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公开(公告)号：US20210407088A1
公开(公告)日：2021-12-30
申请号：US17447465
申请日：2021-09-13
Applicant: Topcon Corporation
Inventor： Zaixing Mao , Zhenguo Wang , Kinpui Chan , Jonathan Liu , Jongsik Kim
Abstract: A multimodal imaging system and method is capable of taking fundus images, automatically identifying regions of interest (ROIs) of the eye from the fundus images, and performing OCT imaging in the identified ROIs, where the OCT images can provide clinically relevant information for screening purposes. By automatically identifying the ROIs, expert intervention is not required to perform specialized OCT imaging and thus, such imaging and analysis can be provided at more facilities and for more subjects for a lower cost.
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公开(公告)号：US11185220B2
公开(公告)日：2021-11-30
申请号：US16845928
申请日：2020-04-10
Applicant: Topcon Corporation
Inventor： Zhenguo Wang , Zaixing Mao , Hideharu Suzuki , Kazuhiro Oomori , Makoto Fujino
Abstract: An ophthalmologic apparatus includes: an ophthalmologic apparatus body having: an objective lens that faces a subject's eye; a first illumination optical system that irradiates a cornea of the subject's eye with illumination light emitted from a first illumination light source along an optical axis overlapping an optical axis center of the objective lens; an interference image capturing camera that takes an image of a corneal reflection light through the objective lens and outputs an imaging signal; and a calculation unit that calculates, based on a corneal reflection image, of a corneal reflection light, input from the interference image capturing camera, a thickness of a tear fluid film at each position on the corneal surface; and a guide rail that supports the ophthalmologic apparatus body. The guide rail supports the ophthalmologic apparatus body in a rotatable manner such that an optical axis center of the objective lens is positioned obliquely with respect to a horizontal direction orthogonal to a gravity direction.
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公开(公告)号：US20210319551A1
公开(公告)日：2021-10-14
申请号：US16845307
申请日：2020-04-10
Applicant: TOPCON CORPORATION
Inventor： Song Mei , Zaixing Mao , Xin Sui , Zhenguo Wang , Kinpui Chan
Abstract: A method for generating clinically valuable analyses and visualizations of 3D volumetric OCT data by combining a plurality of segmentation techniques of common OCT data in three dimensions following pre-processing techniques. Prior to segmentation, the data may be subject to a plurality of separately applied pre-processing techniques.
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公开(公告)号：US11013401B2
公开(公告)日：2021-05-25
申请号：US16200676
申请日：2018-11-27
Applicant: Topcon Corporation
Inventor： Yasufumi Fukuma , Hideharu Suzuki , Zhenguo Wang , Kazuhiro Oomori , Makoto Fujino
Abstract: An ophthalmologic apparatus of some exemplary embodiments includes an illumination system, interference photographing system, anterior eye segment photographing system, first optical path coupling element, and controller. The illumination system projects illumination light output from a light source, onto the anterior eye segment of a subject's eye. The interference photographing system performs photographing of an interference pattern formed on the cornea by the illumination light. The anterior eye segment photographing system performs photographing of the anterior eye segment onto which the illumination light is being projected. The first optical path coupling element couples the optical path of the interference photographing system and the optical path of the anterior eye segment photographing system with one another. The controller controls a display device to display an interference image acquired by the interference photographing system, over an anterior eye segment image acquired by the anterior eye segment photographing system.
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公开(公告)号：US12186020B2
公开(公告)日：2025-01-07
申请号：US17594552
申请日：2020-04-24
Applicant: Topcon Corporation
Inventor： Zhenguo Wang , Zaixing Mao , Kazuhiro Oomori , Makoto Fujino
Abstract: An ophthalmologic apparatus includes: an objective lens that faces a subject's eye; an alignment light emitting unit that irradiates the subject's eye with alignment light to perform measurement of alignment between the objective lens and the subject's eye; an alignment reflection light receiving unit that receives alignment reflection light, which is a reflection of the alignment light from the subject's eye; an anterior segment camera that receives corneal reflection light; and a holder positioned between the anterior segment camera and the objective lens to hold the anterior segment camera, wherein the holder includes an imaging transmissive portion that transmits the corneal reflection light to the anterior segment camera, a first light-transmissive portion that transmits the alignment light from the alignment light emitting unit, and a second light-transmissive portion that transmits the alignment reflection light from the subject's eye.
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Patent Agency Ranking
公开(公告)号：US11972544B2
公开(公告)日：2024-04-30
申请号：US17318233
申请日：2021-05-12
Applicant: TOPCON CORPORATION
Inventor： Song Mei , Toshihiro Mino , Dawei Li , Zaixing Mao , Zhenguo Wang , Kinpui Chan
CPC classification number: G06T5/50 , A61B5/0066 , A61B5/0261 , A61B5/489 , A61B5/7267 , A61B5/742 , G01B9/02041 , G01B9/02091 , G06T7/33 , G06T2200/04 , G06T2207/10101 , G06T2207/20081 , G06T2207/20221 , G06T2207/30104
Abstract: Optical coherence tomography (OCT) angiography (OCTA) data is generated by one or more machine learning systems to which OCT data is input. The OCTA data is capable of visualization in three dimensions (3D) and can be generated from a single OCT scan. Further, motion artifact can be removed or attenuated in the OCTA data by performing the OCT scans according to special scan patterns and/or capturing redundant data, and by the one or more machine learning systems.
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公开(公告)号：US20220130021A1
公开(公告)日：2022-04-28
申请号：US17647527
申请日：2022-01-10
Applicant: Topcon Corporation
Inventor： Zaixing Mao , Zhenguo Wang , Kinpui Chan
Abstract: Ophthalmological images generated by coherent imaging modalities have multiple types of noise, including random noise caused by the imaging system and speckle noise caused by turbid objects such as living tissues. These noises can occur at different levels in different locations. A noise-reduction method and system of the present disclosure thus relates to applying different filters for different types of noise and/or different locations of images, sequentially or in parallel and combined, to produce a final noise-reduced image.
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公开(公告)号：US11302006B2
公开(公告)日：2022-04-12
申请号：US17103058
申请日：2020-11-24
Applicant: Topcon Corporation
Inventor： Zaixing Mao , Zhenguo Wang , Kinpui Chan , Yasufumi Fukuma
Abstract: A machine learning model is trained to identify the texture difference between the different layers of a multilayer object. By training with data in full 3D space, the resulting model is capable of predicting the probability that each pixel in a 3D image belongs to a certain layer. With the resulting probability map, comparing probabilities allows one to determine boundaries between layers, and/or other properties and useful information such as volume data.
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公开(公告)号：US11257190B2
公开(公告)日：2022-02-22
申请号：US16797848
申请日：2020-02-21
Applicant: Topcon Corporation
Inventor： Zaixing Mao , Zhenguo Wang , Kinpui Chan
Abstract: Ophthalmological images generated by coherent imaging modalities have multiple types of noise, including random noise caused by the imaging system and speckle noise caused by turbid objects such as living tissues. These noises can occur at different levels in different locations. A noise-reduction method and system of the present disclosure thus relates to applying different filters for different types of noise and/or different locations of images, sequentially or in parallel and combined, to produce a final noise-reduced image.
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公开(公告)号：US20210358096A1
公开(公告)日：2021-11-18
申请号：US17318233
申请日：2021-05-12
Applicant: TOPCON CORPORATION
Inventor： Song Mei , Toshihiro Mino , Dawei Li , Zaixing Mao , Zhenguo Wang , Kinpui Chan
Abstract: Optical coherence tomography (OCT) angiography (OCTA) data is generated by one or more machine learning systems to which OCT data is input. The OCTA data is capable of visualization in three dimensions (3D) and can be generated from a single OCT scan. Further, motion artifact can be removed or attenuated in the OCTA data by performing the OCT scans according to special scan patterns and/or capturing redundant data, and by the one or more machine learning systems.
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