公开(公告)号：US20210319551A1

公开(公告)日：2021-10-14

申请号：US16845307

申请日：2020-04-10

Applicant: TOPCON CORPORATION

Inventor： Song Mei ,  Zaixing Mao ,  Xin Sui ,  Zhenguo Wang ,  Kinpui Chan

IPC: G06T7/00 ,  G06T7/11 ,  G06T5/00 ,  A61B3/10

Abstract: A method for generating clinically valuable analyses and visualizations of 3D volumetric OCT data by combining a plurality of segmentation techniques of common OCT data in three dimensions following pre-processing techniques. Prior to segmentation, the data may be subject to a plurality of separately applied pre-processing techniques.

公开(公告)号：US11972544B2

公开(公告)日：2024-04-30

申请号：US17318233

申请日：2021-05-12

Applicant: TOPCON CORPORATION

Inventor： Song Mei ,  Toshihiro Mino ,  Dawei Li ,  Zaixing Mao ,  Zhenguo Wang ,  Kinpui Chan

IPC: G06T5/50 ,  A61B5/00 ,  A61B5/026 ,  G01B9/02 ,  G01B9/02091 ,  G06T7/33

CPC classification number: G06T5/50 ,  A61B5/0066 ,  A61B5/0261 ,  A61B5/489 ,  A61B5/7267 ,  A61B5/742 ,  G01B9/02041 ,  G01B9/02091 ,  G06T7/33 ,  G06T2200/04 ,  G06T2207/10101 ,  G06T2207/20081 ,  G06T2207/20221 ,  G06T2207/30104

Abstract: Optical coherence tomography (OCT) angiography (OCTA) data is generated by one or more machine learning systems to which OCT data is input. The OCTA data is capable of visualization in three dimensions (3D) and can be generated from a single OCT scan. Further, motion artifact can be removed or attenuated in the OCTA data by performing the OCT scans according to special scan patterns and/or capturing redundant data, and by the one or more machine learning systems.

公开(公告)号：US20210358096A1

公开(公告)日：2021-11-18

申请号：US17318233

申请日：2021-05-12

Applicant: TOPCON CORPORATION

Inventor： Song Mei ,  Toshihiro Mino ,  Dawei Li ,  Zaixing Mao ,  Zhenguo Wang ,  Kinpui Chan

IPC: G06T5/50 ,  G01B9/02 ,  G06T7/33 ,  A61B5/00 ,  A61B5/026

Abstract: Optical coherence tomography (OCT) angiography (OCTA) data is generated by one or more machine learning systems to which OCT data is input. The OCTA data is capable of visualization in three dimensions (3D) and can be generated from a single OCT scan. Further, motion artifact can be removed or attenuated in the OCTA data by performing the OCT scans according to special scan patterns and/or capturing redundant data, and by the one or more machine learning systems.

公开(公告)号：US11614321B2

公开(公告)日：2023-03-28

申请号：US16829673

申请日：2020-03-25

Applicant: TOPCON CORPORATION

Inventor： Jongsik Kim ,  Bin Cao ,  Song Mei ,  Kinpui Chan ,  Zhenguo Wang ,  Zaixing Mao

IPC: G01C1/04 ,  A61B3/10 ,  A61B3/113 ,  A61B3/14 ,  A61B3/12 ,  G01B11/06

Abstract: An interferometric method of identifying the thickness of an object that is too thin to be resolved by a Fourier transform of the interference signal includes applying a harmonic frequency modulation to an envelope of the interference signal. Where the object is a tear film, this method may be utilized to determine a thickness of the lipid layer of the tear film.

公开(公告)号：US20200309510A1

公开(公告)日：2020-10-01

申请号：US16829673

申请日：2020-03-25

Applicant: TOPCON CORPORATION

Inventor： Jongsik Kim ,  Bin Cao ,  Song Mei ,  Kinpui Chan ,  Zhenguo Wang ,  Zaixing Mao

IPC: G01B11/06 ,  A61B3/113 ,  A61B3/10 ,  A61B3/14

Abstract: An interferometric method of identifying the thickness of an object that is too thin to be resolved by a Fourier transform of the interference signal includes applying a harmonic frequency modulation to an envelope of the interference signal. Where the object is a tear film, this method may be utilized to determine a thickness of the lipid layer of the tear film.

公开(公告)号：US20240249393A1

公开(公告)日：2024-07-25

申请号：US18624782

申请日：2024-04-02

Applicant: TOPCON CORPORATION

Inventor： Song Mei ,  Toshihiro Mino ,  Dawei Li ,  Zaixing Mao ,  Zhenguo Wang ,  Kinpui Chan

IPC: G06T5/50 ,  A61B5/00 ,  A61B5/026 ,  G01B9/02 ,  G01B9/02091 ,  G06T7/33

CPC classification number: G06T5/50 ,  A61B5/0066 ,  A61B5/0261 ,  A61B5/489 ,  A61B5/7267 ,  A61B5/742 ,  G01B9/02041 ,  G01B9/02091 ,  G06T7/33 ,  G06T2200/04 ,  G06T2207/10101 ,  G06T2207/20081 ,  G06T2207/20221 ,  G06T2207/30104

Abstract: Optical coherence tomography (OCT) angiography (OCTA) data is generated by one or more machine learning systems to which OCT data is input. The OCTA data is capable of visualization in three dimensions (3D) and can be generated from a single OCT scan. Further, motion artifact can be removed or attenuated in the OCTA data by performing the OCT scans according to special scan patterns and/or capturing redundant data, and by the one or more machine learning systems.

公开(公告)号：US11751762B2

公开(公告)日：2023-09-12

申请号：US16719305

申请日：2019-12-18

Applicant: Topcon Corporation

Inventor： Jongsik Kim ,  Ying Dong ,  Song Mei ,  Kinpui Chan ,  Zhenguo Wang ,  Zaixing Mao

IPC: A61B3/10 ,  A61B3/14 ,  A61B3/12 ,  G01N21/17

CPC classification number: A61B3/102 ,  A61B3/1225 ,  A61B3/14 ,  G01N21/17 ,  G01N2021/1787

Abstract: A low coherence imaging method comprises acquiring image data of an object with an interferometric imaging system, where the image data is from a location of the object at first and second times; determining a first depth profile from the image data from the location at the first time and a second depth profile from the image data of the location at the second time; determining a change with respect to depth between the first and second depth profiles; and determining a property, or identifying a location, of at least one dynamic particle in the object based on the change between the first and second depth profiles. The method is able to identify, analyze, and/or visualize dynamic particles with features comparable to at least fluorescein angiography, indocyanine green angiography, confocal scanning laser fluorescein angiography, confocal scanning laser indocyanine green angiography, and fluorescence microscopy images, without the use of a dye.

公开(公告)号：US11361481B2

公开(公告)日：2022-06-14

申请号：US16574453

申请日：2019-09-18

Applicant: Topcon Corporation

Inventor： Song Mei ,  Zaixing Mao ,  Ying Dong ,  Zhenguo Wang ,  Kinpui Chan

IPC: G06T11/00 ,  G06T7/11 ,  G06T5/20 ,  G06T7/00

Abstract: Shadows caused by opacities and obstructions (such as blood vessels) can block detection of structural information of objects below the shadow-causing structure, affecting visualization and analysis of those deeper structures. An image processing method for removing these shadows includes applying a low pass filter to an energy profile of an image to remove high frequency fluctuations in energy, thereby effectively recovering lower energy inside shadow regions and removing high frequency speckle. The image is then adjusted, for example by linear scaling, based on the filtered energy profile. Two dimensional filters may also be applied for volumes.

公开(公告)号：US20210082163A1

公开(公告)日：2021-03-18

申请号：US16574453

申请日：2019-09-18

Applicant: Topcon Corporation

Inventor： Song Mei ,  Zaixing Mao ,  Ying Dong ,  Zhenguo Wang ,  Kinpui Chan

IPC: G06T11/00 ,  G06T7/00 ,  G06T5/20 ,  G06T7/11

Abstract: Shadows caused by opacities and obstructions (such as blood vessels) can block detection of structural information of objects below the shadow-causing structure, affecting visualization and analysis of those deeper structures. An image processing method for removing these shadows includes applying a low pass filter to an energy profile of an image to remove high frequency fluctuations in energy, thereby effectively recovering lower energy inside shadow regions and removing high frequency speckle. The image is then adjusted, for example by linear scaling, based on the filtered energy profile. Two dimensional filters may also be applied for volumes.