,  C07K5/065 ,  C07K5/087

Abstract: The present invention relates to compound (I) or a salt thereof which has a RORγt inhibitory action. In the formula (I), each symbol is as defined in the specification.