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公开(公告)号：US20240157362A1
公开(公告)日：2024-05-16
申请号：US18382591
申请日：2023-10-23
Applicant: THE TEXAS A&M UNIVERSITY SYSTEM
Inventor： Arum Han , Adrian Guzman , Han Zhang , Jose Wippold , Jing Dai
IPC: B01L3/00
CPC classification number: B01L3/502784 , B01L2200/027 , B01L2200/0647 , B01L2200/12 , B01L2200/16 , B01L2400/086
Abstract: A combination micro/macro-fluidic analysis system with one or more of a droplet transition unit, a droplet cleaving unit, a droplet synchronization, and a merging unit to enable highly efficient complex droplet microfluidic assays.
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公开(公告)号：US20220097066A1
公开(公告)日：2022-03-31
申请号：US17239456
申请日：2021-04-23
Applicant: THE TEXAS A&M UNIVERSITY SYSTEM
Inventor： Arum Han , Adrian Guzman , Han Zhang , Jose Wippold , Jing Dai
IPC: B01L3/00
Abstract: A combination micro/macro-fluidic analysis system with one or more of a droplet transition unit, a droplet cleaving unit, a droplet synchronization, and a merging unit to enable highly efficient complex droplet microfluidic assays.
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公开(公告)号：US20250050353A1
公开(公告)日：2025-02-13
申请号：US18721660
申请日：2022-12-23
Applicant: The Texas A&M University System
Inventor： Arum Han , Can Huang , Adrian Ryan Guzman , Han Zhang , Jing Dai , Rohit Kunal Gupte
IPC: B03C5/02 , B01L3/00 , B03C5/00 , G01N27/447
Abstract: In an embodiment, the present disclosure pertains to a droplet system, apparatus, or fluid sample testing system to accomplish high-precision and high-efficiency droplet manipulation (e.g., greater than 99% platform operation efficiency). In some embodiments, the droplet system, apparatus, or fluid sample testing system includes at least one microfluidic channel or chamber and at least one interdigitated electrode (IDE) that can create a localized electric field below and/or within at least one fluidic channel or chamber. In some embodiments, this allows size-specific and/or size-dependent droplet manipulation.
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Patent Agency Ranking
公开(公告)号：US12121900B2
公开(公告)日：2024-10-22
申请号：US18382591
申请日：2023-10-23
Applicant: THE TEXAS A&M UNIVERSITY SYSTEM
Inventor： Arum Han , Adrian Guzman , Han Zhang , Jose Wippold , Jing Dai
IPC: B01L3/00
CPC classification number: B01L3/502784 , B01L2200/027 , B01L2200/0647 , B01L2200/12 , B01L2200/16 , B01L2400/086
Abstract: A combination micro/macro-fluidic analysis system with one or more of a droplet transition unit, a droplet cleaving unit, a droplet synchronization, and a merging unit to enable highly efficient complex droplet microfluidic assays.
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公开(公告)号：US20220364120A1
公开(公告)日：2022-11-17
申请号：US17745488
申请日：2022-05-16
Inventor： Arum Han , Jose Wippold , Bryn L. Adams
Abstract: In an embodiment, the present disclosure pertains to a microfluidic platform composed of a droplet generator having an entry point for donor particles and target particles, a first droplet incubation chamber in fluid communication with the droplet generator, a droplet detection functionality to allow for analysis of the inner content of droplets, and a droplet sorting functionality to allow for the separation of droplets based on the analysis of the inner content of droplets. In another embodiment, the present disclosure pertains to a method for cell-to-cell DNA, RNA, or other genetic material transfer through use of a water-in-oil emulsion microdroplet-based microfluidic platform for automation and high throughput identification or screening of genetic transfer outcomes utilizing the microfluidic platforms as disclosed herein.
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公开(公告)号：US20210221676A1
公开(公告)日：2021-07-22
申请号：US17065471
申请日：2020-10-07
Applicant: The Texas A&M University System
Inventor： Arum Han , Jose A. Wippold , Adrian R. Guzman , Can Huang , Dimitra Stratis-Cullum
Abstract: A microfluidic device includes a microfluidic channel formed in the microfluidic device and defined by a floor and a ceiling positioned vertically above the floor, wherein the microfluidic channel includes at least one fluid inlet configured to receive a fluid flow and at least one fluid outlet, and wherein at least one of the ceiling and the floor of the microfluidic channel is sloped relative to a horizontal plane.
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公开(公告)号：US10914727B2
公开(公告)日：2021-02-09
申请号：US15750022
申请日：2016-08-19
Applicant: The Texas A&M University System
Inventor： Arum Han , Paul J. de Figueiredo
Abstract: The microfluidic platform device of the claimed invention makes use of a high throughput lab-on-a-chip format to determine the functional profile of antibodies elicited by infection or vaccination against infection for any pathogen. It can be used to evaluate vaccines, evaluate whether vaccinated individuals show indices of protection, determine whether individuals display resistance or susceptibility to infection, discover new vaccine antigens, discover and test therapeutic interventions, or evaluate mechanisms of disease.
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公开(公告)号：US09822390B2
公开(公告)日：2017-11-21
申请号：US14438659
申请日：2013-10-28
Applicant: THE TEXAS A&M UNIVERSITY SYSTEM
Inventor： Arum Han , Hyun Soo Kim
CPC classification number: C12Q1/24 , B01L3/502753 , B01L2200/0668 , B01L2200/10 , B01L2300/0636 , B01L2300/0816 , B01L2300/0887 , B01L2300/123 , B01L2400/0655 , B01L2400/086 , C12M47/04 , G01N33/5005
Abstract: The subject invention pertains to a microfluidic apparatus and methods for screening and isolating a target cell from a population of cells. The apparatus comprises a first microfluidic layer comprising microfluidic channels; a second microfluidic layer comprising microfluidic channels; and a microfluidic cell analysis layer comprising a top hanging blocking structure located directly below each location where the first layer microfluidic channels overlap with the second layer microfluidic channels and a cell trap juxtaposed to each of the top hanging blocking structures. The top hanging blocking structures can close or open the juxtaposed cell trap when either or both the first or second layer microfluidic channels located directly above the top hanging blocking structure are sufficiently pressurized and/or sufficiently depressurized. The methods for screening and isolating a target cell from a population of cells comprise screening the population of cells using the apparatus and isolating the target cell interest therefrom.
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