公开(公告)号：US20220175907A1

公开(公告)日：2022-06-09

申请号：US17665285

申请日：2022-02-04

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

Inventor： Theodore Randolph ,  Robert Garcea ,  Kimberly J. Hassett

IPC: A61K39/12 ,  A61K39/295 ,  A61K45/06

Abstract: Embodiments of the present invention provide for novel compositions and methods for making and using a thermally stable human papilloma virus (HPV) formulation or other stabilized multimeric virus formulation. Certain embodiments concern lyophilizing HPV formulations in the presence or absence of adjuvants. Other embodiments concern lypophilizing HPV capsomere vaccines in order to increase stability of an immunogenic composition against HPV infection for storage, delivery and use. In yet other embodiments, a single immunogenic composition can include a thermally stable formulation of multiple virus serotypes. Yet other embodiments disclosed herein concern multi-targeted antigen complexes lyophilized in formulations of use to prolong stability and/or enhance immunogenicity. Other embodiments concern exposing lyophilized multi-targeted antigen complexes to elevated temperatures to enhance immunogenicity of the antigens of the complex to multiple pathogens.

公开(公告)号：US20220143170A1

公开(公告)日：2022-05-12

申请号：US17587953

申请日：2022-01-28

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BOYD CORPORATE

Inventor： Theodore Randolph ,  Robert Garcea ,  Kimberly J. Hassett

IPC: A61K39/12 ,  A61K39/295 ,  A61K45/06

Abstract: Embodiments of the present invention provide for novel compositions and methods for making and using a thermally stable human papilloma virus (HPV) formulation or other stabilized multimeric virus formulation. Certain embodiments concern lyophilizing HPV formulations in the presence or absence of adjuvants. Other embodiments concern lypophilizing HPV capsomere vaccines in order to increase stability of an immunogenic composition against HPV infection for storage, delivery and use. In yet other embodiments, a single immunogenic composition can include a thermally stable formulation of multiple virus serotypes.

公开(公告)号：US20190133954A1

公开(公告)日：2019-05-09

申请号：US16146686

申请日：2018-09-28

Applicant: The Regents of the University of Colorado, A body Corporate

Inventor： Theodore Randolph ,  Robert Garcea

IPC: A61K9/19 ,  A61K39/12 ,  A61K9/16 ,  C12N7/00

Abstract: Embodiments of the present invention provide for novel compositions and methods for making and using a thermally stable human papilloma virus (HPV) formulation or other stabilized multimeric virus formulation. Certain embodiments concern lyophilizing HPV formulations in the presence or absence of adjuvants. Other embodiments concern lypophilizing HPV capsomere vaccines in order to increase stability of an immunogenic composition against HPV infection for storage, delivery and use. In yet other embodiments, a single immunogenic composition can include a thermally stable formulation of multiple virus serotypes. Yet other embodiments disclosed herein concern multi-targeted antigen complexes lyophilized in formulations of use to prolong stability and/or enhance immunogenicity. Other embodiments concern exposing lyophilized multi-targeted antigen complexes to elevated temperatures to enhance immunogenicity of the antigens of the complex to multiple pathogens.

公开(公告)号：US20240226015A9

公开(公告)日：2024-07-11

申请号：US18372556

申请日：2023-09-25

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

Inventor： Theodore Randolph ,  Robert Garcea

IPC: A61K9/19 ,  A61K9/16 ,  A61K39/12 ,  A61K39/295 ,  A61K45/06 ,  C12N7/00

CPC classification number: A61K9/19 ,  A61K9/1623 ,  A61K9/1694 ,  A61K39/12 ,  A61K39/295 ,  A61K45/06 ,  C12N7/00 ,  A61K2039/5258

Abstract: Embodiments of the present invention provide for novel compositions and methods for making and using a thermally stable human papilloma virus (HPV) formulation or other stabilized multimeric virus formulation. Certain embodiments concern lyophilizing HPV formulations in the presence or absence of adjuvants. Other embodiments concern lyophilizing HPV capsomere vaccines in order to increase stability of an immunogenic composition against HPV infection for storage, delivery and use. In yet other embodiments, a single immunogenic composition can include a thermally stable formulation of multiple virus serotypes. Yet other embodiments disclosed herein concern multi-targeted antigen complexes lyophilized in formulations of use to prolong stability and/or enhance immunogenicity. Other embodiments concern exposing lyophilized multi-targeted antigen complexes to elevated temperatures to enhance immunogenicity of the antigens of the complex to multiple pathogens.

公开(公告)号：US11806432B2

公开(公告)日：2023-11-07

申请号：US17665285

申请日：2022-02-04

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

Inventor： Theodore Randolph ,  Robert Garcea

IPC: A61K9/16 ,  A61K9/19 ,  C12N7/00 ,  A61K39/12 ,  A61K39/295 ,  A61K45/06 ,  A61K39/00

CPC classification number: A61K9/19 ,  A61K9/1623 ,  A61K9/1694 ,  A61K39/12 ,  A61K39/295 ,  A61K45/06 ,  C12N7/00 ,  A61K2039/5252 ,  A61K2039/5258 ,  A61K2039/55505 ,  A61K2039/55572 ,  C12N2710/20034 ,  C12N2710/20063 ,  C12N2710/20071

Abstract: Embodiments of the present invention provide for novel compositions and methods for making and using a thermally stable human papilloma virus (HPV) formulation or other stabilized multimeric virus formulation. Certain embodiments concern lyophilizing HPV formulations in the presence or absence of adjuvants. Other embodiments concern lypophilizing HPV capsomere vaccines in order to increase stability of an immunogenic composition against HPV infection for storage, delivery and use. In yet other embodiments, a single immunogenic composition can include a thermally stable formulation of multiple virus serotypes. Yet other embodiments disclosed herein concern multi-targeted antigen complexes lyophilized in formulations of use to prolong stability and/or enhance immunogenicity. Other embodiments concern exposing lyophilized multi-targeted antigen complexes to elevated temperatures to enhance immunogenicity of the antigens of the complex to multiple pathogens.

公开(公告)号：US20220265810A1

公开(公告)日：2022-08-25

申请号：US17741894

申请日：2022-05-11

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

Inventor： Theodore W. Randolph ,  Robert Garcea ,  Alan W. Weimer

IPC: A61K39/12 ,  A61K9/50 ,  A61K39/02 ,  A61K39/39

Abstract: Embodiments of the present disclosure provide novel compositions, methods of use and methods for single composition, multi-dose, thermostable vaccine formulations. In certain embodiments, the present disclosure provides compositions and methods for dehydrating immunogenic agents in the presence of glass-forming agents, and coating the particles formed by the glass-forming agents. In other embodiments, the present disclosure provides for generating compositions for administering an immunogenic composition to a subject multiple times using a single immunogenic composition capable of time-release administration. In other embodiments, single-dose immunogenic agent-containing particles can be directed to two or more pathogens. In other embodiments, incompatible immunogenic agents against two or more different pathogens of immunogenic agent-containing particles disclosed herein can be mixed together and coated for timed-release administration to produce single-administration formulations capable of eliciting an immune response to the two or more pathogens in a subject.

公开(公告)号：US20210077611A1

公开(公告)日：2021-03-18

申请号：US16921253

申请日：2020-07-06

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

Inventor： Theodore Randolph ,  Robert Garcea ,  Kimberly Hassett

IPC: A61K39/12 ,  A61K39/295 ,  A61K45/06

Abstract: Embodiments of the present invention provide for novel compositions and methods for making and using a thermally stable human papilloma virus (HPV) formulation or other stabilized multimeric virus formulation. Certain embodiments concern lyophilizing HPV formulations in the presence or absence of adjuvants. Other embodiments concern lypophilizing HPV capsomere vaccines in order to increase stability of an immunogenic composition against HPV infection for storage, delivery and use. In yet other embodiments, a single immunogenic composition can include a thermally stable formulation of multiple virus serotypes.

公开(公告)号：US10751408B2

公开(公告)日：2020-08-25

申请号：US16079507

申请日：2017-02-23

Applicant: The Regents of the University of Colorado, a body corporate

Inventor： Theodore W. Randolph ,  Robert Garcea ,  Alan W. Weimer

IPC: G01N27/403 ,  C12Q1/68 ,  G01N27/414 ,  C12M1/34 ,  C12M3/00 ,  A61K39/12 ,  A61K9/50 ,  A61K39/02 ,  A61K39/39 ,  A61K39/00

Abstract: Embodiments of the present disclosure provide novel compositions, methods of use and methods for single composition, multi-dose, thermostable vaccine formulations. In certain embodiments, the present disclosure provides compositions and methods for dehydrating immunogenic agents in the presence of glass-forming agents, and coating the particles formed by the glass-forming agents. In other embodiments, the present disclosure provides for generating compositions for administering an immunogenic composition to a subject multiple times using a single immunogenic composition capable of time-release administration. In other embodiments, single-dose immunogenic agent-containing particles can be directed to two or more pathogens. In other embodiments, incompatible immunogenic agents against two or more different pathogens of immunogenic agent-containing particles disclosed herein can be mixed together and coated for timed-release administration to produce single-administration formulations capable of eliciting an immune response to the two or more pathogens in a subject.