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22 条记录 (耗时 0.032 秒)

    Glp-1 derivatives and transmicosal absorption preparations thereof
    16.
    发明申请
    Glp-1 derivatives and transmicosal absorption preparations thereof 失效
    Glp-1衍生物及其经半吸收制剂

    公开(公告)号：US20060194720A1

    公开(公告)日：2006-08-31

    申请号：US10530125

    申请日：2003-10-10

    申请人： Yuji Hayashi ,  Mitsuhiro Makino ,  Toshiyuki Kouzaki ,  Motohiro Takeda ,  Takahito Jomori

    发明人： Yuji Hayashi ,  Mitsuhiro Makino ,  Toshiyuki Kouzaki ,  Motohiro Takeda ,  Takahito Jomori

    IPC分类号： C07K14/605 ,  A61K38/22

    CPC分类号： C07K14/605 ,  A61K38/26 ,  Y10S514/866

    摘要： The invention relates to a GLP-1 derivative including an amino acid sequence of GLP-1 (7-35) having deletion, substitution and/or addition of one or more amino acids and having Waa-(Xaa)n-Yaa (in which Waa is Arg or Lys, Xaa is Arg or Lys, n is an integer of 0 to 14, and Yaa is Arg, Arg-NH2, Lys, Lys-NH2 or Hse) added to the C-terminus of the peptide having a GLP-1 activity. These derivatives are derivatives highly absorbable via a mucous membrane. In the invention, the GLP-1 derivative can be conferred with resistance to dipeptidyl peptidase IV by substituting amino acid 8 in its GLP-1 amino acid sequence with Ser, or with resistance to trypsin by substituting amino acids 26 and 34 with Gln and Asn, respectively. The efficiency of absorption of the GLP-1 derivatives of the invention via mucous membranes can be further improved by preparing a composition using a charge-regulated fat emulsion regulated to be negatively charged thereon.

    摘要翻译： 本发明涉及包含具有缺失，取代和/或添加一个或多个氨基酸并具有Waa-（Xaa）n-Yaa）的GLP-1（7-35）氨基酸序列的GLP-1衍生物（其中 Waa为Arg或Lys，Xaa为Arg或Lys，n为0〜14的整数，Yaa为Arg，Arg-NH 2 Lys，Lys-NH 2 >或Hse）加入具有GLP-1活性的肽的C末端。 这些衍生物是通过粘膜高度吸收的衍生物。 在本发明中，通过用Ser取代其GLP-1氨基酸序列中的氨基酸8或通过用Gln和Asn取代氨基酸26和34对胰蛋白酶具有抗性，GLP-1衍生物可赋予对二肽基肽酶IV的抗性 ， 分别。 本发明的GLP-1衍生物通过粘膜吸收的效率可以通过使用调节为带负电荷的电荷调节脂肪乳剂制备组合物而进一步改善。

    Digital camera image display apparatus and digital camera provided with the apparatus
    17.
    发明申请
    Digital camera image display apparatus and digital camera provided with the apparatus 失效
    数码相机图像显示装置和配备有该装置的数码相机

    公开(公告)号：US20050286884A1

    公开(公告)日：2005-12-29

    申请号：US11158988

    申请日：2005-06-22

    申请人： Koichi Otsuka ,  Ippei Yamauchi ,  Akira Suzuki ,  Motohiro Takeda ,  Kazuhiko Kanda

    发明人： Koichi Otsuka ,  Ippei Yamauchi ,  Akira Suzuki ,  Motohiro Takeda ,  Kazuhiko Kanda

    IPC分类号： G03B17/00 ,  G03B17/18 ,  H04N5/225

    CPC分类号： H04N5/2251

    摘要： A digital camera includes an imaging unit provided in a camera body to take an image electrically, an optical finder provided at an edge portion of the body, and a display apparatus provided in the body to display the taken image. The display apparatus includes a panel including a display area arranged nearer to a rear surface of the body than the imaging unit in the body, a projection projecting outwardly from a part of a periphery of the display area, a looking-out portion at a predetermined part of the projection, and a pixel drive unit for driving matrix pixels of the display area at the remaining part of the projection. In the body, the area of the panel corresponds to a window formed in the rear surface, the looking-out portion of the projection overlaps with the finder, and the drive unit is arranged in a side of the finder.

    摘要翻译： 数码相机包括：设置在照相机主体中以电摄影的成像单元，设置在身体的边缘部分处的光学取景器;以及设置在身体中以显示拍摄图像的显示装置。 该显示装置包括：面板，其包括布置成比身体中的成像单元更靠近身体的后表面的显示区域;从显示区域的周边的一部分向外突出的突出部， 投影的一部分，以及用于驱动投影的剩余部分的显示区域的矩阵像素的像素驱动单元。 在本体中，面板的区域对应于形成在后表面中的窗口，突出部的外观部分与取景器重叠，驱动单元布置在取景器的一侧。

    AGENT FOR PREVENTING OR TREATING CROHN'S DISEASE, COMPRISING ORGANIC ACID POLYMER
    18.
    发明申请
    AGENT FOR PREVENTING OR TREATING CROHN'S DISEASE, COMPRISING ORGANIC ACID POLYMER 审中-公开
    用于预防或治疗乳腺疾病的药剂，包含有机酸聚合物

    公开(公告)号：US20120244102A1

    公开(公告)日：2012-09-27

    申请号：US13514083

    申请日：2011-01-26

    申请人： Hiroyuki Hashimoto ,  Toshihiko Kumazawa ,  Motohiro Takeda ,  Takahito Jomori ,  Chihiro Hibi ,  Kuniharu Mizuno

    发明人： Hiroyuki Hashimoto ,  Toshihiko Kumazawa ,  Motohiro Takeda ,  Takahito Jomori ,  Chihiro Hibi ,  Kuniharu Mizuno

    IPC分类号： A61K31/765 ,  A61P1/04

    CPC分类号： A61K31/80

    摘要： The present invention is to provide an agent for treating Crohn's disease that is of unknown cause and for which no radical therapeutic drug is present. Provided is an agent for preventing or treating Crohn's disease, comprising an organic acid polymer represented by the following formula: [(O1/2)3Ge-A-CO2H]n, wherein n is 100-1,000, and A is a lower alkyl group. Preferably, A is a C1-C3 lower alkyl group and the degree of polymerization n is 200-900. The organic acid polymer according to the present invention is effective as an agent for treating Crohn's disease.

    摘要翻译： 本发明提供一种用于治疗克罗恩病的药剂，其原因不明，没有基础治疗药物存在。 本发明提供一种预防或治疗克罗恩病的药剂，其含有下式所示的有机酸聚合物：[（O1 / 2）3Ge-A-CO2H] n，其中n为100-1,000，A为低级烷基 。 优选地，A是C1-C3低级烷基，聚合度n是200-900。 根据本发明的有机酸聚合物作为治疗克罗恩病的药剂是有效的。

    GLP-1 derivative and preparation thereof absorbable via mucous membrane
    19.
    发明授权
    GLP-1 derivative and preparation thereof absorbable via mucous membrane 失效
    GLP-1衍生物及其可通过粘膜吸收的制剂

    公开(公告)号：US07291594B2

    公开(公告)日：2007-11-06

    申请号：US10530125

    申请日：2003-10-10

    申请人： Yuji Hayashi ,  Mitsuhiro Makino ,  Toshiyuki Kouzaki ,  Motohiro Takeda ,  Takahito Jomori

    发明人： Yuji Hayashi ,  Mitsuhiro Makino ,  Toshiyuki Kouzaki ,  Motohiro Takeda ,  Takahito Jomori

    IPC分类号： A61K38/26 ,  C07K14/605

    CPC分类号： C07K14/605 ,  A61K38/26 ,  Y10S514/866

    摘要： A GLP-1 derivative is provided including an amino acid sequence of GLP-1 (7-35) having deletion, substitution and/or addition of one or more amino acids and having Waa-(Xaa)n-Yaa (in which Waa is Arg or Lys, Xaa is Arg or Lys, n is an integer of 0 to 14, and Yaa is Arg, Arg-NH2, Lys, Lys-NH2 or Hse) added to the C-terminus of the peptide having a GLP-1 activity. These derivatives are highly absorbable via a mucous membrane. The GLP-1 derivative can be conferred with resistance to dipeptidyl peptidase IV by substituting amino acid 8 in its GLP-1 amino acid sequence with Ser, or with resistance to trypsin by substituting amino acids 26 and 34 with Gln and Asn, respectively.The absorption efficiency of the GLP-1 derivatives via mucous membranes can be further improved by preparing a composition using a charge-regulated fat emulsion regulated to be negatively charged thereon.

    摘要翻译： 提供GLP-1衍生物，其包含具有缺失，取代和/或添加一个或多个氨基酸并具有Waa-（Xaa）n-Yaa的GLP-1（7-35）的氨基酸序列（其中Waa为 Arg或Lys，Xaa是Arg或Lys，n是0-14的整数，Yaa是Arg，Arg-NH 2，Lys，Lys-NH 2或 Hse）加入具有GLP-1活性的肽的C末端。 这些衍生物通过粘膜是高度可吸收的。 通过用Ser取代其GLP-1氨基酸序列中的氨基酸8，或分别用Gln和Asn取代氨基酸26和34，对胰蛋白酶具有抗性，GLP-1衍生物可赋予对二肽基肽酶IV的抗性。 通过使用调节为带负电荷的电荷调节脂肪乳液制备组合物，可以进一步提高通过粘膜的GLP-1衍生物的吸收效率。