公开(公告)号：US10023544B2

公开(公告)日：2018-07-17

申请号：US15117539

申请日：2015-02-12

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Zenichi Ikeda ,  Minoru Sasaki ,  Keiko Kakegawa ,  Fumiaki Kikuchi ,  Yoichi Nishikawa

IPC: C07D261/04 ,  C07D413/10

Abstract: A fused heterocyclic compound having an enteropeptidase inhibitory action and use of the compound as a medicament for treatment or prophylaxis of obesity, diabetes mellitus, etc., are provided. Specifically, a compound represented by the following formula (I): wherein each symbol is as defined herein, or a salt thereof and use of the compound as a medicament for treatment or prophylaxis of obesity, diabetes mellitus, etc., are provided.

公开(公告)号：US09975903B2

公开(公告)日：2018-05-22

申请号：US15539607

申请日：2015-12-24

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Minoru Sasaki ,  Fumiaki Kikuchi ,  Zenichi Ikeda ,  Keiko Kakegawa ,  Yoichi Nishikawa ,  Shigekazu Sasaki ,  Koichiro Fukuda ,  Kazuaki Takami ,  Yoshihiro Banno ,  Masahiro Kamaura

IPC: C07D493/04 ,  C07D495/04 ,  C07D321/00 ,  C07D405/06 ,  C07D321/12 ,  C07D413/06 ,  C07D323/00 ,  C07D491/044 ,  C07D313/00 ,  C07D313/20

CPC classification number: C07D495/04 ,  A61K31/365 ,  A61K31/381 ,  A61K31/4025 ,  A61K31/422 ,  A61K31/662 ,  C07D313/00 ,  C07D313/20 ,  C07D321/00 ,  C07D321/12 ,  C07D323/00 ,  C07D405/06 ,  C07D409/12 ,  C07D413/06 ,  C07D491/044 ,  C07D493/04 ,  C07F9/655

Abstract: The present invention relates to a condensed heterocyclic compound that has an enteropeptidase inhibitory effect and is useful in the treatment or prevention of obesity, diabetes mellitus, or the like, and a medicament containing the same. Specifically, the present invention relates to a compound represented by the following formula (I) or a salt thereof, and a medicament containing the same [in the formula, each symbol is as defined in the specification].

公开(公告)号：US09346776B2

公开(公告)日：2016-05-24

申请号：US14619489

申请日：2015-02-11

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Zenichi Ikeda ,  Minoru Sasaki ,  Keiko Kakegawa ,  Fumiaki Kikuchi ,  Yoichi Nishikawa

IPC: C07D307/81

CPC classification number: C07D307/81

Abstract: A fused heterocyclic compound having an enteropeptidase inhibitory action and use of the compound as a medicament for treatment or prophylaxis of obesity, diabetes mellitus, etc., are provided.Specifically, a compound represented by the following formula (I): wherein each symbol is as defined herein, or a salt thereof and use of the compound as a medicament for treatment or prophylaxis of obesity, diabetes mellitus, etc., are provided.

Abstract translation: 提供具有肠肽酶抑制作用的稠合杂环化合物和该化合物作为治疗或预防肥胖症，糖尿病等的药物的用途。 具体地，提供由下式（I）表示的化合物：其中每个符号如本文所定义，或其盐，并且使用该化合物作为治疗或预防肥胖，糖尿病等的药物。

公开(公告)号：US09133129B2

公开(公告)日：2015-09-15

申请号：US14353622

申请日：2012-10-23

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Tohru Yamashita ,  Takuya Fujimoto ,  Ryo Mizojiri ,  Kazuko Yonemori ,  Hideki Hirose ,  Zenichi Ikeda ,  Ikuo Fujimori ,  Kyoko Toyofuku ,  Tsuneo Yasuma ,  Nobuyuki Matsunaga

IPC: A61K31/437 ,  C07D471/04 ,  C07D231/56 ,  A61K31/343 ,  A61K31/416 ,  A61K31/4184 ,  A61K31/422 ,  A61K31/423 ,  A61K31/4439 ,  C07D413/04 ,  C07D498/04 ,  C07D307/80 ,  C07D235/18 ,  C07D263/57 ,  C07D513/04

CPC classification number: C07D231/56 ,  A61K31/343 ,  A61K31/416 ,  A61K31/4184 ,  A61K31/422 ,  A61K31/423 ,  A61K31/437 ,  A61K31/4439 ,  C07D235/18 ,  C07D263/57 ,  C07D307/80 ,  C07D413/04 ,  C07D498/04 ,  C07D513/04

Abstract: The present invention provides a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.

Abstract translation: 本发明提供由式（I）表示的化合物：其中每个符号如说明书中所定义，或其盐。