公开(公告)号：US11247968B2

公开(公告)日：2022-02-15

申请号：US15265064

申请日：2016-09-14

Applicant: The Board of Regents of the University of Texas System

Inventor： Daniel J. Siegwart ,  Kejin Zhou

IPC: C07C321/14 ,  A61K47/59 ,  C07C323/52 ,  A61K9/51 ,  A61K31/7125 ,  A61K47/20 ,  A61K47/22 ,  C07D295/15

Abstract: Modular dendrimers with cationic groups and lipophilic groups are provided herein. In some aspects, the dendrimers provided herein may be formulated in compositions which contain a nucleic acid and one or more helper excipients. In some aspects, these compositions may also be used to treat diseases or disorders with a therapeutic nucleic acid.

公开(公告)号：US10017598B2

公开(公告)日：2018-07-10

申请号：US15662184

申请日：2017-07-27

Applicant: The Board of Regents of the University of Texas System

Inventor： Jinming Gao ,  David Boothman ,  Kejin Zhou ,  Xiaonan Huang ,  Yiguang Wang

IPC: A61K8/00 ,  C08F293/00 ,  C07D311/92 ,  A61K9/127 ,  A61K9/50 ,  A61K31/337 ,  A61K31/704 ,  A61K49/00 ,  A61K31/352 ,  A61K9/107 ,  A61K47/58 ,  A61K47/62 ,  A61K47/68 ,  C08F220/34

CPC classification number: C08F293/005 ,  A61K9/1075 ,  A61K9/1273 ,  A61K9/5031 ,  A61K31/337 ,  A61K31/352 ,  A61K31/704 ,  A61K47/58 ,  A61K47/62 ,  A61K47/6811 ,  A61K47/6845 ,  A61K49/0032 ,  A61K49/005 ,  A61K49/0054 ,  A61K49/0056 ,  A61K49/0082 ,  C07D311/92 ,  C08F220/34 ,  C08F2438/01

Abstract: Provided herein are block copolymers comprising a hydrophilic polymer segment and a hydrophobic polymer segment, wherein the hydrophilic polymer segment comprises a polymer selected from the group consisting of: poly(ethylene oxide) (PEO), poly(methacrylate phosphatidyl choline) (MPC), and polyvinylpyrrolidone (PVP), wherein the hydrophobic polymer segment comprises wherein R′ is —H or —CH3, wherein R is —NR1R2, wherein R1 and R2 are alkyl groups, wherein R1 and R2 are the same or different, wherein R1 and R2 together have from 5 to 16 carbons, wherein R1 and R2 may optionally join to form a ring, wherein n is 1 to about 10, and wherein x is about 20 to about 200 in total. Also provided are pH-sensitive micelle compositions for therapeutic and diagnostic applications.

公开(公告)号：US09517270B2

公开(公告)日：2016-12-13

申请号：US14962422

申请日：2015-12-08

Applicant: The Board of Regents of the University of Texas System

Inventor： Daniel J. Siegwart ,  Jing Hao ,  Kejin Zhou ,  Jason Miller ,  Petra Kos ,  Lian Xue

IPC: A61K47/34 ,  C07H21/02 ,  C07H21/04 ,  A61K47/28 ,  A61K47/24 ,  A61K47/22 ,  C08G65/48 ,  C08G63/91 ,  A61K31/713

CPC classification number: A61K47/34 ,  A61K9/0019 ,  A61K9/5153 ,  A61K31/713 ,  A61K47/22 ,  A61K47/24 ,  A61K47/28 ,  C08G63/688 ,  C08G63/912 ,  C08G65/48 ,  C12N15/113 ,  C12N2310/14

Abstract: Polymers produced by ring opening polymerization which comprises an amino group that can be used in compositions to deliver a nucleic acid such as a miRNA or a siRNA. In some embodiments, compositions which comprise the polymers described herein and a nucleic acid are also provided herein. In some embodiments, these compositions are used to silence one or more genes in vivo or treat a disease or disorder.

Abstract translation: 通过开环聚合制备的聚合物，其包含可用于递送核酸如miRNA或siRNA的组合物中的氨基。 在一些实施方案中，本文还提供了包含本文所述的聚合物和核酸的组合物。 在一些实施方案中，这些组合物用于在体内沉默一种或多种基因或治疗疾病或病症。