公开(公告)号：US4999196A

公开(公告)日：1991-03-12

申请号：US330990

申请日：1989-03-29

申请人： Hirofumi Nakano ,  Mitsunobu Hara ,  Isami Takahashi ,  Kozo Asano ,  Takao Iida ,  Makoto Morimoto

发明人： Hirofumi Nakano ,  Mitsunobu Hara ,  Isami Takahashi ,  Kozo Asano ,  Takao Iida ,  Makoto Morimoto

IPC分类号： A61K35/74 ,  A61K31/425 ,  A61P35/00 ,  C07D513/20 ,  C12P1/06 ,  C12P17/18 ,  C12R1/465

CPC分类号： C12P1/06 ,  Y10S435/886

摘要： A novel compound, DC-107, is produced by culturing a microorganism belonging to the genus Streptomyces. It is useful as a medicine because of its antibacterial and anti-tumor activity.

公开(公告)号：US4946957A

公开(公告)日：1990-08-07

申请号：US400883

申请日：1989-08-30

申请人： Hiromitsu Saito ,  Yoichi Uosaki ,  Akira Sato ,  Tadashi Hirata ,  Makoto Morimoto ,  Tadashi Ashizawa

发明人： Hiromitsu Saito ,  Yoichi Uosaki ,  Akira Sato ,  Tadashi Hirata ,  Makoto Morimoto ,  Tadashi Ashizawa

IPC分类号： A61K31/495 ,  A61P31/04 ,  C07D471/18 ,  C07D498/22

CPC分类号： C07D471/18 ,  C07D498/22

摘要： The present invention relates to novel derivatives of DC-52 represented by the following formula (I): ##STR1## [wherein X is chlorine, bromine, iodine, hydroxyl, formyl, hydroxyiminomethyl, cyano, nitro, amino or lower alkanoylamino; and Y is hydroxyl and Z is cyano, or Y and Z represent --O-- in the form of --Y--Z--]. These compounds and pharmacologically acceptable salts thereof have high anti-tumor activity.

公开(公告)号：US4863935A

公开(公告)日：1989-09-05

申请号：US131619

申请日：1987-12-11

申请人： Yasushi Shida ,  Tokuyuki Kuroda ,  Ikuo Matsukuma ,  Makoto Morimoto ,  Tadashi Ashizawa

发明人： Yasushi Shida ,  Tokuyuki Kuroda ,  Ikuo Matsukuma ,  Makoto Morimoto ,  Tadashi Ashizawa

IPC分类号： C07D487/04 ,  A61K31/40 ,  A61P35/00 ,  C07D487/14

CPC分类号： C07D487/14

摘要： Mitomycin derivatives having potent anti-tumor activity against solid sarcoma 180 tumors and lymphocytic leukemia P-388 tumors.

公开(公告)号：US4822882A

公开(公告)日：1989-04-18

申请号：US102359

申请日：1987-09-29

申请人： Hiromitsu Saito ,  Yoichi Uosaki ,  Akira Sato ,  Tadashi Hirata ,  Makoto Morimoto ,  Tadashi Ashizawa

发明人： Hiromitsu Saito ,  Yoichi Uosaki ,  Akira Sato ,  Tadashi Hirata ,  Makoto Morimoto ,  Tadashi Ashizawa

IPC分类号： C07D471/18 ,  C07D498/22 ,  A61K31/495 ,  C07D487/18

CPC分类号： C07D471/18 ,  C07D498/22

摘要： Compounds represented by the following formula or by the corresponding hydroquinone type formula: ##STR1## in which R.sup.1 and R.sup.2 are independently hydrogen, lower alkoxy, azido, amino, lower alkylamino, di-lower alkylamino, cyclic amino, lower alkylthio or unsubstituted or substituted arylthio; and X represents hydroxyl and Y represents cyano or X and Y together represents --O-- in the form of --X--Y--, have an excellent antitumor activity.

公开(公告)号：US4820824A

公开(公告)日：1989-04-11

申请号：US87128

申请日：1987-08-19

申请人： Motomichi Kono ,  Masaji Kasai ,  Yutaka Saito ,  Makoto Morimoto ,  Tadashi Ashizawa

发明人： Motomichi Kono ,  Masaji Kasai ,  Yutaka Saito ,  Makoto Morimoto ,  Tadashi Ashizawa

IPC分类号： A61K31/40 ,  A61K31/675 ,  A61P31/04 ,  A61P35/00 ,  C07D487/14 ,  C07F9/02 ,  C07F9/6561

CPC分类号： C07D487/14 ,  C07F9/6561

摘要： Mitomycin compound having potent antitumour activity having the formula: ##STR1## wherein ##STR2## (wherein Ra, Rb and Rc each independently represent lower alkyl, cycloalkyl having 3-7 carbon atoms or phenyl; or Ra and Rb are bonded together to form a poly-methylene group having 2-5 carbon atoms);one of R.sub.1 and R.sub.2 represents carbamoyloxymethyl and the other represents hydrogen; or R.sub.1 and R.sub.2 may together form an exocyclic methylene group;and Y and Z each independently represents hydrogen or methyl.

公开(公告)号：US4795908A

公开(公告)日：1989-01-03

申请号：US924758

申请日：1986-10-30

申请人： Makoto Morimoto ,  Mikio Kondo

发明人： Makoto Morimoto ,  Mikio Kondo

IPC分类号： G08B13/19 ,  G01J5/06

CPC分类号： G08B13/19 ,  Y10S250/01

摘要： An infrared detector is arranged so that a detection-input processing circuit part including an infrared sensor mounted on a circuit board is housed as isolated from ambient air in a chamber inhibiting any ambient air inflow, for sensing infrared rays emitted from a human body or the like object as condensed by a condenser irrespective of the ambient air conditions, the sensing ability of the infrared sensor the accuracy of which is likely to be easily deteriorated even with a very small change in the ambient temperature can be thereby stabilized, and a highly accurate infrared detection can be constantly achieved.

摘要翻译： 红外线检测器被布置成使得包括安装在电路板上的红外线传感器的检测输入处理电路部分被容纳在与环境空气隔离的室中，该室禁止任何环境空气流入，用于感测从人体发射的红外线或 像环境空气条件一样由冷凝器凝结的物体，即使环境温度的非常小的变化也可以容易地恶化其精度的红外传感器的感测能力，并且高度准确 可以不断实现红外检测。

公开(公告)号：US4649199A

公开(公告)日：1987-03-10

申请号：US697918

申请日：1985-02-04

申请人： Shinzo Ishii ,  Shigeo Katsumata ,  Yukou Arai ,  Kazuhisa Fujimoto ,  Makoto Morimoto

发明人： Shinzo Ishii ,  Shigeo Katsumata ,  Yukou Arai ,  Kazuhisa Fujimoto ,  Makoto Morimoto

IPC分类号： C07D498/22 ,  C12P17/18 ,  C12R1/465 ,  A61K31/495

CPC分类号： C07D498/22

摘要： A pharmacologically acceptable acid addition salt of DC-52 with 0.5-2.0 equivalent weight of inorganic acid, sulfonic acid, acidic amino acid, citric acid, transaconitic acid, .alpha.-ketoglutaric acid, itaconic acid, malonic acid or ascorbic acid on the basis of DC-52, having the same degree of antitumor activity as DC-52, is superior to DC-52 in stability at powdering or at preservation.

摘要翻译： 磺酸，酸性氨基酸，柠檬酸，经官能度酸，α-酮戊二酸，衣康酸，丙二酸或抗坏血酸的基础上，加入0.5〜2.0当量的DC-52的药理学上可接受的酸加成盐 与DC-52具有相同程度的抗肿瘤活性的DC-52在粉化或保存时的稳定性优于DC-52。

公开(公告)号：US5187186A

公开(公告)日：1993-02-16

申请号：US755760

申请日：1991-09-06

申请人： Yutaka Kanda ,  Youichi Uosaki ,  Hiromitsu Saito ,  Hiroshi Sano ,  Eiji Kobayashi ,  Makoto Morimoto ,  Satoru Nagamura

发明人： Yutaka Kanda ,  Youichi Uosaki ,  Hiromitsu Saito ,  Hiroshi Sano ,  Eiji Kobayashi ,  Makoto Morimoto ,  Satoru Nagamura

IPC分类号： C07D487/04 ,  C07D487/10

CPC分类号： C07D487/04 ,  C07D487/10

摘要： DC-88A derivatives represented by the general formula: ##STR1## wherein X represents hydrogen or CO.sub.2 R.sup.1 (in which R.sup.1 represents hydrogen, a straight-chain or branched alkyl having 1 to 4 carbon atoms, allyl, or benzyl); and ##STR2## have an excellent anti-tumor activity and are useful as anti-tumor agents.

摘要翻译： 其中X表示氢或CO 2 R 1（其中R 1表示氢，具有1至4个碳原子的直链或支链烷基，烯丙基或苄基）表示的DC-88A衍生物。 和 具有优异的抗肿瘤活性，可用作抗肿瘤剂。

公开(公告)号：US4992551A

公开(公告)日：1991-02-12

申请号：US435246

申请日：1989-11-13

申请人： Hiromitsu Saito ,  Akira Sato ,  Masaji Kasai ,  Makoto Morimoto ,  Tadashi Ashizawa

发明人： Hiromitsu Saito ,  Akira Sato ,  Masaji Kasai ,  Makoto Morimoto ,  Tadashi Ashizawa

IPC分类号： A61K31/495 ,  A61P31/04 ,  A61P35/00 ,  C07D471/18 ,  C07D498/22

CPC分类号： C07D471/18 ,  C07D498/22

摘要： Disclosed are DC-52 derivatives represented by the formula: ##STR1## wherein each of R.sup.1 and R.sup.2 independently represents hydrogen or hydroxyl, X represents hydroxyl and Y represents cyano and Z represents carboxyl or hydroxymethyl, or pharmacologically acceptable salts thereof. The DC-52 derivatives are useful as antitumor agents.

公开(公告)号：US4879386A

公开(公告)日：1989-11-07

申请号：US207639

申请日：1988-05-25

申请人： Hiromitsu Saito ,  Yoichi Uosaki ,  Akira Sato ,  Tadashi Hirata ,  Makoto Morimoto ,  Tadashi Ashizawa

发明人： Hiromitsu Saito ,  Yoichi Uosaki ,  Akira Sato ,  Tadashi Hirata ,  Makoto Morimoto ,  Tadashi Ashizawa

IPC分类号： A61K31/495 ,  A61P31/04 ,  C07D471/18 ,  C07D498/22

CPC分类号： C07D471/18 ,  C07D498/22

摘要： The present invention relates to novel derivatives of DC-52 represented by the following formula (I): ##STR1## ps [wherein X is chlorine, bromine, iodine, hydroxyl, formyl, hydroxyiminomethyl, cyano, nitro, amino or lower alkanoylamino; and Y is hydroxyl and Z is cyano, or Y and Z represent --O-- in the form of --Y--Z--]. These compounds and pharmacologically acceptable salts thereof have high anti-tumor activity.