-
公开(公告)号：US09789083B2
公开(公告)日：2017-10-17
申请号：US15608557
申请日：2017-05-30
发明人： Masami Yamada , Shinkichi Suzuki , Takahiro Sugimoto , Minoru Nakamura , Hiroki Sakamoto , Makoto Kamata
IPC分类号： C07D209/46 , C07D401/10 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/04 , C07D405/14 , A61K31/4035 , A61K31/445 , A61K31/55 , A61K31/4439 , A61K31/325 , A61K31/4155 , A61K31/13
CPC分类号： C07D405/14 , A61K31/045 , A61K31/13 , A61K31/325 , A61K31/4035 , A61K31/4155 , A61K31/4406 , A61K31/4439 , A61K31/445 , A61K31/55 , C07D209/46 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/04 , C07D471/04
摘要： The present invention provides a compound having a cholinergic muscarinic M1 receptor positive allosteric modulator activity and useful as an agent for the prophylaxis or treatment of Alzheimer's disease, schizophrenia, pain, sleep disorder, Parkinson's disease dementia, dementia with Lewy bodies, and the like.The present invention relates to a compound represented by the formula (I) or a salt thereof. wherein each symbol is as described in the specification, or a salt thereof.
-
公开(公告)号：US09777005B2
公开(公告)日：2017-10-03
申请号：US14443598
申请日：2013-11-18
发明人： Takahiro Sugimoto , Minoru Nakamura , Hiroki Sakamoto , Shinkichi Suzuki , Masami Yamada , Makoto Kamata , Takuto Kojima , Ikuo Fujimori , Kenichiro Shimokawa
IPC分类号： C07D221/02 , A61K31/44 , C07D487/04 , C07D401/14 , C07D405/14 , C07D401/06 , C07D403/10 , C07D403/14 , C07D405/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D453/02 , C07D471/04 , C07D471/14 , C07D209/46 , C07D519/00
CPC分类号： C07D487/04 , C07D209/46 , C07D401/06 , C07D401/14 , C07D403/10 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D417/12 , C07D453/02 , C07D471/04 , C07D471/14 , C07D519/00
摘要： Provided is a compound having a cholinergic muscarinic M1 receptor positive allosteric modulator activity, and useful as a prophylactic or therapeutic drug for Alzheimer's disease, schizophrenia, pain, sleep disorder and the like. The present invention relates to a compound represented by the formula wherein ring A is a 4- to 7-membered ring optionally having substituent(s); L is —O—, —S—, —SO— or —SO2—; R1 is a C1-6 alkyl group optionally having substituent(s) (provided that when L is —O—, R1 is not a C1-6 alkyl group optionally substituted by halogen atom(s)), or a cyclic group optionally having substituent(s); X1 is —CRa═ or —N═; X2 is —CRb═ or —N═; X3 is —CRc= or —N═; Ra, Rb and Rc are each a C1-6 alkyl group, C2-6 alkenyl group, C1-6 alkoxy group, C3-6 cycloalkyl group, C3-6 cycloalkoxy group or C6-14 aryl group, each of which optionally having substituent(s), H or halogen, or a salt thereof.
-
公开(公告)号：US09675597B2
公开(公告)日：2017-06-13
申请号：US15291769
申请日：2016-10-12
发明人： Masami Yamada , Shinkichi Suzuki , Takahiro Sugimoto , Minoru Nakamura , Hiroki Sakamoto , Makoto Kamata
IPC分类号： C07D209/46 , C07D403/10 , C07D405/14 , C07D403/04 , C07D401/10 , C07D401/14 , A61K31/4439 , A61K31/4035 , A61K31/4155
CPC分类号： C07D405/14 , A61K31/045 , A61K31/13 , A61K31/325 , A61K31/4035 , A61K31/4155 , A61K31/4406 , A61K31/4439 , A61K31/445 , A61K31/55 , C07D209/46 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/04 , C07D471/04
摘要： The present invention provides a compound having a cholinergic muscarinic M1 receptor positive allosteric modulator activity and useful as an agent for the prophylaxis or treatment of Alzheimer's disease, schizophrenia, pain, sleep disorder, Parkinson's disease dementia, dementia with Lewy bodies, and the like.The present invention relates to a compound represented by the formula (I) or a salt thereof. wherein each symbol is as described in the specification, or a salt thereof.
-
公开(公告)号：US09655881B2
公开(公告)日：2017-05-23
申请号：US15388834
申请日：2016-12-22
发明人： Masami Yamada , Shinkichi Suzuki , Takahiro Sugimoto , Minoru Nakamura , Hiroki Sakamoto , Makoto Kamata
IPC分类号： C07D209/46 , C07D401/10 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/14 , A61K31/4035
CPC分类号： C07D405/14 , A61K31/045 , A61K31/13 , A61K31/325 , A61K31/4035 , A61K31/4155 , A61K31/4406 , A61K31/4439 , A61K31/445 , A61K31/55 , C07D209/46 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/04 , C07D471/04
摘要： The present invention provides a compound having a cholinergic muscarinic M1 receptor positive allosteric modulator activity and useful as an agent for the prophylaxis or treatment of Alzheimer's disease, schizophrenia, pain, sleep disorder, Parkinson's disease dementia, dementia with Lewy bodies, and the like.The present invention relates to a compound represented by the formula (I) or a salt thereof. wherein each symbol is as described in the specification, or a salt thereof.
-
公开(公告)号：US09315458B2
公开(公告)日：2016-04-19
申请号：US14693342
申请日：2015-04-22
发明人： Masami Yamada , Shinkichi Suzuki , Takahiro Sugimoto , Minoru Nakamura , Hiroki Sakamoto , Makoto Kamata
IPC分类号： C07D209/46 , C07D403/10 , C07D405/14 , C07D403/04 , C07D401/10 , C07D401/14
CPC分类号： C07D405/14 , A61K31/045 , A61K31/13 , A61K31/325 , A61K31/4035 , A61K31/4155 , A61K31/4406 , A61K31/4439 , A61K31/445 , A61K31/55 , C07D209/46 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/04 , C07D471/04
摘要： The present invention provides a compound having a cholinergic muscarinic M1 receptor positive allosteric modulator activity and useful as an agent for the prophylaxis or treatment of Alzheimer's disease, schizophrenia, pain, sleep disorder, Parkinson's disease dementia, dementia with Lewy bodies, and the like.The present invention relates to a compound represented by the formula (I) or a salt thereof. wherein each symbol is as described in the specification, or a salt thereof.
摘要翻译： 本发明提供了具有胆碱能毒蕈碱M1受体阳性变构调节剂活性的化合物，可用作预防或治疗阿尔茨海默病，精神分裂症，疼痛，睡眠障碍，帕金森病痴呆，路易体痴呆等。 本发明涉及由式（I）表示的化合物或其盐。 其中每个符号如说明书中所述或其盐。
-
公开(公告)号：US10548899B2
公开(公告)日：2020-02-04
申请号：US15769295
申请日：2016-10-19
发明人： Takahiro Sugimoto , Shinkichi Suzuki , Hiroki Sakamoto , Masami Yamada , Minoru Nakamura , Makoto Kamata , Kenichiro Shimokawa , Masaki Ogino , Eiji Kimura , Masataka Murakami , Takuto Kojima , Jinichi Yonemori
IPC分类号： A61K31/53 , A61K31/517 , C07D403/06 , C07D403/10 , C07D405/14 , C07D401/14 , C07D239/88 , C07D401/06 , A61P25/28 , A61P25/04 , A61P25/18 , A61P25/16
摘要： The present invention provides a compound which has a cholinergic muscarinic M1 receptor positive allosteric modulator activity and may be useful as a medicament such as an agent for the prophylaxis or treatment of Alzheimer's disease, schizophrenia, pain, sleep disorder, Parkinson's disease dementia, Lewy body dementia and the like. The present invention relates to a compound represented by the formula (I) or a salt thereof. In the formula (I), each symbol is as described in the attached specification.
-
公开(公告)号：US10323026B2
公开(公告)日：2019-06-18
申请号：US15474192
申请日：2017-03-30
发明人： Shuhei Ikeda , Hideyuki Sugiyama , Jumpei Aida , Hidekazu Tokuhara , Tomohiro Okawa , Yuya Oguro , Minoru Nakamura , Masataka Murakami
IPC分类号： C07D413/14 , C07D401/08 , C07D405/14 , C07D413/08 , C07D401/06 , C07D413/06
摘要： The present invention provides a compound having an MAGL inhibitory action, and useful as an agent for the prophylaxis or treatment of neurodegenerative diseases (e.g., Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, traumatic brain injury, glaucoma, multiple sclerosis etc.), anxiety disorder, pains (e.g., inflammatory pain, cancerous pain, neurogenic pain etc.), epilepsy, depression and the like.The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.
-
公开(公告)号：US09732086B2
公开(公告)日：2017-08-15
申请号：US14443598
申请日：2013-11-18
发明人： Takahiro Sugimoto , Minoru Nakamura , Hiroki Sakamoto , Shinkichi Suzuki , Masami Yamada , Makoto Kamata , Takuto Kojima , Ikuo Fujimori , Kenichiro Shimokawa
IPC分类号： C07D221/02 , A61K31/44 , C07D487/04 , C07D401/14 , C07D405/14 , C07D401/06 , C07D403/10 , C07D403/14 , C07D405/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D453/02 , C07D471/04 , C07D471/14 , C07D209/46 , C07D519/00
摘要： Provided is a compound having a cholinergic muscarinic M1 receptor positive allosteric modulator activity, and useful as a prophylactic or therapeutic drug for Alzheimer's disease, schizophrenia, pain, sleep disorder and the like. The present invention relates to a compound represented by the formula wherein ring A is a 4- to 7-membered ring optionally having substituent(s); L is —O—, —S—, —SO— or —SO2—; R1 is a C1-6 alkyl group optionally having substituent(s) (provided that when L is —O—, R1 is not a C1-6 alkyl group optionally substituted by halogen atom(s)), or a cyclic group optionally having substituent(s); X1 is —CRa═ or —N═; X2 is —CRb═ or —N═; X3 is —CRc= or —N═; Ra, Rb and Rc are each a C1-6 alkyl group, C2-6 alkenyl group, C1-6 alkoxy group, C3-6 cycloalkyl group, C3-6 cycloalkoxy group or C6-14 aryl group, each of which optionally having substituent(s), H or halogen, or a salt thereof.
-
公开(公告)号：US09499516B2
公开(公告)日：2016-11-22
申请号：US15013625
申请日：2016-02-02
发明人： Masami Yamada , Shinkichi Suzuki , Takahiro Sugimoto , Minoru Nakamura , Hiroki Sakamoto , Makoto Kamata
IPC分类号： C07D209/46 , C07D403/10 , C07D405/14 , C07D403/04 , C07D401/10 , C07D401/14 , C07D401/06 , C07D405/04
CPC分类号： C07D405/14 , A61K31/045 , A61K31/13 , A61K31/325 , A61K31/4035 , A61K31/4155 , A61K31/4406 , A61K31/4439 , A61K31/445 , A61K31/55 , C07D209/46 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/04 , C07D471/04
摘要： The present invention provides a compound having a cholinergic muscarinic M1 receptor positive allosteric modulator activity and useful as an agent for the prophylaxis or treatment of Alzheimer's disease, schizophrenia, pain, sleep disorder, Parkinson's disease dementia, dementia with Lewy bodies, and the like.The present invention relates to a compound represented by the formula (I) or a salt thereof. wherein each symbol is as described in the specification, or a salt thereof.
-
20.发明授权公开(公告)号：US10899752B2
公开(公告)日：2021-01-26
申请号：US16394762
申请日：2019-04-25
发明人： Takahiro Sugimoto , Shinkichi Suzuki , Hiroki Sakamoto , Masami Yamada , Minoru Nakamura , Makoto Kamata , Kenichiro Shimokawa , Masataka Murakami , Jinichi Yonemori , Takuto Kojima
IPC分类号： C07D413/14 , C07D413/04 , C07D413/06 , C07D413/10 , C07D417/06 , C07D471/04 , C07D491/107 , C07D265/22 , C07F7/02 , A61P25/28 , C07D417/10 , C07F7/08
摘要： The present invention provides a compound having a cholinergic muscarinic M1 receptor positive allosteric modulator activity, which may be useful as a prophylactic or therapeutic drug for Alzheimer's disease, schizophrenia, pain, sleep disorder, Parkinson's disease dementia, dementia with Lewy bodies and the like. The present invention relates to a compound represented by the formula (I) or a salt thereof: wherein each symbol is as defined in the attached DESCRIPTION.
-
-
-
-
-
-
-
-
-
搜索结果
29 条记录 (耗时 0.06 秒)
